
Ivana UjevićInstitute of Oceanography and Fisheries | IZOR · Laboratory of Plankton and Shellfish Toxicity
Ivana Ujević
phD
Shellfish Poisoning,
LC-MS/MS,
UHPLC,
Chromatography,
Aquaculture,
Oceanography,
Heavy Metal,
PAH,
bisphenol A
About
62
Publications
29,351
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Introduction
Ivana Ujević currently works at the Laboratory of Plankton and Shellfish Toxicity, Institute of Oceanography and Fisheries. Ivana does research in Environmental Chemistry, Spectroscopy and Analytical Chemistry. Their current project is 'Determination of marine biotoxins HPLC and LC-MS / MS method: tetrodotoxins, gymnodimine spirolide, lipophilic toxins, PSP, domoic acid. bisphenol A'.
Additional affiliations
July 2007 - present
November 1990 - July 2007
Publications
Publications (62)
The seasonal and spatial distributions of particulate phosphorus (PP) in the water column of the coastal area and open sea of the middle Adriatic Sea area were investigated for the first time. The relationship between PP and two other important forms of phosphorus (dissolved inorganic phosphorus (DIP), and organic phosphorus (P-ORG)), and the relat...
Pollution of the aquatic environment is a real threat across the globe. It is becoming a topic of intense study for researchers. It has been updated and almost completely revised. The Mediterranean Sea has been recognized as a target hotspot of the world as the pollutant concentration in this region is greater than the levels in other oceans.
The b...
Diatoms of the genus Pseudo-nitzschia are cosmopolitans spread in seas and oceans worldwide, with more than 50 described species, dozens of which have been confirmed to produce domoic acid (DA). Here, we characterized and investigated the toxicological activity of secondary metabolites excreted into the growth media of different Pseudo-nitzschia sp...
Pufferfishes are among the best-known marine organisms that accumulate marine biotoxins such as Tetrodotoxin (TTX). In the Mediterranean Sea, the silver-cheeked toadfish Lagocephalus sceleratus is the most reported TTX-bearer, causing many fatal and non-fatal cases. In Lebanon, no previous studies have measured TTX levels although the possibility o...
Marine biotoxins are naturally existing chemicals produced by toxic algae and can accumulate in marine biota. When consumed with seafood, these phycotoxins can cause human intoxication with symptoms varying from barely-noticed illness to death depending on the type of toxin and its concentration. Recently, the occurrence of marine biotoxins has bee...
In this study, three isolates of the potentially toxic diatom genus Pseudo-nitzschia were analysed for morphological and toxicological features. Cultures of Pseudo-nitzschia were established from seawater samples collected from the southern part of the Velebit Channel (central Adriatic Sea) during February 2019. All culture isolates were identified...
In this study, three isolates of the potentially toxic diatom genus Pseudo-nitzschia were analysed for morphological and toxicological features. Cultures of Pseudo-nitzschia were established from seawater samples collected from the southern part of the Velebit Channel (central Adriatic Sea) during February 2019. All culture isolates were identified...
It is commonly thought that toxic compounds come only from anthropogenic sources; however, toxic compounds can be of natural origin; hence, we call them natural toxins. In the marine environment, some molluscs and crabs contain natural toxins produced by symbiotic bacteria. Shellfish in addition to the accumulation of natural toxins (biotoxins) may...
This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal,...
The first survey of the phycotoxin profile in mussels (Mytilus galloprovincialis) from the coastal waters of Bosnia and Herzegovina (The Bay of Neum, Middle Adriatic Sea) in correlation to the Makarska City Bay (Croatia, Middle Adriatic Sea) was conducted in 2017. Throughout the monitoring period, occasions of gymnodimine (GYM) and azaspiracid (AZA...
The first survey of the phycotoxin profile in mussels (Mytilus galloprovincialis) from the coastal waters of Bosnia and Herzegovina (The Bay of Neum, Middle Adriatic Sea) in correlation to the Makarska City Bay (Croatia, Middle Adriatic Sea) was conducted in 2017. Throughout the monitoring period, occasions of gymnodimine (GYM) and azaspiracid (AZA...
