Isabelle Simoes Loureiro

Université de Mons · Department of Cognitive Psychology and Neuropsychology

Prospectively registered systematic reviews in health about the particularity of depressive symptomatology when depression is comorbid with Alzheimer's disease at mild, moderate or severe stages.

Les troubles lexico-sémantiques sont connus pour être l’une des manifestations majeures de l’aphasie, qu’elle soit d’origine vasculaire (comme l’aphasie sémantique -AS-) ou dégénérative (comme l’aphasie sémantique progressive primaire -APPvs- et la maladie d’Alzheimer -MA-). En pratique clinique, ces troubles sont principalement évalués par des tes...

Object The cognitive complaints encountered in late-life depression (LLD) make it difficult to distinguish from amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) based on an analysis of neurocognitive disorders. The hypothesis of the early impairment of semantic memory in AD and aMCI is considered a potential differential cogni...

When the first activation was not effective enough to retrieve task-relevant knowledge, controlled retrieval is as top-down mechanism relying on ventro-lateral prefrontal cortex 9 According to the coherence with the context, only the pertinent elements remains activated and selected by inhibition of the unnecessary elements being activated by the a...

In the framework of the Symposium " Exploring the interrelated aspects of neuropsychological, psychoaffective and medical aspects in the clinical care of older adults: bridging the gap between the clinical and the fundamental research by a multi-determined approach", Chaired by Pr. Isabelle Simoes Loureiro (Department of Cognitive Psychology and Ne...

The multimodal approach where cognition is embodied in language, perceptual, motor, and emotional systems is a widely agreed theoretical framework for conceptual representations. However, the lack of work supporting this view of cognition in healthy and pathological aging stands in stark contrast with the ongoing need to understand the factors that...

raiter l’ambiguïté sémantique implique une sélection (comprenant inhibition et gestion d'interférence) proposée comme altérée lors du vieillissement. Cependant, la littérature n’indique pas s’il y aurait une altération différentielle de l'inhibition et de l'interférence. OBJECTIFS (30 mots - 225 caractères) Via une tâche d’association entre mots, s...

CONTEXT: The cognitive complain encountered in late-life depression (LLD) makes it difficult to distinguish it, at first sight, from Mild Cognitive Impairment (MCI) or Alzheimer’s disease (AD). The early impairment of activation of representation in semantic memory in AD and MCI could provide a clue for the diagnostic. However, even if this specifi...

acoby and Whitehouse (JW) (1989) showed that feeling of oldness for words can be manipulated by presenting a prime[1, 2] (repetition; e.g. cat – CAT, or semantic; e.g. cat - DOG) less than 50 ms before the word to be recognised, eliciting more correct (hits) or incorrect (false alarms) recognitions. These ‘old’ responses can rely on familiarity (se...

The logopenic variant of primary progressive aphasia (lvPPA) shows different features from the non-fluent (nfvPPA) and semantic (svPPA) variants of PPA. Although language impairments remain the core symptoms, studies have highlighted the presence of executive disorders at the onset of the disease. Nevertheless, the results are contradictory, partic...

Brain Computer Interfaces (BCIs) consists of an interaction between humans and computers with a specific mean of communication, such as voice, gestures, or even brain signals that are usually recorded by an Electroencephalogram (EEG). To ensure an optimal interaction, the BCI algorithm typically involves the classification of the input signals into...

Two Selection processes intervein when managing lexico-semantic ambiguity; activation/selection (when dealing with Homonyms and their -Dominant (HD; e.g. right-correct) or -Subordinate (HS; e.g. right-direction) meaning); and selection/interference (if ambiguity comes from interfering foils). Assuming that aging would affect selection/interference...

While previous studies have shown the importance of visuo-spatial working memory in the processing of co-speech iconic gestures, clear evidence for a potential involvement of the verbal working memory (vWM) is currently lacking. To address this issue, participants in the present study were presented with a dual task paradigm. The main outcome varia...

