Jack Adam Tuszynski

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Verified

Jack verified their affiliation via an institutional email.

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• M.Sc., Ph.D., D.Sc.
• Professor (Full) at Polytechnic University of Turin

Small interfering RNA (siRNA) has been deemed a promising therapeutic method for treating diverse diseases. siRNA-based therapeutics provide a distinct mechanism of action by selectively targeting and silencing disease-causing genes at the post-transcriptional level. This paper provides an overview of the present state of siRNA-based therapeutics,...

Mortality associated biomarkers are advantageous in that they are strongly associated with general health. Disease specific biomarkers, if optimized for, can often create suboptimal outcomes in another area, thereby compromising the health of the measured person. We use an existing database of mortality associated blood biomarkers to assess their a...

In this paper, we introduce waveguide Quantum Electrodynamics (wQED) for the description of tryptophans in microtubules representing data qubits for information storage and, possibly, information processing. We propose a Hamiltonian in wQED and derive Heisenberg equations for qubits and photons. Using the Heisenberg equations, we derive time-evolut...

This search for magnetic monopoles (MMs) and high electric charge objects (HECOs) with spins 0, 1 / 2 , and 1, uses for the first time the full MoEDAL detector, exposed to 6.46 fb − 1 proton-proton collisions at 13 TeV. The results are interpreted in terms of Drell-Yan and photon-fusion pair production. Mass limits on direct production of MMs of up...

Background: Age-related decline in musculoskeletal function is a significant concern, particularly in Western countries facing demographic shifts and increased healthcare demands. This review examines the typical trajectories of musculoskeletal deterioration with age and evaluates the effectiveness of various interventions in preventing or reversin...

All cells in the human body, including cancer cells, possess specific electrical properties crucial for their functions. These properties are notably different between normal and cancerous cells. Cancer cells are characterized by autonomous oscillations and damped electromagnetic field (EMF) activation. Cancer reduces physiological variability, imp...

A steadily increasing number of publications support the concept of physiological networks, and how cellular bioelectrical properties drive cell proliferation and cell synchronization. All cells, especially cancer cells, are known to possess characteristic electrical properties critical for physiological behavior, with major differences between nor...

This corrects the article DOI: 10.1103/PhysRevLett.126.071801.

We investigate Quantum Electrodynamics (QED) of water coupled with sound and light, namely Quantum Brain Dynamics (QBD) of water, phonons and photons. We provide phonon degrees of freedom as additional quanta in the framework of QBD in this paper. We begin with the Lagrangian density QED with non-relativistic charged bosons, photons and phonons, an...

BACKGROUND Tumor Treating Fields plus maintenance temozolomide (mTMZ) showed a survival advantage in the first-line glioblastoma (GBM) treatment. The survival benefit remains limited in patients with unmethylated MGMT gene promoter. The AutEMsys device emits low-energy amplitude modulated systemic electromagnetic fields (EMF) at patient specific fr...

Background DNA repair plays a major role in maintaining genomic stability, thus limiting the transformation of normal cells into cancer cells. However, in cancer patients treated with DNA‐targeting drugs, DNA repair can decrease efficacy by removing the damage generated by such molecules that is needed to induce pharmacological activity. Inhibiting...

Biomarker-based tests are capable of predicting one’s biological age and mortality risk. To complement the suite of biomarker-based measurements, physical and cognitive performance tests can also improve the predictability of these measurement panels. Importantly, these measurements can be administered quite non-invasively and inexpensively, and tr...

Introducing siRNAs into cells could degrade specific messenger RNA (mRNA) molecules, reducing the expression of the corresponding protein encoded by those mRNA molecules. Norovirus is the leading cause of both epidemic and pandemic acute gastroenteritis, which is inflammation of the stomach and intestine worldwide, and, as of present, no efficient...

Background: Disinfection by-products used to obtain drinking water, including halomethanes (HMs) such as CH2Cl2, CHCl3, and BrCHCl2, induce cytotoxicity and hyperproliferation in human lung fibroblasts (MRC-5). Enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) modulate these damages through their biotransf...

Alzheimer’s disease causes a progressive loss of memory and cognitive ability in the last decades of life. Clues to what causes these symptoms are suggested by the hallmark Alzheimer’s disease pathologies: amyloid plaques, tau tangles, and degeneration in the basal forebrain cholinergic system. Multiple treatment strategies for Alzheimer’s disease...

