Jaba Tkemaladze

Jaba Tkemaladze
  • MD
  • Researcher at Independent Researcher

Rejuvenation = Replacement of Old Centrioles with Young Ones

About

191
Publications
28,922
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2,135
Citations
Introduction
Professor, Scientist, President of Longevity Alliance Georgia. Research Director at Longevity Clinic, Inc, Georgia. Rejuvenation = Replacement of Old Centrioles with Young Ones.
Current institution
Independent Researcher
Current position
  • Researcher
Education
September 1989 - July 1996
Tbilisi State Medical University
Field of study
  • Medicine

Publications

Publications (191)
Article
Full-text available
The centrosome (centriole) and the cytoskeleton produced by it are structures, which probably determine differentiation, morphogenesis, and switching on the mechanism of replicative aging in all somatic cells of multicellular animals. The mechanism of such programming of the events seems to include cytoskeleton influences and small RNAs related to...
Article
Full-text available
Irreversible differentiation (change of morphogenetic status) and programmed death (apoptosis) are observed only in somatic cells. Cell division is the only way by which the morphogenetic status of the offspring cells may be modified. It is known that there is a fixed limit to the number of possible cell divisions, the so-called 'Hayflick limit'. E...
Article
Full-text available
In 2006, a group of scientists studying centrosomes of Spisula solidissima mollusc oocytes under the leadership of Alliegro (Alliegro, M.C.; Alliegro, M.A.; Palazzo, R.E. Centrosome-associated RNA in surf clam oocytes. Proc. Natl. Acad. Sci. USA 2006, 103(24), 9034-9038) reliably demonstrated the existence of specific RNA in centrosome, called cent...
Article
Full-text available
Background All molecules, structures, cells in organisms are subjected to destruction during the process of vital activities. In the organisms of most multicellular animals and humans, the regeneration process always takes place: destruction of old cells and their replacement with the new. The replacement of cells happens even if the cells are in p...
Code
Adaptive systems, including biological organisms and artificial algorithms, form internal world models to interact effectively with their environment. This article explores a learning mechanism based on updating mismatches between a model's predictions and objective reality. Using a software implementation as an example, we analyze a two-tier data...
Article
Full-text available
Adaptive systems, whether biological or artificial, rely on internal models to interact with their environment. This study investigates a learning mechanism driven by discrepancies between predictions and reality. A two-level computational system is analyzed: (1) passive pattern memorization and (2) active model correction. Key adaptive elements in...
Code
The method solves the key problem of limited memory in modern information systems, offering an effective solution for frequency analysis of dynamic flows. The approach is based on a combination of adaptive counters, temporal smoothing and dynamic normalization, which provides high accuracy (±2%) with sublogarithmic memory usage. Experiments on synt...
Preprint
Full-text available
Adaptive systems, including biological organisms and artificial algorithms, form internal world models to interact effectively with their environment. This article explores a learning mechanism based on updating mismatches between a model's predictions and objective reality. Using a software implementation as an example, we analyze a two-tier data...
Article
Full-text available
This code presents an innovative method for creating a flexible chronotropic frequency counter for processing endless data streams. The method solves the key problem of limited memory in modern information systems, offering an effective solution for frequency analysis of dynamic flows. The approach is based on a combination of adaptive counters, te...
Preprint
Full-text available
Aging is associated with the accumulation of damage in long-lived non-renewable structures that are not replaced during an organism's lifetime. These include lens proteins (crystallins), DNA in postmitotic neurons, mitochondria in cardiomyocytes, dental enamel, and stem cell centrioles. Formed during early ontogenesis, these structures act as "accu...
Article
Full-text available
Aging in biological organisms is intricately linked to the accumulation of damage in long-lived irreparable structures, which remain unchanged throughout life. These structures include lens proteins (crystallins)
Article
Full-text available
Schizophrenia, a multifaceted neuropsychiatric disorder characterized by disruptions in neurodevelopmental trajectories, has been robustly linked to dysregulated synaptic pruning mechanisms and persistent immune system activation. The present study investigates the intricate interplay between the activity of the complement C4 gene-a pivotal regulat...
Preprint
Full-text available
Schizophrenia, as a neuropsychiatric disorder, is associated with neurodevelopmental abnormalities, including dysregulation of synaptic pruning, and chronic immune activation. This study focuses on the relationship between the activity of the complement gene C4 (a key player in synaptic pruning) and cancer incidence in schizophrenia patients. Metho...
