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Introduction
Current institution
Additional affiliations
May 2013 - January 2014
September 2006 - present
September 1998 - June 2002
Publications
Publications (59)
Myeloperoxidase (MPO) generated hypochlorous acid (HOCl) formed during catalysis is able to destroy the MPO heme moiety through a feedback mechanism, resulting in the accumulation of free iron. Here we show that the presence of melatonin (MLT) can prevent HOCl-mediated MPO heme destruction using a combination of UV-visible photometry, hydrogen pero...
Hypochlorous acid (HOCl) is a potent oxidant generated by myeloperoxidase (MPO), which is an abundant enzyme used for defense against microbes. We examined the potential role of HOCl in corrin ring destruction and subsequent formation of cyanogen chloride (CNCl) from dicyanocobinamide ((CN)2-Cbi). Stopped-flow analysis revealed that the reaction co...
The photodynamic action of riboflavin is generally considered to involve the generation of reactive oxygen species, whose production is enhanced when Cu(II) is present in the reaction. In the present study we report that photoactivated riboflavin causes K(+) loss from fresh human red blood cells (RBC) in a time dependent manner. Addition of Cu(II)...
The effect of aminophylline on human red blood cells (RBC) has been studied. Under in vitro condition, aminophylline alone does not hemolyse RBC. However, in the presence of riboflavin and visible light, aminophylline causes hemolysis of RBC. This hemolysis depends on the concentration of both riboflavin and aminophylline. Using different free radi...
Photoactivated riboflavin in the presence of Cu(II) generates reactive oxygen species (ROS) which can hemolyze human red blood cells (RBC). In the present work we examined the effect of sodium azide (NaN3) on RBC in the presence of riboflavin and Cu(II). The addition of NaN3 to the riboflavin-Cu(II) system enhanced K+ loss and hemolysis. The extent...
Background: Deodorants are widely used to mask unpleasant body odors. They are reported to cause some adverse effects depending on the form and ingredients. The purpose of this study was to assess the prevalence of deodorant use and related adverse effects among Palestinian students. Methods: This cross-sectional study was carried out at An-Najah N...
Background
End-stage renal disease (ESRD) is a growing cause of morbidity worldwide. Protein malnutrition is common among patients with ESRD. Peritoneal dialysis (PD) offers greater lifestyle flexibility and independence compared to the widely used treatments for ESRD. This study aimed to assess the nutritional status and the quality of life (QOL)...
Introduction: Research has suggested that having low Vitamin D levels is associated with a higher likelihood of developing cardiovascular disease. Specifically, several observational studies have found that Vitamin D is linked to a decreased risk of coronary artery disease. Our study aimed to determine how prevalent Vitamin D deficiency is in Pales...
Background
End-stage renal disease (ESRD) is a growing cause of morbidity worldwide. Protein malnutrition is common among patients with ESRD. Peritoneal dialysis (PD) offers greater lifestyle flexibility and independence compared to the widely used treatments for ESRD. In this study, we aimed to evaluate the nutritional status and the quality of li...
Introduction
Ulcerative Colitis (UC), a type of inflammatory bowel disease (IBD), is defined as chronic inflammation of the superficial mucosal layer of the large intestine. In this study, we aimed to investigate the association between Helicobacter pylori (H. pylori) colonization, and UC in Palestine.
Methods
A total of 35 Palestinian patients of...
Much of the existing literature on vaccine hesitancy and resistance focuses on the explicit reasons individuals justify their opposition to a particular vaccine or vaccination programs in general. We were therefore interested to assess vaccine hesitancy among university students in Palestine. A valid and reliable multi-item questionnaire was made a...
Introduction
Ulcerative Colitis (UC), a type of inflammatory bowel disease (IBD), is defined as chronic inflammation of the superficial mucosal layer of the large intestine. In this study, we aimed to investigate the association between Helicobacter pylori (H. pylori) colonization, and UC in Palestine.
Methods
A total of 35 Palestinian patients of...
Background
Microbial resistance, diabetes mellitus, and obesity are global health care problems that have posed a serious threat to both human and environmental ecosystems. The goals of the present investigations are to investigate the phytoconstituents, antilipase, anti-α-amylase, and antimicrobial activity of Orobanche aegyptiaca Pers. (OA) from...
Artificial Sweeteners (AS) are synthetic sugar substitutes that have sweetening potency hundreds of times more than the table sugar (sucrose). Artificial sweeteners are regarded as attractive alternatives to sugar as they add no calories to food intake. There are many hypotheses suggesting that AS may enhance appetite and cause weight gain. The aim...