Over the last decade, bisphenol A (BPA) has become a chemical of concern in the marine environment. There is little data on BPA levels in the eastern Adriatic Sea, Croatian waters. This study provides concentrations of BPA in marine sediments and suspended matter sampled from the Kaštela Bay (the central part of the Adriatic Sea) for two years. The...
The assessment of chemical pollution and relative mitigation measures, in the Adriatic Ionian (ADRION) Region, is based on objectives defined by the EU Directives (WFD - Water Framework Directive, MSFD - Marine
Strategy Framework Directive), the Barcelona Convention protocols (Dumping Protocol, LBS – Land Based
Sources Protocol, Offshore Protocol,...
The aim of this paper was to assess the content of Cr, Cu, Fe, Mn and Ni in water
and in algae collected in the region of the Makarska Riviera. The samples of water and
algae were collected in August 2016 from nine sampling points: Makarska, Podgora,
Baska Voda, Split ul. Jana Pawła II, Storbeč, Podstrana, Omiš, Mimice, Dvernik. The
concentrations...
Searching for Amnesic (ASP), Paralytic (PSP) and Lipophilic (LT) toxins in seafood is of great importance for consumer protection. Studies are usually focused on the most aquacultured species, the mussel. But, there are a number of potentially commercially important shellfish species as rough cockle Acanthocardia tuberculata (Linnaeus, 1758) and sm...
Anisakiasis is among the most significant emerging food-borne parasitoses contracted through consumption of thermally unprocessed seafood harbouring infective Anisakis spp. larvae. The efficacy of the currently applied anthelminthic therapy in humans and in model organisms has not proven sufficient, so alternative solutions employing natural compou...
Silver-cheeked toadfish, Lagocephalus sceleratus (Gmelin, 1789), a poisonous marine pufferfish that has reached the Mediterranean from the Red Sea through the Suez Canal (Lessepsian migration) where it soon established its own ecological niche due to its exceptional biological features such as rapid growth, high fecundity and fertility. There are i...
Potentially important species in shellfish aquaculture, cockle Acanthocardia tuberculata and sweet clam Calista chione are widespread in the Croatian Adriatic Sea. Assessment of the potential toxin profile of the natural populations of cockle and sweet clam were monitored from March 2009 to February 2010, one per month, with the purpose of a prelim...
Paralytic Shellfish Poisoning (PSP) is caused by the saxitoxins, potent neurotoxins that cause paralysis and death in consumers of contaminated shellfish. This phenomenon may have serious health and economic consequences. Present study is the first attempt to determine PSP toxin types and establish a complete list of PSP toxins for Croatian coastal...
To detect and recognise three structurally related marine biotoxins responsible for the diarrheic shellfish poisoning (DSP) symptom, namely okadaic acid (OA), dinophysistoxin-1 (DTX-1) and dinophysistoxin-2 (DTX-2) respectively, as well as the structurally different yessotoxin (YTX), we developed a novel surface-enhanced micro-Raman scattering (mic...
The aim of our research was to study the composition of Pseudo-nitzschia species during a period when neurotoxin domoic acid (DA) was present in shellfish. Sampling was conducted in Kaštela Bay (Central Adriatic Sea), between November 2015 and January 2016. Concentrations of DA analyzed in various shellfish species were low, below the regulatory li...
Bisphenol A (BPA) presents a serious threat to soil ecosystems, yet its effects on soil-inhabiting organisms are mostly unexplored. Therefore, the impact of environmentally relevant BPA concentrations on a terrestrial model organism, the earthworm Eisenia fetida, was assessed. Animals were cutaneously exposed to 100 nM and 10 μM BPA up to 10 days (...
This paper deals with the precise identification of species of Pseudo-nitzschia, focusing on those which are a potential source of domoic acid, from the Krka River estuary of the Central Adriatic Sea. Domoic acid was measured in phytoplankton net samples and shellfish collected in the winter and early spring of 2011 and 2012. Domoic acid was only d...
The occurrence, seasonal and vertical distribution of bisphenol A (BPA) was investigated in the sediments and suspended matter sampled in Kaštela Bay, Adriatic Sea, Croatia. Granulometric composition of sediment and organic matter (OM) in sediments and suspended matter were also examined. BPA was detected in all samples of sediments and suspended m...