The modeling of fibrotic effects on fluid flow and metabolism in the liver can be computationally challenging. This paper combines innovative concepts based on fundamental physics to address such issues at the level of the liver functional unit, the lobule, and upscales and extends this to a multi-lobule tissue scale analysis. Fibrosis effects on f...

Molecularly imprinted polymers (MIPs) are a growing highlight in polymer chemistry. They are chemically and thermally stable, may be used in a variety of environments, and fulfill a wide range of applications. Computer-aided studies of MIPs often involve the use of computational techniques to design, analyze, and optimize the production of MIPs. Li...

We report on a search for magnetic monopoles (MMs) produced in ultraperipheral Pb-Pb collisions during Run 1 of the LHC. The beam pipe surrounding the interaction region of the CMS experiment was exposed to 184.07 μ b − 1 of Pb-Pb collisions at 2.76 TeV center-of-mass energy per collision in December 2011, before being removed in 2013. It was scann...

The progression of Aβ peptide aggregation in the brain has been suggested to play a significant role in the pathogenesis and development of Alzheimer’s disease. This study is intended to provide insight into the interactions between the zinc-binding site of beta-amyloids and the zinc ion itself. The absence of zinc bonded to the beta-amyloid has be...

Whole-genome sequencing has revealed that TP53, NOTCH1, ATM, SF3B1, BIRC3, ABL, NXF1, BCR, and ZAP70 are often mutated in CLL, but not consistently across all CLL patients. This paper employs a statistical thermodynamics approach in combination with the systems biology of the CLL protein–protein interaction networks to identify the most significant...

Many countries across the globe are experiencing aging populations, which brings into question the fitness and capacity of these populations. Rates of neurodegenerative diseases worldwide are increasing, even after adjusting for increasing lifespans. This worrying trend motivates taking steps in the population to prevent dementia. This review summa...

Disinfection by-products to obtain drinking water, such as CH2Cl2, CHCl3, and BrCHCl2, elicit cytotoxicity and hyperproliferation in human lung fibroblasts (MRC-5). Enzymes of their biotransformation modulate these damages and can generate toxic metabolites. However, it is unknown that the response to oxidative stress is involved in cellular hyperp...

Disinfection by-products to obtain drinking water, such as CH2Cl2, CHCl3, and BrCHCl2, elicit cytotoxicity and hyperproliferation in human lung fibroblasts (MRC-5). Enzymes of their biotransformation modulate these damages and can generate toxic metabolites. However, it is unknown that the response to oxidative stress is involved in cellular hyperp...

In small clinical studies, the application of transcranial photobiomodulation (PBM), which typically delivers low-intensity near-infrared (NIR) to treat the brain, has led to some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, despite the extensive literature detailing the mechanisms of action under...

We aim to derive a super-radiance solution of coherent light and sound waves involving water degrees of freedom in the environment of a microtubule. We introduce a Lagrangian density functional of quantum electrodynamics with non-relativistic charged bosons as a model of quantum brain dynamics (QBD) involving water molecular conformational states a...

The Davydov model was conjectured to describe how an amide I excitation created during ATP hydrolysis in myosin might be significant in providing energy to drive myosin’s chemomechanical cycle. The free energy surfaces of the myosin relay helix peptide dissolved in 2,2,2-trifluoroethanol (TFE), determined by metadynamics simulations, demonstrate lo...

Actin filaments, as key components of the cytoskeleton, have aroused great interest due to their numerous functional roles in eukaryotic cells, including intracellular electrical signaling. The aim of this research is to characterize the alternating current (AC) conduction characteristics of both globular and polymerized actin and quantitatively co...

Combretastatins isolated from the Combretum caffrum tree belong to a group of closely related stilbenes. They are colchicine binding site inhibitors which disrupt the polymerization process of microtubules in tubulins, causing mitotic arrest. In vitro and in vivo studies have proven that some combretastatins exhibit antitumor properties, and among...

Interactions between drugs can lead to adverse side effects for patients taking combination therapies to treat complex diseases such as cancer. Knowledge of drug-action towards a receptor would allow these drug-drug interactions to be predicted, and in this study, we trained a total of 5 different machine learning models to classify whether a given...

