Isain Zapata

Isain Zapata
Rocky Vista University · Department of Biomedical Sciences

Ph.D.
Working on many projects; from global medicine to medical training. From public health to clinical trials.

About

64
Publications
10,536
Reads
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302
Citations
Citations since 2017
53 Research Items
238 Citations
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Introduction
Isain is an academic researcher who specializes in data analysis in the areas of behavior and health disparities. He provides statistical support and analytics for many collaborative research teams.
Additional affiliations
September 2019 - present
Rocky Vista University
Position
  • Professor (Assistant)
May 2016 - September 2018
The Ohio State University
Position
  • PostDoc Position
December 2012 - April 2016
Nationwide Children's Hospital
Position
  • PostDoc Position
Education
January 2006 - December 2011
The Ohio State University
Field of study
  • Animal Science
September 2003 - June 2005
Universidad Autónoma de Chihuahua
Field of study
  • Animal Production
September 1998 - June 2003

Publications

Publications (64)
Article
Full-text available
Background Very little is known about the etiology of personality and psychiatric disorders. Because the core neurobiology of many such traits is evolutionarily conserved, dogs present a powerful model. We previously reported genome scans of breed averages of ten traits related to fear, anxiety, aggression and social behavior in multiple cohorts of...
Article
Full-text available
Latent class analysis (LCA) is a type of modeling analysis approach that has been used to identify unobserved groups or subgroups within multivariate categorical data. LCA has been used for a wide array of psychological evaluations in humans, including the identification of depression subtypes or PTSD comorbidity patterns. However, it has never bee...
Article
Full-text available
The objective of this study was to evaluate the impact of selected sociodemographic factors on childhood vaccination hesitancy and to define their role according to specific exemptions. This population-based cohort study utilized vaccination rate and sociodemographic data from 1st to 12th grade from 2017 to 2021 for all school districts in Colorado...
Article
Full-text available
The emergence of COVID-19 virus has led to a pandemic with staggering morbidity and mortality. There is evidence showing that pre-existing conditions and environmental factors are associated with worse COVID-19 outcomes. Among these conditions, altitude is of particular interest. Altitude has been shown to influence the morbidity and mortality of m...
Article
Full-text available
Previous studies have evaluated comorbidities and sociodemographic factors individually or by type but not comprehensively. This study aims to analyze the influence of a wide variety of factors in a single study to better understand the big picture of their effects on case-fatalities. This cross-sectional study used county-level comorbidities, soci...
Article
Full-text available
Objective Tirzepatide is a dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) approved by the Food and Drug Administration (FDA) in May 2022 for patients with type 2 diabetes mellitus (T2DM). We aimed to determine the rates of individual adverse events (AEs) related to 3 studied doses of tirz...
Article
Full-text available
Context: One of the two major pathways to become a physician in the United States is the Doctor of Osteopathic Medicine (DO) degree. A major distinctive feature is often perceived as the addition of manual training in osteopathic manipulative treatment (OMT) in the DO education. However, the profession also has a distinct philosophy imbedded in th...
Article
Full-text available
Introduction The teach-back method is a communication tool that can improve patient safety and shared decision-making. Its utility in patient care has been studied extensively in many areas of clinical medicine. However, the literature on teach-back in surgical patient education and informed consent is limited, and few studies have been conducted t...
Presentation
Full-text available
Introduction: The teach-back method is a communication tool that can improve patient safety and shared decision-making. Its utility in patient care has been studied extensively in many areas of clinical medicine. However, the literature on teach-back in surgical patient education and informed consent is limited, and few studies have been conducted...
Conference Paper
Introduction: Angiogenesis imbalance is essential for tumour growth, with hypoxia being the most important driver. Moreover, tumour cells can contribute to forming blood vessels by vasculogenic mimicry (VM) or recalling the endothelial-progenitor-cells through vasculogenesis. Microvessel density (MVD) increase and VM are associated with poor progno...
Article
Full-text available
Research on working dogs is growing rapidly due to increasing global demand. Here we report genome scanning of the risk of puppies being eliminated for behavioral reasons prior to entering the training phase of the US Transportation Security Administration’s (TSA) canine olfactory detection breeding and training program through 2013. Elimination of...