Preprint
Full-text available
This paper presents an innovative method for creating a plastic counter of chronotropic frequencies for processing infinite data streams. The method addresses the critical challenge of memory limitations in modern information systems by offering an efficient solution for frequency analysis of dynamic data streams. The approach combines adaptive cou...
Thesis
There was a scientist named Leonard Hayflick. Before him, scientists thought that cells multiply infinitely. Aging was explained by ignorance of the "ideal" conditions for cells, and the efforts of immortalists were aimed at studying nutrition, sleep, and breathing patterns. Hayflick debunked this myth by proving that cells do not divide infinitely...
Article
Full-text available
Aging is a multifaceted biological process characterized by a gradual decline in physiological functions, ultimately resulting in reduced reproductive capacity and eventual death of the organism. For over a century, Drosophila melanogaster, the common fruit fly, has served as a pivotal model for investigating the underlying mechanisms of aging, owi...
Article
Full-text available
Stem cell systems are pivotal in biological development, tissue maintenance, and regenerative medicine due to their dual capacity for self-renewal and differentiation. This review explores the heterogeneity and regulatory mechanisms governing stem cells across potency states-pluripotent, multipotent, and unipotent-emphasizing dynamic transcriptiona...
Preprint
Full-text available
Aging is a complex biological process characterized by progressive deterioration of physiological functions, ultimately leading to reduced fertility and organismal death. Drosophila melanogaster, the fruit fly, has been a pivotal model for studying aging mechanisms for over a century due to its short lifespan, genetic tractability, and high conserv...
Preprint
Full-text available
დამხმარე საშუალება სიმსივნის, დიაბეტის, გლაუკომის, კრონის სინდრომისას. არ შველის დეპრესიას. არ ეხმარება ადდიქტიებისაგან განთავისუფლებას.
Preprint
Full-text available
ასკილის სიროფი უებარი ნაღვლდენი საშუალებაა. უკუჩვენება დიაბეტი, თროპბოციტოზი
Article
Full-text available
Centrioles, once thought to be simple structural components of the cell, have emerged as critical players in the aging process. This article reviews the existing theories linking centrioles to organismal aging, focusing on their roles in genomic stability, stem cell function, ciliary signaling, oxidative stress, and replicative Hayflick limit. Exp...
Article
Full-text available
Aging is a complex biological process that has intrigued humanity for millennia, shaping cultural beliefs, scientific exploration, and medical advancements. From ancient Egyptian notions of "heart exhaustion" to contemporary models of cellular senescence, the perception of aging has evolved alongside technological progress. This article provides an...
Article
Full-text available
Drosophila melanogaster serves as a powerful and versatile model organism for studying tissue allotransplantation due to its short life cycle, genetic manipulability, and significant homology to mammalian signaling pathways. This protocol outlines a procedure for performing tissue transplants between adult individuals of different ages and sexes. K...
Preprint
Full-text available
Aging, as a biological phenomenon, has accompanied humanity throughout its history. From mythological searches for the "elixir of immortality" to CRISPR-Cas9 and cell reprogramming, the evolution of ideas about aging reflects the progress of science and the transformation of cultural paradigms. This article provides an interdisciplinary analysis of...
Preprint
Full-text available
Drosophila melanogaster serves as a powerful model for studying tissue allotransplantation due to its short life cycle, genetic tractability, and homology of key signaling pathways with mammals. This study presents a protocol for tissue transplantation between adult individuals of different ages and sexes, including donor midgut dissection, microin...
Article
Full-text available
Centrioles are highly conserved organelles within the eukaryotic domain of life, playing an indispensable role in microtubule organization, cellular differentiation, and the formation of cilia and flagella. However, in the processes of oogenesis and spermatogenesis in certain organisms, centrioles undergo elimination, thereby preventing the transmi...
Preprint
Full-text available
Центриоли, ранее рассматривавшиеся исключительно как структурные компоненты клетки, сегодня признаны ключевыми регуляторами процессов дифференциации и старения. Они абсолютно не нужны для деления и распределения хромосом или других молекул во время митоза и тем более мейоза, когда они элиминируются. Более того, создается впечатление, что организм п...
Preprint
Full-text available
Центриоли – консервативные органоиды на эукариотической ветке древа жизни, необходимые для организации микротрубочек, дифференциации клеток и формирования ресничек. Однако в процессе оогенеза и сперматогенеза у ряда организмов происходит их элиминация, что предотвращает передачу молодых или старых центриолей в зиготу в зависимости от системы асимме...
