Jacques De Mouzon

French Institute of Health and Medical Research | Inserm

Research question: What part do maternal context and medically assisted reproduction (MAR) techniques play in the risk of fetal growth disorders? Design: This retrospective nationwide cohort study uses data available in the French National Health System database and focuses on the period from 2013 to 2017. Fetal growth disorders were divided int...

Research question: What are the risk factors for prematurity other than intrauterine growth restriction in singletons after IVF? Design: Data were collected from a national registry, based on an observational prospective cohort of 30,737 live births after assisted reproductive technology (fresh embryo transfers: n = 20,932 and frozen embryo tran...

Objective To determine whether pregnancies with donated embryos are at a higher risk of complications than the pregnancies from autologous frozen-thawed embryo transfer (FET). Design Anonymous, multicenter, comparative, observational, retrospective, matched-cohort study. Setting Six French assisted reproductive technique centers from 2003 to 2018...

STUDY QUESTION What are the data and trends on ART and IUI cycle numbers and their outcomes, and on fertility preservation (FP) interventions, reported in 2018 as compared to previous years? SUMMARY ANSWER The 22nd ESHRE report shows a continued increase in reported numbers of ART treatment cycles and children born in Europe, a decrease in transfe...

Background To the best of our knowledge, no study has exhaustively evaluated the association between maternal morbidities and Coronavirus Disease 2019 (COVID-19) during the first wave of the pandemic in pregnant women. We investigated, in natural conceptions and assisted reproductive technique (ART) pregnancies, whether maternal morbidities were mo...

STUDY QUESTION What were the utilization, effectiveness and safety of practices in assisted reproductive technologies (ART) globally in 2014 and what global trends could be observed? SUMMARY ANSWER The estimated total number of ART cycles conducted in 76 participating countries in 2014 was 1.93 million representing ∼66% of global activity, with 5-...

Study question Is there an increased risk of preeclampsia after Frozen-thawed Embryo Transfer(FET) compared to In Vitro Fertilization-fresh transfer(IVF-fresh-ET) according to endometrial type of preparation for FET? Summary answer The frequency of preeclampsia and hypertension were significantly higher in the group of artificial cycle (AC-FET) co...

STUDY QUESTION What are the data on ART and IUI cycles, and fertility preservation (FP) interventions reported in 2017 as compared to previous years, as well as the main trends over the years? SUMMARY ANSWER The 21st ESHRE report on ART and IUI shows the continual increase in reported treatment cycle numbers in Europe, with a decrease in the propo...

Collecting and reporting data is a crucial aspect of IVF practice. During the following two decades after the first report of European IVF-monitoring Consortium (EIM) on IVF data, the number of contributing countries increased gradually reaching nearly fourty. In 2004 for the first time Turkey took part in European registry and accordingly in World...

Objective To report the utilization, effectiveness, and safety of practices in assisted reproductive technology (ART) globally in 2013 and assess global trends over time. Design Retrospective, cross-sectional survey on the utilization, effectiveness, and safety of ART procedures performed globally during 2013. Setting Seventy-five countries and 2...

Study question: Do IVF, IUI or female infertility (i.e. endometriosis, polycystic ovary syndrome [PCOS] and primary ovarian insufficiency [POI]) lead to an increased risk of congenital anomalies in singletons? Summary answer: After multivariable adjustments, the increased risks of congenital defects associated with IUI were no longer significant...

Background Epidemiological studies suggest that singletons born from assisted reproductive technologies (ART) have a high risk of adverse perinatal outcomes, specifically for imprinting disorders. Because ART processes take place at times when epigenetic reprogramming/imprinting are occurring, there is concern that ART can affect genomic imprints....

Research question Does endometriosis increase obstetric and neonatal complications, and does assisted reproductive technology (ART) cause additional risk of maternal or fetal morbidity? Design A nationwide cohort study (2013–2018) comparing maternal and perinatal morbidities in three groups of single pregnancies: spontaneous pregnancies without en...

Study question: What was the utilization, effectiveness and safety of practices in ART globally in 2012 and what global trends could be observed? Summary answer: The total number of ART cycles increased by almost 20% since 2011 and the main trends were an increase in frozen embryo transfers (FET), oocyte donation, preimplantation genetic testing...

