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Introduction
Ivan Kmezic currently works as a specialist in neurology at the Department of Neurology, Karolinska University Hospital, Stockholm, Sweden. His research focuses on neurology, particularly immune-mediated neuropathies, and he is pursuing a PhD in the field of biomarkers and experimental autoimmune neuritis (EAN).
Current institution
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Publications
Publications (9)
Background
Biomarkers for diagnosis of inflammatory neuropathies, assessment of prognosis, and treatment response are lacking.
Methods
CSF and EDTA plasma from patients with Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), healthy controls (HC) and disease controls were analyzed with Olink multiplex proximit...
Importance
Rituximab is a third-line option for refractory generalized myasthenia gravis (MG) based on empirical evidence, but its effect in new-onset disease is unknown.
Objective
To investigate the efficacy and safety of rituximab compared with placebo as an add-on to standard of care for MG.
Design, Setting, and Participants
This randomized, d...
Background and purpose:
To investigate the diagnostic and prognostic value of axonal injury biomarkers in patients with inflammatory polyneuropathies.
Methods:
Neurofilament light (NfL) chain and total tau (T-tau) were measured in the CSF and plasma in 41 patients with Guillain-Barré syndrome (GBS), 32 patients with chronic inflammatory demyelin...
Autoimmune nodopathy (AN) is an emerging diagnostic category with antibodies targeting the peripheral node of Ranvier. Clinically, AN overlaps with Guillain-Barré syndrome (GBS) and acute-onset CIDP. However, the immunopathology of AN is different, hence AN is considered as a separate entity. Antibodies targeting all neurofascin isoforms are associ...
Objective:
To describe the diagnostic and prognostic performance, and longitudinal trajectories, of potential biomarkers of neuroaxonal degeneration and neuroinflammation in amyotrophic lateral sclerosis (ALS).
Methods:
This case-control study included 192 incident ALS patients, 42 ALS mimics, 114 neurological controls, and 117 healthy controls...
Background:
Laboratory tests to assist in the diagnosis and monitoring of neuroinflammatory diseases are scarce. The soluble form of the CD27 molecule (sCD27) is shed in high concentrations by activated T cells and can be detected in the cerebrospinal fluid. The aim of this study was to investigate whether CSF quantitation of sCD27 could discrimin...
Background
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disorder of the central nervous system caused by reactivation of the JC-virus and is in most cases associated with underlying immunosuppression. Acquired immune deficiency syndrome (AIDS) and hematological malignancies are well-known predisposing factors for PML. However...
