Jacobus J.C. Arts

Jacobus J.C. Arts
Maastricht University | UM · Dept Orthopaedic surgery

Ph.D.
Principal investigator NWA DARTBAC project -> design material technology to counter antimicrobial resistance

About

140
Publications
26,918
Reads
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2,468
Citations
Citations since 2017
70 Research Items
1721 Citations
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Introduction
Translational biomaterials research and building interdisciplinary bridges between medicine, engineering and imaging. Focus on biomaterials in peri-prosthetic joint infection prevention and treatment, delayed bone healing and spinal deformity correction. Focus on AntiMicrobial Resistance (AMR) Focus on imaging: HR-pQCT, 18fl PET-CT, PET-MRI. Focus on additive manufacturing / 3-D printing of medical devices for use in hip, knee, spine and trauma surgery.
Additional affiliations
April 2017 - present
Eindhoven University of Technology
Position
  • Professor
May 2010 - present
Maastricht University
Position
  • BMM spineguide
Description
  • Fusionless correction of idiopathic scoliosis with metal rods and constructions made with Dyneema Purity® (UHMWPE) providing 3-D deformity correction over time, spinal growth and preservation of spine mobility. PI of the consortium.
January 2009 - April 2017
Eindhoven University of Technology
Position
  • Lecturer
Description
  • teaching and research on bone healing, bone mechanics, imaging of bone healing and biomaterials
Education
November 2000 - September 2005
Radboud University
Field of study
  • hip revision surgery and bone substitute materials
August 1997 - May 2000
Maastricht University
Field of study
  • Human Movement Sciences

Publications

Publications (140)
Book
Full-text available
Dear reader, The second edition of this booklet summarizes the basic terminology regarding material/mechanical properties of Ca-P ceramics and will explain their effect on biological and mechanical behaviour. Also the Diamond/Pentagon concept for bone healing is explained and supported by illustrative cases. In this second edition, additional infor...
Article
Full-text available
Background Magnetic resonance imaging (MRI) and 2-[¹⁸F]-fluoro-2-deoxy-d-glucose (¹⁸F-FDG) Positron Emission Tomography, paired with Computed Tomography (PET/CT) are commonly used modalities in the complicated diagnostic work-up of osteomyelitis. PET/MRI is a relatively novel hybrid modality with suggested applications in bone infection imaging, ba...
Article
Background Total ankle arthroplasty (TAA) is increasingly used as a treatment for end-stage ankle arthropathy. However, TAA may be more sensitive to complications, failure and subsequent re-operations compared to ankle arthrodesis. The aim of this systematic review and meta-analysis is to generate an overview of complications of TAA surgery. Metho...
Article
Full-text available
Introduction Malalignment of the Total Ankle Replacement (TAR) has often been postulated as the main reason for the high incidence of TAR failure. As the ankle joint has a small contact area, stresses are typically high, and malalignment may lead to non-homogeneous stress distributions, including stress peaks that may initiate failure. This study a...
Article
Full-text available
Introduction: 3D printed trussed titanium interbody cages may deliver bone stimulating mechanobiological strains to cells attached at their surface. The exact size and distribution of these strains may depend on patient-specific factors, but the influence of these factors remains unknown. Therefore, this study aimed to determine patient-specific va...
Article
Periprosthetic joint infections are a major complication after total joint arthroplasty. Pseudomonas aeruginosa and Staphylococcus aureus are of great clinical concern, due to high antibiotic resistance, which is even increased when they form a biofilm on the implant surface. In this qualitative systematic review based on the PRISMA statement, biof...
Article
Background Studies concerning total ankle arthroplasty could be influenced by several forms of bias. Independent national arthroplasty registries represent objective data on survival and patient reported outcomes. The aim of this study was to determine survival and identify risk factors for early failure in a nationwide series of total ankle arthro...
Article
Full-text available
Introduction: Chronic osteomyelitis is a challenging condition in the orthopedic practice and traditionally treated using local and systemic antibiotics in a two-stage surgical procedure. With the introduction of the antimicrobial biomaterial S53P4 bioactive glass (Bonalive®), chronic osteomyelitis can be treated in a one-stage procedure. This stud...
Article
Introduction: Although computed tomography (CT) can identify the presence of eventual bony bridges following lumbar interbody fusion (LIF) surgery, it does not provide information on the ongoing formation process of new bony structures. 18F sodium fluoride (18F-NaF) positron emission tomography (PET) could be used as complementary modality to add...
Article
Full-text available
Background Post-Market Clinical Follow-Up has been integrated into the new Medical Device Regulations since 2020. The CD Horizon Solera 4.75 mm instrumentation (CD-Solera) was introduced worldwide in 2009, and specifically intended for surgical treatment of pediatric and adolescent scoliosis patients. The objective of this study was to evaluate the...
