J Ulrich Sommer

J Ulrich Sommer
HNO-Zentrum Mangfall-Inn

Prof. Dr. med.

About

123
Publications
12,180
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1,411
Citations
Citations since 2017
68 Research Items
1095 Citations
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2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250
2017201820192020202120222023050100150200250

Publications

Publications (123)
Article
Full-text available
Objective Unilateral hypoglossal nerve stimulation (uniHNS) is an effective treatment for obstructive sleep apnea. Bilateral hypoglossal nerve stimulation (biHNS) is a novel therapeutic option and a different approach to hypoglossal nerve stimulation. The aim of this study was to analyze the clinical outcome of the first 10 biHNS cases vs the first...
Article
Full-text available
Purpose In patients with a high pre-test probability of suffering from obstructive sleep apnea (OSA), (cardio)-respiratory polygraphy (RP; level 3) is commonly used for home sleep testing (HST); however, testing based on peripheral arterial tonometry (PAT) is increasingly recognized as an alternative method. The aim of the study was to compare slee...
Article
Full-text available
Background Patients with recurrent epistaxis, particularly due to hereditary hemorrhagic telangiectasia (HHT) are recommended to apply topical tranexamic acid (TXA) to reduce bleeding events. Those patients may suffer ciliary dysfunction due to TXA’s effects on ciliary beating frequency (CBF) and their consequences. Methodology/principal Human nas...
Article
Full-text available
Study objectivesSnoring is a common phenomenon which is generated by vibration of soft tissue of the upper airway during sleep. Due to the high incidence of isolated snoring and the substantial burden for the patient and the bed partner, a thorough examination and appropriate therapy are required. Many recommendations for the treatment of isolated...
Article
Full-text available
Background Obstructive sleep apnea (OSA) is a sleep disorder with a prevalence of 9–38%. The underlying pathology in OSA is a collapse of the upper airway. Especially in more severely affected patients, this collapse is often located at the level of the tongue base. Therefore, various implantable systems (anchors and ligament techniques) were devel...
Chapter
This chapter serves as a practical guide for standard surgical techniques in upper airway stimulation. The major topics covered in this chapter are device implantation, operative device programming, and guidelines for anesthesia. Upper airway stimulation surgery can be technically demanding, particularly in the portions of the procedure involving n...
Article
Upper Airway Stimulation Therapy for Obstructive Sleep Apnea provides the current state of knowledge regarding this novel therapy. It reviews the pathophysiologic basis of sleep apnea and the specific mechanism by which upper airway stimulation provides airway support in this disorder. It also provides practical insights into this therapy related t...
Article
Background: Head and neck squamous cell cancer (HNSCC) affects the oral cavity and the pharynx. The aim of the study was to investigate the effects of selective tyrosine kinase inhibitors (TKIs) erlotinib, gefitinib, nilotinib and dasatinib and the mammalian target of rapamycin (mTOR) inhibitor everolimus on the expression of apoptosis-related pro...
Article
Background/aim: Cocaine is a widely used recreational drug and is known for its nasal complications including epithelial, cartilage and bone damage. The aim of the study was to analyze the impact of cocaine on ciliary beat frequency (CBF) of human nasal epithelial cells and therefore better understand its side effects on nasal mucosa. Materials a...
Article
Full-text available
Purpose Upper airway stimulation (UAS) is an effective treatment for obstructive sleep apnea (OSA) in positive airway pressure (PAP) failure. Most reports have presented short-term data, so long-term safety and efficacy reports are rare. The German post-market study (G-PMS) has followed approximately 60 patients from three implanting centers for se...
Article
Full-text available
Objectives Obstructive sleep apnea (OSA) is a common sleep disorder, which is associated with recurrent oxygen desaturation during sleep. It has already been shown that nocturnal hypoxia may lead to cochlear dysfunction in patients with OSA. Less is known whether hypoxia during sleep also impacts vestibular function in those patients. Thus, the aim...
Article
Full-text available
Upper Airway Stimulation (UAS) is a well‐established therapy option for obstructive sleep apnea (OSA). There are no data on whether respiratory sensing contributes to successful UAS therapy. After initial measurements of 3 implanted patients (M1), the sensing signal was inverted (M2) without changing other parameters. Two weeks later, the signal wa...
