Jacob Bumgarner

Jacob Bumgarner
West Virginia University | WVU · The Blanchette Rockefeller Neurosciences Institute (BRNI)

About

18
Publications
1,737
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
111
Citations

Publications

Publications (18)
Article
Full-text available
Background Circadian rhythms are important for all aspects of biology; virtually every aspect of biological function varies according to time of day. Although this is well known, variation across the day is also often ignored in the design and reporting of research. For this review, we analyzed the top 50 cited papers across 10 major domains of the...
Article
Changes to photoperiod (day length) occur in anticipation of seasonal environmental changes, altering physiology and behavior to maximize fitness. In order for photoperiod to be useful as a predictive factor of temperature or food availability, day and night must be distinct. The increasing prevalence of exposure to artificial light at night (ALAN)...
Article
Full-text available
Vascular networks are fundamental components of biological systems. Quantitative analysis and observation of the features of these networks can improve our understanding of their roles in health and disease. Recent advancements in imaging technologies have enabled the generation of large-scale vasculature datasets, but barriers to analyzing these d...
Article
Full-text available
Light at night is a pervasive problem in our society; over 80% of the world’s population experiences significant light pollution. Exacerbating this issue is the reality that artificially lit outdoor areas are growing by 2.2% per year and continuously lit areas brighten by 2.2% each year due to the rapid growths in population and urbanization. Furth...
Article
Sex as a biological variable is the focus of much literature and has been emphasized by the National Institutes of Health, in part, to remedy a long history of male-dominated studies in preclinical and clinical research. We propose that time-of-day is also a crucial biological variable in biomedical research. In common with sex differences, time-of...
Article
Disruption of circadian rhythms has detrimental host consequences. Indeed, both clinical and foundational science demonstrate a clear relationship between disruption of circadian rhythms and cancer initiation and progression. Because timing of food intake can act as a zeitgeber (i.e., entrainment signal) for the circadian clock, and most individual...
Article
Full-text available
Chemotherapy is more effective in the treatment of peripheral tumors than brain metastases, likely reflecting the reduced ability of chemotherapy to cross the blood-brain barrier (BBB) and blood-tumor barrier at efficacious concentrations. Recent studies demonstrate circadian regulation of the BBB. Thus, we predicted that optimally timed chemothera...
Article
Full-text available
Artificial light at night (ALAN) is a pervasive phenomenon. Although initially assumed to be innocuous, recent research has demonstrated its deleterious effects on physiology and behavior. Exposure to ALAN is associated with disruptions to sleep/wake cycles, development of mood disorders, metabolic disorders, and cancer. However, the influence of A...
Article
Full-text available
The goal of this review is to provide a perspective on the nature and importance of the relationship between the circadian and pain systems. We provide: 1) An overview of the circadian and pain systems, 2) a review of direct and correlative evidence that demonstrates diurnal and circadian rhythms within the pain system; 3) a perspective highlightin...
Preprint
Full-text available
Vascular networks can dictate and indicate states of health and disease. Structural analyses of these networks can facilitate improved understanding of disease states. Recent advances in preclinical imaging techniques and segmentation software have led to the generation of large-scale vasculature datasets. However, these advances have not been acco...
Article
Time-of-day is a crucial, yet often overlooked, biological variable in biomedical research. We examined the top 25 most cited papers in several domains of behavioral phenotyping to determine whether time-of-day information was reported. The majority of studies report behavioral testing conducted during the day, which does not coincide with the opti...
Article
Life on earth has evolved during the past several billion years under relatively bright days and dark nights. Virtually, all organisms on the planet display an internal representation of the solar days in the form of circadian rhythms driven by biological clocks. Nearly every aspect of physiology and behavior is mediated by these internal clocks. T...
Article
Full-text available
For many individuals in industrialized nations, the widespread adoption of electric lighting has dramatically affected the circadian organization of physiology and behavior. Although initially assumed to be innocuous, exposure to artificial light at night (ALAN) is associated with several disorders, including increased incidence of cancer, metaboli...
Article
Although much has been learned about circadian clocks and rhythms over the past few decades, translation of this foundational science underlying the temporal regulation of physiology and behavior to clinical applications has been slow. Indeed, acceptance of the modern study of circadian rhythms has been blunted because the phenomenology of cyclic c...
Article
Circadian rhythms are endogenous biological cycles that synchronize physiology and behavior to promote optimal function. These ~24‐hour internal rhythms are set to precisely 24 hours daily by exposure to the sun. However, the prevalence of night‐time lighting has the potential to dysregulate these biological functions. Hospital patients may be part...
Article
Full-text available
The growing presence of artificial lighting across the globe presents a number of challenges to human and ecological health despite its societal benefits. Exposure to artificial light at night, a seemingly innocuous aspect of modern life, disrupts behavior and physiological functions. Specifically, light at night induces neuroinflammation, which is...
Article
Background: Cytokines are key signaling molecules within the immune system that regulate a host's response to pathogens and neuronal damage. Aberrant cytokine signaling has been implicated in many neurological diseases. Therefore, accurately measuring cytokine concentrations within the brain is crucial. New method: This study demonstrates that r...
Article
Full-text available
Brain metastases encompass nearly 80% of all intracranial tumors. A late stage diagnosis confers a poor prognosis, with patients typically surviving less than 2 years. Poor survival can be equated to limited effective treatment modalities. One reason for the failure rates is the presence of the blood–brain barrier (BBB) and blood–tumor barrier (BTB...

Network

Cited By