Ivana T. Drvenica

• PhD MSc Pharm
• Institute for Medical Research, Serbia

The function of immune complexes in rheumatoid arthritis (RA) is related to their composition and size. Using dynamic light scattering (DLS), we investigated the link between the RA circulating immune complex (CIC) particles’ size and the CIC immunoglobulin level. In this study, 30 RA patients and 30 healthy individuals were included. IgA, IgG, and...

The size of circulating immune complexes (CICs) in rheumatoid arthritis (RA) could be an emerging criterion in disease diagnosis. This study analyzed size and electrokinetic potential of CICs from RA patients, healthy young adults, and RA patients age-matched controls aiming to establish their unique CIC features. Pooled CIC of 30 RA patients, 30 y...

Redox imbalance in peripartum period influences health of dairy cows and their foetus and, through the colostrum, health of new-born calves. Oxidative stress in cattle can be suppressed by dietary supplementation with natural minerals, and we investigated the effect of supplementation with organically modified clinoptilolite on redox status paramet...

Hemoglobin is essential for maintaining cellular bioenergetic homeostasis through its ability to bind and transport oxygen to the tissues. Besides its ability to transport oxygen, hemoglobin within erythrocytes plays an important role in cellular signaling and modulation of the inflammatory response either directly by binding gas molecules (NO, CO,...

Exploring the potential usage of the acellular preparation of porcine hemoglobin (PHb) isolated from slaughterhouse blood as a cell culture media component, we have tested its effects on the functional characteristics of stromal cells of mesodermal origin. Human peripheral blood mesenchymal stromal cells (PB-MSCs) were used in this study as a prima...

Encapsulation of sinigrin in liposomes with the proliposomal method was performed in order to evaluate the effect of this process on in vitro simulated digestion and antioxidant potential of sinigrin. The recovery of sinigrin after simulated gastric and duodenal digestion of its free and liposomal forms was determined with HPLC-UV using human diges...

Flow cytometry (FC) analysis of erythrocyte shape and related biomechanical properties, such as osmotic fragility, have not moved from a research tool to regular clinical testing. The main reason is existing evidence that various pre-analytical factors influence the mathematical interpretation of the data obtained. With an aim to contribute to the...

Henna is the current name of the dye prepared from the dry leaf powder of Lawsonia inermis (Lythraceae). Several studies have focused on the chemistry and pharmacology of the henna dyeing active compound, lawsone, obtained from the main constituents of leaves, hennosides, during the processing of plant material. However, knowledge regarding the bio...

The aim of the present research was to study the chemical profile of volatile and non‐volatile compounds in freeze‐ and spray‐dried oregano, thyme, sage, and rosemary as well as to study the gastrointestinal stability and the biological activity of the samples after encapsulation using two proteins (soy and whey). Chemical analysis was performed by...

Calf bronchopneumonia is accompanied by increased level of circulating immune complexes (CIC), and we analysed size, and protein and lipid constituents of these CIC with an attempt to elucidate the connection between the CIC structural properties and their capacity to modulate leukocyte function. CIC of heathy calves (CICH) and calves with naturall...

Functional characteristics of satellite cells (SCs) that act as myogenesis initiators and have emerged as a promising target for cell therapy, are dependent on their microenvironment. The aim of this study was to investigate the effect of cell-free hemoglobin, as a part of the microenvironment of SCs, on their functional characteristics. The C2C12...

The purpose of this paper is to introduce a model for measuring the efficiency in managing peer-review of scientific manuscripts by editors. The approach employed is based on the assumption that the editorial aim is to manage publication with high efficiency, employing the least amount of editorial resources. Efficiency is defined in this research...

We have tested in vitro effects of hemoglobin from bovine slaughterhouse blood (BHb) on stromal cells of mesodermal origin, with an aim to explore its use as a component of cell culture media. Human peripheral blood mesenchymal stromal cells (PB-MSCs) and three mouse cell lines (ATDC5, MC3T3-E1 and 3T3-L1) were employed to study BHb effects on thei...

For many decades, the red blood cell membranes were in focus of research interest solely as a model system for an investigation into the various membrane-related phenomena, composition/organization or membrane transport properties, as well as the comparative proteomic and lipidomic analyses in health and disease. During 50s, along with the first ex...

Slaughterhouse blood represents a valuable source of hemoglobin, which can be used in production of heme-iron based supplements for prevention/treatment of iron-deficiency anemia. In order to obtain stable solid-state formulation, we have investigated the effect of maltose addition (30 % (w/v)) on stability and storage of bovine and porcine hemoglo...

Introduction. Blood products, i.e. platelet rich plasma (PRP), leukocyte-poor plasma (PRP) and platelet poor plasma (PPP), have previously been used to improve muscle regeneration. In this study, six months’ frozen-stored PPP of individuals who practiced different types of physical exercise was analysed; it could steer mouse C2C12 myoblast cells to...