Abstract: The Croatian National Monitoring Program revealed the presence of Diarrhetic Shellfish Poisoning (DSP) toxicity in Mediterranean blue mussel (Mytilus galloprovincialis) from breeding farms in southern Adriatic Sea through January to June 2011. The mouse bioassay tests (MBA; at the time the official method for DSP toxins) were accompanied...
Lipophilic toxins were analysed in shellfish along eastern Adriatic coast during one-year period. Samples which provided a positive mouse bioassay test (MBA) for lipophilic toxins were analysed by LC-MS/MS. Results of LC-MS/MS analyses revealed okadaates (OAs), yessotoxins (YTXs) and gymnodimine (GYM). YTXs were the most common in all investigated...
a b s t r a c t Four species of shellfish (Mytilus galloprovincialis, Ostrea edulis, Chlamis varia and Venus verrucosa) were collected during the autumn 2011 and spring 2012 along the eastern Adriatic coast from six shellfish har-vesting areas (all species) and 13 breeding sampling areas (mussels) to assess As, Cd, Hg and Pb levels and the human ri...
Dinophysis spp. blooms and related shellfish toxicity events of diarrhetic shellfish poisoning (DSP) have been the most reported toxicity event through the Croatian National monitoring program. With the aim to characterize the DSP toxin profile in shellfish farmed in Croatia, for the first time a complete analysis of the toxin profile of Croatian m...
The population dynamics of Pseudo-nitzschia in relation to environmental factors was investigated from March 2002 to July 2008 in Lim Bay, in the north-eastern Adriatic Sea. Domoic acid was monitored in the breeding population of Mytilus galloprovincialis from 2005 to 2008. The principal-component analysis of environmental parameters showed that th...
a b s t r a c t The genus Pseudo-nitzschia contains more than 30 species, though most of them are discernible only on the basis of ultrastructural or genetic differences. We present a taxonomic study of Pseudo-nitzschia calliantha Lundhum, Hasle & Moestrup in the coastal waters of the northern Adriatic Sea together with domoic acid (DA) measurement...
This is the first study that presents concentrations of domoic acid detected in the whole shellfish tissue from breeding and harvesting areas along the Croatian coast of the Adriatic Sea during the period 2006 to 2008. Shellfish sample analyses after SAX cleaning procedures, using a UV-DAD-HPLC system, showed the presence of domoic acid in four spe...
Seasonal and spatial distributions of cadmium (Cd) and organic matter (OM) in sediment and suspended matter of the semi-enclosed Kaštela Bay (middle Adriatic Sea) were investigated at four stations during a one year period (April 2000 - April 2001). Samples of surface sediment and suspended matter were collected monthly. One sediment core was sampl...
With the aim of investigating whether yessotoxin (YTX) is responsible for diarrhetic shellfish poisoning (DSP) events in Croatian waters, three different methods were combined: a modified mouse bioassay (MBA) that discriminates YTX from other DSP toxins, the enzyme-linked immunosorbent assay method (ELISA) and liquid chromatography-mass spectrometr...
Vertical profiles of trace metal (Cd, Pb, Zn, Cu, Ni) concentrations, organic matter content, carbonate content and granulometric composition were determined in two sediment cores from the submarine pit Dragon Ear (Middle Adriatic). Concentrations of the analyzed metals (Cd: 0.06–0.12 mg kg -1 , Pb: 28.5–67.3 mg kg -1 , Zn: 17.0-65.4 mg kg -1 , Cu:...
Vertical profiles of trace metal (Cd, Pb, Zn, Cu, Ni) concentrations, organic matter content, carbonate content and granulometric
composition were determined in two sediment cores from the submarine pit Dragon Ear (Middle Adriatic). Concentrations of the
analyzed metals (Cd: 0.06–0.12mgkg−1, Pb: 28.5–67.3mgkg−1, Zn: 17.0-65.4mgkg−1, Cu: 21.1–51.9mg...