Article
Full-text available
This study tested whether electrical stimulation of the pharyngeal mucosa is able to induce reliably the swallowing reflex in awake and asleep obstructive sleep apnea (OSA) patients, and whether the induced reflexes affect the sleep variables. In addition, the latency, occurrence, and morphology of swallows were evaluated. Eight patients received a...
Article
Full-text available
Objectives: This report describes the surgical implantation of a novel bilateral hypoglossal nerve stimulator (Genio system®, Nyxoah S.A., Belgium) and the successful treatment of a patient with moderate obstructive sleep apnea (OSA). Study design: Surgical technique description and case study report. Methods: The bilateral implantable stimula...
Article
Full-text available
Objective/hypothesis: The ADHERE Registry is a multicenter prospective observational study following outcomes of upper airway stimulation (UAS) therapy in patients who have failed continuous positive airway pressure therapy for obstructive sleep apnea (OSA). The aim of this registry and purpose of this article were to examine the outcomes of patie...
Article
Background Surgical treatment for obstructive sleep apnea (OSA) has gained increasing interest in recent years. This is partly the result of a more intensive evaluation of traditional soft palatal surgery (uvulopalatopharyngoplasty, UPPP), but also because of new treatment options such as selective hypoglossal nerve stimulation (sHNS). Additionally...
Article
Objective To examine whether previous palate or hypopharyngeal surgery was associated with efficacy of treatment of obstructive sleep apnea with hypoglossal nerve stimulation. Study Design Cohort (retrospective and prospective). Setting Eleven academic medical centers. Subjects and Methods Adults treated with hypoglossal nerve stimulation were e...
Article
Full-text available
Upper airway stimulation (UAS) has been shown to reduce severity of obstructive sleep apnoea. The aim of this study was to identify predictors of UAS therapy response in an international multicentre registry. Patients who underwent UAS implantation in the United States and Germany were enrolled in an observational registry. Data collected included...
Article
Full-text available
Purpose: Upper airway stimulation (UAS) is an alternative second-line treatment option for patients with obstructive sleep apnea (OSA). In our substudy of a previous multicentre study of patients implanted with UAS, we focused on patient-related outcomes like Epworth Sleepiness Scale (ESS), the Functional Outcomes of Sleep Questionnaire (FOSQ), sn...
Article
Full-text available
Purpose: MP 29-02, which contains fluticasone propionate and azelastine hydrochloride, is used as a topical nasal application for the treatment of seasonal and perennial allergic rhinitis. Although a multitude of data is available on the clinical symptom reduction and treatment safety of MP 29-02, the effect of MP 29-02 on ciliary beat frequency (...
Article
Die obstruktive Schlafapnoe (OSA) ist eine der häufigsten schlafbezogenen Atmungsstörungen. Sie betrifft 2–26 % der Gesamtbevölkerung. Die Überdruckbeatmung mittels „continuous positive airway pressure“ (CPAP) wird nach wie vor als Goldstandard in der Therapie angesehen, wobei die Evidenz anderer Behandlungsverfahren stetig wächst. Die am häufigste...
Article
Background: The most commonly performed surgical procedure for obstructive sleep apnea (OSA) is uvulopalatopharyngoplasty with or without tonsillectomy (UPPP ± TE). However, there is currently no review solely focusing on clinically relevant effects of standard UPPP technique with or without tonsillectomy as a monotherapy in patients with OSA. Me...
Article
Objective Upper airway stimulation (UAS) is an alternative treatment option for patients unable to tolerate continuous positive airway pressure (CPAP) for the treatment of obstructive sleep apnea (OSA). Studies support the safety and efficacy of this therapy. The aim of this registry is to collect retrospective and prospective objective and subject...
Article
Heubi CH et al. Polysomnography in Pediatric Otolaryngology: If Not Obstructive Sleep Apnea, What Is It? Otolaryngol Head Neck Surg 2017; 157: 1053–1059 Ärzte der Abteilung für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie der Universität von Cincinnati überprüften die Polysomnographie- Diagnosen von Kindern mit Verdacht auf schlafbezogene A...
