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Publications (141)
Health-related quality of life can be assessed using specially developed instruments. One of these questionnaires, specific to pediatric practice, is KINDL R . It is a short, methodologically suitable, psychometrically sound and flexible tool, available in three versions which cover the different age groups and stages of development of children and...
Abstract. Syringomyelia is a chronic polyetiological disease characterized by the development of a
fluid-filled cyst in the spinal cord. Neuropathic arthropathy is a chronic degenerative joint disease
conditioned by reduced sensory innervation of the joints associated with various diseases. We
experienced a case of a of a 46-year-old male with a pa...
Gerstmann syndrome is a classical cerebral syndrome in neurology, named after Joseph Gerstmann, a Jewish Austrian-born American neurologist. Patients present with a tetrad of cognitive symptoms, including agraphia, acalculia, finger agnosia and left-right disorientation. The syndrome is known to result from a lesion of the posterior portion of the...
Нарушенията на съня, описани още от Дж. Паркинсон, се срещат често при Паркинсоновата болест (ПБ) и сериозно влошават качеството на живот. Те се проявяват в различен момент от заболяването и са описани при 98% от пациентите. Възникват в резултат на самата ПБ, на лечението или на коморбидни състояния.
Съвременни невропатологични проучвания при ПБ с...
Chronic neurotoxicity of lead is a major problem in all countries around the world. Long-term exposure to lead in the environment has recently become of interest as a possible risk factor for cognitive impairment in the involved workers. The consequences for the brain after cessation of the exposure are also subject to research.
Our study aimed at...
Chronic neurotoxicity of lead is a major problem in all countries around the world. Long-term exposure to lead in the environment has recently become of interest as a possible risk factor for cognitive impairment in workers exposed to lead. The consequences for the brain after cessation of the exposure are also subject to research.
The aims of our...
Amyotrophic lateral sclerosis (ALS) is a severe and fatal neurodegenerative disorder affecting both the upper and lower motor neurons. We present the clinical cases of four patients with ALS and vibration syndrome. All patients had over 20 years of exposure to general and local vibrations and common subjective complaints: pain, paresthesia, twitchi...
Background: Happiness is an emotional state reflecting positive feelings and satisfaction of life, which, as an outcome in multiple sclerosis (MS) is an neglected concept in most therapeutic areas. It provides a reliable overview of patient’s general status over and above standard parameters for quality of life and is more wide-ranging than the mea...
Anti-NMDAR encephalitis is the most common autoimmune encephalitis in childhood. It presents with neurologic and psychiatric symptoms: epileptic seizures (often drug-resistant), cognitive disorders, sleep disturbances, extrapyramidal symptoms, etc., as well as depression, pathologic fear, obsessions, compulsions, and attention deficit. Diagnostic d...
Анти-NMDAR енцефалитът е най-честият автоимунен енцефалит, наблюдаван в детската възраст. Клинично се представя като комплекс от неврологични и психиатрични симптоми: епилептични пристъпи, нерядко терапевтично резистентни, когнитивни нарушения, разстройства на съня, екстрапирамидна симптоматика и др., както и депресия, необоснован страх, обсцесии,...
Introduction: Multiple sclerosis (MS) is a progressive demyelinating and degenerative neurological disease. The degree of disability increases along with pathological damage, especially in cases with comorbidity.
Methodology: The objective of this study was to analyze the influence of MS alone and with comorbidity on some neuropsychological pattern...
Background: The lack of a total numeric score of the CERAD neuropsychological battery may to some extent limit the possibilities for presenting the cognitive status and the degree of dementia.
The objective of the present study is to apply the CERAD battery in a Bulgarian population of demented and control subjects, to compute the total score for...
Background: Seeking and receiving psychological help after a stressful life event is associated with certain prejudice attitudes, especially present in minority ethnic groups.
Case description: This case report describes the specific reactions and psychopathological dynamics of a female patient, the age of 43, who survived the terrible accident on...
Background: Autism is a mental developmental disorder, manifested in the early childhood. Attention deficit hyperactivity disorder is another psychiatric condition of the neurodevelopmental type. Both disorders affect information processing in the nervous system, altering the mechanisms which control how neurons and their synapses are connected and...
There is accumulating evidence of a mutual relationship between multiple sclerosis and structural epilepsy. Comorbidity of these severe neurological disorders is reported in numerous recent publications in the available foreign literature. Modern diagnostic tools include comprehensive neurological examinations as well as computed tomography, electr...
Background: The continuous progress of information technology has made possible the creation of tools for post processing of magnetic resonance and other imaging modalities, including software programmes aimed at volumetric studies of the brain. They have the potential to enrich visual data with precise numeric values but have to be used with cauti...
Background: Demyelination and neurodegeneration are hallmarks of multiple sclerosis (MS). Axonal damage is considered to be the leading factor for persisting disability in the course of the disease. In different studies, expanded disability status scale (EDSS) scores have been found to correlate with brain atrophy, lesion load, or both.
Objective:...
