J. Lee

• Korea Advanced Institute of Science and Technology

Flexible and wearable nanogenerators (NGs) have been spotlighted as next-generation healthcare electronics by enabling self-powered operation and convenient telemedicine. NGs based on mechanisms of piezoelectricity and triboelectricity with novel strategies will pave the way for an innovative healthcare system. Here, representative healthcare NGs a...

Phototherapy based on micro light‐emitting diodes (µLEDs) has gained enormous attention in the medical field as a patient‐friendly therapeutic method due to its advantages of minimal invasiveness, fewer side effects, and versatile device form factors with high stability in biological environment. Effective cosmetic and medical phototherapy depends...

Samples obtained via self-assembly-assisted dynamic placement exhibited outstanding mass activity among state-of-the-art AEMWE electrocatalysts.

Electrolyte engineering is emerging as a key strategy for enhancing the cycle life of lithium metal batteries (LMBs). Fluorinated electrolytes have dramatically extended cycle life; however, intractable challenges regarding the...

Controlled photooxidation‐mediated disruption of collagens in the tumor microenvironment can reduce desmoplasia and enhance immune responsiveness. However, achieving effective light delivery to solid tumors, particularly those with dynamic volumetric changes like pancreatic ductal adenocarcinoma (PDAC), remains challenging and limits the repeated a...

Extensively explored for their distinctive pseudocapacitance characteristics, MXenes, a distinguished group of 2D materials, have led to remarkable achievements, particularly in the realm of energy storage devices. This work presents an innovative Pseudocapacitive Sensor. The key lies in switching the energy storage kinetics from pseudocapacitor to...

High‐entropy alloy (HEA) nanoparticles possess finely tunable and multifunctional catalytic activity due to their extremely diverse adsorption sites. Their unique properties enable HEA nanoparticles to mimic the complex interactions of the redox homeostasis system, which is composed of cascade and multiple enzymatic reactions. The application of HE...

Proton exchange membrane water electrolyzer (PEMWE) is the most promising green hydrogen production device suitable for responding to the intermittency of renewable energy sources [1]. However, anodes in acidic and oxidizing environments require the use of noble Ir that is resistant to harsh conditions. Although many efforts have been made to devel...

Na‐seawater batteries (SWBs) are environmentally friendly energy storage system that utilizes abundant seawater as an electrolyte alternative to conventional distilled water‐based and organic electrolytes. To achieve high energy efficiency in Na‐SWBs, it is necessary to enhance the activity of bifunctional oxygen electrocatalysts. In this study, an...

It remains unclear whether pulmonary fibrosis-like changes differ in patients with different SARS-CoV-2 variants. This study aimed to compare pulmonary fibrotic changes between two SARS-CoV-2 variant periods (delta vs. pre-delta) in critically ill patients with SARS-CoV-2 pneumonia. Clinical data and chest CT images of patients with SARS-CoV-2 pneu...

Realizing practical lithium–sulfur batteries (LSBs) with high energy density requires a lean electrolyte design. However, under low electrolyte/sulfur (E/S) ratios, highly concentrated lithium polysulfides (LiPSs) in the electrolyte phase limit cycling and capacity. Here, we report that a small amount of Lewis acidic calcium cation (Ca²⁺) in the el...

Photobiomodulation therapy based on micro light‐emitting diodes (µLEDs) holds remarkable potential for the beauty industry. Here, a cosmetically effective face‐fit surface‐lighting µLED mask for skin anti‐aging is introduced. The face‐conformable mask enables deep tissue treatment through proximal light irradiation, with a 3D origami structure capa...

Glycerol-based biorefinery can be a highly profitable process by producing highly value-added products such as dihydroxyacetone via combined catalytic strategies. Here, two-enzyme system is adopted for the transformation of glycerol into highly valuable dihydroxyacetone as well as cofactor regeneration at the same time. Glycerol dehydrogenase (GDH)...

Atomically dispersed metal and nitrogen co‐doped carbon (MNC) is a promising oxygen reduction reaction (ORR) catalyst for electrochemical energy storage and conversion applications but typically suffers from low durability and activity under the acidic conditions of practical polymer electrolyte exchange membrane fuel cells (PEMFCs). Recently, the...

Backgrounds The management of lung complications, especially fibrosis, after COVID-19 pneumonia, is an important issue in the COVID-19 post-pandemic era. We aimed to investigate risk factors for pulmonary fibrosis development in patients with severe COVID-19 pneumonia. Methods Clinical and radiological data were prospectively collected from 64 pat...