Cells utilize bioelectricity to form networks as well as regulate and control a variety of processes such as apoptosis, tumor suppression, and voltage-gated ion channels. In-silico modeling of bioelectrical networks can be performed using BETSE, an application that models gap junctions and ion channel activity of networked cells, but its usage of m...

Many people in the USA have lost their lives or become addicted to opioids via prescription opioids given for chronic pain. The chronic pain epidemic has emerged due to a convergence of factors, including the medicalization of pain as well as injuries happening in the workplace, in the home, or during recreation. Opioid prescriptions rose precipito...

Whole-genome sequencing has revealed that TP53, NOTCH1, ATM, SF3B1, BIRC3, ABL, NXF1, BCR, ZAP70 are often mutated in CLL, but not consistently across all CLL patients. This paper employs a statistical thermo-dynamics approach in combination with the systems biology of the CLL protein-protein interaction networks to identify the most significant pa...

Virtually all cells use energy-driven, ion-specific membrane pumps to maintain large transmembrane gradients of Na⁺, K⁺, Cl⁻, Mg⁺⁺, and Ca⁺⁺, but the corresponding evolutionary benefit remains unclear. We propose that these gradients enable a dynamic and versatile biological system that acquires, analyzes, and responds to environmental information....

We investigate Quantum Electrodynamics corresponding to the holographic brain theory introduced by Pribram to describe memory in the human brain. First, we derive a super-radiance solution in Quantum Electrodynamics with non-relativistic charged bosons (a model of molecular conformational states of water) for coherent light sources of holograms. Ne...

Volatile anesthetics (VAs) are medicinal chemistry compounds commonly used to enable surgical procedures for patients who undergo painful treatments and can be partially or fully sedated, remaining in an unconscious state during the operation. The specific molecular mechanism of anesthesia is still an open issue, but scientific evidence supports th...

Due to the stimulation of neuronal membrane dipoles by action potentials, under suitable conditions coherent dipole oscillations can be formed. We argue that these dipole oscillations satisfy the weak Bose-Einstein condensate criteria of the Froehlich model of biological coherence. They can subsequently generate electromagnetic fields (EMFs) propag...

Fear conditioning constitutes the best and most reproducible paradigm to study the neurobiological mechanisms underlying emotions. On the other hand, studies on the synaptic plasticity phenomena underlying fear conditioning present neural circuits enforcing this learning pattern related to post-traumatic stress disorder (PTSD). Notably, in both hum...

We describe a strategy for the development of a rational approach of neoplastic disease therapy based on the demonstration that scale-free networks are susceptible to specific attacks directed against its connective hubs. This strategy involves the (i) selection of up-regulated hubs of connectivity in the tumors interactome, (ii) drug repurposing o...

In small clinical studies, the application of photobiomodulation (PBM), which typically delivers near-infrared (NIR) to treat the brain, has presented some remarkable results in the treatment of dementia and several neurodegenerative diseases. However, while the literature is rich with the mechanisms of action underlying PBM outcomes, the underlyin...

Nonlinear physics has grown from a collection of exotic examples of nonstandard behavior to an all-embracing scientific methodology. Many examples come from condensed matter physics. This book presents a unified view of many-body condensed matter systems as essentially nonlinear structures capable of exhibiting such features as chaos, coherence, so...

Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be affected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have an altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to t...

One of the most important aspects of successful cancer therapy is the identification of a target protein for inhibition interaction. Conventionally, this consists of screening a panel of genes to assess which is mutated and then developing a small molecule to inhibit the interaction of two proteins or to simply inhibit a specific protein from all i...

Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be effected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to targ...

Cancer is amenable to low-cost treatments, given that it has a significant metabolic component, which can be effected through diet and lifestyle change at minimal cost. The Warburg hypothesis states that cancer cells have altered cell metabolism towards anaerobic glycolysis. Given this metabolic reprogramming in cancer cells, it is possible to targ...

Hypercoagulability and formation of extensive and difficult-to-lyse microclots are a hallmark of both acute COVID-19 and long COVID. Fibrinogen, when converted to fibrin, is responsible for clot formation, but abnormal structural and mechanical clot properties can lead to pathologic thrombosis. Recent experimental evidence suggests that the spike p...

Microtubules and actin filaments are protein polymers that play a variety of energy conversion roles in the biological cell. While these polymers are being increasingly harnessed for mechanochemical roles both inside and outside physiological conditions, their capabilities for photonic energy conversion are not well understood. In this Perspective,...

