Jacob C Nordman

Jacob C Nordman
Southern Illinois University School of Medicine | SIU School of Medicine · Department of Physiology

PhD

About

23
Publications
5,227
Reads
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617
Citations
Citations since 2017
6 Research Items
433 Citations
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Introduction
My lab studies the impact of early life stress on the neurocircuitry of aggression.
Additional affiliations
September 2016 - September 2020
National Institute of General Medical Sciences
Position
  • PostDoc Position
Description
  • The PRAT Program is a competitive 3 year postdoctoral fellowship program to pursue research in one of the laboratories of the National Institutes of Health (NIH).
May 2014 - September 2021
National Institute of Mental Health (NIMH)
Position
  • PostDoc Position
September 2009 - May 2014
George Mason University
Position
  • Research Assistant
Education
September 2009 - May 2014
George Mason University
Field of study
  • Neuroscience

Publications

Publications (23)
Article
Full-text available
Treatment options for chronically aggressive individuals remain limited despite recent medical advances. Traditional pharmacological agents used to treat aggression, such as atypical antipsychotics, have limited efficacy and are often replete with dangerous side effects. The non-competitive NMDAR antagonists ketamine and memantine are promising alt...
Article
Full-text available
Rates of childhood trauma are high amongst violent offenders who frequently recidivate. Few clinical options are available to treat excessive and recurring violent aggression associated with childhood trauma. Those that do exist are largely ineffective and often replete with side effects. One promising pharmacological target is the glutamate bindin...
Article
Full-text available
Excessive and recurring violent aggression is a serious concern for society and a symptom of many psychiatric diseases. Substance abuse, attack experience, and social and traumatic stress increase the vulnerability to developing this type of aggression. Glutamate receptors are an intriguing target for long-term treatment. This review will assess th...
Article
Full-text available
The dorsal raphe (DR) is an evolutionarily conserved brain structure that is involved in aggressive behavior. It projects onto numerous cortical and limbic areas underlying attack behavior. The specific neurocircuit through which the DR regulates aggression, however, is largely unclear. In this study we show that DR neurons expressing CaMKIIα are a...
Article
Full-text available
Traumatic stress can lead to heightened aggression which may be a symptom of psychiatric diseases such as PTSD and intermittent explosive disorder. The medial amygdala (MeA) is an evolutionarily conserved subnucleus of the amygdala that regulates attack behavior and behavioral responses to stressors. The precise contribution of the MeA in traumatic...
Article
Full-text available
Recurring and excessive violence and aggression are serious concerns for the individual and society at large and is a symptom of many psychiatric illnesses such as PTSD. The circuit and synaptic mechanisms underlying experience-induced aggression escalation, however, are poorly understood. Here we find that prior attack experience leading to an inc...
Article
Full-text available
Although menthol, a common flavoring additive to cigarettes, has been found to impact the addictive properties of nicotine cigarettes in smokers little is known about its pharmacological and molecular actions in the brain. Studies were undertaken to examine whether the systemic administration of menthol would modulate nicotine pharmacokinetics, acu...
Article
Full-text available
α7 nicotinic acetylcholine receptors (nAChRs) play an important role in synaptic transmission and inflammation. In response to ligands, this receptor channel opens to conduct cations into the cell but desensitizes rapidly. In recent studies we show that α7 nAChRs bind intracellular signaling proteins such as heterotrimeric GTP binding proteins (G p...
Article
Full-text available
Dysbindin is a schizophrenia susceptibility gene required for the development of dendritic spines. The expression of dysbindin proteins is decreased in the brains of schizophrenia patients, and neurons in mice carrying a deletion in the dysbindin gene have fewer dendritic spines. Hence, dysbindin might contribute to the spine pathology of schizophr...
Thesis
Full-text available
Historically neurotransmitter receptor classes have been divided into two categories: ionotropic and metabotropic. Ionotropic receptors are typically multi-subunit structures that when activated conduct ions through a central pore, leading directly to the depolarization/hyperpolarization of the plasma membrane, generation of action potentials, and...
