Isiah Warner

Isiah Warner
Louisiana State University | LSU · Department of Chemistry

PhD

About

442
Publications
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13,227
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Publications

Publications (442)
Article
Nanoparticles derived from a group of uniform materials based on organic salts (nanoGUMBOS) are considered promising candidates for protein analysis due to their facile synthesis in aqueous media and high tunability. In this study, a phosphonium-erythrosin B-based nanoGUMBOS (i.e., [P4444]2[EB]) was prepared using an ultrasound-assisted reprecipita...
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Although institutions of higher education have placed a large emphasis on increasing the number of underrepresented minority (URM) students matriculating in higher education, the disparities in STEM retention and graduation rates between URM and non-URM students emphasize the dire need for increased support to help URM students navigate challenges...
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In recent years, advanced materials with properties resembling biological systems, particularly artificial muscles, have received intense scrutiny. This is because the interesting conformational shape characteristics of such materials have benefited a variety of technologies, including textiles, 3D printing, and medical devices. Although a multitud...
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Here we report a thermoset shape memory polymer-based syntactic foam inherently integrated with flame retardancy, good mechanical properties, excellent shape memory effect, and 3D printability. The syntactic foam is fabricated by incorporating a high-temperature shape memory polymer (HTSMP) as the matrix, with 40 vol % hollow glass microspheres (HG...
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The quartz crystal microbalance (QCM) has been widely used in laboratory settings as an analytical tool for recognizing and discriminating biological and chemical molecules of interest. As a result, recent studies have shown there to be considerable attention in practical applications of the QCM technique beyond the laboratory. However, most commer...
Article
GUMBOS (Group of Uniform Materials Based on Organic Salts) have recently emerged as interesting materials for protein analysis due to their unique features and high tunability. In this regard, four novel erythrosin B (EB)-based GUMBOS were synthesized and their potential to discriminate among proteins with distinct properties (e.g., size, charge, a...
Article
Three novel small organic heterocyclic compounds: 2-(1,2-diphenyl)-1H-benzimidazole-7-tert-butylpyrene (compound A), 1,3-di(1,2-diphenyl)-1H-benzimidazole-7-tert-butylpyrene (compound B), and 1,3,6,8-tetra(1,2-diphenyl)-1H-benzimidazolepyrene (compound C) were synthesized and characterized for possible applications as blue OLED emitters. The specif...
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Herein, a solvent-based green recycling procedure is reported for recycling thermoset epoxy resins (TERs) and carbon fiber reinforced epoxy composites (CFRECs) employing ionic liquids (ILs) and alcohols under mild conditions. With melting points less than 100 °C, ILs are defined as organic salts, typically composed of bulky cations with organic or...
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Herein, an inexpensive commercially available sensor is presented for the detection of 4-nitrophenol (4NP) pollutant. Sodium fluorescein (NaFl) is used as a sensor to detect trace amounts of 4NP in acetonitrile (MeCN). The photophysical properties of NaFl were studied in two different solvents, MeCN (aprotic) and water (protic), with varying concen...
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Volatile organic compounds (VOCs) that evaporate under standard atmospheric conditions are of growing concern. This is because it is well established that VOCs represent major contamination risks since release of these compounds into the atmosphere can contribute to global warming, and thus, can also be detrimental to the overall health of worldwid...
Chapter
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Ionic liquids (ILs) are defined as organic salts with melting points below 100 °C. Such ionic compounds are typically formed using bulky cations and/or bulky anions in order to produce liquids or lower melting solids. ILs have been widely explored in several research areas including catalysis, remediation, solvents, separations, and many others. Th...
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In this study, three magnetic ionic liquids (MILs) were investigated for extraction of four estrogens, i.e., estrone (E1), estradiol (E2), estriol (E3), and ethinylestradiol (EE2), from environmental water. The cation trihexyl(tetradecyl)phosphonium ([P66614]+), selected to confer hydrophobicity to the resulting MIL, was combined with tetrachlorofe...
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Quality checks, assessments, and the assurance of food products, raw materials, and food ingredients is critically important to ensure the safeguard of foods of high quality for safety and public health. Nevertheless, quality checks, assessments, and the assurance of food products along distribution and supply chains is impacted by various challeng...
Article
Background: Reducing Neisseria gonorrhoeae colonies in the oropharynx is a viable solution to minimize the transmission of this bacterium amongst individuals. Objectives: A strategy involving the electrostatic interaction between a common antiseptic and a discontinued antibiotic (i.e. octenidine and carbenicillin) was evaluated as a potential tr...