Background: Patients with advanced hepatocellular carcinoma (HCC) and poor liver function lack effective systemic therapies. Low-energy electromagnetic fields (EMFs) can influence cell biological processes via non-thermal effects and may represent a new treatment option. Methods: This single-site feasibility trial enrolled patients with advanced...

The etiology of Alzheimer's dementia is, at best multifactorial. Before the emergence of cognitive impairment, symptoms such as thinning of the cortex, accumulation of β-amyloid, and decreased hippocampal volume are common. Hence, the accumulation of β-amyloid and hyperphosphorylated tau fibrillary tangles are two pathological hallmarks in Alzheime...

Simple Summary The glaziovianin A derivative gatastatin, presented as a γ-tubulin-specific inhibitor, could represent a viable chemotherapeutic strategy to solve the specificity issues associated with targeting α and β tubulin. Since gatastatin’s specificity for γ tubulin has not been confirmed by an in silico analysis or verified experimentally by...

In the middle of World War II while in exile at Trinity College, Dublin, the famous Nobel-Prize winning Austrian physicist Erwin Schroedinger wrote a book called “What is Life?”, which affected several generations of biophysicists although he himself was not trained in biology but was a genius who grasped the main questions in all of science. He di...

Microtubules are cylindrical protein polymers assembled in the cytoplasm of all eukaryotic cells by polymerization of aβ tubulin dimers, which are involved in cell division, migration, signaling, and intracellular traffic. These functions make them essential in the proliferation of cancerous cells and metastases. Tubulin has been the molecular targ...

We show renormalization in Quantum Brain Dynamics (QBD) in 3+1 dimensions, namely Quantum Electrodynamics with water rotational dipole fields. First, we introduce the Lagrangian density for QBD involving terms of water rotational dipole fields, photon fields and their interactions. Next, we show Feynman diagrams with 1-loop self-energy and vertex f...

Over the past two decades, it was discovered that introducing synthetic small interfering RNAs (siRNAs) into the cytoplasm facilitates effective gene-targeted silencing. This compromises gene expression and regulation by repressing transcription or stimulating sequence-specific RNA degradation. Substantial investments in developing RNA therapeutics...

Purpose Neuroblastoma is a pediatric solid tumor with a prognosis associated with histology and age of the patient, which are the parameters of the well-established current classification (Shimada classification). Despite the development of new treatment options, the prognosis of high-risk neuroblastoma patients is still poor. Therefore, there is a...

The repeating arrangement of tubulin dimers confers great mechanical strength to microtubules, which are used as scaffolds for intracellular macromolecular transport in cells and exploited in biohybrid devices. The crystalline order in a microtubule, with lattice constants short enough to allow energy transfer between amino acid chromophores, is si...

We describe non-equilibrium ϕ4 theory in a hierarchical manner to develop a method for manipulating coherent fields as a toy model of introducing control into Quantum Field Theory (QFT) of the brain, which is called Quantum Brain Dynamics (QBD). We begin with the Lagrangian density of ϕ4 model, where we adopt 2-Particle-Irreducible (2PI) effective...

The time taken and the cost of producing novel therapeutic drugs presents a significant burden – a typical target-based drug discovery process involves computational screening of drug libraries, compound assays and expensive clinical trials. This review summarises the value of dynamic conformational information obtained by optical tweezers and how...

In vitro and in animal models of various tumor cell types, empirical data suggest tumor-treating fields (TTFields) can attain 100% efficacy, with two pre-conditions: 1) Delivering sufficient electric field strength to the target tumor cells, and 2) Changing the direction of the imposed electric field such that intra-cellular structures at any angle...

The liver is the body’s primary metabolic organ and its functions operate at multiple time and spatial scales. Here we employ multiscale modelling techniques to describe these functions consistently, based on methods originally developed to describe reactive fluid flow processes in naturally-fractured geological sediments. Using a fully discretized...

Omicron is the dominant strain of COVID-19 in the United States and worldwide. Although this variant is highly transmissible and may evade natural immunity, vaccines, and therapeutic antibodies, preclinical results in animal models and clinical data in humans suggest omicron causes a less severe form of infection. The molecular basis for the attenu...