Résumé Objectifs: Depuis l’autorisation aux nullipares françaises de faire un don d’ovocytes, qui sont les nouvelles donneuses? Quels sont les points similaires et différentiels avec les donneuses initiales ayant déjà procréé? Méthodes: étude de cohorte rétrospective multicentrique à partir d’un questionnaire. Résultats: Le taux de réponse est de 9...

This commentary outlines the importance of utilization of assisted reproductive technology as an indicator of access to infertility care and provides a standard way of reporting utilization to facilitate international comparisons. Factors that influence ART utilization as well as underlying inequalities and inequities in access to care are discusse...

Objectives: The objective of this study was to quantify the risk of maternal and perinatal morbidity with in vitro fertilization (IVF) technology compared to non-IVF pregnancies in a recent French national cohort. Method: The data was extracted from the hospital information data system, including all pregnancies with a delivery from 2013 to 2016...

Controlled ovarian hyperstimulation adversely affects clinical outcome in ART cycles with fresh transfer (FT) in comparison with frozen embryo transfer (FRET) cycles probably due to the abnormal concentrations of estradiol and progesterone that may alter endometrial receptivity. Design Prospective observational study (2012-2014) between two groups...

Objective To evaluate the influence of body mass index (BMI) on semen characteristics. Design Cohort study. Setting Single private andrology laboratory. Patient(s) All patients (n = 10,665) consulting for a semen analysis from October 9, 2010, to October 8, 2011. When analyses were repeated on the same patient, only the first was included. Inte...

STUDY QUESTION The 14th European IVF—monitoring (EIM) report presents the results of medically assisted reproduction treatments including assisted reproductive technology (ART) cycles and intrauterine insemination (IUI) cycles initiated in Europe during 2010: are there changes in the trends compared with previous years?

STUDY QUESTION: The 14th European IVF-monitoring (EIM) report presents the results of medically assisted reproduction treatments including assisted reproductive technology (ART) cycles and intrauterine insemination (IUI) cycles initiated in Europe during 2010: are there changes in the trends compared with previous years? SUMMARY ANSWER: Despite som...

Do the socio-demographic and fertility-related characteristics and motivations of oocyte donors differ in European countries? The socio-demographic and fertility-related characteristics and motivations of oocyte donors differ considerably across countries. There have been no other international studies comparing the characteristics of oocyte donors...

A retrospective study carried on a large sample of men close to the general population recently showed a significant and strong decline in sperm concentration and morphology in the whole of France between 1989 and 2005. We studied these trends within each French region.Data were provided from the Fivnat database. The study sample was constituted by...

STUDY QUESTION Have changes in assisted reproductive technology (ART) practice and outcomes occurred globally between 2003 and 2004? SUMMARY ANSWER Globally, ART practice has changed with an increasing prevalence of the use of ICSI rather than conventional IVF. In 2004, a small but increasing number of countries are incorporating single embryo tra...

This 11th European IVF-monitoring report presents the results of assisted reproductive technology (ART) treatments initiated in Europe during 2007. From 33 countries, 1029 clinics reported 493 184 treatment cycles: IVF (120 761), ICSI (256 642), frozen embryo replacement (91 145), egg donation (15 731), preimplantation genetic diagnosis/preimplanta...

For abstracts see the DOI resource. https://doi.org/10.1093/humrep/26.s1.75

This paper outlines ESHRE's guidance for centers and physicians providing fertility treatment to foreign patients. This guide aims to ensure high-quality and safe assisted reproduction treatment, taking into account the patients, their future child and the interests of third-party collaborators such as gametes donors and surrogates. This is achieve...

L’infertilité est, depuis plusieurs années, considérée par l’Organisation médicale de la santé comme une pathologie à part entière, dans le cadre du concept de santé reproductive qui reconnaît à chaque être humain le droit à la procréation (1). Elle est le siège de nombreux enjeux de société, et tout ce qui la concerne est fortement médiatisé, nota...

In this 10th European IVF-monitoring (EIM) report, the results of assisted reproductive techniques from treatments initiated in Europe during 2006 are presented. Data were mainly collected from existing national registers. From 32 countries, 998 clinics reported 458 759 treatment cycles including: IVF (117 318), ICSI (232 844), frozen embryo replac...

This is the eleventh report of the European IVF-monitoring (EIM), the ESHRE register on assisted reproductive techniques (ART) organization. This report deals with the results of treatments initiated during 2007. Methods Data were collected from existing national registries in 31 countries and directly entered by each national coordinator into the...

