Isabelle Poizot-Martin

Isabelle Poizot-Martin
Aix-Marseille Université | AMU · INSERM SESSTIM U912

MD

About

390
Publications
16,946
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9,226
Citations
Citations since 2017
134 Research Items
2832 Citations
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20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500
Introduction
HIV infection and métabolic comorbidities HIV infection and malignancies Hepatitis C

Publications

Publications (390)
Article
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Background Thanks to direct-acting antivirals, hepatitis C virus (HCV) infection can be cured, with similar rates in HCV-infected and HIV–HCV co-infected patients. HCV cure is likely to foster behavioral changes in psychoactive substance use, which is highly prevalent in people living with HIV (PLWH). Cannabis is one substance that is very commonly...
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Background & Aims A growing literature shows an improvement of chronic hepatitis C virus (HCV)-related depression after successful treatment with direct-acting antivirals. However, depression after HCV cure remains insufficiently documented in people living with HIV (PLWH) and HCV, a population with specific mental health challenges. This study aim...
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Objectives: Our objective was to identify missed opportunities for the use of pre-exposure prophylaxis (PrEP) in people with recently acquired HIV, factors associated with PrEP knowledge, and reasons for not using PrEP. Design: This was a French national cross-sectional multicentre study enrolling people diagnosed with recent HIV (incomplete Wes...
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Heterologous prime-boost strategies are of interest for HIV vaccine development. The order of prime-boost components could be important for the induction of T cell responses. In this phase I/II multi-arm trial, three vaccine candidates were used as prime or boost: modified vaccinia Ankara (MVA) HIV-B (coding for Gag, Pol, Nef); HIV LIPO-5 (five lip...
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Background We aimed to evaluate the incidence rates between 2010 and 2015 for invasive cervical cancer (ICC), breast cancer (BC), and colorectal cancer (CRC) in people living with HIV (PLWH) in France, and to compare them with those in the French general population. These cancers are targeted by the national cancer-screening program. Setting This...
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People living with HIV (PLWH) with advanced immunosuppression who initiate antiretroviral therapy (ART) are susceptible to the occurrence of an immune reconstitution inflammatory syndrome (IRIS). Although ART is responsible for AIDS- associated Kaposi sarcoma (KS) improvement and resolution, new onset (unmasking KS-IRIS) or sudden progression of pr...
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Background: We aimed to describe the prevalence and spectrum of second primary cancer (SPC) in HIV-positive cancer survivors. Methods: A multicenter retrospective study was performed using longitudinal data from the French Dat'AIDS cohort. Subjects who had developed at least two primary cancers were selected. The spectrum of SPCs was stratified...
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Objectives People who survive after primary cancer are at an increased risk for subsequent primary cancers. We aimed to investigate the possible determinants of second primary cancer (SPC) in HIV-positive cancer survivors. Methods This was a multicenter retrospective study using longitudinal data from the French Dat’AIDS cohort. Subjects who devel...
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Since the advent of highly effective combined antiretroviral treatment (cART), and with the implementation of large HIV testing programs and universal access to cART, the burden of AIDS-related comorbidities has dramatically decreased over time. The incidence of Kaposi’s sarcoma (SK), strongly associated with HIV replication and CD4 immunosuppressi...
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Background Maintenance ART with dolutegravir-based dual regimens have proved their efficacy among HIV-1-infected subjects in randomized trials. However, real-life data are scarce, with limited populations and follow-up. Objectives We assessed virological failure (VF) and resistance-associated mutations (RAMs) on dolutegravir maintenance regimens i...
Article
Objectives: Our aim was to assess if switching from a protease inhibitors (PI)-based regimen to a PI-free one is associated with an increased risk of Kaposi Sarcoma (KS) relapse among patients living with HIV (PLHIV) with history of KS and controlled HIV replication. Methods: In a retrospective analysis of the prospectively collected Dat'AIDS da...
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Objectives HIV-coinfected patients experience higher incidences of non-liver-related cancers than HCV-monoinfected patients. Chronic inflammation, immunosuppression, but also higher tobacco or alcohol consumption and metabolic dysregulation could explain this higher risk. We aimed to estimate the direct, indirect and total effects of HIV coinfectio...
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Introduction La prophylaxie pré exposition (PrEP) est un outil de prévention qui cible les personnes à risque de contamination par le VIH. À ce jour, aucune information n’est disponible concernant la proportion de personnes qui auraient pu bénéficier de la PrEP en France parmi les personnes nouvellement infectées. Matériels et méthodes Enquête nat...
