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Isidoor Bergfeld

Isidoor Bergfeld
Amsterdam UMC; University of Amsterdam · Psychiatry

Ph.D.

About

33
Publications
3,910
Reads
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429
Citations
Introduction
Isidoor Bergfeld currently works at the Amsterdam UMC (locatoin AMC) on projects involving deep brain stimulation (DBS) in psychiatry. He mainly focuses on the effects of DBS on treatment-resistant depression and cognitive functions. He also assists in projects involving neuro-imaging of DBS, and DBS for obsessive-compulsive disorder. In addition, he works on the effects of electroconvulsive therapy (ECT) on cognitive functions with a focus on autobiographical memory.
Additional affiliations
June 2016 - December 2020
Amsterdam UMC (University of Amsterdam)
Position
  • Researcher
November 2009 - June 2016
Academic Medical Center, University of Amsterdam
Position
  • PhD Student
Education
November 2009 - July 2018
Amsterdam UMC (University of Amsterdam)
Field of study
  • Psychiatry
December 2005 - October 2008
University of Amsterdam
Field of study
  • Clinical neuropsychology
September 2002 - November 2005
University of Amsterdam
Field of study
  • Psychology

Publications

Publications (33)
Article
Importance: Patients with treatment-resistant depression (TRD) do not respond sufficiently to several consecutive treatments for major depressive disorder. Deep brain stimulation (DBS) is a promising treatment for these patients, but presently placebo effects cannot be ruled out. Objective: To assess the efficacy of DBS of the ventral anterior l...
Article
Background Electroconvulsive Therapy (ECT) and Deep Brain Stimulation (DBS) are effective treatments for patients with treatment-resistant depression (TRD). However, a common side effect of ECT is autobiographical memory loss (e.g., personal experiences), whereas the impact of DBS on autobiographical memories has never been established. Objective...
Article
Background: Thirty percent of patients with treatment-resistant depression (TRD) attempt suicide at least once during their lifetime. However, it is unclear what the attempted and completed suicide incidences are in TRD patients after initiating a treatment, and whether specific treatments increase or decrease these incidences. Methods: We searc...
Article
Full-text available
Objective Deep brain stimulation (DBS) reduces depressive symptoms in approximately 40%–60% of patients with treatment-resistant depression (TRD), but data on long-term efficacy and safety are scarce. Our objective was to assess the efficacy and safety of DBS targeted at the ventral anterior limb of the internal capsule (vALIC) in 25 patients with...
Article
Full-text available
Treatment-resistant depression (TRD) is a debilitating condition associated with higher medical costs, increased illness burden, and reduced quality of life compared to non-treatment-resistant major depressive disorder (MDD). The question arises whether TRD can be considered a distinct MDD sub-type based on neurobiological features. To answer this...
Presentation
Full-text available
Background: Our aim was to examine long-term effectiveness and tolerability of DBS in treatment-refractory obsessive-compulsive disorder (OCD), depression and anorexia nervosa. Moreover, we investigated factors that could predict treatment response and compare to meta-analytical outcomes. Methods: From our worldwide largest cohort of treatment-ref...
Presentation
Full-text available
Background: A new generation of deep brain stimulation (DBS) stimulators hold promise for closed loop stimulation, with personalized adaptive stimulation in response to biological signals. This approach requires network biomarkers that indicate when stimulation is needed. We present data on intracranial and extracranial electrophysiological recordi...
Poster
Full-text available
Background: Deep brain stimulation (DBS) of the ventral anterior limb of the internal capsule (vALIC) is a promising intervention for treatment-resistant major depressive disorder (MDD). Depression has been associated with aberrant amygdala responsivity to emotional stimuli. We therefore tested whether vALIC DBS could normalize amygdala responsivit...
Presentation
Full-text available
Deep brain stimulation (DBS) targeted to several brain areas has shown considerable promise in treating treatment-resistant depression with 40-60% of patients improving after one year of treatment. Because in virtually all included patients white matter was stimulated, several research groups started imaging white matter tracts to investigate wheth...
Presentation
Full-text available
Introduction: Recent evidence for refractory obsessive compulsive disorder (OCD) showed that response in vALIC-DBS is associated with active stimulation closer to the supero-lateral branch of the medial forebrain bundle (MFB). In the present study, we compared results of diffusion tensor imaging (DTI) fiber tractographically (FT)-assisted MFB-DBS t...
Article
Full-text available
Background Patients with misophonia suffer from anger or disgust confronted with specific sounds such as smacking or breathing. Avoidance of cue‐related situations results in social isolation and significant functional impairment. This is the first randomized, controlled cognitive behavioral therapy (CBT) trial for misophonia, evaluating the short‐...