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Sensitive and selective detection of proteins from complex samples has gained substantial interest within the scientific community. Early and precise detection of key proteins play an important role in potential clinical diagnosis, treatment of different diseases, as well as in proteomic research. In the study reported here, six different compounds...
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Rhodamine derivatives have been widely investigated for their mitochondrial targeting and chemotherapeutic properties that result from their lipophilic cationic structures. In previous research, we have found that conversion of Rhodamine 6G into nanoGUMBOS, i.e., nanomaterials derived from a group of uniform materials based on organic salts (GUMBOS...
Article
GUMBOS (group of uniform materials based on organic salts) is a novel class of materials that exhibits similar features to those of ionic liquids, but have melting points between 25 and 250 °C. GUMBOS can be easily converted into nanomaterials (nanoGUMBOS), with advantages of working at nanoscale. Due to the huge number of possible cation-anion com...
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A facile method was used to synthesize biocomposites containing differing ratios of hyaluronic acid (HA) and cellulose (CEL). Based on the properties of the individual polymers, the resultant composite materials may have potentially great wound care properties. In the method outlined here, 1-butyl-3-methylimidazolium chloride ([Bmim][Cl]), a simple...
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Herein, we examine two sensing schemes for detection and discrimination of chlorinated volatile organic compounds (VOCs). In this work, phosphonium ionic liquids (ILs) were synthesized and vapor sensing properties examined and compared to phosphonium IL-polymer composites. Pure IL sensors were used to develop a QCM-based multisensory array (MSA), w...
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A novel sky-blue-emitting tripyrenylpyridine derivative, 2,4,6-tri(1-pyrenyl)pyridine (2,4,6-TPP), has been synthesized using a Suzuki coupling reaction and compared with three previously reported isomeric dipyrenylpyridine (DPP) analogues (2,4-di(1-pyrenyl)pyridine (2,4-DPP), 2,6-di(1-pyrenyl)pyridine (2,6-DPP), and 3,5-di(1-pyrenyl)pyridine (3,5-...
Article
The near-infrared fluorescent (NIRF) dye, IR780, is recognized as a promising theranostic agent and has been widely investigated for imaging, chemotherapeutic, and phototherapeutic applications. However, its poor photostability and non-selective toxicities towards both cancer and normal cells limit its biological applications. Herein, we introduce...
Article
Ensuring the integrity of quality control and assurance of consumable products across consumer goods distribution and supply chains is pertinent to ensure consumer products of high quality to guarantee public health. Several analytical strategies, and technological innovations have been developed over the years for the quality control and assurance...
Article
A novel imidazolium-dysprosium-based magnetic nanomaterial, i.e. [C16mim]5[Dy(SCN)8] nanoGUMBOS (nanomaterials fabricated from a group of uniform material based on organic salts), was prepared using a facile method for selective hemoglobin (Hb) isolation. In this nanomaterial, the imidazolium cation serves as a selective Hb affinity group, while dy...
Chapter
Louisiana State University (LSU)’s Office of Strategic Initiatives (OSI) is an award-winning office devoted to developing effective, educational approaches that incorporate guidance and exploration, increase students’ academic standing, and support measures to improve the institution’s diversity, predominantly in science, technology, engineering, a...
Article
Herein, we report the synthesis and characterization of a nanosensor developed from a group of uniform materials based on organic salts (GUMBOS). This sensor is composed of three ionic species, namely, fluorescein, rhodamine B, and tetradecyltrihexyl phosphonium (P66614) ions. Nanoparticles prepared from this three-component GUMBOS, termed nanoGUMB...
Article
Propidium iodide (3,8-diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodide, [P][I]), is a well-known red fluorescent dye that is widely used for biological applications such as staining. In this study, we have replaced the iodide counter-anion of [P][I] with three hydrophobic and bulky organic anions: trifluoromethanesulfona...
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Herein, a simple counter-ion variation strategy is proposed and demonstrated for design of an array of near infrared IR780-based nanoGUMBOS (nanomaterials from a Group of Uniform Materials Based on Organic Salts) to produce enhanced anticancer activity. These nanomaterials were synthesized by direct nanoengineering of IR780-based GUMBOS using a rep...
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Nanodrugs have been widely investigated for combating the large number of side effects associated with conventional therapeutics. Several investigations of such nanomedicines have demonstrated the profound role of nanoparticle size in therapeutic efficacy. Herein, we report the role of cyclodextrin (CD)-templating on the size and therapeutic proper...