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Introduction L’épidémie du VIH reste active en France malgré les différentes actions mises en place parmi lesquelles l’implémentation de la PrEP en 2016 ; mais au sein de l’objectif 90/90/90 fixé par l’OMS, le dépistage en France reste insuffisant. Matériels et méthodes Analyse des données de l’enquête nationale sur les opportunités manquées de Pr...
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Introduction People living with HIV (PLWHIV) are at a higher risk of cancer compared to the general population. With improved cancer treatments and the increased life expectancy of PLWHIV, the incidence of second cancers is also expected to increase. Methods We reviewed the cases of PLWHIV with cancer that have been presented to the CANCERVIH nati...
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BACKGROUND: A persistently low CD4/CD8 ratio has been reported to inversely correlate with the risk of non-AIDS defining cancer in people living with human immunodeficiency virus (HIV; PLWH) efficiently treated by combination antiretroviral therapy (cART). We evaluated the impact of the CD4/CD8 ratio on the risk of Kaposi sarcoma (KS) or non-Hodgki...
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Résumé Le dépistage de l’infection par le VIH est recommandé lors du bilan initial de tout cancer, celui de l’hépatite B et C en raison d’un risque de réactivation avec certains anticancéreux. Il s’agit d’une étude prospective transversale. Les objectifs étaient d’évaluer les pratiques de dépistage chez des patients atteints de cancer et la satisfa...
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Background: Cannabis use and elevated fatty liver index (FLI≥ 60) (a biomarker of hepatic steatosis in the general population) have been identified as predictors of HCV-related and overall mortality, respectively, in HIV-HCV co-infected patients. However, the relationship between cannabis use and the risk of elevated FLI has never been explored. Me...
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Background The arrival of highly effective, well tolerated direct-acting antiviral agents (DAA) led to a dramatic decrease in HCV prevalence. HIV-HCV coinfected patients are deemed a priority population for HCV elimination, while a rise of recently acquired HCV infections in MSM has been described. We describe the variations in HIV-HCV epidemiology...
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Background: Cancer risk is higher in people living with HIV (PLWH) compared with the general population and cancers related to age are expected being most prevalent. Methods: We determined the spectrum and incidence rates of AIDS-defining cancers (ADCs), non-AIDS-defining cancers (NADCs) and of lung, Hodgkin lymphoma (HL), head and neck (HNC), c...
Article
Introduction Depuis 2004, les recommandations françaises préconisent une prophylaxie systématique de la pneumocystose et de la toxoplasmose chez les personnes vivant avec le VIH (PVVIH) traitées pour un cancer solide. Son application est toutefois inconnue. L’objectif principal était d’évaluer la survenue de pneumocystose ou de toxoplasmose chez de...
Article
Introduction En France, l’enquête nationale OBEPI 2012 a rapporté une prévalence de surpoids et d’obésité respectivement de 32 % et 15 %, avec un gradient décroissant Nord/Sud. L’objectif de l’étude est de comparer la prévalence du surpoids et de l’obésité au sein de la cohorte Dat’AIDS par rapport à la population générale, de façon globale, selon...
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There remains a substantial gap in our understandings of the life experiences of patients following HCV cure among HIV‐HCV co‐infected people who inject drugs (PWID) and men who have sex with men (MSM), two key populations targeted for HCV elimination. We described the experiences and perspectives of HIV‐positive PWID and MSM, HCV‐cured following t...
Article
Background: An increased risk of cardiovascular disease (CVD) was reported in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV), without identifying factors associated with atherosclerotic CVD (ASCVD) events. Methods: HIV-HCV coinfected patients were enrolled in the ANRS CO13 HEPAVIH nationwide cohort. Prima...
Article
Background: The screening strategy for HIV-Associated Neurocognitive Disorders (HAND) is challenging. The French Expert Report recommend the use of the Cognitive Complaints Questionnaire (QPC) and the Montreal Cognitive assessment. However, the QPC has never been studied in People Living with HIV (PLWH). This study aims to determine the degree of...
Article
The HIV infection remains a serious public health concern in France and around the World. Cancers are frequent among people living with HIV (PLWH) and have become the leading cause of mortality among this population in France. Certain non-AIDS-defining cancers are much more common among PLWH, such as anal carcinoma, Hodgkin lymphoma, hepatocellular...
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Background: Although antiretroviral therapy (ART) has reduced the risk of Kaposi sarcoma (KS), KS cases still occur in HIV-infected people. Objective: To describe all KS cases observed between 2010 and 2015 in a country with high ART coverage. Methods: Retrospective study using longitudinal data from 44 642 patients in the French Dat'AIDS mult...
