Issifou YAYA

Assistance Publique – Hôpitaux de Paris | AP-HP · URC-ECO Hôpital Hôtel-Dieu

Background: Among people living with HIV/AIDS (PLWHA), comorbid conditions, including COVID-19, could favor impairment of health-related quality of life (HRQL). This study aimed to assess HRQL and its correlates among PLWHA co-infected with SARS-CoV-2 in France. Methods: This cross-sectional study was conducted using data from PLWHA co-infected wit...

Background: Burkholderia pseudomallei is the agent of melioidosis. It is a bacterium from the hydrotelluric environment, highly pathogenic for humans. The geographical distribution of this disease is spreading and now affects the southwest of the Indian Ocean and in Mayotte Case presentation: We report four new cases of melioidosis with a case that...

Background: Nocardiae is an opportunistic infection mainly of the immunocompromised patient without sparing the immunocompetent subject or without any identified risk factors. They can be localized or disseminated. The extreme rarity of this infection often results in a deleterious diagnostic delay. Case presentation: We report a first case of c...

Background: Data on HIV seroconversion among men who have sex with men (MSM) using pre-exposure prophylaxis (PrEP) in West Africa are needed. This study aimed to document HIV seroconversion and associated determinants, PrEP adherence, plasma drug concentrations, and HIV drug resistance in MSM using event-driven or daily PrEP in Burkina Faso, Côte...

Introduction The sexual quality of life is a neglected concern in women living with HIV (WHIV) or with HCV (WHCV), which can further be affected by their experience with stigma, social instability, fear of transmission and reduced access to treatment. The objective of this study was to identify sociodemographic, psychosocial, and behavioural factor...

Background: Migrants from high HIV, HBV or HCV endemicity regions, have a great burden of these infections and related diseases in the host countries. This study aimed to assess the predictive capacity of the TROD Screen questionnaire for HIV, HBV and HCV infections among migrants arriving in France. Methods: An observational and multicenter study...

Background Antimicrobial resistance to macrolides and fluoroquinolones in Mycoplasma genitalium among men who have sex with men (MSM) is worryingly high in high-resource countries. Data in Africa are lacking. We aimed to assess the burden of M. genitalium including the presence of resistance associated mutations (RAMs) in M. genitalium among MSM us...

Loss to follow-up (LTFU) from HIV pre-exposure prophylaxis (PrEP) care compromises the goal of HIV elimination. We investigated the proportion of LTFU and associated risk factors among men who have sex with men (MSM) enrolled in a PrEP demonstration project in Burkina Faso, Côte d’Ivoire, Mali, and Togo. CohMSM-PrEP, a prospective cohort study, was...

Objectives: Asymptomatic sexually transmitted infections (STI) are frequent among men who have sex with men (MSM). Identifying asymptomatic STIs is a crucial issue, not only for secondary but also for primary prevention, as early treatment can reduce transmission risk. We aimed to develop a self-reported predictive score for early identification o...

Background: Multiple barriers compromise pre-exposure prophylaxis (PrEP) engagement (i.e., use and adherence) in men who have sex with men (MSM). In low/middle-income countries, little is known about PrEP engagement in this population. In West Africa, the CohMSM-PrEP study was one of the rare interventions providing PrEP to MSM. We estimated PrEP...

Coronavirus disease 2019 (COVID-19) has been reported in association with a variety of brain imaging findings such as acute hemorrhagic necrotizing encephalopathy. To the best of our knowledge, we are reporting a second case of acute necrotizing hemorrhagic encephalopathy associated with COVID-19, which was fatal in a few hours in a 56-year-old mal...

Background Multiple barriers compromise pre-exposure prophylaxis (PrEP) engagement (i.e., use and adherence) in men who have sex with men (MSM). In low/middle-income countries, little is known about PrEP engagement in this population. In West Africa, the CohMSM-PrEP study was one of the rare interventions providing PrEP to MSM. We estimated PrEP us...

