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Whilst most body tissues have an intrinsic ability to withstand day-to-day stresses, even more intriguing (and of enormous clinical potential) is the striking adaptive responses to stress that drive increased ‘resilience’ against further insult. Numerous species are now known to exploit these ‘preconditioning’ (hormetic-like) responses to boost the...
Body tissues are frequently exposed to stress, from toxic byproducts generated during cellular metabolism through to infection or wounding. Although it is well-established that tissues respond to exogenous injury by rapidly upregulating cytoprotective machinery, how energetically demanding tissues – vulnerable to persistent endogenous insult – with...