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Objective: Treatment recommendations for hepatitis C now make no distinction between HIV/HCV-coinfected and HCV-monoinfected patients. The largest challenge remained lack of effective models to eliminate HCV in people living with HIV. We report the results of a microelimination program evaluating the possibility of eradicating HCV in an HIV-outpat...
Article
Background Prospective data on the natural history of anal human papillomavirus (HPV) infection are scarce in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). Methods We analyzed incidence and clearance of HPV-16 and HPV-18 in a French cohort of HIV-infected MSM, aged ≥35 years, followed-up annually (n = 438, 2014–2018)...
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Design: Current international guidelines recommend either boosted protease inhibitor (PI/r)-based or integrase inhibitors (INSTI)-based regimens during primary HIV infection (PHI), even though the latter have only demonstrated their superiority at the chronic stage. We compared the effectiveness of INSTI- versus PI/r-based combined antiretroviral...
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Objective: Kaposi sarcoma (KS) is still observed among people living with HIV (PLHIV) including those on ART with undetectable HIV viral load (HIV-VL). We aimed to assess KS incidence and trends between 2010 and 2015 in France and to highlight associated factors. Design: Retrospective study using longitudinal data from the Dat'AIDS cohort includ...
Article
Background Cancer incidence is increasing but cancer survival is improving. The life expectancy of PLWHIV also increases with improved HAART, so it is to be expected that PLWHIV are likely to develop a second primitive cancer. It is known that the risk of second cancer is slightly higher after a first cancer and depends on several parameters: the l...
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Background HIV screening is recommended at time of cancer diagnosis. Moreover, HBV screening, is recommended during immunotherapy due to its risk of reactivation. Furthermore, HCV screening, before using immunotherapy is justified by the prevalence of dysimmune disorders during HCV infection. The main objective of this survey was to evaluate screen...
Article
Background: HIV-HCV co-infected patients are at high risk of metabolic complications and liver-related events, which are both associated with hepatic steatosis and its progressive form, non-alcoholic steatohepatitis (NASH), a known risk factor for mortality. The fatty liver index (FLI), a non-invasive steatosis biomarker, has recently drawn attent...
Article
In 21 cutaneous and/or visceral Kaposi's sarcoma cases, occurring in patients living with human immunodeficiency virus (HIV) who were on antiretroviral therapy with suppressed HIV viremia and high CD4 T cell counts, the efficacy of conventional chemotherapies was limited due to cumulative toxicities, comedications, and a lack of immune improvement.
Article
Background: In late 2013, France was one of the first countries to recommend initiation of combination antiretroviral therapy (cART) irrespective of CD4 cell count. Methods: To assess the impact of achieving the second and third Joint United Nations Programme on HIV/AIDS 90-90-90 targets (ie, 90% of diagnosed people on sustained cART, and, of thos...
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Human immunodeficiency virus type 1 (HIV-1) infection promotes a generalized activation of host responses that involves not only CD4 T cells, but also cells of the microenvironment, which are not directly infected, such as endothelial cells. The mechanisms triggering HIV-1-associated vascular alterations remain poorly understood. Extracellular vesi...
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Darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg was investigated through 96 weeks in EMERALD (NCT02269917). Virologically-suppressed, HIV-1-positive treatment-experienced adults (previous non-darunavir virologic failure [VF] allowed) were randomized (2:1) to D/C/F/TAF or boosted protease inhibitor (PI) plus em...
Article
Background: The ANRS COV1-COHVAC cohort was a long-term safety cohort of healthy volunteers who received preventive HIV-vaccine candidates in 17 phase I/II clinical trials. Methods: Data collected from the first vaccine candidate administration and annually after inclusion in the cohort included grade 3/4 adverse events and all grade adverse eve...
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Introduction Compte tenu de la forte prévalence des infections sexuellement transmissibles (IST) en France, un dépistage annuel est recommandé selon les situations à risque chez les personnes vivant avec le VIH (PVVIH) ainsi que dans le cadre d’un traitement préexposition (PrEP) en prévention d’une infection par le VIH. L’objectif de cette étude es...
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Introduction Le risque de carcinome épidermoïde du canal anal est multiplié par 100 dans la population homosexuelle masculine (HSH) vivant avec le VIH, par rapport à la population générale justifiant d’un dépistage dont les modalités ne font pas l’objet d’un consensus international. En France, celui-ci repose actuellement sur un examen proctologiqu...
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Introduction Les comorbidités telles que le diabète, l’insulinorésistance ou le surpoids sont fréquentes chez les patients vivants avec le VIH (PVVIH), qui sont donc à haut risque de développer une stéatose hépatique, et ce même en dehors de toute co-infection VHB/VHC. La recherche d’une stéatose hépatique chez les PVVIH présentant des troubles mét...