Background Since the last decade, prevalence of hepatitis C virus (HCV)-infection has increased among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). We aimed to assess the prevalence of HCV coinfection in HIV-positive MSM and identify associated factors in Île-de-France Method This was a multicentric study conducted a...

We investigated the rate and predictors of ineffective HIV protection in men who have sex with men (MSM) taking pre-exposure prophylaxis (PrEP) in a prospective cohort study from November 2017 to November 2020 in Mali, Côte d’Ivoire, Burkina Faso, and Togo. MSM had to be 18 years or older and at high risk of HIV infection to participate. They also...

Background Access to tailored HIV prevention services remains limited for West African MSM. We assessed adherence to quarterly HIV prevention services and its impact on HIV incidence in MSM followed up in four cities in Burkina Faso, Côte d’Ivoire, Mali, and Togo. Methods We performed a prospective cohort study between 2015 and 2018. HIV-negative...

Objective: To assess the time from HIV diagnosis to ART initiation and the effect of rapid ART initiation (i.e., within seven days of HIV diagnosis) on attrition and virologic and immunologic responses among MSM in Burkina Faso, Côte d'Ivoire, Mali, and Togo. Design: Prospective cohort study between 2015 and 2019. Methods: MSM aged 18 years or...

Background An alarming high prevalence of antimicrobial resistance in Mycoplasma genitalium (MG) has been reported among men who have sex with men (MSM) in many parts of the world. However, data on West-Africa are lacking. Our aim was to assess the prevalence of macrolide and fluoroquinolone resistance-associated mutations (RAMs) of MG among MSM in...

Background HIV pre-exposure prophylaxis (PrEP) data in men who have sex with men (MSM) in west Africa are essential to guide its large-scale implementation. We assessed the uptake of event-driven and daily PrEP, HIV incidence, and changes over time in sexual behaviours and prevalence of bacterial sexually transmitted infections (STIs) in MSM in Bur...

Objective Although men who have sex with men (MSM) are at high risk of STI, their access to tailored healthcare services remains limited in West Africa. We assessed the change in STI symptoms incidence over time among MSM enrolled in a quarterly HIV prevention and care programme in four cities in Burkina Faso, Côte d’Ivoire, Mali and Togo. Methods...

Background: Men who have sex with men (MSM) are at high risk of human papillomavirus (HPV) infection. We assessed (i) the prevalence of high-risk HPV (HR-HPV) infection and associated factors, and (ii) the prevalence of vaccine-preventable HPV infections in MSM in Burkina Faso, Côte d'Ivoire, Mali, and Togo. Methods: A cross-sectional study was...

Objective: The study aimed to explore longitudinal interactions between homonegativity and sexual behaviors with female partners among HIV-negative West African men who have sex with men and women (MSMW) DESIGN AND METHOD:: The community-based cohort CohMSM ANRS 12324 - Expertise France enrolled MSM in Togo, Burkina Faso, Côte d'Ivoire and Mali. S...

Introduction L’anémie infantile (AI) reste un problème de santé publique majeur dans les pays en développement, en particulier en Afrique subsaharienne. L’objectif de cette étude était d’estimer la part d’AI attribuable à des facteurs de risque (FdR) liés à l’enfant, à sa mère et à son environnement chez les enfants âgés de 6–59 mois au Togo. Méth...

Introduction Acinetobacter baumannii est un pathogène opportuniste causant diverses infections nosocomiales. La prescription abusive et non rationalisée d’antibiotiques a entraîné une augmentation des bactéries multirésistantes. L’objectif principal était de décrire une prévalence élevée de la coexistence NDM-1/OXA-23 au cours d’une épidémie liée à...

Background: Multidrug-resistant Acinetobacter baumannii is an increasing problem worldwide. The objective of this study was to describe the outbreak of Acinetobacter baumannii producing carbapenemases at the Mayotte Hospital Center.

Objectives: Despite free access to antiretroviral therapy (ART) from 1996 onward, and treatment for all people living with HIV (PLWHIV) from 2013, mortality in Brazil has not homogeneously decreased. We investigated to what extent delayed ART, hepatitis coinfections and sociodemographic factors predict all-cause mortality in Brazilian PLWHIV. Des...