Construction of a robust artificial solid‐electrolyte interphase (SEI) layer has proposed an effective strategy to overcome the instability of the lithium (Li). However, existing artificial SEI layers inadequately controlled ion distribution, leading to dendritic growth and penetration. Furthermore, the environmental impact of the manufacturing pro...

This review provides a comprehensive overview of the progress in light–material interactions (LMIs), focusing on lasers and flash lights for energy conversion and storage applications. We discuss intricate LMI parameters such as light sources, interaction time, and fluence to elucidate their importance in material processing. In addition, this stud...

Practical utilization of zinc‐iodine (Zn‐I2) batteries is hindered by significant challenges, primarily stemming from the polyiodide shuttle effect on the cathode and dendrite growth on the anode. Herein, a feasible redox‐active electrolyte has been introduced with tetraethylammonium iodide as an additive that simultaneously addresses the above men...

This study determined whether compared to conventional mechanical ventilation (MV), extracorporeal membrane oxygenation (ECMO) is associated with decreased hospital mortality or fibrotic changes in patients with COVID-19 acute respiratory distress syndrome. A cohort of 72 patients treated with ECMO and 390 with conventional MV were analyzed (Februa...

Backgruound: To identify a screening tool for obstructive sleep apnea (OSA) and evaluate the effects of endoscopic transsphenoidal surgery on improving OSA in patients with acromegaly. Methods: We prospectively enrolled adults with acromegaly scheduled for endoscopic transsphenoidal surgery. All measurements were conducted when participants were...

Glycerol-based biorefinery can be a highly profitable process by producing highly value-added products such as dihydroxyacetone via combined catalytic strategies. Here, two-enzyme system is adopted for cofactor regeneration as well as the transformation of glycerol into highly-valuable dihydroxyacetone. Glycerol dehydrogenase (GDH) and alcohol dehy...

Lithium-sulfur batteries (LSBs) have garnered significant attention as a promising next-generation rechargeable battery, offering superior energy density and cost-effectiveness. However, the commercialization of LSBs faces several challenges, including the ionic/electronic insulating nature of the active materials, lithium polysulfide (LiPS) shuttl...

Endotracheal suctioning is an essential but labor-intensive procedure, with the risk of serious complications. A brand new automatic closed-suction device was developed to alleviate the workload of healthcare providers and minimize those complications. We evaluated the clinical efficacy and safety of the automatic suction system in mechanically ven...

Background/Aims: Risk factors for progression to critical illness in hospital-acquired coronavirus disease 2019 (COVID-19) remain unknown. Here, we assessed the incidence and risk factors for progression to critical illness and determined their effects on clinical outcomes in patients with hospital-acquired COVID-19.Methods: This retrospective coho...

Employing the alkaline water electrolysis system to generate hydrogen holds great prospects but still poses significant challenges, particularly for the construction of hydrogen evolution reaction (HER) catalysts operating at ampere-level current density. Herein, the unique Ru and RuP2 dual nano-islands are deliberately implanted on N-doped carbon...

Aqueous zinc-ion batteries provide a most promising alternative to the existing lithium-ion batteries due to their high theoretical capacity, intrinsic safety, and low cost. However, commercializing aqueous zinc-ion batteries suffer from dendritic growth and side reactions on the surface of metallic zinc, resulting in poor reversibility. To overcom...

Background Prolonged length of hospital stay (LOS) is associated with an increased risk of hospital-acquired conditions and worse outcomes. We conducted a nationwide, multicenter, retrospective cohort study to determine whether prolonged hospitalization before developing sepsis has a negative impact on its prognosis. Methods We analyzed data from...

In this study, the cathode was coated with Super P, a low-cost conductive carbon, to simplify the process and reduce cost. Electrodes with different sulfur ratios were assembled into cells to characterize their CV curves and impedances. The S0.6-sp cell shows a high discharge capacity of 600 mAh g−1 at 2 C and 967 mAh g−1 at 0.5 C. These values are...

Background: Pulmonary fibrosis persists long after recovering from coronavirus disease 2019 (COVID-19) infection, thereby reducing quality of life and lung function. We aimed to evaluate the prevalence and risk factors for pulmonary fibrosis in patients with severe COVID-19 pneumonia requiring mechanical ventilation, a high-risk group for developin...

Importance The prevalence of obesity is increasing in the intensive care unit (ICU). Although obesity is a known risk factor for chronic kidney disease, its association with early sepsis-associated acute kidney injury (SA-AKI) and their combined association with patient outcomes warrant further investigation. Objective To explore the association b...