The rate of scientific information generation has increased tremendously in the last few years as a result of the increase in both the number of researchers, studies and papers, and the number of scientific journals. In 2015, approximately 1.3 million articles were submitted to Elsevier journals by 1.8 million authors (it is estimated that there we...

The aim of this study was to investigate the opinion of authors on the overall quality and effectiveness of reviewers’ contributions to reviewed papers. We employed an on-line survey of thirteen journals which publish articles in the field of life, social or technological sciences. Responses received from 193 authors were analysed using a mixed-eff...

Adipose tissue (AT) homeostasis and expansion are dependent on complex crosstalk between resident adipose stromal/stem cells (ASCs) and AT extracellular matrix (ECM). Although adipose tissue ECM (atECM) is one of the key players in the stem cell niche, data on bidirectional interaction of ASCs and atECM are still scarce. Here, we investigated how a...

The purpose of this paper is to introduce a model for measuring the efficiency in managing peer-review of scientific manuscripts by editors. The approach employed is based on the assumption that the editorial aim is to manage publication with high efficiency, employing the least amount of editorial resources. Efficiency is defined in this research...

The biological activity of three previously synthesized 17β‐carboxamide glucocorticoids (BG, BEG, and MPEA) was tested in vitro on mitogen stimulated and non‐stimulated peripheral blood mononuclear cells (MNCs) and granulocytes from human healthy donors, and the results were compared to the conventional glucocorticoid dexamethasone. The tested 17β‐...

Introduction: Nonlinear laser scanning microscopy (NLSM) with its three modalities, two-photon excited fluorescence (TPEF), second and third harmonic generation (SHG/THG) is advanced optical technique mostly used in biomedicine for label free imaging [1]. Hemoglobin, the main intracellular component of erythrocytes, emits strong Soret fluorescence...

Introduction: Nonlinear laser scanning microscopy (NLSM) with its three modalities, two-photon excited fluorescence (TPEF), second and third harmonic generation (SHG/THG) is advanced optical technique mostly used in biomedicine for label free imaging [1]. Hemoglobin, the main intracellular component of erythrocytes, emits strong Soret fluorescence...

Fluorescence of hemoglobin, the main intracellular component of erythrocytes, upon excitation by ultra-short pulses in red and near infrared region [1-3], allows two-photon excited fluorescence (TPEF) microscopy to be used as a tool for label-free imaging of these cells, even in vivo [4]. Despite wide applicability of erythrocytes in diagnostic tes...

The present study describes utilization of two photon excitation fluorescence (2PE) microscopy for visualization of the hemoglobin in human and porcine erythrocytes and their empty membranes (i.e., ghosts). High-quality, label-and fixation-free visualization of hemoglobin was achieved at excitation wavelength 730 nm by detecting visible autofluores...

This chapter gives an overview of nanoencapsulation technologies that can be used by food manufacturers to develop effective nutrient delivery systems. The direct use of essential nutrients (vitamins, minerals, polyunsaturated fatty acids, peptides, amino acids, etc.) in food production and their biological activity on consumption are restricted by...

Ruthenium oxide coating on titanium was prepared by the sol–gel procedure from well-defined colloidal oxide dispersions synthesized by the microwave (MW)-assisted hydrothermal route under defined temperature and pressure heating conditions. The dispersions were characterized by dynamic light scattering (DLS) measurements and scanning electron micro...

Lipase B from Candida antarctica was immobilized by adsorption onto laboratory prepared metakaolin. This support has great potential for enzyme immobilization since it has good mechanical characteristics and thermal stability and it is easily obtained from naturally abundant raw kaolin, as presented in this paper. Immobilization process was studied...

The present study investigated preparation of bovine and porcine erythrocyte membranes from slaughterhouse blood as bio-derived materials for delivery of dexamethasone-sodium phosphate (DexP). The obtained biomembranes i.e. ghosts were characterized in vitro in terms of morphological properties, loading parameters, and release behavior. For the las...

A survey was conducted among editors of journals publishing in the field of chemistry, chemical technology and related topics in Serbia, aiming to collect information on their experience, problems and difficulties during peer-review process. Editors from 22 journals out of 27 which regularly published during 2015 replied. General data on journals w...

Encapsulation is a well-established process that allows formulation of a wide range of active agents within a defined carrier material using various techniques. This chapter describes the general concept and benefits of microbial and non-microbial active food ingredient encapsulation, existing encapsulation technologies and examples of the use of l...

Carqueja (Pterospartum tridentatum) is an endemic species and various bioactive compounds have been identified in its aqueous extract. The aim of this study was to protect the natural antioxidants from the aqueous extract of carqueja by encapsulation in Ca-alginate microbeads and Ca-alginate microbeads containing 10% and 20% (w/v) of inulin. The mi...