Izabelle M Gindri

• Doctor of Philosophy
• PostDoc Position at Universidade Federal de Santa Catarina

To manufacture, feature and analyze the potential of materials to be used as raw material for drug delivery systems for the treatment of overactive bladder. Four distinct mixtures of oxybutynin and polymers ethylene vinyl acetate (EVA) and high-density polyethylene (PE) were prepared via compression molding and hot melt extrusion. The materials wer...

The overactive bladder is a condition characterized by a sudden urge to urinate, even with small volumes of urine present in the bladder. The current treatments available for this pathology consist on conservative approaches and the continuous administration of drugs, which when made by conventional methods has limitations related to the first pass...

Purpose: NAD+ is an essential pyridine nucleotide cofactor that is present in cells and in several important biological processes, including oxidative phosphorylation and production of adenosine triphosphate, DNA repair, calcium-dependent secondary messenger and gene expression. The purpose of this systematic review is to examine whether the coenz...

Although ibuprofen has been employed as a postoperative treatment in TJR to reduce inflammation, the incorporation of this drug on UHMWPE bearing components prior to implantation is incipient. The present study investigated the effect of the incorporation ibuprofen into the polymeric matrix of UHMWPE. Particularly, the mechanical, tribological, and...

PurposeEndometriosis is a common chronic gynecological disease defined as the presence of endometrial glands and stroma tissue outside the uterus. Gestrinone is an effective antiestrogen that induces endometrial atrophy and/or amenorrhea. The purpose of this systematic review is to provide an evaluation of safety and effectiveness of gestrinone for...

The present work proposes a complete set of experiments for chemical characterization of PMMA-based hip implant centralizers and spacers screening. Evaluation of chemical structure, including screening for residual monomer and other impurities from manufacturing process, was performed. Data from FTIR and NMR confirmed chemical structure while resul...

The influence of the surface finishing of breast implants on physicochemical and mechanical properties, before and after extreme degradation experiments, was investigated in this study. Removal of superficial layers after degradation was verified for both smooth and rough membranes, in which local erosion was verified. FTIR results demonstrated the...

Hydrophilic-coated catheters reduce the endovascular friction between the device and blood and increase the biocompatibility of catheters. This study investigated three surface treatments to improve catheter surface. Oxygen plasma, hydrogen peroxide, and flame exposure coating equipment were manufactured. Polyamide 11 (PA11) catheter surfaces were...

In this study, the preparation of a novel functional material for orthopedic implants using compression molding was investigated. The new functional material is envisioned to avoid inflammatory reactions in vivo after prosthesis implantation. Ibuprofen-loaded UHMWPE samples were prepared in two concentrations (3% and 5%) and samples were characteri...

The synthesis and characterization of the multicomponent crystals formed by salicylic acid and 1,2-phenylenediamine (a diarylamine) are reported. The crystals are in the salt rather than cocrystal form, as witnessed by X-ray photoelectron spectroscopy, solid-state NMR, and infrared spectroscopy. 1H double-quantum–single-quantum NMR was pivotal in c...

In this study, implantable polyethylene/fluorouracil (PE/FU) rods were manufactured by hot extrusion under different processing conditions. SEM–EDS analyses revealed the effect of temperature on the morphology of the samples. Furthermore, small particles of fluorouracil were observed on the surface and in the PE matrix. Both the FTIR and NIR spectr...

In this work, we proposed a set of techniques and respective methodologies to investigate the physicochemical properties of six models of ultra high molecular weight polyethylene (UHMWPE) acetabular liners commercially available. The correlation between chemical properties, sterilization techniques, and potential performance of material were propos...

This paper evaluated corn starch/cellulose acetate (SCA) specimens 3D-printed by the fused deposition modeling (FDM) method. The influence of the printing parameters, nozzle temperature, and flow rate on the morphological and mechanical properties of the specimens was evaluated. Scanning electron microscopy (SEM) showed smooth surfaces on all the 3...

This paper investigates the morphology and mechanical properties of poly (l-co-d,l-lactic acid) (PLDLA) specimens injection-molded using different melt temperatures and stress concentrator in the specimen geometry. The values for the tensile strength and ultimate strain increased with a reduction in the melt injection temperature for unnotched spec...

Progesterone and fluorouracil loaded-intrauterine drug delivery systems were prepared using selective laser sintering (SLS). PE/FU/PG IUDs had small particles of fluorouracil spread over the IUD surface and progesterone was dispersed within the porous PE matrix. The existence of additional peaks related to the fluorouracil and progesterone confirm...

Nanostructured Biomaterials for Cranio-Facial and Oral Applications examines the combined impact of materials science, biomedical and chemical engineering and biology to provide enhanced biomaterials for applications in the field of maxillo-facial rehabilitation and implantology. With a strong focus on a variety of material classes, the book also e...

In this chapter, a brief review is devoted on polymer matrix composites for current dental restoration and prosthetic structures as well as on tissue healing. Emphasis is given on different chemical composition and properties for each application. https://www.elsevier.com/books/nanostructured-biomaterials-for-cranio-maxillofacial-and-oral-applicat...