Backgrounds : The management of lung complications, especially fibrosis, after coronavirus disease (COVID-19) pneumonia, is an important issue in the COVID-19 post-pandemic era. We aimed to investigate risk factors for pulmonary fibrosis development in patients with severe COVID-19 pneumonia. Methods Clinical and radiologic data were prospectively...

Single‐atom nanozymes (SAzyme) constitute a promising category of enzyme‐mimicking materials with outstanding catalytic performance. The performance of SAzymes has been improved through modification of the coordination environments around the metal center. However, the catalytic turnover rates of SAzymes, which are key measures of the effectiveness...

Anisotropic lens-shaped nitrogen-doped carbon (Lens-NMC) with unidirectionally aligned mesopores was achieved via perpendicular block copolymer self-assembly at the polymer interface.

Fluorine (F) is regarded as a key element in electrolytes for sodium metal anodes (SMAs) because of the formation of NaF containing solid–electrolyte interphase (SEI) layers; however, the high-cost and HF formation issues experienced by F-based electrolytes should be addressed. Herein, F-free, cost-effective 1 M NaBH 4 /ether-based electrolytes are...

Seawater is a promising electrolyte that can replace conventional distilled water-based electrolytes in that they are affordable and abundant. In the Na seawater battery, oxygen evolution reaction and oxygen reduction reaction occur in a single electrode during the charge and discharge process respectively. To obtain high energy efficiency of the N...

Flexible piezoelectric sensors have been spotlighted as an essential human–machine interface (HMI) by obtaining high‐quality data from omnipresent biomechanical inputs. Because human voice is the most intuitive bio‐signal among them, flexible piezoelectric acoustic sensors (f‐PAS) have a potential to shift the paradigm of HMI technologies. Despite...

text. The sluggish kinetics of the hydrogen oxidation reaction (HOR) in alkaline conditions continue to pose a significant challenge for the practical implementation of anion‐exchange membrane fuel cells. Developing single‐atom catalysts can accelerate the pace of new HOR catalyst discovery for highly cost‐effective and active HOR performance. Howe...

Transfer printing of inorganic thin-film semiconductors has attracted considerable attention to realize high-performance soft electronics on unusual substrates. However, conventional transfer technologies including elastomeric transfer printing, laser-assisted transfer, and electrostatic transfer still have challenging issues such as stamp reusabil...

Hierarchical superstructures have novel shape‐dependent properties, but well‐defined anisotropic carbon superstructures with controllable size, shape, and building block dimensionality have rarely been accomplished thus far. Here, a hierarchical assembly technique is presented that uses spinodal decomposition (SD) to synthesize anisotropic oblate p...

Aqueous rechargeable static zinc–iodine (Zn–I2) batteries are regarded as competitive candidates for next-generation energy storage devices owing to their safety and high energy density. However, their inherent limitations such as the shuttle effect, sluggish electrochemical kinetics, and the poor electrical conductivity of iodine have been challen...

Lithium–sulfur batteries exhibit a high energy density of 2500–2600 Wh/kg with affordability and environmental advantages, positioning them as a promising next-generation energy source. However, the insulating nature of sulfur/Li2S and the rapid capacity fading due to the shuttle effect have hindered their commercialization. In this study, we propo...

Atomically dispersed and nitrogen coordinated iron catalysts (Fe‐NCs) demonstrate potential as alternatives to platinum‐group metal (PGM) catalysts in oxygen reduction reaction (ORR). However, in the context of practical proton exchange membrane fuel cell (PEMFC) applications, the membrane electrode assembly (MEA) performances of Fe‐NCs remain unsa...

Background High quality cardiopulmonary resuscitation (CPR) is one of the key elements of the survival chain in cardiac arrest. Audiovisual feedback of chest compressions have been suggested to be beneficial by increasing the quality of CPR in the simulated cardiac arrests. Methods A prospective before and after study was performed to investigate...

Anode-free sodium-metal batteries are considered one of the most promising alternatives for developing high-end batteries due to their high theoretical capacity, low cost, and high natural abundance. However, they have severe drawbacks in the form of inferior long-term cyclic stability. We engineered mechanically resilient MXene/CNT nano-accordion...

Owing to the emergenceof energy storage and electric vehicles, the desire for safe high‐energy‐density energy storage devices has increased research interest in anode‐free lithium metal batteries (AFLMBs). Unlike general lithium metal batteries (LMBs), in which excess Li exists to compensate for the irreversible loss of Li, only the current collect...

Neuromorphic hardware with a spiking neural network (SNN) can significantly enhance the energy efficiency for artificial intelligence (AI) functions owing to its event‐driven and spatiotemporally sparse operations. However, an artificial neuron and synapse based on complex complementary metal‐oxide‐semiconductor (CMOS) circuits limit the scalabilit...