Pellitory plant (Parietaria judaica (PJ)) is one of the most widely used Arabian traditional medicinal plants due to its ability to cure several infectious diseases and other illnesses. The current study is aimed at assessing the phytoconstituents, antilipase, antiamylase, antimicrobial, and cytotoxic characters of the Pellitory plant (Parietaria j...
Objectives
A “potential drug-drug interaction” (pDDI) is the possibility one drug has to alter the effects of another when both are administered simultaneously. Intensive care unit (ICU) patients are especially prone to these pDDIs. This study aimed to determine the frequency and severity of pDDIs during the hospitalization of patients in the ICU....
Background
Respiratory distress syndrome (RDS), a consequence of lung immaturity, is a serious complication of preterm birth and the primary cause of early neonatal mortality. Administration of antenatal steroids is a standard care method for mothers with anticipated preterm labor. However, the gestational age range at which antenatal corticosteroi...
Background and Aims: Bedside teaching is seen as one of the most important component of medical education. A balance must be found between the best management of the patient and the education process. This study aims to determine patients' attitudes toward the presence of medical students during consultations in the newly established teaching hospi...
Sesame oil has many cosmeceutical and pharmaceutical benefits. These can be exploited to produce cosmeceuticals such as sunscreens and wound healing creams according to their sun protection factor (SPF) value and β-sitosterol content. The aim of this study was to assess the quality of sesame oil available on the Palestinian market for cosmeceutical...
Sesame oil has many cosmeceutical and pharmaceutical benefits. These can be exploited to produce cosmeceuticals such as sunscreens and wound healing creams according to their sun protection factor (SPF) value and β-sitosterol content. The aim of this study was to assess the quality of sesame oil available on the Palestinian market for cosmeceutical...
Background/aim:
Stroke or cerebrovascular accident is defined as sudden or sub acute onset of focal neurologic deficit, caused by the interruption of blood flow to parts of the brain. In this study, we aimed to investigate the prevalence of dyslipidemia and hyperglycemia among stroke patients in Palestine.
Materials and methods:
A total of 70 pa...
Introduction:
Dyslipidemia is the most important modifiable risk factor that leads to cardiovascular diseases. The screening for dyslipidemia in Palestine is not established in primary health care centers for healthy people. Our study aims to determine the prevalence of dyslipidemia among healthy undiagnosed adult men in Palestine in order to asse...
Background and Aim: Long-term aspirin therapy is crucial for patients at increased risk for cardiovascular diseases. However, differing perceptions among healthcare providers profoundly shape the challenges observed in risk assessment. This study assessed the knowledge, attitudes and current practices of internists who prescribe aspirin as a preven...
Background
Orlistat is an irreversible inhibitor of the lipase enzyme that prevents trigylcerides from being digested, thereby inhibiting triglyceride hydrolysis and absorption. The resultant reduced calorie uptake enables a positive effect on weight control. Systemic absorption of the drug is, therefore, not necessary for its mode of action. An al...
Background: Since ancient times, the treatment of various diseases has relied on medicinal plants. The replacement of chemically synthesized drugs with natural medications gave the later advantageous due to their safety for humans. This study aimed to screen and to evaluate preliminarily phytoconstituents, total contents of flavonoids, tannins, and...
Background
Throughout history, every civilization in the world used plants or their derivatives for treatment or prevention of diseases. In Palestine as in many other countries, herbal medicines are broadly used in the treatment of wide range of diseases including urological diseases. The main objective of this research is to study the use of herba...
The cooking method may affect antioxidant capacity and total phenol and flavonoid content in many fruits and
vegetables. These effects may cause degradation of anti-oxidant compounds, formation of new products or destruction
of active metabolites. The aim of this study is to measure the antioxidant activity, total phenol and flavonoid contents of
f...
The potential association between impaired renal function and the incidence of cardiovascular events has been thoroughly studied. The focus of this study was to describe the renal function for patients admitted with Myocardial Infarction (MI). This retrospective descriptive study was based on reviewing the medical files of MI patients admitted to t...
The food composition tables, which are necessary tools for nutritional and epidemiological studies, are representative of food stuffs consumed in only raw state. These studies don’t take into consideration the facts that, the concentration of nutrients and their biological activity may be changed by processing methods. The aim of this study is to i...
Preservation methods may affect total phenols, flavonoids contents, and antioxidant capacity of many vegetables and fruits. These effects may cause degradation of antioxidant compounds, formation of new products, or destruction of the active metabolites. This study investigated the effects of different preservation methods, such as canning and free...