Article
Study design: A porcine cadaveric biomechanical study. Objective: To biomechanically evaluate a novel Cable Anchor System as semi-rigid junctional fixation technique for the prevention of proximal junctional failure after adult spinal deformity surgery and to make a comparison to alternative promising prophylactic techniques. Summary of backgro...
Article
Full-text available
BACKGROUND CONTEXT Lumbar interbody fusion is an effective treatment for unstable spinal segments. However, the time needed to establish a solid bony interbody fusion between the two vertebrae may be longer than twelve months after surgery. During this time window, the instrumented spinal segment is assumed to be at increased risk for instability r...
Article
Full-text available
Vitamin D is an important factor in bone metabolism. Animal studies have shown a positive effect of vitamin D3 supplementation on fracture healing, but evidence from clinical trials is inconclusive. A randomized controlled trial was performed to assess the effect of vitamin D3 supplementation on fracture healing using high‐resolution peripheral qua...
Article
Full-text available
Aims Previous studies have already shown early proximal ingrowth, fast osseous integration, and a stable fit of the uncemented Symax hip stem, with excellent clinical and radiographic performance. Aims were to evaluate cumulative revision rates and reasons for revision of the Symax hip stem using Dutch Arthroplasty Register (LROI) data and to asses...
Article
Full-text available
Purpose:To identify the life domains that are most frequently reported to be affected in scoliosis patients undergoing brace treatment. Methods: A search within the PubMed database was conducted and a total of 60 publications were selected. We classified the studies based on the methods used to measure patients' quality of life (QoL) and categoriz...
Article
Full-text available
Growth-guidance constructs are an alternative to growing rods for the surgical treatment of early onset scoliosis (EOS). Constructs containing ultra-high molecular weight polyethylene (UHMWPE) sublaminar tape have been proposed as an improvement to the traditional Luque trolley. Ideally, a certain minimum number of levels is instrumented, thus offe...
Article
Background context Adult spinal deformity patients treated operatively by long-segment instrumented spinal fusion are prone to develop proximal junctional kyphosis (PJK) and failure (PJF). A gradual transition in range of motion (ROM) at the proximal end of spinal instrumentation may reduce the incidence of PJK and PJF, however previously evaluated...
Article
Full-text available
Study design Preclinical ovine model. Objective To assess the in vivo efficacy and safety of the P-15 L bone graft substitute and compare its performance to autologous iliac crest bone graft (ICBG) for lumbar interbody fusion indications. Methods Thirty skeletally mature sheep underwent lumbar interbody fusion surgery. Half of the sheep received...
Article
Full-text available
Chronic osteomyelitis has always been a therapeutic challenge for patient and surgeon due to the specific problems related with bone infection and bacterial biofilm eradication. Other than being the cause of infection or facilitating spread or persistence of infection, biomaterials are also becoming a tool in the treatment of infection. Certain nov...
Article
Objective: Complications after adult spinal deformity surgery are common, with implant-related complications occurring in up to 27.8% of cases. Sublaminar wire fixation strength is less affected by decreasing trabecular bone density in comparison to pedicle screw (PS) fixation due to the predominant cortical bone composition of the lamina. Sublami...
Article
Full-text available
Purpose: To identify the life domains that are most frequently reported to be affected in scoliosis patients undergoing brace treatment. Methods: A search within the PubMed database was conducted and a total of 60 publications were selected. We classified the studies based on the methods used to measure patients’ quality of life (QoL) and categoriz...
Article
Full-text available
The one-stage treatment of chronic osteomyelitis with S53P4 bioactive glass (BAG) granules has shown excellent results. However, these granules possess suboptimal handling properties. Therefore, new injectable S53P4 putty materials have been developed by the incorporation of a synthetic binder to contain glass granules. The goal of the current stud...
Article
Background: To avoid early fusion and allow residual growth of the spine in early onset scoliosis (EOS) treatment, growth-guided scoliosis surgery can be performed. Four patients with EOS are presented in which a growth-guidance instrumentation is used with sliding titanium (Ti) sublaminar cables. Residual growth of the spine can be preserved usin...
Article
Full-text available
Due to increasing rates of periprosthetic joint infections (PJI), new approaches are needed to minimize the infection risk. The first goal of this study was to modify a well-established infection model to test surface-active antimicrobial systems. The second goal was to evaluate the antimicrobial activity of a silver multilayer (SML) coating. In vi...
Article
Full-text available
Background and purpose — The uncemented Symax hip stem has shown early proximal ingrowth as result of the BONIT-hydroxyapatite (HA) coating and the distal DOTIZE surface treatment. We evaluated 2-year postoperative radiostereometric analysis (RSA) migration of the Symax hip stem in THA patients. We also investigated the correlation between migratio...