Preprint
Full-text available
Асимметричное деление стволовых клеток играет ключевую роль в поддержании тканевого гомеостаза, обеспечивая баланс между самообновлением и дифференцировкой. В этом процессе центросома и её компоненты, включая центриоли, демонстрируют функциональную и структурную асимметрию. Материнская и дочерняя центриоли наследуются стереотипно, влияя на судьбу к...
Article
Full-text available
Asymmetric division of stem cells plays a fundamental role in maintaining tissue homeostasis by ensuring a delicate balance between self-renewal and differentiation. Within this process, the centrosome and its components, including centrioles, exhibit both functional and structural asymmetry. The mother and daughter centrioles are inherited in a st...
Article
Full-text available
Multicellular organisms employ intricate gene regulatory networks (GRNs) to orchestrate cell fate decisions, yet the precise regulatory mechanisms that govern transcription factors (TFs) within these networks remain exceptionally complex. A long-standing question in this field pertains to how these intricate interactions synergistically contribute...
Preprint
Full-text available
GRN) для принятия решений о судьбе, но механизмы регуляции факторов транскрипции (TF) в GRN чрезвычайно сложны. Давний вопрос в этой области заключается в том, как эти запутанные взаимодействия синергически способствуют процедурам принятия решений. Чтобы всесторонне понять роль регуляторной логики в решениях о судьбе клеток, мы построили модель GRN...
Article
Full-text available
In the mid-20th century, Leonard Hayflick discovered that normal human cells have a limited number of divisions, which became a significant contribution to the study of replicative aging. Together with Paul Moorhead, he demonstrated that the replicative limit of cells is a fundamental biological feature. Their research led to the concept of the rep...
Article
Full-text available
Centrioles are essential cellular organelles that play a key role in cell division, cytoskeletal organization, and microtubule dynamics. Their unique structure and ability to self-replicate make centrioles indispensable for the regulation of cellular processes. This article focuses on the anatomy of centrioles, their biogenesis, and their role in c...
Preprint
Full-text available
In the mid-20th century, Leonard Hayflick discovered that normal human cells have a limited number of divisions, which became a significant contribution to the study of replicative aging. Together with Paul Moorhead, he demonstrated that the replicative limit of cells is a fundamental biological feature. Their research led to the concept of the rep...
Preprint
Full-text available
Центриоли представляют собой важные клеточные органеллы, играющие ключевую роль в процессе клеточного деления, формировании цитоскелета и организации микротрубочек. Их уникальная структура и способность к самовоспроизведению делают центриоли незаменимыми в регуляции клеточных процессов. Настоящая статья посвящена изучению анатомии центриолей, их би...
Article
Full-text available
This article focuses on the slow and deliberate process of altering the dogmas established by Jesus Christ, using the example of the Holy Communion ritual. It argues that any deviation from the original practices instituted by Christ represents a clear and inexcusable error, both theologically and historically. The Eucharist, or Holy Communion, was...
Article
Full-text available
The "Eurasian Balkans" region remains a focal point of global political and economic strategies due to its geographical, geopolitical, and geo-economic significance. Drawing on classical geopolitical theories by Mackinder and Spykman, this paper explores the strategic importance of the Heartland, with a specific focus on the Caucasus region, conc...
Preprint
Full-text available
The Eucharist, or Holy Communion, is a central sacrament in Christian theology, deeply intertwined with the life, teachings, and divinity of Jesus Christ. This article examines the epistemological reorganization and transubstantial reinterpretation of Eucharistic practices, focusing on the evolving understanding of the essence of the Eucharist, fro...
Article
Full-text available
The Alive Language Hypothesis posits that language functions as a dynamic, self-sustaining system capable of resisting informational entropy. Unlike a passive communication tool, language is framed as an active, evolving entity that interacts with its speakers, shaping their psyche, physiology, and consciousness. Analogous to biological organisms t...
Article
Full-text available
Eternal youth, a concept once relegated to the realm of fantasy, is becoming a reality through advancements in regenerative medicine and cellular technologies. Central to this breakthrough is the replacement of aged adult stem cells, which lose their regenerative potential and accumulate old centrioles and mutations, with rejuvenated, functional st...