Embodied approach postulates that knowledge and conceptual representations are grounded in action and perception. In order to investigate the involvement of sensorimotor information in conceptual and cognitive processing, researchers have collected various norms in young adults. For instance, the perceptual strength (PS) assesses perceptual experie...

Introduction Pour distinguer l’atteinte cognitive entre dépression (D) et maladie d’Alzheimer (MA), la mémoire sémantique (MS) peur être un marqueur différentiel puisque c’est la sémantique exécutive qui est atteinte par la D et le fonctionnement central de la MS pour la MA. Objectifs Révéler dans la littérature la pertinence des tests neuropsycho...

Numerous studies have explored the benefit of iconic gestures in speech comprehension. However, only few studies have investigated how visual attention was allocated to these gestures in the context of clear versus degraded speech and the way information is extracted for enhancing comprehension. This study aimed to explore the effect of iconic gest...

This narrative review aimed to explore the existing knowledge in order to examine the multiple forms of late-life depression (LLD) within a non-neurodegenerative or a neuro-degenerative context, in particular Alzheimer's disease (AD). This review will first provide information about different pathogenic hypotheses proposed to describe LLD when it i...

Notre étude propose un outil rapide destiné au dépistage des troubles de la dénomination d’images dans la maladie d’Alzheimer (MA), lesquels apparaissent dès le stade débutant de la MA. Le test court de dénomination adapté à la maladie d’Alzheimer (TCD-MA) est composé de 10 images en noir et blanc. La première étude visait à administrer le TCD-MA à...

Notre objectif est de distinguer l’atteinte du stock sémantique central (activation) du processus de traitement sémantique périphérique (inhibition) afin de renforcer le diagnostic différentiel entre la maladie d’Alzheimer (MA) à son stade débutant et la dépression rencontrée dans le vieillissement. Le protocole d’amorçage sémantique avec une condi...

Mots clefs : Maladie d'Alzheimer (MA)-dépression-Mémoire sémantique (MS)-vieillissement-bilan cognitif-mesures sémantiques-diagnostic différentiel Objectifs : Les similitudes cognitives entre les profils pathologiques de la MA (stade débutant) avec symptômes dépressifs et la dépression sans neurodégénérescence dans le vieillissement rendent le diag...

PROSPERO 2021 CRD42021266476 https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=266476 This protocol was fixed in order to perform a systematic review of the literature. Depression over 60 is accompanied by an alteration of cognitive profile, for which the neuropsychological assessment does not always allow the separation of the depres...

Perceptual experience through the five modalities (i.e., vision, hearing, touch, taste, and smell) has demonstrated its key role in semantics. Researchers also highlighted the role of interoceptive information in the grounded representation of concepts. However, to this day, there is no available data across these modalities in the French language....

(GIGA-Cyclotron Research Center -in vivo imaging, University of Liege, Belgium / Cognitive Psychology and Neuropsychology Department, University of Mons, Belgium *The first two authors contributed equally to this presentation) Abstract : Alzheimer's disease patients (AD) show an impairment of recognition memory, mainly characterized by deficient r...

Objective : Late-life depression (LLD), mild cognitive impairment (MCI) and early stage of Alzheimer's disease (AD) can share a similar pattern of cognitive impairment, even if they don’t share the same functional causes. However, this overlap of cognitive profile, which is challenging for differential diagnosis between these pathologies, is not ex...

Iconic gesture-speech integration is a relatively recent field of investigation with numerous researchers studying its various aspects. The results obtained are just as diverse. The definition of iconic gestures is often overlooked in the interpretations of results. Furthermore, while most behavioral studies have demonstrated an advantage of bimoda...

Introduction La perte progressive des connaissances sémantiques caractérise l’aphasie primaire progressive variant sémantique (APPvs) et la maladie d’Alzheimer (MA). Dans la pratique clinique, les connaissances sémantiques sont essentiellement évaluées par des épreuves verbales alors qu’il est admis que le déficit doit être constaté dans plusieurs...

Many studies require standardized and replicable protocols composed of emotional stimuli. To this aim, several databases of emotional pictures are available. However, there are only few images directly depicting interpersonal violence, which is a specific emotion evocative stimulus for research on aggressive behavior or post-traumatic stress disord...