Background: Reactive oxygen species (ROS) are formed as a
natural byproduct of the normal metabolism of oxygen and have
important roles in cell signaling and homeostasis. However, during times
of oxidative stress, ROS levels can rise dramatically. This may result in
significant damage to cell structures. In this work we are interested to
show the e...
Antioxidant activity of natural compounds in food and in dietary supplements plays an important role in healthy
life. Scientific evidences suggest that antioxidants reduce the risk for chronic diseases including cancer, diabetes
mellitus and heart diseases. The antioxidant activity of wild Cyclamen persicum, Malva sylvestris and Urtica
pilulifera l...
We investigated the ability of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), hydroxyl radical ((·)OH), and hypochlorous acid (HOCl), to overcome the defensive capacity of cumulus cells and elucidate the mechanism through which ROS differentially deteriorate oocyte quality. Metaphase II mouse oocytes with (n = 1634) and without cu...
Order of Authors: Iyad A Ali, PhD; Faten Shaeib; Ibrahim Abdulhamid; Ghassan M Saed ; Subramaniam
Pennathur; Husam M. Abu-Soud, PhD
Abstract: Catalase (CAT) and myeloperoxiase (MPO) are heme-containing enzymes that have attracted
much attention in their role in the etiology of numerous respiratory disorders such as cystic fibrosis,
bronchial asthma...
Aims:
The main aims of the study were to investigate the prevalence of pre-diabetes and diabetes mellitus (DM) in patients with schizophrenia, to compare it with those published in the general population, and to assess significant associations with dysglycemia defined as having either pre-DM or DM.
Methods:
A cross-sectional study carried out in...
A convenience sample of 400 students was recruited to investigate gender differences in sleep habits and sleep related problems using a self-administered questionnaire. Univaraiate analysis showed that females went to bed (p<0.01) and rose earlier (p<0.01), had longer sleep duration (p<0.01), more nightmares (p<0.01), lesser snoring (p<0.01), lesse...
Background
Metabolic syndrome (MS) is a cluster of the most dangerous cardiac risk factors and is associated with high mortality. Ethnic differences in metabolic syndrome (MS) criteria and prevalence rates have been reported. The purpose of this study was to investigate the MS prevalence among patients with schizophrenia in Palestine.
Methods
We r...
In this work, the mild conditions of Mitsunobu reaction were used to convert the hydroxyl group of 6-triphenylmethylaminopenicillanyl alcohol to amines by using different nuleophiles such as phthalimide, di-tert-butyliminodicarboxylate and potassium cyanate. The existence of the β-lactam carbonyl group increased the instability towards nucleophilic...
A convenience sample of 400 students were recruited to investigate gender differences in sleep habits and sleep-related problems using a self-administered questionnaire. Univaraiate analysis showed that females went to bed earlier (p<0.01) and rose earlier (p<0.01), had longer sleep duration (p<0.01), more nightmares (p<0.01), lesser snoring (p<0.0...
The aim of this study was to describe sleep habits and sleep problems in a population of undergraduates in Palestine. Association between self-reported sleep quality and self-reported academic achievement was also investigated.
Sleep habits and problems were investigated using a convenience sample of students from An-Najah National University, Pale...
Sleep questionnaire used to evaluate sleep pattern and sleep problems in the study sample. A sleep questionnaire composed of 35 questions was constructed based on Diagnostic and Statistical Manual of Mental Disorders IV criteria and Pittsburgh Sleep Quality Index.
Riboflavin (RF) upon irradiation with fluorescent light generates reactive oxygen species like superoxide anion, singlet and triplet oxygen, flavin radicals and substantial amounts of hydrogen peroxide (H2O2). H2O2 can freely penetrate cell membrane and react with a transition metal ion like Cu(ll), generating hydroxyl radical via the modified meta...
Riboflavin finds ubiquitous occurrence in plants and animals and functions as a coenzyme participating in various oxidation-reduction reactions during the course of metabolism. Photosensitized riboflavin generates reactive oxygen species (ROS). Aminophylline is an antiasthmatic drug and a known phosphodiesterase inhibitor. In this study we examined...
It has been suggested that Lys 234 residue participates in β-lactamase catalysis by acting as an electrostatic anchor for the C-3 carboxylate of penicillin. The aim of the present work is to test the role of the carboxylate group at C-3 in binding with the enzyme. A novel penicillin derivative, 3-aminomethyl-6-phenylacetamidopenicillanate, was prep...
