J. A. Astrom

CSC-IT Center for Science Ltd · comp

Tissue growth kinetics and interface dynamics depend on the properties of the tissue environment and cell-cell interactions. In cellular environments, substrate heterogeneity and geometry arise from a variety factors, such as the structure of the extracellular matrix and nutrient concentration. We used the CellSim3D model, a kinetic division simula...

The universality of interfacial roughness in growing epithelial tissue has remained a controversial issue. Kardar-Parisi-Zhang (KPZ) and molecular beam epitaxy (MBE) universality classes have been reported among other behaviors including a total lack of universality. Here, we simulate tissues using the cellsim3d kinetic division model for deformabl...

Ice shelves play a key role in the dynamics of marine ice sheets by buttressing grounded ice and limiting rates of ice flux to the oceans. In response to recent climatic and oceanic change, ice shelves fringing the West Antarctic Ice Sheet (WAIS) have begun to fragment and retreat, with major implications for ice-sheet stability. Here, we focus on...

This paper describes bonded particle method-based modeling of ice blocks failing under compressive ice-to-ice contacts. Ice block contacts transmit ice loads; thus, local failure of ice blocks has an important role in ice-structure interaction processes. The model is shortly described and laboratory-scale experiments on saline ice block failure are...

A major challenge within material science is the proper modeling of force transmission through fragmenting materials under compression. A particularly demanding material is sea ice, which on small scales is an anisotropic material with quasibrittle characteristics under failure. Here we use the particle-based model HiDEM and laboratory-scale experi...

Universality of interfacial roughness in growing epithelial tissue has remained a controversial issue. Kardar-Parisi-Zhang (KPZ) and Molecular Beam Epitaxy (MBE) universality classes have been reported among other behaviors including total lack of universality. Here, we utilize a kinetic division model for deformable cells to investigate cell-colon...

Ice shelves play a key role in the dynamics of marine ice sheets, by buttressing grounded ice and limiting rates of ice flux to the oceans. In response to recent climatic and oceanic change, ice shelves fringing the West Antarctic Ice Sheet (WAIS) have begun to fragment and retreat, with major implications for ice sheet stability. Here, we focus on...

Iceberg calving strongly controls glacier mass loss, but the fracture processes leading to iceberg formation are poorly understood due to the stochastic nature of calving. The size distributions of icebergs produced during the calving process can yield information on the processes driving calving and also affect the timing, magnitude, and spatial d...

We investigate morphologies of proliferating cellular tissues using a numerical simulation model for mechanical cell division and migration in two dimensions. The model is applied to a bimodal mixture consisting of stiff cells with a low growth potential and soft cells with a high growth potential; cancer cells are typically considered to be softer...

Marine ice-cliff instability could accelerate ice loss from Antarctica, and according to some model predictions could potentially contribute >1 m of global mean sea level rise by 2100 at current emission rates. Regions with over-deepening basins >1 km in depth (e.g., the West Antarctic Ice Sheet) are particularly susceptible to this instability, as...

Projections of future ice sheet mass loss and thus sea level rise rely on the parametrization of iceberg calving in ice sheet models. The interconnection between submarine melt-induced undercutting and calving is still poorly understood, which makes predicted contributions of tidewater glaciers to sea level rise uncertain. Here, we compare detailed...

We investigate morphologies of proliferating cellular tissues using a newly developed numerical simulation model for mechanical cell division and migration in 2D. The model is applied to a bimodal mixture consisting of stiff cells with a low growth potential and soft cells with a high growth potential; cancer cells are typically considered to be so...

High-resolution numerical simulations of cracks driven by an internal pressure in a heterogeneous and brittle granular medium produce fragment-size distributions with the same characteristics as experiments on blasted cylinders of mortar and rock in both the fine- and the intermediate-size-fragment regions. To mimic full-scale blasts used, e.g., wi...

We investigate morphologies of proliferating cellular tissues using a newly developed numerical simulation model for mechanical cell division in 2D. The model is applied to a bimodal mixture of stiff cells with a low growth potential and soft cells with a high growth potential. In an even mixture, the soft cells develop into a tissue matrix and the...

