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May 2018 - present
University Hospital Leipzig
- Reserach on breast cancer and gynecologic cancer, Detection and Characterization of DTCs and CTCs,
September 2017 - February 2018
- Literature Research, Medical and Scientific Writing , online editing, online communication, networking, cooperations, marketing,
May 2017 - August 2017
ABA Antibodies and Aptamers GmBH & Co.KG
- Head of Department
- Project Planning, Project-Coordination, Budget Responsibility, Human Resources, Networking, Colaoborations, Supervision of PhD, Master and Bachelor Students and Technical Staff. Report Writing. SOP Writing. Quality Controll.
Circulating tumor cells (CTC) could serve as a "liquid biopsy" for individualizing and monitoring treatment in patients with solid tumors as recently shown by our group. We assessed which non-hematopoietic cell types are identifiable in the peripheral blood of patients with non-small cell lung cancer (NSCLC) and correlated those to clinical charact...
Background: Patients suffering from squamous cell carcinoma of the larynx (LSCC) with lymphatic metastasis have a relatively poor prognosis and often require radical therapeutic management. The mechanisms which drive metastasis to the lymph nodes are largely unknown but may be promoted by a pro-angiogenic tumor microenvironment. In this study, we...
Purpose: Due to their minimal-invasive yet potentially current character circulating tumor cells (CTC) might be useful as a "liquid biopsy" in solid tumors. However, successful application in metastatic renal cell carcinoma (mRCC) has been very limited so far. High plasticity and heterogeneity of CTC morphology challenges currently available enric...
Flowcytometric immunophenotyping. Flowcytometric analysis and validation of the CD133 cell surface expression on K562 cells engineered to express the CD133 splice variant s1 encoded by an IRES-eGFP expression cassette (CD133:IEG). Cells were stained with PE-conjugated isotype control or anti-CD133 antibodies. (TIF)
Since image based diagnostic tools fail to detect early metastasis in head and neck squamous cell carcinoma (HNSCC) it is crucial to develop minimal invasive diagnostic methods. A promising approach is to identify and characterize circulating tumor cells (CTC) in the peripheral blood of HNSCC patients. In this pilot study, we assessed which non-hem...
Circulating tumor cells (CTC) and cancer stem cells (CSC) have been proposed as tools for detection and characterization of disease and individualization of therapy in patients with many solid tumors. Several automated and semi-automated techniques for identification and isolation of these cells from blood have been proposed and reviewed mostly foc...
Background: Local ablative techniques such as selective internal radiation therapy (SIRT) have become the mainstay of treating hepatocellular carcinoma (HCC) in the bridging-to-transplant and palliative setting. We recently demonstrated that epithelial circulating tumor cells (CTCs) correlate to an unfavorable outcome. We wanted to scrutinize whet...
Background: Pt-(GpG) intrastrand crosslinks are the major DNA adducts induced by platinum-based anticancer drugs. In the cell lines and mouse models, the persistence of these lesions correlates significantly with cell damage. Here we studied Pt-(GpG) DNA adducts in circulating tumour cells (CTC) treated with cisplatin in medium upfront to systemic...
Circulating tumor cells (CTCs) have been proposed as a monitoring tool in patients with solid tumors. So far, automated approaches are challenged by the cellular heterogeneity of CTC, especially the epithelial-mesenchymal transition. Recently, Yu and colleagues showed that shifts in these cell populations correlated with response and progression, r...
Background: Using liver-derived circulating tumor cells (CTC) as “liquid biopsy” may be a promising approach for individualizing and monitoring treatment in patients with HCC. However, this is challenged by cellular heterogeneity. Therefore, we wanted to assess whether CTC subtypes are identifiable in the peripheral blood of patients with HCC and w...
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Effective profiling of defined biomarkers on the surface of cell such as circulating tumor cells might offer a broad perspective of applications in the fields of diagnostics, therapy monitoring and cancer research.