The role of lipid metabolism in the pathogenesis of Parkinson`s disease is still controversial. Most authors suggest that higher The role of lipid metabolism in the pathogenesis of Parkinson`s disease is still controversial. Most authors suggest that higher serum cholesterol may be associated with a lower risk of Parkinson`s disease. Debates exist...
Introduction:
Impairment of memory is frequent in multiple sclerosis. Being part of the specific cognitive impairment profile of the disease, it is an important criterion for assessment of quality of life and disability, for monitoring
the efficacy of treatment, and for rehabilitation planning. The study of immediate recall in patients with relaps...
Parkinson’s disease (PD) is the second most common neurodegenerative disease. Its prevalence is
expected to double in the next 20 years due to the increase in life expectancy. The disease symptoms
negatively impact patients’ oral and dental health.
Dental specialists must be aware of PD clinical manifestations and meet effectively the challenges fo...
Introduction: A modest number of studies reported contradictory results for brain glucose metabolism in essential tremor (ET) patients. Aim: To study the brain glucose metabolism in ET patients with (18F)-FDG PET/CT. Materials and Methods: Ten patients were included, aged 60.4 years, with 8 months diseases duration. Five healthy persons, aged 60.2...
We describe a clinical case of coexisting osteoid os-teoma of the femoral head and L4-L5 disc herniation in a 17-year-old female patient. After a minor incident when she lost her footing while walking, she started to experience acute right groin pain, followed later by hip joint pain. Paraspinal muscle tenderness and pain at the L4-5 level were fou...
Introduction: A modest number of studies reported
contradictory results for brain glucose metabolism in essential
tremor (ET) patients.
Aim: To study the brain glucose metabolism in ET
patients with (18F)-FDG PET/CT.
Materials and Methods: Ten patients were included,
aged 60.4 years, with 8 months diseases duration. Five
healthy persons, aged 60.2...
Background: The clinical features of multiple sclerosis during a relapse may raise the suspicion of a brain tumor as a possible differential diagnosis. Regardless of the high informative value of neuroimaging, some clinical cases remain challenging for neurologists, neurosurgeons and ra-diologists. Associations of brain tumors and relapsing-remitti...
INTRODUCTION: Brain volumetry is a contemporary method used in scientific and clinical research in neurodegenerative diseases. The process can be fully automated but it allows some parameters to be manually adjusted in order to minimize errors. The purpose of the present study is to analyze the use of additional settings in the process of extractin...
INTRODUCTION: Cognitive impairment is frequent in multiple sclerosis and predominantly affects visuo-spatial abilities, memory, attention, and executive functions. Because of the specific cognitive profile, different from that in Alzheimer's disease and other frequent disorders presenting with dementia, specific neu-ropsychological instruments need...
inflammatoire chronique du système nerveux central d'origine
auto-immune. Au cours des dernières décennies, quelques
traitements modificateurs de la maladie ont été autorisés
pour améliorer le cours de la maladie. Le but de ces TMM
(Traitements modificateurs de la maladie) est la réduction de
l'inflammation, de l'activité de la maladie mesurée par...
Background: Syphilis is not only a disease of historical importance. It has been recognized that nowadays, in the era of AIDS, it still remains a serious challenge. For the last two decades there has been a resumption of neu-rosyphilis cases. This has revived the interest in the diagnostic and therapeutic challenges that the disease presents to cli...
Background: Syphilis is not only a disease of historical importance. It has been recognized that nowadays, in the era of AIDS, it still remains a serious challenge. For the last two decades there has been a resumption of neurosyphilis cases. This has revived the interest in the diagnostic and therapeutic challenges that the disease presents to clin...
Stroke is without any doubt among the top reasons for disability and mortality in neurology. This is especially true in Bulgaria, where vascular diseases in general, and cerebrovascular disease (CVD) in particular, are significantly more prevalent than in other European countries. More than 80’000 cases of CVD are registered yearly in Bulgaria, ove...
Abstract
Background
A modest number of studies reported contradictory results for brain glucose metabolism in essential tremor (ET) patients.
Objective
Assessment of brain glucose metabolism in ET patients.
Methods
Ten patients were included (6 males), aged 60, 4 years, with 8 months diseases duration.
Five healthy persons (3 males), aged 60, 2 ye...
Abstract
We describe a clinical case of coexisting osteoid osteoma of the femoral head and L4-L5 disc herniation in a 17-year-old female patient. After a minor incident when she lost her footing while walking, she started to experience acute right groin pain, followed later by hip joint pain. Paraspinal muscle tenderness and pain at the L4-5 level...
This comparative report looks at the development of the concept “dementia-friendly communities” in Europe.
In addition, building on the framework developed by the World Health Organisation to create age-friendly cities, it provides a comparative overview of national policies and notable practices in Europe that aim at creating physical and social...
25 пациента с ПРМС, от които 18 жени (72%) и 7 мъже (28%) е открита различна гастроинтесинална патология-32% с язвена болест на стомаха и дванадесетопръстника, 20% с хроничен гастрит, 44% с ГЕРБ и 4% с хроничен булбит. Гастроентерологичните заболявания са установени при 52% болни преди поставяне на диагнозата МС, а при 48%-след това. Установяваме,...
