Iva Škrinjar

Iva Škrinjar
Ruđer Bošković Institute | RBI · Division of Molecular Medicine

PhD

About

26
Publications
2,077
Reads
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181
Citations
Introduction
Iva Škrinjar currently works as a research associate at the Division of Molecular Medicine, Ruđer Bošković Institute. Iva does research in Mitochondrial bioenergetics, Virology, Evolutionary Biology and Bioinformatics. Her most recent publication is 'Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in Ovariectomized Sirt3 KO Mice.'
Additional affiliations
May 2021 - May 2021
Ruđer Bošković Institute
Position
  • Research Associate
January 2017 - May 2021
Ruđer Bošković Institute
Position
  • PostDoc Position
October 2012 - March 2016
ÁTKI
Position
  • PhD Student
Education
September 2013 - July 2016
Szent István University, Godollo
Field of study
  • Veterinary Postgraduate (Doctoral) School
October 2010 - July 2012
University of Zagreb
Field of study
  • Faculty of Science, molecular biology
October 2007 - September 2010
University of Zagreb
Field of study
  • Faculty of Science, molecular biology

Publications

Publications (26)
Article
Full-text available
Adhesion between cells and the extracellular matrix (ECM) is one of the prerequisites for multicellularity, motility, and tissue specialization. Focal adhesions (FAs) are defined as protein complexes that mediate signals from the ECM to major components of the cytoskeleton (microtubules, actin, and intermediate filaments), and their mutual communic...
Article
Full-text available
The family Adenoviridae includes non-enveloped viruses with linear dsDNA genomes of 25–48 kb and medium-sized icosahedral capsids. Adenoviruses have been discovered in vertebrates from fish to humans. The family is divided into six genera, each of which is more common in certain animal groups. The outcome of infection may vary from subclinical to l...
Article
Full-text available
High fat diet (HFD) is an important factor in the development of metabolic diseases, with liver as metabolic center being highly exposed to its influence. However, the effect of HFD-induced metabolic stress with respect to ovary hormone depletion and sirtuin 3 (Sirt3) is not clear. Here we investigated the effect of Sirt3 in liver of ovariectomized...
Article
Aims Since the role of the major mitochondrial NAD⁺-dependent deacetylase, sirtuin 3 (Sirt3), is differential in cancer, opposite to the well-known tumor-suppressing effect of hyperoxia, this study aimed to investigate the role of Sirt3 in triple-negative breast cancer (TNBC) cell line MDA-MB-231 upon hyperoxic (95% O2) conditions. Main methods MD...
Article
Full-text available
Estrogen (E2) is a major risk factor for the initiation and progression of malignancy in estrogen receptor (ER) positive breast cancers, whereas sirtuin 3 (Sirt3), a major mitochondrial NAD+-dependent deacetylase, has the inhibitory effect on the tumorigenic properties of ER positive MCF-7 breast cancer cells. Since it is unclear if this effect is...
Article
Full-text available
Metabolic homeostasis is differently regulated in males and females. Little is known about the mitochondrial Sirtuin 3 (Sirt3) protein in the context of sex-related differences in the development of metabolic dysregulation. To test our hypothesis that the role of Sirt3 in response to a high-fat diet (HFD) is sex-related, we measured metabolic, anti...
Article
Full-text available
The presence of a novel adenovirus (AdV) was detected by PCR and sequencing, in the internal organs of a captive polar bear that had died in the Budapest zoo. The virus content of the samples proved to be high enough to allow for conventional Sanger sequencing on PCR-amplified genomic fragments. With this approach, the sequence of the entire genome...
Poster
Hyperoxic treatment (inducer of reactive oxygen species) was shown to support some tumorigenic properties, but finally suppresses growth of certain mammary carcinoma cells. While estrogen receptor α cancers are more receptive to hormonal therapy, triple negative breast cancers (TNBC) are characterized by an aggressive behaviour and the lack of targ...
Poster
Breast cancer is the most frequent cancer among women, and 70% of all breast cancer cases are estrogen receptor (ER) positive. Sirtuin 3 (Sirt3) has a promising role in cancer tumorigenesis and treatment, but there have been controversies about its role as oncogene or tumor suppressor in different types of cancer. We have recently shown that de nov...
Presentation
Sirtuin 3 (Sirt3), a major mitochondrial NAD+-dependent deacetylase, has bifunctional role in cancer tumorigenesis, acting as both oncogene and tumor suppressor, depending on the tissue and cancer-type specific metabolic programs. Changes in its expression are associated with the excessive production of reactive oxygen species (ROS), thus contribut...
Article
Full-text available
The scarcity or complete lack of information on the adenoviruses (AdVs) occurring in the most ancient non-human primates resulted in the initiation of a study for exploring their abundance and diversity in prosimians and New World monkeys (NWMs). In order to assess the variability of these AdVs and the possible signs of the hypothesised virus-host...
Article
Sirtuin 3 (Sirt3) has a promising role in cancer tumourigenesis and treatment, but there have been controversies about its role as oncogene or tumour suppressor in different types of cancer. Changes in its expression are associated with the excessive production of reactive oxygen species (ROS), thus contributing to mitochondrial dysfunction and age...
Article
Full-text available
Human adenovirus 52 (HAdV-52) is one of only three known HAdVs equipped with both a long and a short fiber protein. While the long fiber binds to the coxsackie and adenovirus receptor, the function of the short fiber in the virus life cycle is poorly understood. Here, we show, by glycan microarray analysis and cellular studies, that the short fiber...
Article
Full-text available
Within the family Adenoviridae presently, Simian mastadenovirus A is the single species approved officially for monkey AdVs, whilst the establishment of six further species (Simian mastadenovirus B to Simian mastadenovirus G) has been proposed in the last few years. We examined the genetic content and phylogenetic relationships of four Old World mo...
Article
Full-text available
A species classification regarding Old World monkey adenoviruses is proposed. We determined the nucleotide sequences of PCR-amplified fragments from the genes of the IVa2, DNA-dependent DNA polymerase, penton base, and hexon proteins from every simian adenovirus (SAdV) serotype that originated from Old World monkeys for which the full genome sequen...
Article
Full-text available
Adenoviruses are efficient gene delivery vectors based on their ability to transduce a wide variety of cell types and drive high-level transient transgene expression. While there have been advances in modifying human adenoviral (HAdV) vectors to increase their safety profile, there are still pitfalls that need to be further addressed. Preexisting h...