Article
Objectives The purpose of this non interventional study was to define changes in anxiety, depression, and sleep quality of medical students in their first two years of medical school while considering potential risk factors of self-reported chronic disease, sleep quantity, year of medical school and exercise habits. Since this study was ongoing dur...
Preprint
Full-text available
Objective This study compares the utility of palpation-based and ultrasound-guided teaching techniques for subclavian central venous access using formalin-embalmed cadavers. Methods The subclavian veins of 20 formalin-embalmed cadavers were imaged with ultrasound to evaluate vein patency and sonographic clarity prior to venous access. Twenty-three...
Article
Full-text available
Background Hyperemesis gravidarum is the most severe form of nausea and vomiting of pregnancy, or morning sickness. 2% of pregnancies in the United States are affected by hyperemesis gravidarum. The condition is characterized by severe vomiting in pregnant people, especially during the first trimester, often leading to hypovolemia and weight loss....
Article
Full-text available
Goals To analyze our experience with adenoma detection rates in patients with liver cirrhosis in a community setting. Background Colorectal cancer (CRC) is the third most common cancer and leading cause of cancer death in men and women in the USA. The majority of CRCs arise from premalignant polyps (adenomas), which are typically detected and remo...
Preprint
Full-text available
Introduction Previous studies have evaluated comorbidities and sociodemographic factors individually or by type but not comprehensively. This study aims to analyze the influence of a wide variety of factors in a single study to better understand the big picture of their effects on case-fatalities. Methods County-level comorbidities, social determi...
Article
Full-text available
1) Background: Glaucoma is a leading cause of irreversible blindness worldwide. Unfortunately , no noticeable symptoms exist until mid-to late-stage glaucoma, leading to substantial costs to the patient and the healthcare system. (2) Methods: The Student Sight Savers Program, an initiative started at Johns Hopkins University, was designed to meet t...
Preprint
Full-text available
Background: Hyperemesis gravidarum is the most severe form of nausea and vomiting of pregnancy, or morning sickness. 2% of pregnancies in the United States are affected by hyperemesis gravidarum. The condition is characterized by severe vomiting in pregnant people, especially during the first trimester, often leading to hypovolemia and weight loss....
Article
Objective Despite increased demand and worsening burnout among US endocrinologists, there is a paucity of data on job satisfaction and associated factors. This study examines factors associated with job satisfaction among a nationally representative sample of US endocrinologists. Method We conducted a cross-sectional survey of 1700 US adult endocr...
Article
Full-text available
This brief report examines the feasibility of using formalin-embalmed cadavers in training medical students to use ultrasound guidance to access the subclavian. This novel educational approach is discussed in the context of the ongoing integration of point-of-care ultrasound training into medical education. Additionally, this report explores how ca...
Article
Aim: The purpose of this study is to investigate what factors make students feel confident and competent when performing a female genitourinary exam (FGUE) with normal, nonpathologic findings. We anticipated that students would increase their confidence and perceived competence from the first year to the second year of medical school, would prefer...
Preprint
Full-text available
BACKGROUND and OBJECTIVES: This study aims to define changes in anxiety and depression among medical students while evaluating the association of sleep habits and other risk factors, including exercise habits and a diagnosis of chronic disease. The effect of the COVID-19 pandemic was also evaluated. DESIGN: A cohort of first- and second-year medic...
Article
Full-text available
This study explores the rate of Imposter Syndrome (IS) in osteopathic medical students specifically in regard to gender. Additionally, we compare IS with previous performance on the Medical College Admission Test (MCAT) and undergraduate science GPA. IS has been described as a psychological term that refers to a pattern of behavior wherein people d...
Article
Aim Paramedics received training in point-of-care ultrasound (POCUS) to assess for cardiac contractility during management of medical out-of-hospital cardiac arrest (OHCA). The primary outcome was the percentage of adequate POCUS video acquisition and accurate video interpretation during OHCA resuscitations. Secondary outcomes included POCUS impact...
Article
Full-text available
The use of glycosylated hemoglobin as a diabetic glycemic control and cardiovascular risk marker is well documented. It has also been suggested as a marker for early diastolic hemodynamic changes leading to clinical heart failure, but is less well characterized. This study explored the association between elevated glycosylated hemoglobin and liver...