Introduction: Head trauma and general anesthesia are discussed and considered as risk factors for Parkinson’s disease (PD). Their role in the etiopathogenesis of essential tremor (ET), the most common movement disorder, is not extensively studied. Aim: To assess the prevalence of previous surgery with general anesthesia and of previous head trauma...
2 Катедра по Нервни болести, МУ-Варна 3 Катедра по Здравни грижи, МУ-Варна, Филиал Сливен Литература 1. Hanson RL, Habibi M, Khamo N, Abdou S, Stubbings J. Integrated clinical and specialty pharmacy practice model for management of patients with multiple sclerosis. Am J Health Syst Pharm. 2014 Mar 15;71(6):463-9. 2. Kleebauer A. Vital role of speci...
Abstract
Magnetic resonance imaging has been widely used to aid the diagnostic process in patients with various
disorders of the nervous system. White matter hyperintensities represent a frequent T2-MRI finding. They
may be due to multiple sclerosis and other demyelinating diseases, systemic diseases and cerebrovascular
disease, among other example...
The Dementia in Europe Yearbook 2014 is a comparative report on care pathways for people with dementia living at home in Europe.
The pathways to get a diagnosis of dementia are complex and are likely to be multifactorial. Many people living with dementia in Europe are still not diagnosed, and often the diagnosis comes too late. Every person with d...
SUMMARY
Neurosyphilis has various clinical presentations. It is relatively rare in neurological practice, but remains a significant diagnostic and therapeutic challenge. In the present article we present a clinical case of hypertrophic spinal syphilitic meningitis, presenting as a transverse lesion of the spinal cord at the thoracic level, with spa...
The development of sophisticated magnetic resonance imaging techniques and software for medical imaging processing and analysis has led to a significant progress in multiple sclerosis research and clinical care. The measurement of brain volumes provides a quantitative representation of damage, thus facilitating the objective follow-up process. The...
Неопластични заболявания при хоспитализирани пациенти с Паркинсонова болест и есенциален тремор
Б. Иванов, А. Капрелян*, И. Димитров, Н. Ушева**, М. Грудкова*, В. Несторова***, Н. Делева*
Катедра по клинични медицински науки, Факултет по дентална медицина, Медицински Университет Варна
*Катедра по неврология, Факултет по медицина, Медицински Униве...
Коморбидност при хоспитализирани пациенти с Паркинсонова болест и есенциален тремор
Б. Иванов, А. Капрелян*, И. Димитров, Н. Ушева**, М. Грудкова*, В. Несторова***, Н. Делева*
Катедра по клинични медицински науки, Факултет по дентална медицина, Медицински Университет Варна
*Катедра по неврология, Факултет по медицина, Медицински Университет Варна...
Objectives: The CERAD battery is a well known neuropsychological tool used in Alzheimer's disease. The lack of a total score in
the original version may, to some extent, limit its usefulness in the daily practice. A method created by Chandler at al. allows the
results to be presented as a single score. Our study aimed at applying the method in a de...
Objectives: During the last decade it has become evident that autonomic dysfunction is an integral part of the pathological process
in Parkinson's disease (PD). Dysautonomic symptoms may not only precede the cardinal motor signs, but even dominate the clinical
picture, thus impairing the quality of life of the affected patients. The objective of th...
syrinx) в гръбначния мозък и прогресираща неврологична симптоматика. В литературата са описани редки случаи на коморбидност на МС и сирингомиелия. ВЪВЕДЕНИЕ КЛИНИЧЕН СЛУЧАЙ: Представяме случай на 41-годишна жена (ИДГ) с начални оплаквания от слабост, изтръпване, болки и скованост, започнали от левите крайници, нарушени тазоворезервоарни функции (ин...
Keratoconus is a disorder affecting the cornea, characterized by its variably progressive central thinning, which results in conically shaped protrusion. Patients with keratoconus are sometimes described as having peculiar personality characteristics. We present the case of a patient with keratoconus, complaining of impairment of concentration and...
The process of diagnosing dementia and
mild cognitive impairment requires the
physician to know how the patient copes
with routine activities of daily living. Their
quantification, on the other hand, not
only facilitates the judgment of the de-
gree of cognitive deficit, but allows the ac-
cumulation of comparable data which can
be useful for monit...
Prevalence of cognitive impairment and dementia has not been studied in Bulgaria up to date. A 2-phase cross-sectional study was designed in order to determine the prevalence of dementia, its subtypes, and mild cognitive impairment in a Bulgarian population.
The study sample consisted of 605 participants over the age of 65, residents of the city of...
Idiopathic intracranial hypertension (IIH) or benign intracranial hypertension is a neurological syndrome characterized by elevated intracranial pressure. This uncommon disorder occurs primarily in obese women aged 10 to 50 years, sometimes in association with endocrine and metabolic dysfunction, with systemic diseases or when treated with multiple...