ABSTRACT : Les mots homonymes (e.g. REFLEXION) sont polarisés, c’est-à-dire qu’ils comportent une acception dominante (e.g. PENSEE) et une acception subordonnée (e.g. REFLET). Ils constituent un matériel expérimental utilisé notamment dans des protocoles d’amorçage lors de l’investigation de la mémoire sémantique. Afin d’explorer les processus séma...

Cognitive profiles of early stage of Alzheimer's disease (AD) and Late-Life depression (LLD) show a clinical overlap, including in the memory domain. Nevertheless, the typical and ordered alteration of the semantic memory (SM) content in AD could be a distinctive element compared to in LLD where it would remain intact. A systematic review was condu...

Commented Poster presented at the annual conference of BAPS (Belgian Association of Psychological Sciences) Collaborative research between : - GIGA-Cyclotron Research Center -in vivo imaging, University of Liege, Belgium - Cognitive Psychology and Neuropsychology Department, University of Mons, Belgium The first two authors contributed equally t...

Résumé Cet article constitue une réflexion concernant l’importance de considérer l’évolution neurocognitive dans une perspective vie-entière afin de mieux appréhender le profil neuropsychologique des personnes atteintes de la maladie d’Alzheimer (MA). Pour cela, nous commencerons par présenter la théorie de la rétrogenèse originale telle que dévelo...

L’Échelle de Contrôle attentionnel-ECA, (Derryberry & Reed, 2002) est un autoquestionnaire de 20 items ayant été conçu afin d’évaluer deux processus distincts du contrôle attentionnel (CA) via des mises en situation écologiques. Cependant, malgré l’importance grandissante du CA dans la compréhension des processus exécutifs sous-jacents aux symptôme...

Validation study for iconic gesture videos among French speaking participants

Iconic gestures represent a form of non verbal communication intended to convey meaning during conversation. This meaning is linked to the verbal speech it accompanies suggesting a simultaneuous online processing of the spoken words and gestures. Given the online nature of the processing, it is plausible to expect the involvement of the verbal work...

Objectives: Although the influence of prior knowledge on associative memory in healthy aging has received great attention, it has never been studied in Alzheimer's disease (AD). This study aimed at assessing whether AD patients could benefit from prior knowledge in associative memory and whether such benefit would be related to the integrity of th...

Manipulable man-made objects are characterized by semantic features of different formats. While it is clear that functional declarative knowledge related to objects (i.e. what is an object for) belongs to semantic knowledge stored in memory, the nature of knowledge associated with object gesture of use (i.e. manipulation) remains unclear. We assume...

The breakdown of semantic memory appears early in Alzheimer's disease (AD). Lexico-semantic difficulties (e.g. difficulties in retrieving words and their meaning) are among the first symptoms of the disease. In order to screen this lexico-semantic decline, we propose the mini-SKQ, a semantic knowledge questionnaire. Mini-SKQ explores semantic impai...

Les gestes constituent une part importante de la communication non verbale. Parmi eux, les gestes iconiques véhiculent une information sémantiquement et formellement liée au message verbal émis. La compréhension des processus impliqués dans l'intégration geste/parole est un champ de recherche récent. De part leur lien sémantique avec le message ver...

Verbal and nonverbal communication impairments are often observed in the context of neurodegenerative diseases. Identifying the most appropriate communication strategies for each patient, by a better understanding of his communicational difficulties, would help to maintain his autonomy and to improve his quality of life. Objective: To propose a r...

Nonverbal communication skills have been a growing subject of research. A main component of these skills consists of gesturing. Because they convey semantic information related to the verbal utterance, iconic gestures are particularly interesting to investigate. Studies showed that the iconic gesture/speech integration improved following congruent...

The Attentional Control Scale (ACS, Derryberry & Reed, 2002) is a self-report questionnaire that has been internationally used to assess executive control. However, no French translation of this scale is available. The current study addressed this need and investigated the psychometric properties of a French version of the ACS. Firstly we examined...

