About
15
Publications
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Introduction
My research focuses on MRI image analysis for Crohn's disease (CD).
I use advanced MRI image processing algorithms to uncover radiological biomarkers for CD disease activity and attempt to automate the analysis process for easier adaptation of those metrics into clinical practice.
Skills and Expertise
Current institution
Education
October 2018 - December 2022
Publications
Publications (15)
Background
Robust and sensitive therapeutic targets are key in effective management of Inflammatory Bowel Disease1. Mesenteric hyperaemia is a recognized sign of active disease and in cross-sectional image is described as the comb sign. Although it is subjectively described, no automated quantitative MRI-based measures have been developed.
We aim t...
The use of cross-sectional imaging and ultrasonography has long complemented endoscopic assessment of inflammatory bowel disease (IBD). Clinical symptoms alone are often not enough to assess disease activity, so a reliance on non-invasive techniques is essential. In this paper, we aim to examine the current use of radiological modalities in aiding...
Objectives
To compare the responsiveness of linear and volumetric assessments of intestinal inflammation in children with newly diagnosed ileal Crohn disease (CD) into treatment.
Materials and methods
Twenty children with ileal CD (8 girls; mean age = 14.0 years) between May 2019 and April 2021 underwent research MRI at three time points—diagnosis...
Background
After colectomy, many patients with ileo-anal pouch anastomosis develop high bowel frequency and become refractory to antimotility agents despite normal pouch morphology. Recently, it has been shown that Liraglutide but not placebo reduces bowel frequency1. We investigate the potential underlying contractility (hereafter referred to as ‘...
Background
Changes in small bowel motility have been quantified by magnetic resonance enterography (MRE) in Crohn’s disease to assess disease activity, but there is no data about colon motility changes in ulcerative colitis (UC). The aim of this study was to examine the correlation between colon motility (bowel wall motion) and endoscopic and labor...
Background
Assessing small bowel (SB) Crohn’s Disease (CD) is challenging due to finite accuracy of Faecal Calprotectin and the invasive nature of ileocolonoscopy. While SB motility is a validated biomarker, its impact on clinical decision-making remains unstudied. This study aims to evaluate the influence of GIQuant lesion-specific motility score...
Background
Magnetic resonance imaging (MRI) is the gold standard for diagnosing, classifying, and monitoring perianal Crohn’s disease (pCD). Fistula T2 signal intensity and volume/complexity are predictive of treatment response. We developed pTRACK, an interactive tool that enables radiologists to measure fistula volume, normalised average T2 signa...
Aims
To examine the impact of impaired glycaemic regulation (IGR) and exercise training on hepatic lipid composition in men with metabolic dysfunction‐associated steatotic liver disease (MASLD).
Materials and Methods
In Part A (cross‐sectional design), 40 men with MASLD (liver proton density fat fraction [PDFF] ≥5.56%) were recruited to one of two...
Aims
To examine the impact of impaired glycaemic regulation and exercise training on hepatic lipid composition in men with metabolic dysfunction-associated steatotic liver disease (MASLD).
Materials and methods
In Part A (cross-sectional design), 40 men with MASLD (liver proton density fat fraction [PDFF]≥5.56%) were recruited to one-of-two groups...
Background
In Crohn’s Disease (CD), 10% of patients present with fibrostenosis with a further 10% progressing from inflammatory to a fibrostenotic disease behaviour over 7 years. 40% of fibrostenotic CD patients need surgery at 5 years compared to ~10% with inflammatory disease. Present non-invasive fibrosis biomarkers lack the required accuracy ne...
Background
Traditionally, mural thickness and disease length have been the radiological standards for assessing Crohn's Disease (CD) severity and treatment response. Our study aimed to evaluate and compare these linear measurements with volumetric ones in newly diagnosed pediatric CD, as well as to assess the concordance between manual and semi-aut...
Parallel transmit MRI at 7 T has increasingly been adopted in research projects and provides increased signal-to-noise ratios and novel contrasts. However, the interactions of fields in the body need to be carefully considered to ensure safe scanning. Recent advances in physically flexible body coils have allowed for high-field abdominal imaging, b...
Crohn’s disease (CD) is an inflammatory bowel disease which affects 150k people in the UK alone. Visceral fat hypertrophy is a characteristic radiological finding in CD.To date radiologists just describe it but are not able to provide more objective data regarding visceral fat volume. In this retrospective study we used 2-point mDixon fat Images al...