Background: In West Africa, few HIV services target men who have sex with men (MSM). In 2015, the interventional cohort CohMSM started offering a community-based prevention package for MSM. Participants expressed interest in pre-exposure prophylaxis (PrEP) and their eligibility was demonstrated. In 2017, PrEP was added to services already offered...

Background Access to tailored HIV prevention services remains limited for West African MSM. We assessed adherence to quarterly HIV prevention services and its impact on HIV incidence in MSM followed up in four cities in Burkina Faso, Côte d’Ivoire, Mali, and Togo.Methods We performed a prospective cohort study between 2015 and 2018. HIV-negative MS...

Background: Multidrug-resistant Acinetobacter baumannii is an increasing problem worldwide. The objective of this study was to describe the outbreak of Acinetobacter baumannii producing carbapenemases at the Mayotte Hospital Center. Methods: This is a descriptive study using routine data collected prospectively in patients' medical records. From th...

Dengue fever, transmitted by Aedes aegypti mosquitoes, is one of the most common vector-borne disease. Its incidence is increasing steadily worldwide, becoming a major public health problem in the tropical and subtropical zone. Neurological manifestations after dengue are not very common and acute disseminated encephalomyelitis (ADEM) following den...

Background Access to antiretroviral treatment has improved the life expectancy of HIV-positive patients, most often associated with a desire to limit childbearing. Women living with HIV (WLHIV) commonly have unmet need for contraception and could be at risk of unintended pregnancy. Preventing unintended pregnancies among women living with HIV are e...

Mortality among individuals co-infected with HIV and hepatitis C virus (HCV) is relatively high. We evaluated the association between psychoactive substance use and both HCV and non-HCV mortality in HIV/HCV co-infected patients in France, using Fine and Gray’s competing-risk model adjusted for socio-demographic, clinical predictors and confounding...

Background: Men who have sex with Men (MSM) using Pre-exposure prophylaxis (PrEP) are at risk for Sexually Transmitted Infections (STIs). Therefore, PrEP services should include regular screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) at urethra, anorectum and pharynx. However, financial and logistic challenges arise in low...

Background: The widespread under-screening and under-treatment of alcohol use disorder (AUD) contributes to its health and socioeconomic burden. We conducted a mixed-methods (qualitative and qualitative) study in people with alcohol use disorder (PWAUD) to explore their expectations, as well as barriers and levers to AUD care. Methods: Individua...

Background: Men who have sex with Men (MSM) using Pre-exposure prophylaxis (PrEP) are at risk for Sexually Transmitted Infections (STIs). Therefore, PrEP services should include regular screening for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) at urethra, anorectum and pharynx. However, financial and logistic challenges arise in low r...

Objective The objective of this study is to assess the quality of life and to identify factors associated with good global quality of life among people living with HIV/AIDS (PLWHA) in Togo. Results In total, 880 PLWHA with mean age (standard deviation) of 39.6 (10.1) years, were interviewed. Most of them (78.4%) were female. The global score of qu...

Background In Brazil there are 926,742 people living with HIV/AIDS (PLWHA). Despite the introduction of antiretroviral therapy (ART) in 1996 and treatment for all in 2014, mortality has increased in some regions. This study aimed to estimate the factors associated with overall mortality in PLWHA to recommend public health actions. Methods We studi...

Background Syndromic diagnosis of sexually transmitted infections (STIs) has shown its limits among MSM using PrEP due to the many asymptomatic infections. However, testing three biological sites (urethra, pharynx and anorectum) is expensive. Our objective was to implement and to evaluate a pooling method using the locally available GeneXpert instr...

Background Men who have sex with men (MSM) coming forward for Pre-Exposure Prophylaxis (PrEP) are at high risk for HIV and other Sexually Transmitted Infections (STIs). However, little is known about the prevalence of STIs among MSM in West-Africa. Yet, understanding the STI epidemic among MSM will improve STI management. In the framework of a PrEP...