L’Échelle de Communication fonctionnelle globale pour patients atteints de Maladie Neurodégénérative (ECMN) a été développée afin de permettre une évaluation des compétences communicationnelles verbales et non-verbales des personnes atteintes de troubles neurodégénératifs à des stades avancés. L’objectif des auteurs est de proposer un outil rapide,...

Impact of iconic gestures on speech comprehension and link to inhibition difficulties in mild and moderate Alzheimer’s patients

Taxonomic and thematic relationships are core elements of lexico-semantic networks. However, the weight of both links differs in semantic memory, with distinct support for natural and manufactured objects: natural objects tend to be more taxonomically identified while manufactured objects benefit more from the underlying thematic relationships. Alz...

Objective: Semantic memory is the result of progressive development during childhood. During the construction of the lexico-semantic network, the features of the objects are progressively stored to build our knowledge. Alzheimer’s disease (AD) disrupts conceptual links that support semantic memory. Individuals suffering from AD lose access to words...

Le développement conceptuel des connaissances sémantiques chez l’enfant reste à ce jour peu documenté. Notre étude vise à proposer un outil de quantification de l’importance des aspects catégoriels, perceptifs et fonctionnels des objets dans le développement des connaissances sémantiques de l’enfant. Ces aspects sont évalués à l’aide d’un test de c...

If the semantic memory organization in adults is today relatively well-documented, the semantic knowledge development in childhood is still a matter of debate. This paper aims to describe the adjustment of the semantic knowledge questionnaire of Laiacona, Barbarotto, Trivelli and Capitani (1993) for adults in a children population. The adjusted ver...

Le développement conceptuel des connaissances sémantiques chez l’enfant reste à ce jour peu documenté. Notre étude vise à proposer un outil de quantification de l’importance des aspects catégoriels, perceptifs et fonctionnels des objets dans le développement des connaissances sémantiques de l’enfant. Ces aspects sont évalués à l’aide d’un test de c...

Lexico-semantic difficulties are common in Alzheimer's disease (AD). The bottom-up process theory is today well accepted: superordinate attributes tend to decline slower than subordinate ones. However, a specific issue in semantic memory investigation in AD is to determine the severity of the semantic impairment. Given that the regularity of the se...

The aim of this study was to generalize the positive impact of auditory-visual bimodality on lexical retrieval in Alzheimer's disease (AD) patients. In practice, the naming skills of healthy elderly persons improve when additional sensory signals are included. The hypothesis of this study was that the same influence would be observable in AD patien...

According to Rubial-Alvarez et al. (2013), the comparison of cognitive functioning between children and patients with an Alzheimer’s disease shows an inverse evolution pattern that supports the hypothesis of retrogenesis. The purpose of our research is to analyze the retrogenesis of the lexico-semantic network in order to better understand the conc...

In this paper, we synthesize results about intellectual, cognitive, social, psychological, developmental and physiological profiles of highly gifted children obtained in previously works. Moreover, socio-economical measures are equally considered. The criterion currently used to determine highly potentialities is the Intelligence Quotient (IQ), de...

Cette étude a pour objectif de mettre en évidence l’expression clinique du trouble de l’attention avec ou sans hyperactivité (TDAH) et du diagnostic de haut potentiel. En effet, la présence du TDAH chez l’enfant à haut potentiel est souvent controversée. Toutefois, des observations cliniques récentes vont à l’encontre de la réfutation du diagnostic...

Résumé Cette étude a pour objectif de mettre en évidence les profils psychologiques et physiologiques des enfants à haut potentiel. En effet, certaines caractéristiques sont plus fréquemment associées aux hautes potentialités (grossesses anormales, naissances prématurées, myopie, allergies, migraines...). Ces caractéristiques nous amènent à formule...

This study had as aim the examination of a possible association between attention deficit with or without hyperactivity disorder (ADHD) and diagnostic of highly gifted. Indeed, the diagnostic of ADHD is often debatable. However, recent clinical observations go against the dispute of the ADHD diagnostic in highly gifted children. We wanted to suppor...