Article
The results of surgical repair of extensive muscle tissue defects are still of primary concern, leaving patients with residual cosmetic and functional impairments. Therefore, skeletal muscle tissue engineering attempts to grow functional neo‑tissue from human stem cells to promote tissue regeneration and support defect closure. Despite intensive re...
Article
Full-text available
Background: After tracheostomy, the airway lacks an essential mechanism for warming and humidifying the inspired air with the consequent functional impairment and discomfort. The purpose of this study was to compare airway hydration with cold-air nebulization versus heated high-flow humidification on medical interventions and tracheal ciliary beat...
Chapter
Obstructive sleep apnea (OSA) as a multifactorial disease is treated with continuous positive airway pressure (CPAP) as the gold standard. Yet, if patients suffer from CPAP incompliance, traditional OSA surgery only targets morphological changes of the upper airway while neglecting functional issues. With the advent of upper airway stimulation, and...
Article
Zusammenfassung Zahlreiche Gesetze, Vorgaben, Richtlinien und Empfehlungen regeln und beeinflussen den Umgang und die Aufbereitung semikritischer Medizinprodukte in der HNO. Obwohl als vorrangig zu verwenden charakterisiert, wird nach wie vor in den meisten HNO-Kliniken und Praxen aus Kosten- und Praktikabilitätsgründen die manuelle der maschinelle...
Article
Objective/hypothesis: Upper airway stimulation (UAS) of the hypoglossal nerve has been implemented in the routine clinical practice for patients with moderate-to-severe obstructive sleep apnea (OSA) who could not adhere to continuous positive airway pressure. This study reports objective and patient-reported outcome after 12 months of implantation...
Article
Introduction Selective stimulation of the hypoglossal nerve is a new implanted therapy for obstructive sleep apnea (OSA) with proven efficacy in well-designed clinical trials. The aim of the study is to obtain additional safety and efficacy data on the use of selective upper airway stimulation during daily clinical routine. Methods A multi-center,...
Article
Background: Positional obstructive sleep apnea (POSA) is common in mild and moderate forms of obstructive sleep apnea (OSA). Two smartphone applications (apps) professing to avoid the supine position (SP) are available: for Android the "Apnea Sleep Position Trainer" and for iOS the "SomnoPose-Sleep Position Monitor". The smartphone needs to be att...
Article
Full-text available
Mupirocin is used worldwide for topical treatment of infected skin lesions, impetigo, and especially for nasal decolonization of patients with carriage of Staphylococci, including methicillin-resistant Staphylococcus aureus. Nevertheless, data regarding the effects of mupirocin on the nasal mucosa, in particular on ciliary beat frequency (CBF), is...
Article
Objective Selective stimulation of the hypoglossal nerve is a new surgical therapy for obstructive sleep apnea, with proven efficacy in well-designed clinical trials. The aim of the study is to obtain additional safety and efficacy data on the use of selective upper airway stimulation during daily clinical routine. Study Design Prospective single-a...
Article
Following tracheotomy the airways lack a mechanism of warming and humidifying the inspired air. Nebulization of saline is a common clinical practice to prevent desiccation of airways. The aim of the study was to compare cold-air-nebulization (CAN) and heated humidification (HH) on cilia activity and the necessary healthcare support. Method: Tracheo...
Article
The processing of nociceptive, visual, vibrotactile, thermal and acoustic stimuli during sleep has been extensively investigated in the past. Recently, interest has focused on the impact of olfactory stimulation on sleep. In contrast to all other sensory systems, olfactory stimulation does not lead to an increased arousal frequency, regardless of h...
Article
Full-text available
Background: Obstructive sleep apnea (OSA) is a very common disorder (prevalence 2-7% in women, 7-14% in men). It impairs the quality of life and increases mortality. Conservative treatment with continuous positive airway pressure is highly effective, but patient compliance is variable. Surgical treatments are controversial, as only a few are suppo...
Article
Decreased sensitivity of the pharyngeal mucosa is thought to impair protective upper airway reflexes and play a role in increased airway collapsibility in OSA subjects during sleep. We report here on the sensitivity to pharyngeal electrical stimulation as measured by the elicited swallow reflex in waking and sleeping OSA subjects. In addition to a...