Objectives: Although common among patients coinfected with HIV and hepatitis C virus (HCV), sleep disturbances (SD) are still poorly documented in this population in the HCV cure era. This longitudinal study aimed at analysing SD in HIV-HCV coinfected patients and identifying their clinical and sociobehavioural correlates. Methods: We used 5-yea...

Background Anemia in children continues to be a major public health challenge in developing countries and particularly in Sub-Saharan Africa. Anemia has serious consequences on the growth and development of the children in the early stages of life. This study aimed to determine the prevalence and associated factors of anemia among children from 6 t...

RESUME Contexte : Le VHC et le VIH créent un état d’inflammation systémique chronique favorisant des complications hépatiques importantes telles que la fibrose hépatique, la cirrhose ou le carcinome hépatocellulaire (CHC), mais aussi des troubles métaboliques. Le genre influence l’évolution de l'infection chronique par le VHC avec une progression...

Alcohol use disorders (AUD) is a major public health concern. General practitioners (GP) must play a key role in identifying this disorder and offering appropriate interventions. The authors conducted a survey among French GP in the Provence–Alpes–Côte-d’Azur (PACA) region to better understand their practices regarding AUD. Random sampling was used...

Background: Inadequate immunization coverage remains a public health problem in Africa. In Togo, only 62% of children under one year of age were fully immunized in 2013. This study aimed to estimate the immunization coverage among children aged 12-23 months, and to identify factors associated with incomplete immunization status in Togo. Methods:...

Direct-acting antivirals (DAA) have dramatically increased HCV cure rates with minimal toxicity in HIV-HCV co-infected patients. This study aimed to compare the socio-behavioral characteristics of patients initiating pegylated-interferon (PEG-IFN)-based HCV treatment with those of patients initiating DAA-based treatment.ANRS CO13 HEPAVIH is a natio...

Introduction Inadequate immunization coverage remains a public health problem in Africa. In Togo, only 62% of children under one year of age were fully immunized as assessed by the third Demographic and Health Survey conducted in 2013, hence not achieving the 90% or more immunization target for national coverage as set by the World Health Organizat...

Background: Coffee intake has been shown to modulate both the effect of ethanol on serum GGT activities in some alcohol consumers and the risk of alcoholic cirrhosis in some patients with chronic diseases. This study aimed to analyze the impact of coffee intake and alcohol consumption on advanced liver fibrosis (ALF) in HIV-HCV co-infected patient...

International Liver Congress (ILC), Paris, FRANCE, APR 11-15, 2018

Introduction Contraceptive use among HIV-infected women in Togo is poorly documented. We aim at assessing the prevalence of modern contraceptive use and associated factors among HIV-infected women in Togo. Design Cross-sectional study. Setting The study was conducted in five HIV care centres in the Centrale and Kara regions in Togo. Participants...

Impact of children with multiple disabilities on families in Abidjan Introduction: A child’s multiple disabilities have a major impact on families in both developed and developing countries. In Côte d’Ivoire, very few data are available concerning the real experiences of families of children with multiple disabilities. The objective of this study w...

Background Lassa fever belongs to the group of potentially fatal hemorrhagic fevers, never reported in Togo. The aim of this paper is to report the first two cases of Lassa fever infection in Togo. Case Presentation The two first Lassa fever cases occurred in two expatriate's health professionals working in Togo for more than two years. The sympto...

Method: We conducted a survey from 9 to 14 March 2015 (for approximately 3 months) after the end of the vaccination campaign in these four regions. Interviewees were selected using two stages cluster sampling stratified according to the regions. MenAfriVac vaccine in Controlled Temperature Chain (CTC) was used in 10 districts, in Togo. Results:...

Background During the last ten years, a resurgence of syphilis has occurred in many countries worldwide, including Togo. Previous studies have shown a wide range of syphilis infection among the female sex workers (FSWs), from 1.5 to 42.1%. In Togo, Key populations, including FSWs, are rarely involved in the sentinel surveillance programs to determi...