Book
Full-text available
Calcium phosphate biomaterials for bone healing; practical guideline for implementation in clinical practice This booklet summarizes basic terminology with regard to material and mechanical properties of Calcium Phosphate ceramics (Ca-P) and describes the effect of material properties on biological and mechanical behavior. The Diamond / Pentagon c...
Article
Full-text available
Bioactive glass (BAG) granules (S53P4) have shown good clinical results in one-stage treatment of osteomyelitis. During this treatment, a cortical window is created, and infected bone is debrided, which results in large defects that affect the mechanical properties of the bone. This study aimed to evaluate the role of BAG granules in load-bearing b...
Article
Full-text available
Blount's disease or bowed leg deformity, is a unilateral or bilateral growth deformity of the medial proximal tibia that leads to a tibial varus deformity. A distinction can be made in an early and late onset type. The disease seems to have a predisposition for certain descends. Since the first publication of Blount's disease, different hypotheses...
Article
Full-text available
This study was set up to evaluate the costs of a one-stage treatment of chronic osteomyelitis using bioactive glass S53P4 versus a two-stage treatment using gentamicin-loaded PMMA beads. Furthermore, a cost-effectiveness analysis was performed from a hospital’s perspective together with the evaluation of clinical outcome. A treatment group (n = 25)...
Article
Full-text available
Clinically, S53P4 bioactive glass (BAG) has shown very promising results in bone infection treatment, but it is also known to degrade very slowly in vivo. To evaluate which mechanisms (cellular or dissolution) can play a role in the degradation of S53P4 BAG and S53P4 BAG putty, in vitro degradation experiments at different pH (7.4 and 4.6) were per...
Article
Full-text available
Polymethylmethacrylate (PMMA) also referred as (acrylic) bone cement is a non-degradable biomaterial that has been used in clinical orthopedic practice for several decades. PMMA can be used in a plain formulation, but is often used in an antibiotic-loaded formulation in (primary and revision) arthroplasty and in treatment of orthopedic infections a...
Article
Identifying determinants of long-term functional outcome after a distal radius fracture is challenging. Previously, we reported on the association between early HR-pQCT measurements and clinical outcome 12 weeks after a conservatively treated distal radius fracture. We extended the follow-up and assessed functional outcome after two years in relati...
Article
Full-text available
Background Magnetic resonance imaging (MRI) and 2-[18F]-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography paired with computed tomography (PET/CT) are two commonly used imaging modalities in the complicated diagnostic workup of osteomyelitis. Diagnosis using these modalities relies on, respectively, anatomical (MRI) and metabolic (PET) si...
Article
Full-text available
Background: Chronic osteomyelitis is caused by bacterial infection of the bone and is a major problem in orthopaedic surgery. Treatment of chronic osteomyelitis requires surgical debridement accompanied by local and systemic admin- istration of antibiotics. A widely established biodegradable local antibiotic carrier is antibiotic-loaded collagen sp...
Article
Full-text available
Background: The uncemented Symax hip stem is developed through optimization of the uncemented Omnifit hip stem. The Symax stem design combines an anatomical anteverted proximal geometry with a straight distal section. The proximal part is coated with a biomimetic hydroxyapatite (HA) coating for improved osseointegration to enhance load transfer an...
Article
Full-text available
Adverse events have been reported with acrylic bone cements. However, current test standards for acrylic materials fail to characterize the potentially harmful monomers released during the curing stage. In clinical applications, materials are implanted into the human body during this phase. Silicone may be a safer alternative to acrylic cements. Si...
Article
Full-text available
In the field of orthopaedic surgery, bacterial invasion of implants and the resulting periprosthetic infections are a common and unresolved problem. Antimicrobial susceptibility testing methods help to define the optimal treatment and identify antimicrobial resistance. This review discusses proven gold-standard techniques and recently developed mod...
Article
Background: Epileptic patients have increased risk of fractures. This is related to the traumatic event itself and to concomitant factors. Clear fracture related complaints are not always present at primary survey of these patients. This indicates a thorough primary evaluation of the complete individual post-seizure. We present a unique case of abd...
Article
Calcium phosphate cements (CPCs) are commonly used as bone substitute materials. However, their slow degradation rate and lack of macroporosity hinders new bone formation. Poly(DL-lactic-co-glycolic acid) (PLGA) incorporation is of great interest as, upon degradation, produces acidic by-products that enhance CPC degradation. Yet, new bone formation...
Article
Full-text available
Loss of sagittal alignment and balance in adult spinal deformity can cause severe pain, disability and progressive neurological deficit. When conservative treatment has failed, spinal fusion using rigid instrumentation is currently the salvage treatment to stop further curve progression. However, fusion surgery is associated with high revision rate...
Article
Full-text available
We developed a semi-automated algorithm for the detection of cortical interruptions in finger joints using high-resolution peripheral quantitative computed tomography (HR-pQCT). Here, we tested its reliability compared to microCT (?CT) as gold standard. Nineteen joints of 10 female anatomic index fingers were imaged by HR-pQCT and ?CT (82 and 18??m...
