• Home
  • Jacinthe Leclerc
Jacinthe Leclerc

Jacinthe Leclerc
Université du Québec à Trois-Rivières / Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval

RN, PhD, FAHA

About

55
Publications
7,410
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
126
Citations
Introduction
Jacinthe Leclerc currently works at the Département des Sciences Infirmières, Université du Québec à Trois-Rivières (adjunct professor). She is also a postdoctoral fellow at McGill University, Department of Surgery. Jacinthe conducts research in pharmacoepidemiology, health economics and outcomes research.

Publications

Publications (55)
Article
Contexte Les amputations des membres inférieurs (ADMI) représentent une complication du diabète et/ou de la maladie artérielle périphérique (MAP) pouvant être prévenues. En raison des changements de pratique et démographiques au Québec et des changements observés dans l'incidence des ADMI dans d'autres provinces canadiennes, notre objectif était de...
Article
Full-text available
Introduction Antidepressant drugs are the most frequently prescribed medication for mental disorders. They are also used off-label and for non-psychiatric indications. Prescriptions of antidepressants have increased in the last decades, but no systematic review exists on the extent of their use in the community. Methods and analysis We will conduc...
Article
Full-text available
Introduction The survivability of mass casualties exposed to a chemical attack is dependent on clinical knowledge, evidence-based practice, as well as protection and decontamination capabilities. The aim of this systematic review was to identify the knowledge gaps that relate to an efficient extraction and care of mass casualties caused by exposure...
Article
Introduction: The progression of type 2 diabetes (T2D) is unique to each patient and can be depicted through individual temporal trajectories. Latent group trajectory methods (latent growth mixture models [LGMM] or latent class growth analysis [LCGA]) can be used to classify similar individual trajectories in a priori non-observed groups (latent gr...
Article
Introduction: Non-traumatic lower limb amputations (LLA) represent an important complication of diabetes (DM) and peripheral arterial disease (PAD). In Quebec, Canada, the latest data between 1996 to 2004 suggested a reduction in the incidence of LLA while other Canadian provinces observed a recent increase between 2010 and 2016. Our objective was...
Preprint
Full-text available
Background Antidepressant drugs are the most frequently prescribed medication for mental disorders. They are also used off-label and for non-psychiatric indications. Prescriptions of antidepressants have increased in the last decades, but no systematic review exists on the extent of their use in the community. Methods and analysis We will conduct...
Article
Full-text available
Background: Cost studies appear sporadically in the scientific literature and are rarely revised unless drastic technological advancements occur. However, health technologies and medical guidelines evolve over time. It is unclear if these changes render obsolete prior estimates. We examined this issue in a cost study in the context of patients' fi...
Article
Full-text available
Background: Patients with chronic or acute/postoperative pain frequently use opioids. However, opioids may cause considerable adverse reactions (ARs), such as respiratory depression, which could be lethal. Unfortunately, only 5% of drug-related ARs (including those to opioids) are reported to health authorities. Therefore, little is known regarding...
Article
Introduction: In the last decade, an increase in the prevalence and a reduction in the incidence of diabetes have been observed in many countries including Canada. Yet, some Canadian provinces depicted an elevation in incidence rates among younger age groups. Our objective was to document these trends in the province of Quebec from fiscal years 200...
Article
Background: Exaggerated blood pressure response to exercise is a cardiovascular risk factor associated to higher morbidity and mortality. Severely obese patients have an increased risk of exercise-induced hypertension (EIH). We aimed to assess the blood pressure response to exercise in patients with severe obesity who underwent bariatric surgery a...
Article
Full-text available
Many widely used medications may cause or exacerbate a variety of arrhythmias. Numerous antiarrhythmic agents, antimicrobial drugs, psychotropic medications, and methadone, as well as a growing list of drugs from other therapeutic classes (neurological drugs, anticancer agents, and many others), can prolong the QT interval and provoke torsades de p...
Article
Full-text available
IntroductionPost-marketing studies involve the detection and interpretation of potential problems associated with the use of a given drug. Post-marketing spontaneous pharmacovigilance systems, such as the Canada Vigilance program, may constitute a gold mine of free data for drug safety research. However, the quantity and the quality of data remain...
Article
Full-text available
Background It is unclear whether generics are as safe as brand-name drugs in cardiology. For public health surveillance purposes, we evaluated if switching from the brand-name losartan, valsartan, or candesartan impacted the occurrence of the following outcomes: emergency room (ER) consultations, hospitalizations, or death.Study DesignThis was a re...
Article
Background Previous systematic reviews (2008; 2016) concluded similarity in outcomes between brand-name and generic drugs in cardiology, but they included ≥ 50% comparative bioavailability studies, not designed or powered to detect a difference in efficacy or safety between drug types. We aimed to summarise best-evidence regarding the effectiveness...
Article
Background: Generic drugs constitute lower cost alternatives when the original drug patent expires. Two large systematic reviews and meta-analyses (2008; 2016) concluded to similarity in outcomes between brand-name and generic drugs in cardiology. These meta-analyses were possibly biased by the inclusion of ≥ 50% comparative bioavailability studies...
Article
Background Severely obese patients have decreased cardiorespiratory fitness (CRF) and poor functional capacity. Bariatric surgery-induced weight loss improves CRF, however the determinants of this improvement are not well known. We aimed to assess the determinants of CRF before and after bariatric surgery and the impact of an exercise training prog...
Article
Background: The prevalence of mood disorders was estimated at 5.4% according to the latest Canadian survey. It has been suggested to use administrative data and self-reported data to optimize the estimation for mental health care in the population. Using administrative data, algorithms (combination of codes from the International Classification of...