Article
Full-text available
The use of glycosylated hemoglobin as a diabetic glycemic control and cardiovascular risk marker is well documented. It has also been suggested as a marker for early diastolic hemodynamic changes leading to clinical heart failure, but is less well characterized. This study explored the association between elevated glycosylated hemoglobin and liver...
Article
Full-text available
Behavioral traits like aggression, anxiety, and trainability differ significantly across dog breeds and are highly heritable. However, the neural bases of these differences are unknown. Here we analyzed structural MRI scans of 62 dogs in relation to breed-average scores for the 14 major dimensions in the Canine Behavioral Assessment and Research Qu...
Article
Full-text available
Background: There is growing concern about the recent increase in oil and gas development using hydraulic fracturing. Studies linking adverse birth outcomes and maternal proximity to hydraulic fracturing wells exist but tend to use individualized maternal and infant data contained in protected health care records. In this study, we extended the fin...
Article
PurposeThe objective of this study was to examine the effects that pre-medical patient care clinical experiences and anatomical education had on undergraduate medical course grades and anatomy practical exam scores. This study provides a unique perspective to this line of inquiry in that it included data from 9 class year cohorts between academic y...
Article
Full-text available
Background: The use of ultrasound guidance during knee arthrocentesis has proven to increase operator confidence and accuracy, particularly in novice healthcare providers. Realistic and practical means of teaching this procedure to medical trainees are needed. This study is intended to assess the feasibility and efficacy of using formalin-embalmed...
Article
Full-text available
Background: The opioid epidemic is a complex national crisis in the United States with a 400% increase in related deaths over the past two decades with no signs of slowing. The purpose of this study was to assess the incidence of opioid use, based on the geographic and population characteristics. Methods: The opioid-related hospital inpatient st...
Article
Full-text available
Medical education is an ever-changing field fraught with uncertainty for students. Events over the four years determine the majority of their careers, which makes the task daunting and stressful. When a pandemic that hinders their learning experience enters the mix, many feel lost and left behind (Ferrel and Ryan, 2020). The recent pandemic has pla...
Preprint
Full-text available
Background The classic association of glycemic control as represented by glycosylated hemoglobin (Glyco% or HbA1c) with progression of micro and macro vascular clinical complications is well documented. However use of the advanced glycation end product (AGE) axis as a marker for early diastolic hemodynamic changes leading to clinical heart failure...
Data
Data for survey responses and questionnaire by faculty/staff and students on their perception of the COVID pandemic. Data was acquired in April and June 2020 at Rocky Vista University Colorado and Utah campuses.
Article
Full-text available
Lifetime exposure to stress leads to risk of suffering from cumulative detrimental physiological and psychological ailments. Due to the nature of healthcare and exposure to trauma, medical professionals are particularly susceptible to the negative impacts of high stress environments. emotional intelligence plays a role in ameliorating the risk of b...
Article
Full-text available
Background Burnout is being experienced by medical students, residents, and practicing physicians at significant rates. Higher levels of Hardiness and Emotional Intelligence may protect individuals against burnout symptoms. Previous studies have shown both Hardiness and Emotional IntelIigence protect against detrimental effects of stress and can be...
Preprint
Full-text available
Very little is known about the etiology of personality and psychiatric disorders. Because the core neurobiology of many such traits is evolutionarily conserved, dogs present a powerful model. We previously reported genome scans of breed averages of ten traits related to fear, anxiety, aggression and social behavior in multiple cohorts of pedigree d...
Preprint
Full-text available
Genetic studies show a general factor associated with all human psychopathology and strongly correlated with personality and intelligence, but its basis is unknown. We performed genome scans of 17 normal and problem behaviors in three multi-breed dog cohorts. 21 of 90 mapped loci were supported for the same, or a related, trait in a second cohort....
Article
Full-text available
Background Despite the tremendous therapeutic advances that have stemmed from somatic oncogenetics, survival of some cancers has not improved in 50 years. Osteosarcoma still has a 5-year survival rate of 66%. We propose the natural canine osteosarcoma model can change that: it is extremely similar to the human condition, except for being highly her...