Article
Background: The aim of this study was to compare the accuracy of the oscillating tip saw system (Precision Saw=PS) with the more conventional fully oscillating blade system (Sagittal Saw=SS) during computer-assisted total knee arthroplasty (CAS-TKA). Methods: A prospective, randomised, controlled trial included 58 consecutive patients who underw...
Article
Full-text available
Objectives: The aim of this systematic literature review was to assess the clinical level of evidence of commercially available demineralised bone matrix (DBM) products for their use in trauma and orthopaedic related surgery. Methods: A total of 17 DBM products were used as search terms in two available databases: Embase and PubMed according to...
Article
Full-text available
Background Despite growing evidence in the literature, there is still a lack of consensus regarding the use of the mobile-bearing (MB) design total knee arthroplasty (TKA). Methods In a prospective, comparative, randomised, single centre trial, 106 patients with end-stage osteoarthritis of the knee were randomised to either an MB or fixed-bearing...
Article
Fracture healing is a complex repair process with the primary objective of restoring the mechanical function of the fractured bone (1). Quantifying outcome in clinical fracture healing trials remains challenging (2,3). Using highresolution peripheral quantitative computed tomography (HR-pQCT) in combination with micro finite element analysis (FEA),...
Article
To improve the handling properties of S53P4 bioactive glass granules for clinical applications, bioactive glass putty formulations were developed. These formulations contain both granules and a synthetic binder to form an injectable material that is easy to shape. To explore its applicability in load-bearing bone defect grafting, the relation betwe...
Article
OBJECTIVES: To introduce a fully-automated algorithm for the detection of small cortical interruptions (≥0.246mm in diameter) on high resolution peripheral quantitative computed tomography (HR-pQCT) images, and to investigate the additional value of manual correction of the automatically obtained contours (semi-automated procedure). METHODS: Ten me...
Article
Full-text available
Objectives To introduce a fully-automated algorithm for the detection of small cortical interruptions (≥0.246mm in diameter) on high resolution peripheral quantitative computed tomography (HR-pQCT) images, and to investigate the additional value of manual correction of the automatically obtained contours (semi-automated procedure). Methods Ten met...
Data
An illustration of the auto-contouring script. An illustration of the auto-contouring script of a 2D grayscale image with a cortical interruption. The grayscale image (a) is thresholded for a first structure approximation using Gaussian filtering (sigma = 0.8, support = 1 voxel) and a constant threshold of 105 per 1000 of maximum possible voxel val...
Data
MP_InterruptionDetection_246um.com;1Code of the algorithm for (semi-)automated detection of interruptions ≥0.246mm. (COM;1)
Data
AlgorithmVisual_MatchingBreaks.xlsx. Data of the number of matching interruptions of the algorithm and visual scoring. Thus, between AUTO-OP1, AUTO-OP2, OP1-OP2, and AUTO-Visual, OP1-Visual and OP2-Visual. (XLSX)
Data
DATA OP1-OP2-AUTO-Visual_FINAL.sav. Data of the number of interruptions detected with the algorithm and visually. (SAV)
Article
Polymeric sublaminar cables have a number of advantages over metal cables in the field of spinal deformity surgery, with decreased risk of neurological injury and potential for higher correction forces as the two most predominant. However, currently available polymer cables are radiolucent, precluding postoperative radiological assessment of instru...
Article
Full-text available
Background Carbon-fiber-reinforced poly-ether-ether-ketone (CFR-PEEK) has superior radiolucency compared to other orthopedic implant materials, e.g. titanium or stainless steel, thus allowing metal-artifact-free postoperative monitoring by computed tomography (CT). Recently, high-resolution peripheral quantitative CT (HRpQCT) proved to be a promisi...
Article
STUDY DESIGN: In vivo analysis in a porcine model. OBJECTIVES: To develop a porcine experimental scoliosis model representative of early-onset scoliosis (EOS) with the use of a radiopaque ultra-high molecular weight polyethylene (UHMWPE) posterior spinal tether. SUMMARY OF BACKGROUND DATA: Large animal experimental scoliosis models with substantial...
Article
Osteomyelitis is an infectious process in bone that occasionally leads to bone destruction. Traditionally, the surgical treatment procedure is performed in combination with systemic and local antibiotics as a two-stage procedure that uses autograft or allograft bone for filling of the cavitary defect. Bioactive glass (BAG-S53P4) is a bone substitut...
Chapter
Osteomyelitis is a devastating disease of the bone tissue and is a severe complication in orthopedic and trauma surgery, especially when combined with prostheses and osteosynthesis. The infection risk of a prosthesis/osteosynthesis is depending on the location of the implant and the health status of the patient. Hip and knee prostheses have an infe...