Article
Einleitung: Um Patienten mit dieser Erkrankung eine mögliche Alternative zur Beatmungstherapie zu bieten, ist es auch möglich die Rückenlage mittels mechanischer Verfahren wie einer Rückenlageverhinderungsweste oder eines elektronischen Sleep-Position-Trainers (SPT) welcher auch Smartphone basiert sein kann zu verhindern. Die Wirksamkeit und Verträ...
Article
Einleitung: Extrakranielle Meningeome der Nase und Nasennebenhöhlen sind sehr selten. Auf Grund von häufigen Fehl- und Spätdiagnosen liegt die Prognose der Tumoren in realitas häufig hinter der zu erwartenden. Zusätzlich zur typischen Symptomatik intrakranieller Raumforderungen – wie Cephalgien, Übelkeit und neurologischen Defizite – kommt es häufi...
Article
Materials and methods: Twenty samples from CRS patients with (CRSwNP) and without nasal polyposis (CRSsNP) were cultivated. The expression of interleukin 5 (IL-5), eotaxin 3 and matrix metalloprotease 9 (MMP-9) were evaluated with and without CpG-ODN. Results: Addition of CpG did not influence the expression of IL-5 and eotaxin-3 DNA. Elevated M...
Article
Head and neck squamous cell carcinoma (HNSCC) is an aggressive epithelial malignancy. It is the most common neoplasm appearing in the upper aerodigestive tract and the sixth most common cancer worldwide. The five-year survival rate remains poor despite advances in surgery, radiation and chemotherapy. Furthermore, the incidence of human papillomavir...
Conference Paper
Einleitung: Eine rückenlagebezogene obstruktive Schlafapnoe (RL-OSA) wird derzeit als Goldstandard mittels CPAP-Beatmung (Continuous Positive Airway Pressure) therapiert. Diese wird von den Patienten jedoch häufig nicht toleriert. Um Patienten mit dieser Erkrankung eine mögliche Alternative zur Beatmungstherapie zu bieten, ist es auch möglich, die...
Article
Prognosis for patients with head and neck squamous cell carcinoma (HNSCC) is poor in most cases and has not improved despite advances in therapy. Novel therapeutic approaches are mandatory in order to improve the situation. Everolimus, an inhibitor of mammalian target of rapamycin, as well as the multi-tyrosine kinase inhibitors sorafenib and sunit...
Article
Einleitung: Eine rückenlagebezogene obstruktive Schlafapnoe (RL-OSA) wird derzeit als Goldstandard mittels CPAP-Beatmung (Continuous Positive Airway Pressure) therapiert. Diese wird von den Patienten jedoch häufig nicht toleriert. Um Patienten mit dieser Erkrankung eine mögliche Alternative zur Beatmungstherapie zu bieten, ist es auch möglich, die...
Article
Purpose Research has indicated that olfactory stimuli presented during sleep might reactivate memories that are associated with this odor. The present study is the first to examine whether learned associations between odor and images can be reactivated during sleep. Methods Sixteen healthy, normosmic volunteers underwent a balanced learning task in...
Article
Tissue engineering represents a promising research field, targeting the creation of new functional muscle tissue in vitro. The aim of the present study was to show the influence of static magnetic fields (SMF) and insulin-like growth factor-1 (IGF1), as enhancing stimuli on human satellite cell cultures, which are preferred sources of stem cells in...
Article
Background: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world. While the incidence of HNSCC associated with tobacco and alcohol abuse is falling, the incidence of HNSCC associated with human papilloma virus (HPV) is rising. Proliferation, cell migration and formation of metastases are dependent on interacti...
Article
Background: Arousals caused by external stimuli during human sleep have been studied for most of the sensorial systems. It could be shown that a pure nasal trigeminal stimulus leads to arousals during sleep. The frequency of arousals increases dependent on the stimulus concentration. The aim of the study was to evaluate the influence of different...
Article
The majority of patients affected by chronic rhinosinusitis (CRS) suffer from eosinophilic infiltration. We hypothesised that polihexanide and polyethylene glycol as an antiseptic might alter the eosinophil-associated IL-5 and eotaxin-3 expression in CRS and also the expression of MMP-9, being involved in the tissue-remodelling in CRS. After obtain...