Sea ice and ice shelves can be described by a viscoelastic rheology that is approximately linear elastic and brittle at high strain rates and viscously shear thinning at low strain rates. Brittle ice easily fractures under compressive shear and forms shear bands as the material undergoes a transition to a fragmented, granular state. This transition...

Considerable experimental and theoretical research has been dedicated to understanding the connection between the biochemical activity of cells and their mechanical environment. This is exemplified by the common structures of developing epithelial cells between various species, and the decay of cell population growth rate over time. We study these...

Scientific computing applications involving complex simulations and data-intensive processing are often composed of multiple tasks forming a workflow of computing jobs. Scientific communities running such applications on computing resources often find it cumbersome to manage and monitor the execution of these tasks and their associated data. These...

We investigate morphologies of proliferating cellular tissue using a newly developed numerical simulation model for mechanical cell division. The model reproduces structures of simple multi-cellular organisms via simple rules for selective division and division plane orientation. The model is applied to a bimodal mixture of stiff cells with a low g...

We investigate morphologies of proliferating cellular tissue using a newly developed numerical simulation model for mechanical cell division. The model reproduces structures of simple multi-cellular organisms via simple rules for selective division and division plane orientation. The model is applied to a bimodal mixture of stiff cells with a low g...

Blasting with explosives and crushing with mills are two major processes for extracting ore minerals. Longstanding problems with these processes are "fines" production in blasting and the related energy consumption of mills. Here, we demonstrate, using numerical simulations and comparison with experiments, that both problems emerge from two univers...

The Totten Ice Shelf (IS) has a large drainage basin, much of which is grounded below sea level, leaving the glacier vulnerable to retreat through the marine ice sheet instability mechanism. The ice shelf has also been shown to be sensitive to changes in calving rate, as a very small retreat of the calving front from its current position is predict...

Scientific computing applications involving complex simulations and data-intensive processing are often composed of multiple tasks forming a workflow of computing jobs. Scientific communities running such applications on distributed and heterogeneous computing resources find it cumbersome to manage and monitor the execution of these tasks. Scientif...

This paper investigates the blast fragmentation of a mortar cylinder by numerical simulations. The aim of the project is to understand the underlying mechanisms causing blast induced fines. Two numerical methods: Finite and Discrete Element Methods (FEM, DEM) with explicit time integration were used and the results were compared with the results of...

We present a new open source software package CellSim3D for computer simulations of mechanical aspects (that is, biochemical details are not accounted for) of cell division in three dimensions. It is also possible to use the software in the mode with cell division and growth turned off which allows for simulations of soft colloidal matter. The code...

The marine-terminating outlet in Basin 3, Austfonna ice cap, has been accelerating since the mid-1990s. Stepwise multi-annual acceleration associated with seasonal summer speed-up events was observed before the outlet entered the basin-wide surge in autumn 2012. We used multiple numerical models to explore hydrologic activation mechanisms for the s...

In this paper, we study the effects of basal friction, sub-aqueous undercutting and glacier geometry on the calving process by combining six different models in an offline-coupled workflow: a continuum–mechanical ice flow model (Elmer/Ice), a climatic mass balance model, a simple subglacial hydrology model, a plume model, an undercutting model and...

The Totten Ice Shelf (IS) has a large drainage basin, much of which is grounded below sea level, leaving the glacier vulnerable to retreat through the Marine Ice Shelf Instability mechanism. The ice shelf has also been shown to be sensitive to changes in calving rate, as a very small retreat of the calving front from its current position is predict...

Calving, or the release of icebergs from glaciers and floating ice shelves, is an important process transferring mass into the world’s oceans. Calving glaciers and ice sheets make a large contribution to sea-level rise, but large uncertainty remains about future ice sheet response to alternative carbon scenarios. In this review, we summarize recent...