Article
Full-text available
The α7 nicotinic receptor (α7) plays an important role in neuronal growth and structural plasticity in the developing brain. We have recently characterized a G-protein-signaling pathway regulated by α7 that directs the growth of neurites in developing neural cells. Now we show that choline activation of α7 promotes a rise in intracellular calcium f...
Article
Full-text available
Receptor function is dependent on interaction with various intracellular proteins that ensure the localization and signaling of the receptor. While a number of approaches have been optimized for the isolation, purification, and proteomic characterization of receptor-protein interaction networks (interactomes) in cells, the capture of receptor inter...
Article
Full-text available
Cholinergic signaling plays an important role in regulating the growth and regeneration of axons in the nervous system. The α7 nicotinic receptor (α7) can drive synaptic development and plasticity in the hippocampus. Here we show that activation of α7 significantly reduces axon growth in hippocampal neurons by coupling to G protein regulated induce...
Article
Full-text available
It was, until recently, accepted that the two classes of acetylcholine (ACh) receptors are distinct in an important sense: muscarinic ACh receptors signal via heterotrimeric GTP binding proteins (G proteins), whereas nicotinic ACh receptors (nAChRs) open to allow flux of Na(+), Ca(2+), and K(+) ions into the cell after activation. Here we present e...
Article
Full-text available
Smoking is a common addiction and a leading cause of disease. Chronic nicotine exposure is known to activate nicotinic acetylcholine receptors (nAChRs) in immune cells. We demonstrate a novel role for α4 nAChRs in the effect of nicotine on T-cell proliferation and immunity. Using cell based sorting and proteomic analysis we define an α4 nAChR expre...
Article
Full-text available
The effects of alcohol monoterpene menthol, a major active ingredient of peppermint plant was tested on the function of human hydroxytryptamine type 3 (5-HT3) receptors expressed in Xenopus oocytes. 5-HT (1 μM)-evoked currents recorded by two-electrode voltage clamp technique, were reversibly inhibited by menthol in a concentration-dependent (IC50=...
Article
Full-text available
Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes. The molecular targets of menthol remain poorly defined. In this study we show an effect of menthol on the α7 subunit of the nicotinic acetylcholine (nACh) receptor function. Using a two-electrode voltage-clamp technique, menthol was found to...
Article
In recent years advancements in proteomic techniques have contributed to the understanding of protein interaction networks (Interactomes) in various cell types. Today, high throughput proteomics promises to define virtually all of the components of a signaling and a regulatory network within cells for various molecules including membrane-spanning r...
Article
Full-text available
The α7 acetylcholine nicotinic receptor (α7) is an important mediator of cholinergic transmission during brain development. Here we present an intracellular signaling mechanism for the α7 receptor. Proteomic analysis of immunoprecipitated α7 subunits reveals an interaction with a G protein pathway complex (GPC) comprising Gα(i/o), GAP-43 and the G...
Article
Full-text available
D2 dopamine receptors (D2Rs) represent an important class of receptors in the pharmacological development of novel therapeutic drugs for the treatment of schizophrenia. Recent research into D2R signaling suggests that receptor properties are dependent on interaction with a cohort of dopamine receptor interacting proteins (DRIPs) within a macromolec...

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Projects

Projects (3)
Project
Through this research, we hope to identify new drug targets that can treat pathological aggression at different life stages.
Project
There is growing evidence that social isolation is a significant contributor to chronic aggressive behavior and can exacerbate aggression brought on by traumatic stress. However, the neural mechanisms that link social isolation and traumatic stress to chronic aggression are poorly understood. In this project, we study how social isolation and acute traumatic stress during adolescence induce plasticity changes to limbic circuits, leading to maladaptive chronic aggression in the adult.
Project
To determine the neurocircuitry of the dorsal raphe in regulating attack duration.