Preprint
Full-text available
The Living Language Hypothesis proposes that language functions as a dynamic, living system capable of resisting informational entropy. This hypothesis suggests that language is not a passive tool for communication but an active, evolving entity that interacts with its speakers, shaping their psyche, physiology, and consciousness. Just as biologica...
Presentation
Full-text available
ადამიანი რომ დაბადებიდან ზარდო სხვა ადამიანებისაგან მოწყვეტილად, ის არ დაიწყებს რომელიმე ენაზე და არც შეეცდება შექმნას რაიმე ენა. ადამინს არ აქვს არანაირი თანდაყოლილი ან მით უმეტეს გენეტიკური მიზეზი “გამოიგონოს” ამ “ეძებოს” ენა ან ენის მატარებელი არსება. ეს დამტკიცებულია უამრავი შემთხვევების კვლევებით, როცა ბავშვი ამა თუ იმ მიზეზით ხვდებოდა და იზრდ...
Article
Full-text available
Modern medicine primarily addresses symptoms rather than the root causes of diseases, often resulting in temporary relief without resolving underlying issues. This article introduces a novel perspective, viewing diseases as adaptive protective mechanisms that signal imbalances within the body and mind. From acute inflammation to chronic conditions,...
Preprint
Full-text available
Eternal youth, once a dream, is now within reach through groundbreaking advancements in regenerative medicine and cellular technologies. A central pillar of this concept is the targeted removal of aged adult stem cells, which lose their regenerative capacity over time, and their replacement with induced, rejuvenated adult stem cells. Aged stem cell...
Method
Full-text available
To promote good health, try to abstain from consuming the following items.
Preprint
Full-text available
Modern medicine constantly seeks new approaches to treating diseases, but most methods focus on combating symptoms rather than addressing the root causes of illness. This often leads to temporary improvements but does not resolve the underlying issues. The concept presented here offers a radically new perspective: to view diseases as protective mec...
Article
Full-text available
Global food security remains a pressing challenge as population growth, resource scarcity, and climate change place increasing pressure on agricultural systems. Traditional methods struggle to meet growing demands without significant environmental consequences. This article proposes a scalable and sustainable framework to address food security, int...
Preprint
Full-text available
Global food security remains an urgent challenge, especially in the context of continuous population growth and environmental constraints. This article presents a scalable and sustainable concept aimed at addressing the food security problem for any population size. The proposed approach emphasizes efficiency, equity, and environmental sustainabili...
Article
Full-text available
Humanity, as a part of the biosphere, has disrupted its equilibrium with Earth's system, inevitably leading to a critical juncture that demands a fundamental choice and a radical change in behavioral strategy. On an individual level, if a person does not believe in the existence of an afterlife, death, and hell, they are likely to choose hedonism,...
Preprint
Full-text available
The "Eurasian Balkans" region remains a focal point of global political and economic strategies due to its geographical, geopolitical, and geo-economic significance. Drawing on classical geopolitical theories by Mackinder and Spykman, this paper explores the strategic importance of the Heartland, with a specific focus on the Caucasus region, concep...
Preprint
Full-text available
Humanity, as a part of the biosphere, has disrupted its equilibrium with Earth's system, inevitably leading to a critical juncture that demands a fundamental choice and a radical change in behavioral strategy. On an individual level, if a person does not believe in the existence of an afterlife, death, and hell, they are likely to choose hedonism,...
Article
Full-text available
Modern public administration faces challenges requiring enhanced efficiency, transparency, and objectivity in evaluating the performance of government officials. This article proposes an innovative approach based on leveraging modern technologies for data collection, analysis, and application in governance systems. The focus is on comprehensive dat...
Article
Full-text available
Situated at an altitude of approximately 1,300 meters in Borjomi Municipality, Abastumani is famous for its untouched nature, historic sulfur springs and healing microclimate. Historically visited for its healing properties, Abastumani has a rich heritage in health tourism dating back to the era of Alexander the Great. This article examines the sci...
Article
Full-text available
Centrioles, microtubule-based cylindrical structures, are pivotal for generating centrosomes, cilia, flagella, and somatic cells differentiation thereby supporting essential cellular functions such as motility, signaling, and tissue development. While known for their durability and ability to persist through multiple cell cycles, centrioles can und...
Article
Full-text available
Intracellular repair and protection mechanisms determine the lifespan of an individual cell. Somatic stem cells determine the lifespan of all tissues and thus play an important role in the aging process of the body. Stem cells possess extensive self-renewal properties, but there is considerable evidence of their decline and erosion over time. The r...