A shear fracture of brittle solids under compression undergoes a substantial evolution from the initial microcracking to a fully formed powder-filled shear zone. Experiments covering the entire process are relatively easy to conduct, but they are very difficult to investigate in detail. Numerically, the large strain limit has remained a challenge....

The marine-terminating outlet in Basin 3, Austfonna ice-cap has been accelerating since the mid-1990s. Step-wise multiannual acceleration associated with seasonal summer speed-up events was observed before the outlet enters the basin-wide surge in autumn 2012. We use multiple numerical models to explore hydrologic activation mechanisms for the surg...

In this paper, we study the effects of basal friction, sub-aqueous undercutting and glacier geometry on the calving process with six different models: a continuum-mechanical ice flow model (Elmer/Ice), a climatic mass balance model, a simple subglacial hydrology model, a plume model, an undercut model and a discrete particle model to investigate fr...

The simple calving laws currently used in ice-sheet models do not adequately reflect the complexity and diversity of calving processes. To be effective, calving laws must be grounded in a sound understanding of how calving actually works. Here, we develop a new strategy for formulating calving laws, using (a) the Helsinki Discrete Element Model (Hi...

Precipitation of exceptionally 13C-depleted authigenic carbonate is a result of, and thus a tracer for, sulphate-dependent anaerobic methane oxidation, particularly in marine sediments. Although these carbonates typically are less depleted in 13C than in the source methane, because of incorporation of C also from other sources, they are far more de...

Over the next century, one of the largest contributions to sea level rise will come from ice sheets and glaciers calving ice into the ocean. Factors controlling the rapid and nonlinear variations in calving fluxes are poorly understood, and therefore difficult to include in prognostic climate-forced land-ice models. Here we analyse globally distrib...

Tissue topology, in particular proliferating epithelium topology, is remarkably similar between various species. Understanding the mechanisms that result in the observed topologies is needed for better insight into the processes governing tissue formation. We present a two-dimensional single-cell based model for cell divisions and tissue growth. Th...

A particle-based computer simulation model was developed for investigating the dynamics of glaciers. In the model, large ice bodies are made of discrete elastic particles which are bound together by massless elastic beams. These beams can break, which induces brittle behaviour. At loads below fracture, beams may also break and reform with small pro...

A particle-based computer simulation model was developed for investigating the dynamics of glaciers. In the current model, large ice bodies are made of discrete elastic particles which are bound together by massless and elastic beams. The beams can break which induces brittle behaviour. At loads below fracture, beams may also break and reform with...

We demonstrate the existence of a percolationlike stiffness transition in fiber networks with a bidisperse orientation distribution and with fiber densities clearly above the geometrical and the ordinary stiffness transition. The fibers are oriented parallel and perpendicular to a strain direction and they have a large fiber aspect ratio. The stiff...

Many of the most widely used scientifc application software of today were developed largely during a time when the typical amount of compute cores was calculated in tens or hundreds. Within a not too distant future the number of cores will be calculated in at least hundreds of thousands or even millions. A European collaboration group CRESTA has re...

Appearance of self-similar space-filling ball bearings has been suggested to provide the explanation for seismic gaps, shear weakness, and lack of detectable frictional heat formation in mature tectonic faults (shear zones). As the material in a shear zone fractures and grinds, it could be thought to eventually form a conformation that allows fragm...

Actin filament networks play an active role in cytokinesis of eukaryotic cells. These networks, linked mainly by myosin, are concentrated below the cell membrane forming a spherical supporting shell. During cytokinesis, this network is modified such that a contractile ring is formed along the diameter of the shell. We present a realistic three-dime...

The mechanics and stability of thin-walled structures is a challenging and important branch in structural mechanics. Under vertical compression the deformation of a thin-walled box differs from that of, e.g., a cylindrical shell. It is demonstrated here that compression of a box can be described by a set of generic scaling laws representing three s...

Membranes at a microscopic scale are affected by thermal fluctuations and self-adhesion due to van der Waals forces. Methods to prepare membranes of even molecular scale, e.g., graphene, have recently been developed, and the question of their mechanical and thermal stability is of crucial importance. To this end we modeled microscopic membranes wit...

