Jacob Jan Sloots

University Medical Center Utrecht | UMC Utrecht · Department of Radiology

Background Heartbeat and respiration induce cyclic brain tissue deformations, which receive increasing attention as potential driving force for brain clearance. These deformations can now be assessed using a novel 3D strain tensor imaging (STI) method at 7 T MRI. Methods An 18-year-old man had suffered a traumatic brain injury and was treated with...

Purpose: The ADC of brain tissue slightly varies over the cardiac cycle. This variation could reflect physiology, including mixing of the interstitial fluid, relevant for brain waste clearance. However, it is known from cardiac diffusion imaging that tissue deformation by itself affects the magnitude of the MRI signal , leading to artificial ADC va...

The cardiac cycle induces blood volume pulsations in the cerebral microvasculature that cause subtle deformation of the surrounding tissue. These tissue deformations are highly relevant as a potential source of information on the brain's microvasculature as well as of tissue condition. Besides, cyclic brain tissue deformations may be a driving forc...

Microvascular blood volume pulsations due to the cardiac and respiratory cycles induce brain tissue deformation and, as such, are considered to drive the brain's waste clearance system. We have developed a high-field magnetic resonance imaging (MRI) technique to quantify both cardiac and respiration-induced tissue deformations, which could not be a...

Brain tissue strain could be a valuable source of information on the brains tissue properties. Therefore, accurate DENSE measurements are crucial, since the computation of tissue strain requires spatial derivatives, which amplifies noise present in the displacement maps. In this work, we optimize the SNR in the displacement maps and substantiate th...

The cardiac cycle and respiration both influence CSF dynamics and therefore the displacement of brain tissue. In this work we unravel their contribution to brain tissue displacement using a single shot 2D cine displacement-encoded imaging method employing stimulated echoes (DENSE) for brain motion measurements. Displacement-encoded data sets in the...

Brain tissue motion induced by the cardiac and respiration cycles is considered to be involved in the drainage of cerebral waste [1]. We aim to unravel the influence of cardiac and respiratory contributions by specifically measuring the displacement of brain tissue with a single shot 2D DENSE acquisition and fitting a linear model to the observed d...