Article
Full-text here: https://rdcu.be/bA3UL Background: Clopidogrel has been widely used to prevent atherothrombotic events. Since 2011, pharmacists offer their patients the opportunity to switch to generic clopidogrel, an economical alternative. Whether bioequivalence of generic cardiovascular drugs translates into clinical equivalence at a population...
Conference Paper
To assess a potential nocebo effect of generic substitution by comparing adverse events in patients switched to pseudogenerics or continuing brand-name valsartan in the population. Circulation (Vol 138, Suppl 1): https://www.ahajournals.org/doi/10.1161/circ.138.suppl_1.10772
Conference Paper
We found some differences in time to adverse event between patients who switched to generics compared to those who remained on the brand-name. This uncertainty regarding generic substitution merits in-depth clinical investigation to delineate causality. Circulation (Vol 138, Suppl 1): https://www.ahajournals.org/doi/10.1161/circ.138.suppl_1.10777
Article
Full-text available
Background: Blood pressure measurement in severe obesity may be technically challenging as the cuff of the device may not fit adequately around the upper arm. The aim of the study was to assess the agreement between intra-arterial blood pressure values (gold standard) compared with forearm blood pressure measurements in severely obese patients in...
Article
Full-text available
Parenthood is always demanding, but dealing with children during postgraduate training is a special kind of challenge. Is it really feasible to combine responsible parenting with academic success while you are a postgraduate trainee? In this short paper, we speak to trainees who have to manage this reality.
Article
A comprehensive review of direct oral anticoagulants.
Article
L’infirmière administre des médicaments par voie intraveineuse (IV) périphérique au quotidien : « NaCl 0,9 % à 100 mL/h », « D5 % 1/2S à 80 mL/h », « culot globulaire de 100 à 140 mL/h en moins de 4 heures », « TVO », « Bolus », etc. À chaque patient, son ordonnance et à chaque ordonnance, sa vitesse de perfusion! Cette dernière se définit comme le...
Article
Full-text available
La dysfonction diastolique ventriculaire gauche (DDVG) représente l’anomalie cardiaque la plus fréquente. Cet article porte sur les principes de base de la diastologie, les déterminants et les caractéristiques de la DDVG, de même que sur les moyens diagnostiques et les traitements en prévention primaire.
Article
Full-text available
L’Institut national de santé publique du Québec (INSPQ) effectue la surveillance des maladies chroniques de l’ensemble des Québécoises et Québécois dans le cadre d’un mandat ministériel de surveillance octroyé par le ministère de la Santé et des Services sociaux (MSSS). Cette surveillance s’effectue grâce aux fichiers médico-administratifs jumelés...
Article
Background: Even with many direct oral anticoagulant options, brand-name or generic warfarin is still widely used to prevent atherothrombotic events in cardiology. Federal standards regulate bioequivalence of generic vs. brand-name drugs through comparative bioavailability studies but does not regulate clinical equivalence nor tolerability in a “re...
Article
Full-text available
Deux médicaments visant à soutenir la perte pondérale sont approuvés au Canada : l'orlistat (Xenical MD) et le liraglutide (Saxenda MD). Cet article propose un tour d'horizon des indications, des effets indésirables et des mises en garde de ces deux molécules pharmacologiques indiquées dans le traitement de l'obésité.
Article
Full-text available
Background—Once the patent of a brand-name drug expires, generic drugs are commercialized, and substitution from brand-name to generics may occur. Generic drug equivalence is evaluated through comparative bioavailability studies. Few studies have assessed outcomes after generic drug commercialization at a population level. We evaluated the impact o...
Article
Full-text available
Les nausées et vomissements de la grossesse (NVG) peuvent entraîner des conséquences importantes sur la qualité de vie des futures mères, et parfois nuire à leur santé. Lors du suivi prénatal, ou de tout autre contact avec la femme enceinte, comment l’infirmière peut-elle aider sa patiente touchée par ces symptômes et quels sont les éléments de sur...
Conference Paper
Background: Substitution from brand-name to generic drugs is one way to reduce costs of pharmacological treatments. Generic drugs licensing is obtained through comparative bioavailability studies for which a variation of up to 20% is generally accepted. However, “real-life” efficacy and tolerance of generic drugs are not studied prior to commercial...
Article
Background: Clopidogrel is widely used to prevent atherothrombotic events. Federal standards regulate bioequivalence of generic and brand-name drugs through comparative bioavailability studies but does not regulate clinical equivalence nor tolerability in “real-life” settings. We evaluated the impact of the generic clopidogrel commercialization on...
Article
Background: Substitution from brand-name to generic drugs is one way to reduce costs of pharmacological treatments. Generic drugs licensing is obtained through comparative bioavailability studies for which a variation of up to 20% is generally accepted. However, “real-life” efficacy and tolerance of generic drugs are not studied prior to commercial...
Article
Full-text available
Quelles sont les différences entre médicaments originaux et médicaments génériques. Qu'en est-il de leur biodisponibilité? Sont-ils vraiment bioéquivalents? Cet article contribue à améliorer la pharmacovigilance infirmière en comparant les processus d'homologation des médicaments originaux et génériques tout en expliquant les concepts de base de la...
Article
Background: Abdominal obesity and presence of the metabolic syndrome (MetS) are associated with cardiac abnormalities. Among those, left ventricular diastolic dysfunction (LVDD) is the most frequently encountered in clinical practice. Few studies evaluated the reversibility of LVDD by an approach promoting lifestyle modifications in abdominally ob...
Article
Full-text available
Abstract Weight loss is a popular topic and may be of serious concern for many patients. Even with the abundant literature on obesity and cardiometabolic risk, it is always challenging to demystify and reinforce the determinants of safe approaches to lose weight. Measures of central obesity are essential to characterize the patient's adiposity dist...

Network

Cited By

Projects

Projects (7)