Jacqueline Larouche

Jacqueline Larouche
University of Michigan | U-M · Department of Biomedical Engineering

Master of Science

About

14
Publications
21,381
Reads
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504
Citations
Citations since 2017
14 Research Items
503 Citations
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2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
Introduction
Jacqueline Larouche currently works at the Australian Regenerative Medicine Institute, Monash University (Australia). She is currently engineering a protein to promote regulatory T cell mediated tissue repair.
Additional affiliations
July 2017 - July 2018
Monash University (Australia)
Position
  • Fellow
Education
August 2018 - May 2023
University of Michigan
Field of study
  • Biomedical Engineering
August 2018 - May 2020
University of Michigan
Field of study
  • Biomedical Engineering
August 2013 - May 2017
Georgia Institute of Technology
Field of study
  • Biomedical Engineering

Publications

Publications (14)
Article
Full-text available
During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle volume and function impacting mobility and quality of life. Muscle loss is often associated with denervation and a loss of resident muscle stem cells (satellite cells or MuSCs), however, the relationship between MuSCs and innervation has not been established. He...
Article
Full-text available
Specialized pro-resolving mediators actively limit inflammation and support tissue regeneration, but their role in age-related muscle dysfunction has not been explored. We profiled the mediator lipidome of aging muscle via liquid chromatography-tandem mass spectrometry and tested whether treatment with the pro-resolving mediator resolvin D1 (RvD1)...
Preprint
Full-text available
Chronic inflammation and deregulated acute immune cell responses to injury contribute to age-associated skeletal muscle dysfunction. Specialized pro-resolving mediators (SPMs) control inflammation and support myofiber regeneration in young mice, but their role in aging muscle remains unknown. Here we examined the effect of age on the mediator lipid...
Article
Full-text available
Specialized pro-resolving mediators (SPMs) actively limit inflammation and expedite its resolution by modulating leukocyte recruitment and function. Here we profiled intramuscular lipid mediators via LC-MS based metabolipidomics following myofiber injury and investigated the potential role of SPMs in skeletal muscle inflammation and repair. Both pr...
Article
Full-text available
During aging, there is a progressive loss of volume and function in skeletal muscle that impacts mobility and quality of life. The repair of skeletal muscle is regulated by tissue-resident stem cells called satellite cells (or muscle stem cells [MuSCs]), but in aging, MuSCs decrease in numbers and regenerative capacity. The transcriptional networks...
Preprint
Full-text available
During aging and neuromuscular diseases, there is a progressive loss of skeletal muscle volume and function in that impacts mobility and quality of life. Muscle loss is often associated with denervation and a loss of resident muscle stem cells (satellite cells or MuSCs), but the relationship between MuSCs and neural control has not been established...
Preprint
The Biointerfaces Interlaboratory Committees, the student organization for the Biointerfaces Institute at the University of Michigan, organized and executed an 8 hour “BioHackathon” on the broadly defined clinical topic of ‘Aging.’ The event began with experts in the field (a clinician and an engineer) highlighting the areas of greatest need in whi...
Article
Cellular identity and state are determined by a collection of molecular components that are specified during development and stabilized thereafter to maintain and protect tissue functions. Alteration of the molecular elements (gene expression program and chromatin state) as a result of disease or age can induce somatic cells to assume different ide...
Article
Full-text available
Skeletal muscle possesses a remarkable capacity to regenerate when injured, but when confronted with major traumatic injury resulting in volumetric muscle loss (VML), the regenerative process consistently fails. The loss of muscle tissue and function from VML injury has prompted development of a suite of therapeutic approaches but these strategies...
Article
Full-text available
Significance: The immune system plays a central role in orchestrating the tissue healing process. Hence, controlling the immune system to promote tissue repair and regeneration is an attractive approach when designing regenerative strategies. This review discusses the pathophysiology of both acute and chronic wounds and possible strategies to contr...

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Projects

Project (1)
Project
To develop a novel growth factor that enhances bone, skin and muscle repair by increasing the numbers of regulatory T cells at the injury site and increases their suppressive activity.