Jackson Weako

Jackson Weako
Koc University · College of Engineering

Doctor of Philosophy
https://linktr.ee/Jweako

About

4
Publications
314
Reads
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25
Citations
Citations since 2016
4 Research Items
25 Citations
20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810
20162017201820192020202120220246810
Introduction
Graduate Research Assistant at Koç University . Research interests: Protein-protein interaction, protein-ligand interaction, protein-ligand interaction, and computer aided drug design . Current project : Investigating the role of the Pleckstrin Homology (PH) domain in Protein Kinase translocation and activation via molecular dynamics (MD) simulations.

Publications

Publications (4)
Article
Full-text available
Akt plays a key role in the Ras/PI3K/Akt/mTOR signaling pathway. In breast cancer, Akt translocation to the plasma membrane is enabled by the interaction of its pleckstrin homology domain (PHD) with calmodulin (CaM). At the membrane, the conformational change promoted by PIP3 releases CaM and facilitates Thr308 and Ser473 phosphorylation and activa...
Article
Methionine Aminopeptidases (MetAPs) are divalent-cofactor dependent enzymes that are responsible for the cleavage of the initiator Methionine from the nascent polypeptides. MetAPs are classified into two isoforms: namely, MetAP1 and MetAP2. Several studies have revealed that MetAP2 is upregulated in various cancers, and its inhibition has shown to...
Article
Histone deacetylase (HDAC) 8 has been implicated as a potential therapeutic target in a variety of cancers, neurodegenerative disorders, metabolic dysregulation, and autoimmune and inflammatory diseases. Several nonselective HDAC inhibitors have been co-crystallized with HDAC8. Molecular dynamics (MD) studies may yield valuable information on the s...

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Projects

Project (1)
Project
To develop novel synthetic agents for prostate cancer treatment