Article
Full-text available
Microelements take the most active part in many vital processes occurring in living organisms at the molecular level. Acting through the enzyme system, microelements can stimulate or inhibit growth, development and reproductive functions. At present, the medical aspects of the doctrine of microelementoses have not yet been sufficiently developed. T...
Article
Full-text available
A characteristic feature of animal cells is the centrosome, a cytoplasmic organelle that almost always contains a pair of cylindrical centrioles and an organizing matrix of microtubules. Centrosomes are essential for the development of all animal species described so far. Centrioles with centrioles are essential for cells undergoing differentiation...
Article
Full-text available
Georgia has many millennia of climatic and balneological traditions. Borjomi is distinguished by its unique carbonated mineral waters, the composition of which contributes to the normalization of the digestive system and metabolic functions. Tskaltubo healing waters, which are characterized by high radon activity, are successfully used in the treat...
Article
Full-text available
The association of leukocyte telomere length (LTL) with structural and cognitive changes in the brain suggests a specific canonical effect, particularly in the elderly and in women. Unfortunately, the feedback does not appear - brain training exercises do not increase the length of telomeres. It turns out that intelligence is almost entirely due to...
Article
Full-text available
A centrosome consists of two centrioles surrounded by pericentriolar material. It is a unique structure that retains its basic features in organisms of different taxonomic groups, from single-celled algae to mammals. In addition to the most notable function of organizing the microtubule system in mitosis and interphase, the centrosome performs many...
Article
Full-text available
The accepted view is that animal-type organisms originated in the ocean/sea depths and then some of them migrated to land. Consumption of the electrolyte composition of deep sea water (below 200 meters) is expected to moderate the presence of organisms under terrestrial conditions. It is a fact that dehydration caused by prolonged exercise inhibits...
Article
Full-text available
Planarians, a type of flatworm, possess the remarkable ability of complete bodily regeneration, enabling them to redevelop any absent anatomical component following injury or surgical removal. The remarkable regenerative potential exhibited by planarians is underpinned by the existence of a substantial population of somatic pluripotent stem cells i...
Article
Full-text available
Several classes of drugs have been introduced to cellular senescence. Senomorphics that target senescence-associated secretory phenotype and senolytics, which clear senescent cells, have been shown to attenuate ageing impacts. This article introduces the strategies and advances in senomorphics and senolytic treatments of age-related diseases.
Article
Full-text available
All molecules, structures, cells of organisms are subject to destruction in the process of vital activity. In the organisms of multicellular animals and humans, the process of regeneration is always taking place: the destruction of old cells and their replacement with new ones. Cells are replaced even if the cells are in perfect condition. The earl...
Article
Full-text available
Introduction: Senescent cells are toxic cells. Their number increases every day and after some time it leads to the appearance of signs of aging. Senescent cells cause age-related pathologies. Objective: Simultaneous administration of dasatinib and quercetin in Ercc1-/∆ mice resulted in the partial killing of senolytic cells and improved and prolon...
Article
Full-text available
At the beginning of the 21st century, a new group of RNAs was discovered in the centrosomes of the mollusc Spisula solidissima eggs. These RNAs were named centrosomal RNAs (cnRNAs). Subsequent sequencing of cnRNA11 revealed the presence of a conserved reverse transcriptase domain in its structure. The discovery of this reverse transcriptase domain...
Preprint
Full-text available
Fully developed multicellular organisms constantly regenerate, replacing old cells with new ones derived from stem cells through asymmetrical division. Despite the theory suggesting an immortal pool of stem cells, their quantity diminishes over time, contributing to the ageing process. During asymmetric stem cell division, old centrioles are preser...
Presentation
Full-text available
The transplantation of safe adult stem cells from a young organism to an old one had a paradoxical effect - the transplant subdued the niche. The old organism was rejuvenated, and its life lengthened. Research should begin on the induction of young stem cells from one's own differentiated cells. Then the rejection risks will practically disappear,...
Preprint
Full-text available
Если центросомы/ центриоли не важны для зарождения микротрубочек, сборки веретена- , то почему центросомы и центриоли присутствуют практически во всех соматических клетках животных? Возможно, что центральной функцией этого органоида соматических клеток животных и человека является ассоциация с индукторами дифференциации(Tkemaladze J. and Chichinadz...
