Jacques Cohen

Jacques Cohen
ART Institute of Washington Inc, Althea Inc, Reprogenetics Inc, LifeGlobal LLC

PhD, HCLD

About

436
Publications
44,036
Reads
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24,760
Citations

Publications

Publications (436)
Poster
P-085 Use of an artificial intelligence tool to assess single-sperm motility variables related to bias preference of ICSI sperm selection practice, normal fertilization, and blastocyst formation Study question: Which single-sperm WHO motility variables are associated with ICSI sperm selection preference, normal fertilization, and blastocyst formati...
Poster
P-249 The location of fragments and degraded zones in blastocysts is associated with ploidy: moving towards explaining an AI-based morphology tool trained on euploidy outcomes. Study question Is the location of degraded areas or fragments an indication of ploidy in blastocyst images? Summary answer Degradation traces observed in a blastocyst’s inn...
Article
Study question Does ERICA’s prognosis ranking based on ploidy, predict early miscarriage following positive biochemical pregnancy test? Summary answer The lower ERICA grades embryos, the higher the likelihood of early miscarriage, irrespective of age group. What is known already The vast majority of early miscarriages are due to aneuploidy, but p...
Article
Study question How does ERICA perform when ranking the most suitable embryos for transfer in terms of clinical pregnancy, and the presence of a fetal heartbeat (FHB)? Summary answer ERICA’s Artificial Intelligence ranking system was positively correlated with outcomes defined as implantation and presence of FHB. Best-ranking embryos outperformed l...
Article
Study question Can real-time artificial vision identify beneficial movement patterns of single spermatozoa in a cohort visualized in PVP during ICSI possibly enhancing fertilization and embryo development? Summary answer Artificial vision seems able to identify advantageous movement patterns of individual spermatozoa having a significant impact on...
Article
Study question Can ERICA’s deep-learning capabilities allow it to learn specifics from individual clinics, and improve its performance through a quality assurance and fine-tuning process? Summary answer Quality assurance and fine-tuning allowed ERICA to adapt to unique specifications of individual clinics, resulting in an improved performance at e...
Article
This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the history, achievements, and medical advancements made over the last 40 years in this rapidly growing field.
Article
Cambridge Core - Obstetrics and Gynecology, Reproductive Medicine - In-Vitro Fertilization - edited by Gabor Kovacs
Article
Full-text available
This proceedings report presents the outcomes from an international Expert Meeting to establish a consensus on the recommended technical and operational requirements for air quality within modern assisted reproduction technology (ART) laboratories. Topics considered included design and construction of the facility, as well as its heating, ventilati...
Article
Objective: To compare two commonly used protocols (fresh vs. vitrified) used to transfer euploid blastocysts after IVF with preimplantation genetic screening. Design: Randomized controlled trial. Setting: Private assisted reproduction center. Patient(s): A total of 179 patients undergoing IVF treatment using preimplantation genetic screening...
Article
Full-text available
Experimental ooplasmic transplantation from donor to recipient oocyte took place between 1996 and 2001 at Saint Barnabas Medical Center, USA. Indication for 33 patients was repeated implantation failure. Thirteen couples had 17 babies. One patient delivered twins from mixed ooplasmic and donor egg embryos. A limited survey-based follow-up study on...
Article
Preimplantation genetic diagnosis of aneuploidy (PGD-A) with comprehensive chromosome analysis has been known to improve pregnancy outcomes. Accuracy in detecting sex chromosomes becomes important when selecting against embryos at risk for sex-linked disorders. A total of 21,356 PGD-A cycles consisting of day-3 (cleavage) or day-5 (blastocyst) biop...
Article
Full-text available
Study hypothesis We wanted to probe the opinions and current practices on preimplantation genetic screening (PGS), and more specifically on PGS in its newest form: PGS 2.0. Study finding Consensus is lacking on which patient groups, if any at all, can benefit from PGS 2.0 and, a fortiori, whether all IVF patients should be offered PGS. What is kn...
Article
Full-text available
Mitochondria play a vital role in embryo development. They are the principal site of energy production and have various other critical cellular functions. Despite the importance of this organelle, little is known about the extent of variation in mitochondrial DNA (mtDNA) between individual human embryos prior to implantation. This study investigate...
Article
Infertility is a common disease, which causes many couples to seek treatment with assisted reproduction techniques. Many factors contribute to successful assisted reproduction technique outcomes. One important factor is laboratory environment and air quality. Our facility had the unique opportunity to compare consecutively used, but separate assist...
Patent
This invention comprises peptides, methods and a kit for identifying DNA fragmentation in non-viable sperm. Specific peptide sequences are claimed that bind to ssDNA and fragmented DNA.
Article
The randomized clinical trial (RCT) was developed to assess the efficacy of medical interventions by comparing a treatment group with a control group that did not receive treatment or received placebo. It has been evident that this study design is more suited to evaluation of drugs and less to complex interventions such as surgical procedures. The...
Article
A response to the Commentary 'More than just a matter of time' by Renee Reijo Pera.
Article
The bi-parental genetic state is not a given after assisted reproduction. This is based on a biological definition of parentage that concerns generational inheritance of genetic material. Often three or more individuals may participate in artificial reproduction. Only cytoplasmic and spindle transfer can result in the genetic tri-parental state. Al...
Article
The ultimate goal of IVF is to achieve healthy, single, live births following each single-embryo transfer. A timeline for this eventuality has never been defined. National implantation rates from 2003-2010 provided by the Society for Assisted Reproductive Technologies (SART) in the USA were evaluated. Regression analysis was applied to the annual t...
Article
The first tissue culture media were developed nearly 150 years ago by Ludwig and Ringer. These were simple salt solutions, which were initially based on the chemical properties of blood serum. The second generation of culture media was developed more than a century later, in the 1970s, aiming to mimic the reproductive environment. In the 1990s, sim...