Introduction: Recently, many efforts have been done to help young patients to preserve their fertility through the storage of their own germ cells before chemo-and/or radiotherapy partially or completely destroys their follicular reserve. To this end whole ovary or ovarian cortical strip may be cryopreserved and transplanted in order to recovery t...

The quantity and the reasons for seeking cross border reproductive care are unknown. The present article provides a picture of this activity in six selected European countries receiving patients. Data were collected from 46 ART centres, participating voluntarily in six European countries receiving cross border patients. All treated patients treated...

For men presenting azoospermia, the development of ICSI with epidydimal (MESA) or testicular (TESE) sperm, allowed them to father their own progeny. Little is known about the issue of these ICSI, in terms of efficiency and quality of the conceptus, and many controversies remain. Some studies emphasized that children born after Assisted Reproductive...

Many definitions used in medically assisted reproduction (MAR) vary in different settings, making it difficult to standardize and compare procedures in different countries and regions. With the expansion of infertility interventions worldwide, including lower resource settings, the importance and value of a common nomenclature is critical. The obje...

For men presenting azoospermia, the development of ICSI with epidydimal (MESA) or testicular (TESE) sperm, allowed them to father their own progeny. Little is known about the issue of these ICSI, in terms of efficiency and quality of the conceptus, and many controversies remain. Some studies emphasized that children born after Assisted Reproductive...

In a preliminary, unpublished randomized study conducted in 2000 on 39 patients, including a placebo group, it was observed that the addition of growth hormone (GH) during ovarian stimulation in patients with poor-quality oocytes increased the pregnancy rate. However, the results were not statistically significant due to the small number of patient...

Results of assisted reproductive techniques from treatments initiated in Europe during 2005 are presented in this ninth report. Data were mainly collected from existing national registers. From 30 countries, 923 clinics reported 418 111 treatment cycles including: IVF (118 074), ICSI (203 329), frozen embryo replacement (79 140), oocyte donation (E...

European results of assisted reproductive techniques from treatments initiated during 2004 are presented in this eighth report. Data were mainly collected from existing national registers. From 29 countries, 785 clinics reported 367,066 treatment cycles including: IVF (114,672), ICSI (167,192), frozen embryo replacement (FER, 71,997), egg donation...

European results of assisted reproductive techniques (ARTs) from treatments initiated during 2003 are presented in this seventh report. Data were mainly collected from already existing national registers. From 28 countries, 725 clinics reported 365 103 treatment cycles with: IVF 132 932, ICSI 162 149, frozen embryo replacement (FER) 60 412, oocyte...

European results of assisted reproductive techniques (ART) from treatments initiated during 2002 are presented in this sixth report. Data was mainly collected from already existing national registers. From 25 countries, 631 clinics reported 324,238 treatment cycles with: IVF 122,634, ICSI 135,048, frozen embryo replacement (FER) 57 162, egg donatio...

To investigate paternal age effect mediated by biological modifications with use of data from assisted reproductive technologies. National IVF registry. Fifty nine French IVF centers. A total of 1,938 men whose partners were totally sterile, with bilateral tubal obstruction or absence of both tubes (to avoid bias sampling in analysis of paternal ag...

European results of assisted reproductive techniques from treatments initiated during 2001 are presented in this fifth report. Data were collected mainly from already existing national registers. From 23 countries, 579 clinics reported 289 690 cycles with: IVF 120 946, ICSI 114 378, frozen embryo transfer (FER) 47 195 and egg donation (ED) 7171. Ov...

The proportion of women over 40 in IVF and in ICSI has been dramatically increasing to reach 12% in 2002. Tubal and unexplained infertility increases with age. Short protocols or protocols with GnRH antagonists are more and more often used for older women. Best results are nevertheless still obtained with long protocols! Up to 35 years, pregancy ra...

L'efficacité des antagonistes du GnRH, connus pour leur action préventive d'une montée indésirable de LH, a été l'objet de nombreuses discussions. La méta-analyse de Al-Inany en 2002, le registre allemand d'AMP et les résultats colligés par FIVNAT présentés à la FFER en 2003 montrent une diminution significative du taux de grossesse chez les femmes...