Data
The database of the Sulkhan Saba Orbeliani knowledge system "Bouquet of Words" created according to the manuscript of Saba and his brother Zosim.wledge system Sulkhan Saba Orbeliani "Bouquet of Words". База данных системы знаний Сулхана Сабы Орбелиани «Букет слов». Создан по рукописи Сабы и его брата Зосима. Знал систему Сулхана Сабы Орбелиани «Бук...
Chapter
Full-text available
Background: The more divisions of cells, the more senescent cells. Senescent cells are one of the most toxic cells in human and animal organisms. When their amount reaches great quantities, it leads to strong manifestation of ageing signs. According to the explanation of the citogenetic centriolar theory of ageing during the division process, the c...
Thesis
The destruction and dissipation of centrioles during prophase of the first meiotic division (Hartung and Stahl, 1977) perhaps testifies that the cell begins the process of acquisition of totipotency- "null" morphogenetic status. As sperm and oocyte undergo fusion, the resulting totipotent zygote divides and gives rise to the first generation - 2...
Cover Page
Full-text available
International Longevity Allliance - Georgia
Presentation
Full-text available
iCure bracelet is a revolutionary technology of modern and future medicine. iCure bracelet brings together the digital and physical worlds to improve the speed and accuracy of diagnosis and treatments, and monitor and modify patient behaviour and health status in real time.
Preprint
Full-text available
90% of being healthy depends on what you eat and how you eat So as to be well try not to eat the following. All the diary products, milk, yoghurt, farmer cheese, ricotta cheese, condensed milk, kefir, matsoni, dairy cream, etc. Only butter, brined and hard pressed cheese and melted butter are recommended. Fried and boiled skin of chicken and pork...
Conference Paper
Full-text available
Participants The experiment included middle aged and elderly men between the ages of 36-60. Average age was 53, 1years. The majority of them led sedentary lifestyle, others were slightly active, some were smokers, some moderately drank alcohol. The participants did not have any specific illnesses that potentially could affect the experiment. These...
Code
We formulate our thoughts in a language for transmission to other people. It has long been noted that the same thought, but expressed in different ways, has a different force of influence. In one case, it can leave the addressee indifferent, in the other, it can move them to take action. It turns out that the language of communication, in addition...
Article
Full-text available
Systemic problems pose many challenges in the European healthcare system of the 21st century, and it need strategies that should be implemented as large-scale euro-pilot projects in which monitoring and evaluation of their effectiveness will serve as the main mechanism that generates the sectoral policy of the European healthcare system with an inn...
Article
Full-text available
Antiterrorist management strategies in dense are associated with the methodology of non-biochemical regulation, including for the purpose of technological development of non-biochemical regulation for market-oriented design work on the commercialization of antiterrorist technical means.
Experiment Findings
Full-text available
Background: Senescent cells are one of the most toxic cells in the human and animal organism. When their amount reaches great quantity, it leads to the strong manifestation of aging signs. According to an explanation of the molecular genetic centriolar theory of aging during the division process cells’ generation reaches ultimate morphogenetic stat...
Conference Paper
Full-text available
S enescent cells are the last generation of cell differentiation. If programmed cell death (apoptosis) is not activated, then it becomes the main source of intoxication for organism. After 36 years their amount is so great, that signs of aging start strongly manifesting. For many years, scientists try to find combination of substances that could ki...
Preprint
Full-text available
ჯაბა ექიმი: ადამიანის ჯანმრთელობას ჯანსაღი ცხოვრების წესი და სწორი კვება განაპირობებს! ჯაბა ექიმი: ღვთის წყალობა ანუ ჯანმრთელობა და კეთილდღეობა არ არსებობს წყლის გარეშე! რუბრიკა “თქვენი ჯანმრთელობისათვის” ამჯერად იმმორტოლოგ ჯაბა ტყემალაძეს მასპინძლობს, რომელიც მრავალი ნომრის მანძილზე საინტერესო და პრაქტიკულ რჩევებს მოგცემთ სწორი კვების და ჯანსაღი ც...
Conference Paper
Full-text available
Epidemiological data indicate that malignant tumors are rare in schizophrenia patients. Interestingly, the concentration of melatonin, a hormone with anticancer activity, is substantially increased in the blood plasma of schizophrenia patients, whereas its level is reduced in cancer diseases. This however could not fully explain the low cancer inci...