Annual dynamics and ecological characteristics of the genus Dinophysis spp. and associated shellfish toxicity events were studied from 2001 to 2005 during monitoring fieldwork in the coastal waters of the eastern Adriatic Sea. Analysis of the seasonal occurrence of Dinophysis species identified D. acuminata and D. sacculus as typical spring species...
This paper presents results of trace metal monitoring in the coastal waters of the eastern Adriatic (Croatian coast), during the 2001-2005 period, using the Mediterranean blue mussel (Mytilus galloprovincialis) as indicator species. Levels of essential (Cu, Zn) and non-essential (Cd, Cr, THg, Pb) metals were determined in a whole soft tissue of mus...
Analysis of Istrian shellfish breeding areas for (Diarrhetic Shellfish Poisoning; DSP) shellfish toxicity were recorded in summer and autumn 2005 as part of Croatian shellfish breeding areas monitoring programme. As well as analysis of Paralytic Shellfish Poisoning (PSP), DSP and Amnesic Shellfish Poisoning (ASP) through mouse bioassay, analysis of...
In Mali Ston Bay, located on the eastern Adriatic coast, mussels and oysters have traditionally been cultivated. However, previous studies showed that water and sediments from Mali Ston Bay contain elevated levels of some trace metals, which was attributed to natural processes of sedimentation and drainage. In order to assess the bioavailability of...
The Kastela Bay is heavily polluted with inorganic mercury originated from direct discharges from the chlor-alkali plant, which operated in the period from 1950 to 1990. Even though the plant was closed 15 years ago, elevated levels of total mercury are still evident in surface sediments of the bay. In order to assess the availability of remobilize...
Surveys of DSP (Diarrheic Shellfish Poisoning) toxin profiles in the mussel Mytilus galloprovincialis from coastal waters of the central Adriatic Sea, over the years 1995 to 2001, demonstrate that incidents of shellfish toxicity in this area are dominated by the occurrence of okadaic acid (OA) and a PTX derivative, 7-epi-pectenotoxin-2-seco acid (7...
Surface sediment samples collected from five stations along the east coast of the Adriatic Sea were analyzed for Cd, Pb, Cu, Zn, Cr, organic matter, carbonate and granulometric composition. Trace metal concentrations in the sediments depend on pollution sources, local environmental characteristics, as well as geology of the surrounding terrestrial...
The Baćina lakes are small coastal inter-connected lakes in a karst area. The lakes are artificially connected to the hinterland Vrgorac field and the nearby sea in order to drain the field during heavy rains and floods. The storm water has changed the natural conditions in the lakes. In this paper the distribution of cadmium, lead and organic matt...
The environmental conditions along the well-indented Croatian coast change over a short distance. The same applies to the concentration of various pollutants in the marine environment. In addition, numerous islands located in front of the mainland in several lines create numerous channels and passages, limiting the exchange of water masses between...
This paper presents the results of the second year of monitoring of heavy metal contamination in the Croatian coastal area using the Mediterranean blue mussel (Mytilus galloprovincialis) as indicator species. The levels of essential (Cu, Zn) and non-essential (Cd, Pb, Cr) metals were determined in the whole soft tissue of mussels collected from 28...
Cluster analysis was applied to identify granulometric similarities between sediment samples from a heavily contaminated semi-enclosed bay (the Kaštela Bay in the Middle Adriatic). Concentrations of Mn, Cr, Pb, Cd and organic matter were determined in four grain-size fractions (A, >300 μm; B, 54–300 μm; C, 20–54 μm; and D, <20 μm) of the sediment s...
The trace metals concentration (Pb, Cd, Cr and Mn) and organic matter content were determined in total sediment and four grain size fractions (A > 300 mu m, B 54-300 mu m, C 20-54 mu m and D < 20 mu m). The linear regression method was applied for statistical analysis of obtained data. A high correlation between Pb and Cr concentrations, and organi...
The spatial distribution of Cd, Cu, Pb and Zn has been studied in surface sediments of the eastern Adriatic coastal region. In addition, Pb concentration has been determined in long sediment cores dating back to preindustrial time. The results indicate that trace metal concentrations in surface sediment layer depend both on pollution sources, and o...