In the present work, dicationic imidazolium-based ionic liquids (ILs) were investigated as multi-functional coatings on a zirconia (ZrO2) surface to prevent biofilm formation and enhance the wear performance of zirconia while maintaining the material’s compatibility with host cells. ILs containing phenylalanine and methionine were synthesized and d...

In this study, high-density polyethylene tubes (HDPE) with the incorporation of ibuprofen (IBP) were investigated with a view to their application as urinary catheters. The melt extrusion process was used to prepare the urinary catheters and the influence of the manufacturing parameters on the material properties was evaluated. Samples prepared a...

Acrylic bone cements lack the osseointegrative characteristic to achieve thorough augmentation in vertebroplasty (VP). Novel premixed composite cements have successfully incorporated a calcium phosphate phase (CaP) within the acrylic matrix, introducing osseointegrative potential. In a recent study, two composite cements (PMMA-hydroxyapatite and PM...

Background: UHMWPE bearing wear is related to bone resorption and aseptic loosening, which is one of the main causes of hip implant failures. In the present work, the wear from a metal-on-polyethylene bearing couple was evaluated through a hip simulator test. Wear mechanisms were identified through the analysis of acetabular cups and wear particles...

Background The use of scanning electron microscopy (SEM) and energy-dispersive spectrometry (EDS) was investigated to understand the wear mechanisms from a metal-on-polyethylene bearing couple. Morphological features of femoral head acetabular liner, and isolated particles resulting from hip wear testing were evaluated. EDS was proposed to investig...

This study investigated the manufacture of resorbable polycaprolactone/ibuprofen (PCL/IBP) meshes by injection molding for application in ocular orbital repair. The pore dimension sizes used demonstrate that micro-porous meshes can be manufactured by injection molding using a prototype mold. The mechanical properties were observed to be dependent o...

In this study, implantable polyethylene/fluorouracil waffles were additively manufactured by selective laser sintering using different laser energy densities. SEM-EDS revealed a porous morphology for both PE and PE/FU waffles. High dispersion of fluorouracil particles were observed in samples prepared under different conditions. The PE/FU waffles m...

The present work investigates the corrosion and wear performance of titanium (Ti6Al4V) and cobalt chromium molybdenum (Co28Cr6Mo) alloys when coated with dicationic imidazolium-based ionic liquids (ILs). As novel, multi-functional compounds, ILs were assessed in terms of coating stability and ability to enhance corrosion resistance and mitigate wea...

In this work, dicationic imidazolium-based ionic liquids (ILs) with amino acid anionic moieties were employed as coatings for commercially pure titanium (Ti) surfaces. Coated and non-coated samples were tested with regard to their anti-corrosive and lubricant properties. Phosphate buffer saline (PBS), artificial saliva, and 50/50 PBS-saliva (v/v) w...

The surface morphology and chemical composition of commercially pure titanium dental implants and healing abutments exposed in vitro or in vivo to oral bacteria were studied. Implants exposed in vitro to media containing S. mutans and healing abutment retrievals were used to evaluate the effect of early bacterial colonizers. Another dental implant...

Cobalt chromium molybdenum alloy (CoCrMo) is widely employed in the orthopedic device industry due to a combination of properties that include low wear, high mechanical strength, and high corrosion resistance. However, when used as the bearing component of total hip implants, this material can be susceptible to wear and corrosion, which can be trig...

This work presents a new strategy to protect titanium surfaces against bacterial colonization and biofilm formation using dicationic imidazolium-based ionic liquid coatings. Ionic liquids (ILs) were designed as multi-functional coatings and their compatibility with human gingival fibroblasts (HGF-1) and pre-osteoblast (MC3T3-E1) cells was investiga...

The present disclosure relates ionic liquids which are used as lubricants for medical devices. In some aspects, the ionic liquids of the present disclosure can exhibit antimicrobial or host cell integrative activity or a combination of functionalities. In some aspects, the present disclosure also provides devices coated with the ionic liquid

Separation, characterization and analysis of target cells demonstrate critical cues for diagnosis and monitoring of chronic diseases. Electrokinetic cell separation methods have been previously established to have greater efficiency when compared to traditional flow cytometry methods. Ionic liquids show promise in the design of conductive buffers w...

Dicationic imidazolium-based ionic liquids (ILs) having bis(trifluoromethylsulfonyl)imide (NTf2) and amino acid-based (methionine and phenylalanine) anionic moieties were synthesized and used to coat titanium surfaces using a dip-coating technique. Dicationic moieties with varying alkyl chains (8 and 10 carbons) and anions with distinct characteris...

This work reports the study of the anion effect on the aggregation behavior of the long-chain spacers of dicationic imidazolium-based ionic liquids (ILs) in a 4.75 % (v/v) ethanol-water solution as well as in ethanol (95 %). The anions studied were Br−, NO3−, BF4−, SCN− and NTf2−. Aggregation behavior was investigated by differential scanning calor...