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Herein, we report on the role of endocytosis in the selective chemotherpeutic toxicity of Rhodamine 6G (R6G) based nanomaterials, i.e. nanoGUMBOS, that are derived from a Group of Uniform Materials Based on Organic Salts (GUMBOS). Evaluation of cellular uptake in the presence and absence of endocytosis inhibitors suggests nanoGUMBOS internalization...
Article
The use of quartz crystal microbalance (QCM) sensor arrays for analyses of volatile organic compounds (VOC) has attracted significant interest in recent years. In this regard, a group of uniformed materials based on organic salts (GUMBOS) has proven to be promising recognition elements in QCM based sensor arrays due to diverse properties afforded b...
Article
Overproduction of reactive oxygen species (ROS) results in oxidative stress, which is closely associated with pathogenesis of many diseases. Visualized detection of ROS in situ enables deeper insight into the mechanisms that underlie such pathological and physiological processes. Among reactive species, selective detection of hydroxyl radical is th...
Article
The synthesis, characterization, ultrafast dynamics, and nonlinear spectroscopy of 30 nm nanospheres of brilliant green-bis(pentafluoroethylsulfonyl)imide ([BG][BETI]) in water are reported. These thermally stable nanoparticles are derived from a group of uniform materials based on organic salts (nanoGUMBOS) that exhibit enhanced near-infrared emis...
Article
Herein, we report the investigation of sodium deoxycholate (NaDC)/TRIS-based hydrogels as delivery vehicles for a broad range of applications. Three hydrogel formulations were chosen for unique rheological behaviors that suggest a change in internal hydrogel structure with the application of a shear force. In this work, we compare solute release fr...
Article
Herein, a simplistic quartz crystal microbalance (QCM) approach for discrimination of petroleum based fuels is presented. In this regard, a quartz crystal microbalance (QCM) virtual multisensor array (V-MSA) was employed to discriminate between different petroleum based fuels and to detect gasoline adulteration with high accuracy. First, an ionic l...
Article
Cationic ionic liquids-based surfactants (ILS), such as 4-methyl pyridinium bromide (CnPBr, where n = 4,6,8), were used in preparation of polyacrylamide gels, sample buffer, and running buffer for cationic ILS polyacrylamide gel electrophoresis (ILS-PAGE). These ILS are liquid in the pure state and were selected for improved separation of ribonucle...
Article
Herein, we present a promising approach for simultaneous identification and molecular weight approximation of closely related pure organic vapors using the quartz crystal microbalance (QCM). In this regard, a QCM virtual sensor array (VSA), was fabricated employing a binary blend of ionic liquid and polymer, i.e. 1-hexyl-3-methylimidazolium bis(tri...
Article
In this study, GUMBOS (group of uniform materials based on organic salts) derived from rhodamine B chloride, 1,1’-diethyl-2,2’-carbocyanine iodide, 3,3′-diethylthiacarbocyanine iodide, and meso-tetra(4-carboxyphenyl) porphine were synthesized and characterized for application as energy relay dyes (ERDs) in dye-sensitized solar cells (DSSCs). A faci...
Article
Porphyrin-based GUMBOS and nanoGUMBOS were synthesized for potential application as improved photosensitizing materials. In this study, porphyrin dyes [meso-tetra(4-carboxyphenyl) porphine (TCPP) and zinc (II) meso-tetra(4-carboxyphenyl) porphine (Zn-TCPP)] were selected as anions, and trihexyltetradecylphosphonium (P66614) was employed as a cation...
Article
There is increasing interest in developing new sensor strategies for accurate detection and identification of proteins, primarily due to their significance in various biological processes. In this regard, fluorometric sensors and sensor arrays have been widely explored as facile and inexpensive analytical tools. In this manuscript, we report a sens...
Article
QCM sensor arrays are promising systems for volatile complex mixture analysis. Such mixtures, sometimes termed odors, can prove to be challenging targets for accurate identification using conventional approaches. As a result, development of novel gas sensing systems and materials for identification of complex mixtures has garnered much interest in...
Article
Fluorescence, Phosphorescence, and Chemiluminescence cover a wide array of topics. One can simply examine the number of topics that arise from photon induced excitation and emission as summarized in Figure 1 to understand the magnitude of this overall topic. Thus, as in previous years, we are not able to provide extensive coverage of all developmen...
Article
The synthesis, characterization, and ultrafast spectroscopy of size-selected nanospheres of ruthenium bipyridine-bis(pentafluoroethylsulfonyl)imide ([Ru(bipy)3][BETI]2) in water are reported. These studies represent the first experimental evidence of phonons with nanosecond lifetimes in organometallic nanomaterials. Thermally stable, crystalline na...