Understanding the dynamics of confined electrolytes through graphene-based channels is essential in multiple fields of science including: a) developing novel artificial membranes for drug delivery, DNA sequencing and water desalination and b) developing quantum nanoelectronic devices. In this work, All-Atom molecular dynamics simulations are used t...

Exposure to Low-Energy Amplitude-Modulated Radiofrequency Electromagnetic Fields (LEAMRFEMF) represents a new treatment option for patients with advanced hepatocellular carcinoma (AHCC). We focus on two medical devices that modulate the amplitude of a 27.12 MHz carrier wave to generate envelope waves in the low Hz to kHz range. Each provides system...

The effects of electric fields (EFs) on various cell types have been thoroughly studied, and exhibit a well-known regulatory effect on cell processes, implicating their usage in several medical applications. While the specific effect exerted on cells is highly parameter-dependent, the majority of past research has focused primarily on low-frequency...

The supplementary materials document for our article, "Real-Time Monitoring of the Effect of Tumour-Treating Fields on Cell Division Using Live-Cell Imaging".

Data obtained in live-cell imaging experiments with HeLa cells exposed to TTFields using the Novocure Inovitro™ Live System. The data was analyzed to determine the durations of mitosis and cytokinesis in both unexposed and TTFields-exposed HeLa and MCF-10A cells.

A search for highly electrically charged objects (HECOs) and magnetic monopoles is presented using 2.2 $$\hbox {fb}{^{-1}}$$ fb - 1 of $$p-p$$ p - p collision data taken at a centre of mass energy (E $$_{CM}$$ CM ) of 8 TeV by the MoEDAL detector during LHC’s Run-1. The data were collected using MoEDAL’s prototype Nuclear Track Detectord array and...

Heterocyclic compounds are a class of compounds of natural origin with favorable properties and hence have major pharmaceutical significance. They have an exceptional adroitness favoring their use as diverse smart biomimetics, in addition to possessing an active pharmacophore in a complex structure. This has made them an indispensable motif in the...

Tumor Treating Fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While anti-mitotic effects were the first recognized biological ant...

Due to the vital role of the p53 protein mutations in about 50% of the human cancers, in this paper we investigate the probability distributions of different mutations in p53 across various human cancer cells. Using the p53 database (IARC TP53), we employed statistical analysis to determine the frequency of occurrence of amino acid mutations across...

Scoulerine is a natural compound that is known to bind to tubulin and has anti-mitotic properties demonstrated in various cancer cells. Its molecular mode of action has not been precisely known. In this work, we perform computational prediction and experimental validation of the mode of action of scoulerine. Based on the existing data in the Protei...

We describe non-equilibrium quantum brain dynamics (QBD) for the breakdown of symmetry and propose the possibility of hologram memory based on QBD. We begin with the Lagrangian density of QBD with water rotational dipole fields and photon fields in 3+1 dimensions, and derive time evolution equations of coherent fields. We show a solution for super-...

We define quantum analogs as vibrational excitations of quasi-particles coupled to electromagnetically-mediated resonance energy transfer in water (a crystal lattice). This paper addresses how neural magnetic resonance spectra of the brain's magnetic field influence dipolar oscillation waves in crystal lattices of interfacial water molecules to pro...

We define quantum analogs as vibrational excitations of quasi-particles coupled to electromagnetically-mediated resonance energy transfer in water (a crystal lattice). This paper addresses how neural magnetic resonance spectra of the brain’s magnetic field influence dipolar oscillation waves in crystal lattices of interfacial water molecules to pro...

Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an important class of compounds for drug development; thus, they have attracted much attention. In the meantime, pyrazole derivatives have been synthesized as target structures and have demonstrated numerous biological activities such as antituberculosis, antimicrobi...

This Special Issue included articles discussing several important psychiatric phenomena whose elucidation can be provided by cellular and subcellular molecular mechanisms [...]

We report the results of experimental investigations involving photobiomodulation (PBM) of living cells, tubulin, and microtubules in buffer solutions exposed to near-infrared (NIR) light emitted from an 810 nm LED with a power density of 25 mW/cm2 pulsed at a frequency of 10 Hz.

Microtubules are cylindrical protein polymers formed from αβ-tubulin heterodimers in the cytoplasm of eukaryotic cells. Microtubule disturbance may cause cell cycle arrest in the G2/M phase, and anomalous mitotic spindles will form. Microtubules are an important target for cancer drug action because of their critical role in mitosis. Several microt...