Background: As sleep disturbances are common in the intensive care unit (ICU), this study assessed the sleep quality in the ICU and identified barriers to sleep. Methods: Patients admitted to the ICUs of a tertiary hospital between June 2022 and December 2022 who were not mechanically ventilated at enrollment were included. The quality of sleep...

Porous 2D materials with high conductivity and large surface area have been proposed for potential electromagnetic interference (EMI) shielding materials in future mobility and wearable applications to prevent signal noise, transmission inaccuracy, system malfunction, and health hazards. Here, we report on the synthesis of lightweight and flexible...

Single-atom catalysts (SACs) are being widely developed for the CO2 reduction reaction (CO2RR) because of their remarkable activity and selectivity. However, insufficient CO2RR performance and the poor long-term stability of the SACs remain obstacles to process scale-up. Herein, we explore Ni SACs (Ni-N/NCNT) under practical conditions using a zero...

We present a novel generative model, called Bidirectional GaitNet, that learns the relationship between human anatomy and its gait. The simulation model of human anatomy is a comprehensive, full-body, simulation-ready, musculoskeletal model with 304 Hill-type musculotendon units. The Bidirectional GaitNet consists of forward and backward models. Th...

Zinc air batteries (ZABs) are considered as one of the most promising energy storage and conversion devices due to their high theoretical energy density and low cost. They generate and store energy through electrochemical reactions, such as oxygen evolution reaction (OER) and oxygen reduction reaction (ORR). But, the sluggish kinetics of ORR and OE...

All-solid-state batteries (ASBs) have been identified as a potential next-generation technology for safe energy storage. However, the current pellet form of solid electrolytes (SEs) exhibits low cell-level energy densities and mechanical brittleness, and this has hampered the commercialization of ASBs. In this work, we report on the development of...

Sodium-ion batteries (SIBs) are emerging as power sources for large-scale storage owing to their abundant and inexpensive sodium (Na) source, but their limited energy density hinders their commercialization. High-capacity anode materials, such as antimony (Sb), which are potential energy boosters for SIBs, suffer from battery degradation owing to l...

Wearable blood pressure sensors have recently attracted attention as healthcare devices for continuous non-invasive arterial pressure (CNAP) monitoring. However, the accuracy of wearable blood pressure (BP) monitoring devices has been controversial due to the low signal quality of sensors, the absence of an accurate transfer function to convert the...

Background: Based on sparse evidence, the current Surviving Sepsis Campaign guideline suggests that critically ill patients with sepsis be admitted to the intensive care unit (ICU) within 6 h. However, limited ICU bed availability often makes immediate transfer difficult, and it is unclear whether all patients will benefit from early admission to...

In patients with sepsis, outcome prediction plays an important role in influencing therapeutic decision making. In this nationwide, prospective, observational cohort study of sepsis patients conducted between September 2019 and December 2020, we evaluated a novel scoring system using serial Sequential Organ Failure Assessment (SOFA) scores and seru...

Owing to the emergence of energy storage and electric vehicles, the desire for safe high-energy-density energy storage devices has increased research interest in anode-free lithium metal batteries (AFLMBs). Unlike general LMBs, in which excess Li exists to compensate for the irreversible loss of Li, only the current collector is employed as an anod...

Background: Bacterial superinfection is not uncommon in critically ill patients with coronavirus disease (COVID-19) pneumonia requiring intensive care unit (ICU) treatment. However, there is still a lack of evidence related to bacterial superinfection and their clinical significance in critically ill patients with COVID-19. Therefore, we assessed...

Recently, interest in batteries with high energy density has greatly increased as a result of the sharp rise in demand for electric vehicles, which are needed to achieve carbon neutrality by the year 2050. Lithium-sulfur (Li-S) batteries are emerging as the next-generation batteries owing to their high theoretical energy density of 2,600 W h kg−1....

High‐energy and long cycle lithium‐sulfur (Li‐S) pouch cells are limited by the insufficient capacities and stabilities of their cathodes under practical electrolyte/sulfur (E/S), electrolyte/capacity (E/C), and negative/positive (N/P) ratios. Herein, an advanced cathode comprising highly active Fe single‐atom catalysts (SACs) are reported to form...

The determination of the oligomeric state of functional enzymes is essential for the mechanistic understanding of their catalytic activities. RecQ helicases have diverse biochemical activities, but it is still unclear how their activities are related to their oligomeric states. We use single-molecule multi-color fluorescence imaging to determine th...