Article
Full-text available
BACKGROUND The integrity of DNA in spermatozoa is considered an additional parameter of semen quality and a potential fertility predictor. Significant progress has been made in recent years towards the development of reliable tests for sperm chromatin integrity and DNA damage assessment. However, most of the techniques available are labor intensive...
Article
To determine whether a mandatory single-blastocyst transfer (mSBT) algorithm reduced multiple gestation rates without sacrificing clinical pregnancy rates. Retrospective review. U.S. university-based assisted reproductive technology (ART) program. All women younger than 38 years undergoing their first ART cycle from 2009 to 2010 with ≥4 high-grade...
Article
Sperm concentration and four motility characteristics (per cent motile spermatozoa, average velocity, average straight line approach and average speed constancy) were determined in three fractions of human split ejaculates from healthy volunteers. A semi-automatic analysis technique was used to determine sperm parameters from multiple exposure phot...
Article
Preimplantation genetic diagnosis has been proposed as a method to improve assisted reproduction technology outcomes, but different techniques have produced conflicting results. The use of appropriate techniques may provide positive outcomes.
Article
Non-invasive methods of assessing embryo quality are critical for pregnancy success following IVF or intracytoplasmic sperm injection (ICSI). The addition of new non-invasive morphological and biochemical analyses may further improve pregnancy success, allowing the transfer of a single embryo, thereby reducing the risks involved in multiple births...
Article
To evaluate trends and outcomes from preimplantation genetic diagnosis (PGD) cycles. Retrospective data review. A reference laboratory specializing in the provision of PGD services. One hundred sixty-two patients at risk of transmitting a serious monogenic disorder to their children. In vitro fertilization and PGD. Results of PGD cycles. Two hundre...
Article
This study examined a new method for vitrification of blastocysts that is safe, simple and easy to learn and use. Current vitrification techniques have shortcomings that include the use of dimethyl sulphoxide, one of the more toxic cryoprotectants, and minute containers that are difficult to handle and are usually open to contamination. Cell handli...
Article
To evaluate effects of luteinizing hormone (LH)-containing gonadotropins (human menopausal gonadotropin, hMG) on ploidy of human cleavage-stage embryos in gonadotropin releasing hormone (GnRH) antagonist cycles. Retrospective matched cohort study. Two academically affiliated private fertility centers, private preimplantation genetics laboratory, an...
Article
Non-invasive methods of assessing embryo quality are critical for pregnancy success following IVF or intracytoplasmic sperm injection (ICSI). The addition of new non-invasive morphological and biochemical analyses may further improve pregnancy success, allowing the transfer of a single embryo, thereby reducing the risks involved in multiple births...
Article
Full-text available
The aim of this study was to evaluate the effect of ovarian stimulation with LH-containing gonadotropins (human menopausal gonadotropin, hMG), on ploidy of human cleavage-stage-embryos. A total of 104 women, at ages 27-43 years, undergoing one cycle of controlled ovarian hyperstimulation for IVF in combination with preimplantation genetic diagnosis...
Article
There is a known correlation between morphology and euploidy, but we believe that the association between the two embryo selection systems is too marginal to claim that it is absolute and that one can simply replace one system by the other. The optimal way to select euploid embryos is through a combination of morphology determination and preimplant...
Article
A randomized clinical trial of 406 patients with advanced maternal age by Mastenbroek and co-workers recently published in the New England Journal of Medicine showed a significant decrease in pregnancy outcome after preimplantation genetic screening (PGS). It is our opinion that this study suffers from a number of insurmountable inaccuracies and th...
Article
To improve preimplantation genetic diagnosis (PGD) accuracy by using "no result rescue" (NRR) consisting of the reanalysis of dubious results with additional probes binding to a locus different from the one previously analyzed. Prospective study of PGD cycles with and without reanalysis of inconclusive results. PGD laboratory. Patients undergoing P...
Article
The age-related decline in female fertility has been attributed to a variety of causes including progressive oocyte depletion, meiotic irregularities and mitochondrial dysfunction. However, additional factors could potentially be involved. To explore this possibility, comprehensive analysis of gene expression in human oocytes, discarded following I...
Article
Full-text available
The present paper focuses on oocyte donation for non-reproductive purposes, i.e. research and future therapy. The general principles of research ethics apply to these interventions. The proportionality principle demands that any possible harms to the oocyte donors should be proportionate to the possible benefits for society. The non-maleficence pri...
Article
Previous studies assessing the relationship between embryo development, maternal age and chromosome abnormalities were either small or analysed mostly embryos not suitable for replacement. The present study includes >6000 embryos, including many suitable for replacement. Embryos with the best morphology and development were 44% euploid in patients...
Article
To evaluate whether differences in results between studies that involve preimplantation genetic diagnosis for chromosome testing are affected by technology, such as the number of cells to be biopsied or by differences in study design. Evaluation of studies of aneuploidy testing according to the use of probes, fixation technology, error determinatio...
Article
Full-text available
Human embryonic stem cells (hESC) have the potential to treat a wide range of diseases. Currently, the use of existing hESC lines in human clinical applications is limited, as they are derived from blastocysts subjected to immunosurgery with animal derived antibodies, and are maintained on mouse embryonic feeder (MEF) cells, in the presence of eith...
Article
Intact zona-free human oocytes were screened using a combinatorial peptide library selection protocol. Pieczenik Peptide Sequence 1 (PPS1) HEHRKRG binds human spermatozoa. A complementary and unique binding sequence HNSSLSPLATPA (PPS2) was developed from the first PPS1 ligand that binds to the human zona pellucida or oolemma. Cytoplasm-free zonae f...