Conference Paper
Full-text available
Epidemiological data indicate that malignant tumors are rare in schizophrenia patients. Interestingly, the concentration of melatonin, a hormone with anticancer activity, is substantially increased in the blood plasma of schizophrenia patients, whereas its level is reduced in cancer diseases. This however could not fully explain the low cancer inci...
Article
Full-text available
Недавное обнаружение нового класса РНК в центросоме, которая была названа центросомной РНК, по нашему мнению, является косвенным под- тверждением центросомной гипотезы дифферен- циации и старения клеток. Наличие в структуре данного класса РНК домена обратной транскрип- тазы, вместе с ее высокой специфичностью к дан- ному органоиду, возможно, делает...
Article
Full-text available
The recent discovery of a new class of RNAs, which are called centrosomal RNAs, in the centrosome is indirect proof of the centrosome hypothesis of cell differentiation and aging, in our opinion. The presence of a reverse transcriptase domain in RNAs of this class and the high specificity of this RNA for the organoid may make the centrosome a site...
Preprint
Full-text available
The recent discovery of a new class of RNA in a centrosome may be an indirect evidence of the centrosomal hypothesis of cellular ageing and differentiation. The presence of a reverse transcriptase domain in this class of RNA, together with its specificity to this organelle, makes the centrosome a place of information memorizing and reproduction. Th...
Article
Full-text available
A novel RNA was detected in the centrosomes of Spisula solidissima mollusk oocytes in 2006. This RNA was named centrosomal RNA (cnRNA); five different cnRNAs were described. During the sequencing of the first transcript, cnRNA 11, it was discovered that the transcript contained a conserved structure-a reverse transcriptase domain. In a 2005 study,...
Chapter
Full-text available
From the songs of my childhood I can remember one such song: " The cranes are flying far and they will never come back, the rumour is spread ... . " The author of the song text assumes that the cranes can not come back , but he/she can't bear the thought of losing lovely birds and adds: " it's a rumour !" However ,I am saying once more he lets the...
Preprint
Full-text available
Недавное обнаружение нового класса РНК в центросоме, которая была названа центросомной РНК, по нашему мнению, является косвенным под- тверждением центросомной гипотезы дифферен- циации и старения клеток. Наличие в структуре данного класса РНК домена обратной транскрип- тазы, вместе с ее высокой специфичностью к дан- ному органоиду, возможно, делает...
Article
Full-text available
Gerontology research carried out in different scientific centers of Georgia follows the basic directions of most work in this field: epidemiology, investigation of the mechanisms of aging, and finding ways to prevent senile pathologies and to prolong life. The genealogy and epidemiology of long-living peaple have been studied in areas with high occ...
Poster
Full-text available
Stem cells exhibit a remarkable ability to divide asymmetrically, ensuring self-renewal and differentiation potential. Recent research has highlighted the pivotal role of centrioles in orchestrating this process. Centrioles, cylindrical organelles composed of microtubule arrangements, are essential for organizing centrosomes and maintaining cellula...
Article
Full-text available
Irreversible differentiation (change of morphogenetic status) and programmed death (apoptosis) are observed only in somatic cells, and cell division is the only way by which the morphogenetic status of the offspring cells may be modified. It is known that there is a fixed limit to the number of possible cell divisions, the so-called Hayflick limit....
Conference Paper
Full-text available
Article
Full-text available
The article is dedicated to analysis of centrosomal hypothesis of cellular aging in the light of new data concerning existence of centrosomal RNA, and also in the light of the role of maternal and daughter centrosomes in processes of asymmetric division of stem cells. It is supposed that these data confirm the central role of centrosomes in aging a...
Preprint
Full-text available
ჯაბა ექიმი: ქერის პროდუქტების დახმარებით შეიძლება ანემიის პრევენცია, საკვებისმიერი სიმსუქნის და კოლიტის პროფილაქტიკა! ჯაბა ექიმი: ფეტვის კერძები ძალიან სასარგებლოა ათეროსკლეროზის, შაქრიანი დიაბეტის და ღვიძლის დაავადებების დროს! ამჯერად ჯაბა ექიმი იმ სასარგებლო მარცვლეულზე გვესაუბრება, რომელთა ყოველდღიურ კვების რაციონში ჩართვა ჩვენი ჯანმრთელობისათვი...