Preprint
Full-text available
Deep brain stimulation is a treatment option for patients with refractory obsessive-compulsive disorder. A new generation of stimulators hold promise for closed loop stimulation, with adaptive stimulation in response to biological signals Here we aimed to discover a suitable biomarker in the ventral striatum in patients with obsessive compulsive di...
Article
It becomes increasingly clear that (non-)invasive neurostimulation is an effective treatment for obsessive-compulsive disorder (OCD). In this chapter we review the available evidence on techniques and targets, clinical results including a meta-analysis, mechanisms of action, and animal research. We focus on deep brain stimulation (DBS), but also co...
Article
Objective Ablative surgery (ABL) and deep brain stimulation (DBS) are last‐resort treatment options for patients suffering from treatment‐refractory obsessive‐compulsive disorder (OCD). The aim of this study was to conduct an updated meta‐analysis comparing the clinical outcomes of the ablative procedures capsulotomy and cingulotomy and deep brain...
Preprint
Full-text available
This the Dutch translation of the Columbia University - Autobiographical Memory Interview, Short From (CU-AMI-SF), orginally authored by Martin McElhiney, Bobba Moody and Harold Sackeim. It contains the manual and forms for recording and scoring the interview. This interview is intended to quantify retrograde amnesia following electroconvulsive th...
Article
Full-text available
Apathy, the loss of motivation, is a common problem in Parkinson's disease (PD) and often observed following deep brain stimulation (DBS) of the subthalamic nucleus (STN). The aim of this meta‐analysis was to determine the occurrence of apathy following STN DBS in literature. Relevant articles were searched in PubMed/Medline, SCOPUS, EMBASE, and We...
Article
Full-text available
Objectives Deep brain stimulation (DBS) is an innovative and effective treatment for patients with therapy‐refractory obsessive–compulsive disorder (OCD). DBS offers unique opportunities for personalized care, but no guidelines on how to choose effective and safe stimulation parameters in patients with OCD are available. Our group gained relevant p...
Article
Full-text available
Background Deep brain stimulation (DBS) is an innovative treatment for treatment-refractory depression. DBS is usually targeted at specific anatomical landmarks, with patients responding to DBS in approximately 50% of cases. Attention has recently shifted to white matter tracts to explain DBS response, with initial open-label trials targeting white...
Chapter
Open-label studies of deep brain stimulation (DBS) for patients with treatment-resistant depression (TRD) are promising: approximately 40% of patients lose at least half of their symptoms following DBS of the subcallosal cingulate cortex (SCC) or ventral capsule and ventral striatum (VC/VS). The results of sham-controlled trials, however, have been...
Article
This is a comment on the paper of Ramasubbu et al (Lancet Psychiatry, 2020), in which they randomized patients to deep brain stimulation with a short or a long pulse width.
Preprint
Full-text available
Objective: Deep brain stimulation (DBS) is an innovative treatment for treatment-resistant depression. DBS is usually targeted at specific anatomical landmarks, with patients responding to DBS in approximately 50% of cases. Attention has recently shifted to white matter tracts to explain DBS response, with initial open-label trials targeting white...
Article
Background: Deep Brain Stimulation (DBS) is effective for obsessive-compulsive disorder (OCD), but requires expensive medical procedures. To date, no study has examined the cost-effectiveness of DBS for OCD. Objective: To perform the first economic evaluation of DBS for therapy refractory OCD. Methods: We conducted a 2-year prospective, open c...
Poster
Background: Deep Brain Stimulation (DBS) is a promising treatment for patients with Treatment Resistant Depression (TRD). Preliminary neuropsychological studies also show DBS does not affect cognitive functions of TRD patients and might even have a cognitive enhancing effect. However, practice effects could not be ruled out in these studies and act...
Article
Background Preliminary studies report no negative and a possible positive impact of deep brain stimulation (DBS) on cognition of patients with treatment-resistant depression (TRD). However, these studies neither controlled for practice effects nor compared active with sham stimulation. Method To address these limitations, we compared 25 TRD patien...
Poster
Cost-effectiveness of deep brain stimulation versus treatment as usual for obsessive-compulsive disorder
Poster
Poster abstract of results published in JAMA Psychiatry (2016), 73(5):456-464. https://doi.org/10.1001/jamapsychiatry.2016.0152
Poster
Preliminary analysis on the impact of deep brain stimulation on autobiographical memory compared to electroconvulsive therapy.

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Projects

Project (1)
Project
We investigate efficacy, side effects and cognitive effects of Deep Brain Stimulation targeted to the ventral Anterior Limb of the Internal Capsule as a treatment for Therapy-Resistant Depression.