Supporting Information for “Anion effect on the aggregation behavior of the long-chain spacers dicationic imidazolium-based ionic liquids”. --- Colloid and Polymer Science, 293, 2901–2910 (2015) --- https://doi.org/10.1007/s00396-015-3680-y

Many applications of ILs are closely related to their aggregate formation. It may be expected from the amphiphilicity of ILs that interfacial phenomena play a major role in the behavior of systems which contain ILs. In recent years, most of the investigations in this field have been focused on the formation of IL aggregates in water. The aggregatio...

A series of pyrazolo[1,5-a]pyrimidines were used as a molecular model in order to understand the crystal packing of compounds with weak electrostatic intermolecular interactions. Additionally, the relationship between the energetic content of intermolecular interactions, the contact surfaces of molecules, and the thermodynamic properties of crystal...

Implant failure can be triggered by metal wear and corrosion in the articular interfaces as well in the modular sections of hip implants, which may induce inflammatory reactions. The goal of this study was to evaluate the surface characteristics related to wear and corrosion of eleven retrieved hip implants due to different clinical causes. Factors...

A systematic study was done in order to evaluate the aggregation behavior of long-chain spacers of dicationic imidazolium-based ionic liquids (ILs) in aqueous solution. The influence of spacer chain length on the self-aggregation of ILs was investigated with surface tension, conductivity, fluorescence, differential scanning calorimetry (DSC), dynam...

The crystal structure of the dicationic ILs [DBMIM][2BF4] (1) and [DBMIM][2Br][2H2O] (2) was investigated in order to explore the intermolecular interactions in these compounds. An energetic and topological approach for characterization of supramolecular clusters in organic crystals was used. The study of the crystals was done by considering the s...

Background Bacteria are major contributors to the rising number of dental implant failures. Inflammation secondary to bacterial colonization and bacterial biofilm is a major etiological factor associated with early and late implant failure (peri-implantitis). Even though there is a strong association between bacteria and bacterial biofilm and failu...

To investigate the impact of treatments used to detoxify dental implants on the oxide layer morphology and to infer how changes in morphology created by these treatments may impact re-osseointegration of an implant. Pure titanium (cpTi) and the alloy Ti6Al4V were subjected to a series of chemical treatments and mechanical abrasion simulating surfac...

Implant failure can be triggered by metal wear and corrosion in the articular interfaces as well in the modular sections of hip implants, which may induce inflammatory reactions. The goal of this study was to evaluate the surface characteristics related to wear and corrosion of eleven retrieved hip implants due to different clinical causes. Factors...

New dicationic imidazolium-based ionic liquids (ILs) were synthesized, characterized and tested in regards to cytotoxicity and antimicrobial activity. Insertion of a new cationic head and use of organic anions increased the biocompatibility of the ILs developed. IC50 (concentration necessary to inhibit 50% of enzymatic activity) values obtained wer...

Powder-liquid poly (methyl methacrylate) (PMMA) bone cements are widely utilized for augmentation of bone fractures and fixation of orthopedic implants. These cements typically have an abundance of beneficial qualities, however their lack of bioactivity allows for continued development. To enhance osseointegration and bioactivity, calcium phosphate...

In this work, an approach is proposed for understanding the crystal arrangements of organic compounds. The crystals are studied, taking into account the stabilization energy and the topological properties like contact surfaces of a molecule (M1) due to the presence of neighboring Mn (cluster). The molecular system models chosen were five heterocycl...

Coated TiO2 nanoparticles by dicationic imidazolium-based ionic liquids (ILs) were prepared and studied by Differential Scanning Calorimetry (DSC), Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM), X-ray Powder Diffraction (XRD) and Scanning Electron Microscopy (SEM). Three ILs with different hydrophobicity degrees and structu...

This work investigated the chemical and mechanical factors that affect cyclocondensation reactions in a ball mill. Chemical characteristics such as the use or non-use of a catalyst, amount of catalyst and reactants, and product formation, as well as the yield and mechanical factors such as rotation frequency and the number, diameter, and material o...

4-(Trifluoromethyl)-2(1H)-pyrimidinones were synthesized from the reaction between 1,1,1-trifluoro-4- methoxy-3-buten-2-ones [CF3C(O)C(R2)C(R1)(OCH3) where R1 = Ph, 4-F-C6H4, 4-Cl-C6H4, 4-Br-C6H4, 4-I- C6H4, 4-CH3-C6H4, naphth-2-yl, 4-OCH3-C6H4, thien-2-yl and R2 = H, CH3] and urea in the presence of ionic liquid [BMIM][BF4] combined with HCl. The...

After having examined the literature in ILs from APIs it is possible to conclude that: (i) this is a research area developed by few groups; (ii) a complete and elaborated work including synthesis, physical and chemical properties studies and pharmacological activity estimation is necessary to produce significant results in this area (some groups ha...