Jack Holcombe

Jack Holcombe
University of Bristol | UB · School of Biochemistry

MSc (Res)

About

2
Publications
54
Reads
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2
Citations
Additional affiliations
October 2019 - October 2023
University of Bristol
Position
  • PhD Student
Description
  • Working to understand tissue resilience and wound repair.
Education
October 2019 - October 2023
University of Bristol
Field of study
September 2018 - September 2019
University of St Andrews
Field of study
  • Biology
September 2015 - July 2018
The University of Sheffield
Field of study
  • Biology

Publications

Publications (2)
Article
Whilst most body tissues have an intrinsic ability to withstand day-to-day stresses, even more intriguing (and of enormous clinical potential) is the striking adaptive responses to stress that drive increased ‘resilience’ against further insult. Numerous species are now known to exploit these ‘preconditioning’ (hormetic-like) responses to boost the...
Article
Full-text available
Body tissues are frequently exposed to stress, from toxic byproducts generated during cellular metabolism through to infection or wounding. Although it is well-established that tissues respond to exogenous injury by rapidly upregulating cytoprotective machinery, how energetically demanding tissues – vulnerable to persistent endogenous insult – with...

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