Questions

Questions (6)
Question
Eternal youth, once a dream, is now within reach through groundbreaking advancements in regenerative medicine and cellular technologies. A central pillar of this concept is the targeted removal of aged adult stem cells, which lose their regenerative capacity over time, and their replacement with induced, rejuvenated adult stem cells. Aged stem cells accumulate old centrioles and mutations, divide slowly, and contribute to tissue dysfunction, making their removal essential for restoring youthful cellular environments.
Induced adult stem cells are created by reprogramming a patient’s own somatic cells into youthful, functional stem cells with enhanced division rates and regenerative potential. This personalized approach ensures biocompatibility and eliminates the risk of immune rejection. Additionally, adult stem cells from ethically sourced umbilical cords and placentas have proven to be both effective and safe for transplantation. These cells are rigorously tested for safety, ensuring they do not carry risks of tumorigenesis or immunogenic reactions.
The combination of removing senescent cells and introducing robust, rejuvenated stem cells revitalizes tissues, enhances metabolic processes, and extends biological youth. This approach, underpinned by rigorous safety protocols, offers a transformative pathway to combat aging and maintain long-term health without compromising safety or ethical standards. Eternal youth is now a scientifically grounded possibility.
Question
Modern medicine constantly seeks new approaches to treating diseases, but most methods focus on combating symptoms rather than addressing the root causes of illness. This often leads to temporary improvements but does not resolve the underlying issues. The concept presented here offers a radically new perspective: to view diseases as protective mechanisms that help the body adapt to internal and external challenges. All bodily reactions—from inflammation to chronic conditions—serve a protective function and signal the need for change.
The key idea of the concept is that disease can be caused by unconscious goals that contradict a person's true needs. These goals, often imposed by society or culture, lead to conflicts that manifest at the bodily level. Thus, illness becomes a way to halt the progression toward destructive outcomes, giving a person the opportunity to reconsider their priorities.
According to this concept, treatment should not only aim to strengthen the body but also to enhance the individual. This includes developing awareness, understanding one's needs, and reevaluating life goals. The approach integrates knowledge from medicine, psychology, and philosophy to create comprehensive therapeutic programs.
Question
Global food security remains a pressing challenge as population growth, resource scarcity, and climate change place increasing pressure on agricultural systems. Traditional methods struggle to meet growing demands without significant environmental consequences. This article proposes a scalable and sustainable framework to address food security, integrating technological innovation, resource efficiency, and strategic policy interventions.
The approach centers on vertical farming and precision agriculture. Vertical farming enables food production in controlled environments, drastically reducing land, water, and pesticide use, while precision agriculture utilizes IoT and AI to optimize inputs, improving efficiency and minimizing waste. Together, these technologies enhance productivity and sustainability.
The framework also emphasizes circular economy principles, recycling agricultural resources and minimizing waste through practices like composting and renewable energy integration. These methods lower costs and improve access to nutritious food.
Equity-focused political strategies are vital for implementation. Policies that ensure resource distribution, education, and technology adoption are necessary, supported by collaboration among governments, private sectors, and global organizations.
Pilot studies and simulations validate the feasibility of this approach, demonstrating increased food production with reduced environmental impact. This integrated solution offers a practical pathway to sustainable, equitable food systems for a growing global population.
Question
Humanity, as a part of the biosphere, has disrupted its equilibrium with Earth's system, inevitably leading to a critical juncture that demands a fundamental choice and a radical change in behavioral strategy. On an individual level, if a person does not believe in the existence of an afterlife, death, and hell, they are likely to choose hedonism, which would result in the extinction of humanity without leaving behind any intelligent beings.However, if a person is allowed to die, experience the afterlife, and then be resurrected while retaining the memory of that experience, their behavior would shift—prioritizing the bliss of self-development over mere pleasure. Ethics dictate that all who have previously died must also be resurrected. Can current technologies provide sufficient living space for a constantly growing population? Yes, this is not only possible but has been feasible for some time.To mitigate risks, living space can be expanded through the use of space-faring starships, large enough to sustain billions of people comfortably on territories exceeding the size of India. Intergalactic ships could have surface areas surpassing that of Earth. Additionally, around stars, including the Sun, it is possible to use the material from a single planet to create spheres whose surface areas would vastly exceed that of the planet itself.
Article Details
Question
If anyone has real experience of allotransplantation from adult fly to adult fly of intestinal stem cells:
Can you recommend literature?
Write valuable instructions?
Collaboration?

Network

Cited By