Article
Full-text available
Background The main function of hemoglobin (Hb) is to transport oxygen in the circulation. It is among the most highly studied proteins due to its roles in physiology and disease, and most of our understanding derives from comparative research. There is great diversity in Hb gene evolution in placental mammals, mostly in the repertoire and regulati...
Chapter
This chapter highlights the unique traits that make dog models effective in the integration of biomedical genomics and translational medicine. A great advantage of dog models is simplified genetics. Most of the strengths of dog models are relevant across all human disease areas, but there are aspects of cancer that differ from all other diseases. I...
Article
Full-text available
Background Fear/anxiety and anger/aggression greatly influence health, quality of life and social interactions. They are a huge burden to wellbeing, and personal and public economics. However, while much is known about the physiology and neuroanatomy of such emotions, little is known about their genetics – most importantly, why some individuals are...
Article
Full-text available
Our objectives were to evaluate potential signaling pathways regulating rumen protozoal chemotaxis using eukaryotic inhibitors potentially coordinated with phagocytosis as assessed by fluorescent bead uptake kinetics. Wortmannin (inhibitor of phosphoinositide 3-kinase), insulin, genistein (purported inhibitor of a receptor tyrosine kinase), U73122...
Article
Full-text available
Genetic selection has been very successful at significantly increasing BW and breast muscle proportion in commercial broiler and turkey strains. The mechanisms of breast muscle growth in poultry and the interactive effects of nutritional status and selection are not fully understood. The hypothesis underlying the current study is that feed restrict...
Article
Full-text available
The selection processes that have resulted in broiler (meat) and leghorn (eggs) chickens have had very different effects on the pectoralis major and supracoracoideus muscles. The objective of this study, therefore, was to analyze the one-dimensional proteomic profiles of sarcoplasmic protein fractions isolated from the p. major and supracoracoideus...
Article
Full-text available
In this review, some of the limitations and issues related to current popular proteomic approaches will be discussed and a case will be made for the benefits of using one-dimensional electrophoresis-based proteomics for agricultural study setups. One-dimensional electrophoresis-based proteomics has an important advantage over conventional two-dimen...
Article
Full-text available
Proteins are the main participants in metabolic pathways. However, the analysis of protein abundance patterns associated with those pathways is complicated by the large number of proteins involved. In this study, the objective was to present the application of principal component analysis (PCA) to permit the visualization of developmental proteomic...
Article
Inconsistent tenderness is one of the most detrimental factors of meat quality. Functional proteomics was used to associate electrophoretic bands from the myofibrillar muscle fraction to meat tenderness in an effort to gain understanding of the mechanisms controlling tenderness. The myofibrillar muscle fraction of the Longissimus dorsi from 22 Angu...
Presentation
Full-text available
The mechanisms controlling meat tenderness involve a multitude of cellular functions. A novel approach to identify the protein(s)/peptide(s) bands associated with tenderness, measured by Warner Bratzler Shear (WBS), is the use of functional proteomics. The aim of this study was to associate electrophoretically separated bands from a muscle myofibri...
Article
Full-text available
The Rendement Napole gene (RN) consists of a mutation at the γ3 subunit of AMP-activated protein kinase (AMPK) in pigs. AMPK works as an energy level sensor and controls numerous cellular pathways. The study aimed at identifying the differences in microstructure occurring between the normal porcine meat and porcine meat encoded by the RN gene. Usin...

Questions

Question (1)
Question
Hi,
I am looking for some botanist expert to assist me on identifying these plant's scientific names along with any relevant information in relation to their use as medicinal remedies.
These names are transcriptions from the Maasai language Maa so they may not be exactly correct.
  • Oremit
  • Iloodua
  • Orkonyil
  • Oloirien
  • Orkokol
  • Ortinigoni
I hope anyone can help.
Sincerely,
Isain

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Projects

Projects (2)
Project
This project seeks to advance the field of public health with the use of datasets obtained from public sources. The goal is to combine these resources and to develop narratives with additional context. The analysis of this data is often challenging because of the limitations that unidentified aggregate data may impose; however, these limitations can be overcome through clever use of statistical applications.
Project
Canine behavioral genetics and comparative genomics for drug target discovery