European results of assisted reproductive techniques from treatments initiated during 1999, are presented in this third report. Data were collected mainly from pre-existing national registers. From 22 countries 538 clinics reported 258 460 cycles: IVF 125 370, ICSI 95 221, frozen embryo replacement (FER) 34 002 and oocyte donations (OD) 3867. In ei...

The existence of a male excess among preterm births is interesting because it could shed light on the aetiology of preterm birth. Possible mechanisms are greater body weight, increased susceptibility to complications of pregnancy, sex-linked biochemical processes and earlier conception in the fertile cycle. We measured the association between fetal...

This prospective study aimed to evaluate the impact of oocyte dysmorphy on the fertilization rate and embryonic development rate in an ICSI programme. Three hundred and two couples have been included during 302 ICSI cycles, and 1970 oocytes have been studied in 4 ART centres. After decoronisation, 18 morphological criteria, including the size and s...

Cigarette smoking is a well recognised cause of mortality and of morbidity, and an increasing number of studies are also in favour of a deleterious action on human reproduction. In natural fertility, most of the papers conclude to an increased time to pregnancy and to a decreased fertility rate of 10% to 20%, with a relationship between the number...

Variations of the male partner fertility according to his age are difficult to study, because of bias represented by some decrease of both sexual activity and fecundity of the female partner beyond 35 years old. The few studies which are available show that sperm concentration as percentage of normal forms, are stable with age. The percentage of mo...

In all species, seasonal patterns in fertility are observed. In humans, seasonal variations of pregnancies are observed in spontaneous reproduction or in IVF. The most important factor seems to be sperm values and specially the morphology. Our study, on 188,075 cases (FIVNAT 1987-1995) shows significant variations of semen characteristics: we obser...

The mean age of IVF patients women and men is always increasing, this is probably due to the late desire for pregnancy nowadays. Pregnancy rate decreases with the age of wife and in a minor way with the age od man. The most important factor is the quality of woman answer to ovarian stimulation. Among women of 42 or over, the one with a high estradi...

The in vitro fertilization (IVF) model allows to differentiate the pregnancy factors related to the fertilization from those related to the implantation. The French national register on IVF has collected, since 1986, individual information on 160,000 oocyte recovery cycles and 12,000 pregnancies. The average implantation rate is 11.4% per embryo. N...

PIP In France, two Paris-based physicians conducted a nationwide survey between November 30 and December 5, 1995, of 120 gynecologists (GYNs) and 262 general practitioners (GPs) to determine whether certain types of oral contraceptives (OCs) are more likely to be prescribed to women with a relative increased risk of venous thromboembolism (VTE). 88...

Objective: To describe the characteristics of pregnancies and children at birth resulting from IVF-ET and to assess whether they differ from those after natural conception. Design: Prospective multicenter survey. Setting: A national registry, representing 80% of all French IVF-ET activity for the period 1986 to 1990. Patients: Data on 7,024 pregnan...

To assess the ability of a new third-generation GnRH antagonist, Cetrorelix (Asta Medica AG, Frankfurt am Main, Germany), to postpone the LH surge after a single injection during the late follicular phase. A single 5-mg (group 1, n = 7) or 3-mg (group 2, n = 3) dose SC of Cetrorelix was administered during the late follicular phase, on the day of t...

Objective: To obtain a broad knowledge of IVF practice in France and to analyze the main success factors. Design: Prospective study. Setting: A national IVF registry was established in France in January 1986 and has been in operation since that time. Patients: Data on more than 77,000 assisted reproductive technology (ART) cycles were collected fro...

To examine the relation of noncontraceptive estrogen use to the risk of breast cancer among postmenopausal women, the authors conducted a case-control study: 1,686 cases were compared with 2,077 hospital control subjects, of whom 1,120 had non-gynecologic cancers and 957 had nonmalignant (also non-gynecologic) conditions. Data were obtained from 19...

Protocol was carried out on 98 patients who were divided into three groups selected as (one control group, two "placebo" group, and three treated with acupuncture). This protocol showed that it was possible to improve cervical maturation if acupuncture sessions were carried out at the beginning of the 9th month. The Bishop scores in the three group...

To examine the relation of noncontraceptive estrogen use to the risk of breast cancer among postmenopausal women, the authors conducted a case-control study: 1,686 cases were compared with 2,077 hospital control subjects, of whom 1,120 had non-gynecologic cancers and 957 had nonmalignant (also non-gynecologic) conditions. Data were obtained from 19...