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In Holding Fast to Dreams , University of Maryland, Baltimore County, President Freeman Hrabowski III reflects on his life and career, from his childhood involvement in the civil rights movement to his growing legacy as an advocate for improving access to STEM higher education. Praising the book as "engaging and thought-provoking," reviewers Isiah...
Article
A novel approach for tuning spectral properties, as well as minimizing aggregation, in zinc porphyrin and zinc phthalocyanine-based compounds is presented. Particular emphasis is placed on use of these compounds as photosensitizers in photodynamic therapy (PDT). To accomplish this aim, a bulky hydrophobic cation, trihexyltetradecylphosphonium, is p...
Article
This study aims at investigating methodologies for better separation of proteins using novel hydrophobic ionic liquids (ILs). In this regard, hydrophobic ILs [CnPBr] (n= 4, 6, 8) were synthesized and examined in ionic liquid-polyacrylamide gel electrophoresis (IL-PAGE) as buffer additives for separation of catalase (Cat), transferrin (Tf), bovine s...
Article
In the present study, sodium deoxycholate (NaDC) was used to produce gelation of tris(hydroxymethyl)amino-methane (TRIS) solutions above, below, and near the pKa of NaDC, respectively, which yielded a neutral gelator, a charged gelator, and a mixture of each. Impacts of ionic interactions on gel formation were studied in detail and showed that pH c...
Article
Herein, we demonstrate an alternative strategy for creating QCM-based sensor arrays by use of a single sensor to provide multiple responses per analyte. The sensor, which simulates a virtual sensor array (VSA), was developed by depositing a thin film of ionic liquid, either 1-octyl-3-methylimidazolium bromide ([OMIm][Br]) or 1-octyl-3-methylimidazo...
Article
In this study, we report on the synthesis and characterization of multifunctional ionic liquid crystals (melting points below 100 °C) which possess chirality, fluorescent behavior, as well as mesomorphic and magnetic properties. In this regard, (1R, 2S) (-)-N-Methylephedrine ((-)MeEph), containing a chiral center, is linked with variable alkyl chai...
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The emergence of multi-drug-resistant bacteria, coupled with the lack of new antibiotics in development, is fast evolving into a global crisis. New strategies utilizing existing antibacterial agents are urgently needed. We propose one such strategy in which four outmoded β-lactam antibiotics (ampicillin, carbenicillin, cephalothin and oxacillin) an...
Article
There is a continuing need to develop high performance sensors for monitoring organic solvents, primarily due to the environmental impact of such compounds. In this regard, colorimetric sensors have been a subject of intense research for such applications. Herein, we report a unique virtual colorimetric sensor array based on a single ionic liquid (...
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Emerging concepts of theranostics have led to development of numerous multifunctional nanomaterials using various synthetic approaches. Herein, we report a simplistic approach towards design of an Iron(III) phthalocyanine based pH responsive-magnetic-fluorescent nanoparticles for combined multimodal diagnosis and possible site selective therapy. Tr...
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Ionic liquids composed of a carbazoleimidizolium-based cation and various hydrophobic anions have been synthesized and characterized. Analyses of the absorption spectra of these compounds indicate significant increases in energy gaps between the first two excited singlet states, which results in inhibition of internal conversion from the S2 to S1 s...
Article
RATIONALE: Detection of hydrophobic peptides remains a major obstacle for matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). This stems from the fact that most matrices for MALDI are hydrophilic and therefore have low affinities for hydrophobic peptides. Herein, 1-aminopyrene (AP) and AP-derived group of uniform materials bas...
Article
For many years, the U.S. has underutilized its human resources, as evidenced by the pervasive underrepresentation of several racial and ethnic groups within academia in general and the science, technology, engineering, and mathematics (STEM) disciplines, in particular. To address this underutilization, academic departments within U.S. universities...
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In this study, we report synthesis and characterization of novel carbazole-based group of uniform materials based on organic salts (GUMBOS), as well as potential applications of these compounds. These organic-based compounds exhibit high thermal stability (decomposition temperatures in the range of 395–432 °C) and photostability. In addition, these...
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An emerging thrust in the design of advanced materials is nanoscale functional materials possessing multiple capabilities, such as those possessing a core–shell architecture. Nanoparticles comprising a dielectric core (e.g., silica, polystyrene) and a gold shell are particularly attractive due to the desirable optical (plasmonic) and biocompatibili...