Vertical compression of an elastic thin-walled box is explored. Such a compression displays three successive regimes: linear, buckled and collapsed. Analogy of the buckled regime to thin-film blisters is demonstrated. The compression force is shown to reach its maximum at the end of that regime, after which the box collapses displaying features (e....

Recently there has been some suggestions that fragmentation of thin brittle sheets is qualitatively different from pure two-dimensional fragmentation. The obvious reason for such a discrepancy is the possibility of the sheet to deform out of plane. There is a generic crack-branching mechanism that creates power-law fragment size distribution in the...

Fibrous active network structures whose properties are regulated by motor proteins, or simply motors, are fundamental to life. Here, a full elastic and three dimensional model for such networks and motors is presented. The effects of surface anchoring are accounted for and we demonstrate that for unidirectional motors two basic contractile phases e...

Forced crumpling of stiff self-avoiding sheets is studied by discrete element simulations. Simulations display stress condensation and scaling of ridge energy in agreement with theoretical expectations for elastic and frictionless sheets, and extends such behavior to elasto-plastic sheets. Crumpling of ideally elastic and frictionless sheets is com...

Crumpling a thin sheet of material into a small volume requires energy for creating a network of deformations such as vertices and ridges. Scaling properties of a single elastic vertex or ridge have been analysed theoretically, and crumpling of a sheet by numerical simulations. Real materials are however elasto-plastic and large local strains induc...

Crumpled membranes have been found to be characterized by complex patterns of spatially seemingly random facets separated by narrow ridges of high elastic energy. We demonstrate by numerical simulations that compression of stiff elastic membranes with small randomness in their initial configurations leads to either random ridge configurations (high...

Actin filament networks enable the cytoskeleton to adjust to internal and external forcing. These dynamic networks can adapt to changes by dynamically adjusting their cross-links. Here, we model actin filaments as cross-linked elastic fibers of finite dimensions, with the cross-links being approximately 1 mum apart, and employ a full three-dimensio...

For 2D regular dense packings of solid mono-size non-sliding disks there is a mechanism for bearing formation under shear that can be explained theoretically. There is, however, no easy way to extend this model to include random dense packings which would better describe natural packings. A numerical model that simulates shear deformation for both...

ITER is the next generation of fusion devices and is intended to demonstrate the scientific and technical feasibility of fusion as a sustainable energy source for the future. To exploit the full potential of the device and to guarantee optimal operation for the device a high degree of physics mod- elling and simulation is needed already in the curr...

ITER is the next generation of fusion devices and is intended to demonstrate the scientific and technical feasibility of fusion as a sustainable energy source for the future. In the fusion scientific community several modeling and simulation programs are available to describe the plasma transport and turbulence in the core and edge, but they are co...

It is well established that rapidly propagating cracks in brittle material are unstable such that they generate side branches. It is also known that cracks are attracted by free surfaces, which means that they attract each other. This information is used here to formulate a generic model of fragmentation in which the small-size part of the fragment...

We analyze large sets of energy-release data created by stress-induced brittle fracture in a pure sapphire crystal at close to zero temperature where stochastic fluctuations are minimal. The waiting-time distribution follows that observed for fracture in rock and for earthquakes. Despite strong time correlations of the events and the presence of la...

A set of 3873 cracks on exposed granite rock surfaces are analyzed in order to investigate possible fracture mechanisms. The fracture patterns are compared with the Mohr-Coulomb and the Roscoe fracture models, which can be combined into a single fracture scheme. A third model for comparison is based on interacting `penny-shaped' micro cracks introd...

Above a small length scale, the distribution of local elastic energies in a material under an external load is typically Gaussian, and the dependence of the average elastic energy on strain defines the stiffness of the material. Some particular materials, such as granular packings, suspensions at the jamming transition, crumpled sheets and dense ce...

We note the striking similarity between earthquake and CRESST microfracture data for waiting times.