Objectif - Introduction Mayotte est un département d’Outremer situé dans le Canal du Mozambique dans l’Océan Indien. Le climat tropical, les conditions sociales souvent précaires et les prescriptions abusées des antibiotiques font émerger des bactéries multirésistantes. Ce travail décrit une épidemie des isolats Acinetobacter baumannii productrice...

Background Incompleteness of vaccination coverage among children is a major public health concern because itcontinues to sustain a high prevalence of vaccine-preventable diseases in some countries. In Togo, very few data on the factors associated with incomplete vaccination coverage among children have been published. We determined the prevalence o...

Background In 2008, the proportion of truck drivers who were not systematically protected during sex was 63% with casual partners and 60% with sex workers. Despite the high level of knowledge on HIV/AIDS and the growing awareness of the existence of the risk of HIV infection, condom use always encounters resistance among truck drivers in Togo. We s...

Introduction Les comportements sexuels à risque des personnes vivant avec le VIH (PVVIH) recevant les traitements antirétroviraux (TAR) constituent une préoccupation majeure en raison du risque de transmission de souches virales résistantes. L’objectif de notre étude était de documenter les facteurs associés aux rapports sexuels à risque chez les P...

Introduction Le partage du statut sérologique avec son partenaire sexuel contribue à la prévention de la transmission de l’infection à VIH. L’objectif de notre étude était de documenter les facteurs influençant ce partage chez les personnes vivant avec le VIH (PVVIH) sous traitement antirétroviral (TAR) au CHR de Sokodé au Togo. Matériel et méthod...

Objectif : L’objectif de cette étude était de documenter l’influence des images pornographiques sur les comportements sexuels des élèves dans la commune de Cocody à Abidjan, Côte d’Ivoire. Méthode : Il s’agissait d’une étude transversale à visée descriptive et analytique réalisée d’octobre à novembre 2013 auprès des élèves dans quatre établissement...

Togo is one of the West African countries in which HIV prevalence remains high in the general population. Several HIV prevention interventions have targeted truck drivers. The purpose of this study was to describe and analyse the perceptions of truck drivers with respect to the HIVprevention message of the billboard. A qualitative study was conduct...

Perception of HIV infection prevention messages by truck drivers in Togo with respect to the « Roulez Protégé » billboard Background: Togo is one of the West African countries in which HIV prevalence remains high in the general population. Several HIV prevention interventions have targeted truck drivers. The purpose of this study was to describe a...

Many studies have reported factors associated with HIV status disclosure among People Living With HIV and AIDS (PLWHA) but very few were conducted among PLWHA receiving ART. In Togo, no study on HIV status disclosure to sexual partners has been conducted among PLWHA on ART yet. We sought to document factors associated with HIV status disclosure amo...

Objective: The objective of this study was to document the influence of pornography on the sexual behaviour of schoolchildren in the Cocody district of Abidjan, Côte d'Ivoire. Method: This cross-sectional, descriptive and analytical study was conducted from October to November 2013 with pupils from four schools in Cocody, Abidjan. Results: A total...

Abstract Background: Adherence to antiretroviral therapy (ART) is beneficial in reducing the risk of emergence of HIV resistant strains. Adherence to ART among Persons Living with HIV/AIDS (PLWHA) is influenced by several factors related to the patient, the medication, and health facilities. In Togo, previous studies on adherence to ART have report...

Background Adherence to antiretroviral therapy (ART) is beneficial in reducing the risk of emergence of HIV resistant strains. Adherence to ART among Persons Living with HIV/AIDS (PLWHA) is influenced by several factors related to the patient, the medication, and health facilities. In Togo, previous studies on adherence to ART have reported good ad...

Background Several studies on the sexual risk behaviors in sub-Saharan Africa have reported that the initiation of antiretroviral therapy leads to safer sexual behaviors. There is however a persistence of risky sexual behavior which is evidenced by a high prevalence of sexually transmitted infections among people living with HIV and AIDS (PLWHA). W...