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Introduction Le dépistage du VIH est recommandé lors du bilan initial de tout cancers, celui du VHB lors du recours à certaines immunothérapies en raison du risque de réactivation. La prévalence de troubles dysimmunitaires justifie le dépistage du VHC avant le recours à une immunothérapie. Cette enquête a pour objectif d’évaluer les pratiques de dé...
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Objective: To report efficacy and tolerance of nivolumab or pembrolizumab, PD-1 inhibitors, in people living with HIV (PLWHIV) and cancer. Design: Series of PLWHIV cancer patients treated with anti-PD1 agents in real life clinical practice. Methods: From May 2014 to January 2019, 575 HIV infected patients have been discussed in the French CANC...
Article
Pre-exposure prophylaxis (PrEP) for the prevention of HIV infection with 300 mg daily tenofovir co-formulated with 200 mg emtricitabine is recommended as one prevention option for people who are at substantial risk of acquiring an HIV infection. We report the case of a 28-year-old man who has sex with men and who was referred to our unit for a prim...
Article
Objectives: HIV/hepatitis C virus (HCV) co-infection leads to major complications, and noninvasive markers developed to stage liver fibrosis could be used as prognostic markers. We aimed to compare the performances of liver stiffness (LS), fibrosis-4 (FIB-4), and aspartate aminotransferase to platelet ratio index (APRI) to predict liver-related ev...
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Background HIV pre-exposure prophylaxis (PrEP) was implemented in France in November 2015 based on individual-level risk factors for HIV infection. We evaluated the proportion of missed opportunities for PrEP among newly HIV-diagnosed people entering the Dat’AIDS cohort in 2016. Methods Multicenter retrospective analysis in 15 French HIV clinical...
Article
Objectives We examined trends in the incidence rates of invasive cervical cancer (ICC) and in the rate of survival after ICC among women living with HIV (WLHIV) in France and compared them to those of the general population. Methods Histologically validated incident cases of ICC in the period 1992–2009 from the French Hospital Database on HIV (FHD...
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Background: The association between liver stiffness measurements (LSM) and mortality has not been fully described. In particular the effect of LSM on all-cause mortality taking sustained virological response (SVR) into account needs further study. Methods: HIV/HCV participants in the French nation-wide, prospective, multicenter ANRS CO13 HEPAVIH...
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Compared to the general population, HIV-infected patients are at higher risk of developing non-AIDS-defining cancers. Chronic HCV infection has also been associated with a higher risk than that of the general population of developing cancers other than hepatocarcinoma. Evaluation of the impact of HCV-related factors on non-AIDS-defining and non HCV...
Article
Background: Hepatitis C virus (HCV) and HIV infections are associated with higher risk of autoimmune diseases and T-cell dysfunction. Setting: We evaluate prevalence and factors associated with the presence of autoimmune antinuclear (ANA), anti-smooth muscle actin (aSMA), and anti-liver kidney microsome (aLKM1) antibodies (Ab) in HCV/HIV-coinfec...
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Aim: To describe factors associated with treatment failure and frequency of resistance-associated substitutions (RAS). Methods: Human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients starting a first direct-acting antiviral (DAA) regimen before February 2016 and included in the French ANRS CO13 HEPAVIH cohort were eligibl...
Article
Objective: To describe the changes in first-line antiretroviral (ART) regimens in France between 2005 and 2015 and patients' characteristics related to the use of protease inhibitors in 2015. Methods: We extracted all patients starting ART between 2005 and 2015 from a large prospective cohort. Regimens were classified as three nucleoside reverse...
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As HIV-infected adults on successful antiretroviral therapy (ART) are expected to have close to normal lifespans, they will increasingly develop age-related comorbidities. The objective of this cross-sectional study was to compare in the French Dat’AIDS cohort, the HIV geriatric population, aged 75 years and over, to the elderly one, aged from 50 t...
Data
Anonymous dataset of the study. (XLS)
Article
Objectives: To quantify within a cohort of HIV-infected individuals the number of medical visits and procedures to be carried out according to comorbidities and risk factors to implement a personalized care pathway. Patients and methods: Retrospective study of 915 patients consulting from January 1 to December 31, 2016 at an outpatient unit of m...
Article
Objective: To assess determinants for histologically proven high-grade anal intraepithelial lesions (hHSIL) in HIV-positive MSM, a population at high-risk of HPV-related anal cancer. Design: APACHES is a prospective study of anal HPV and related-lesions in 513 HIV-positive MSM aged ≥35 in six centres across France. Methods: At baseline, partic...
Article
Objectives People living with HIV (PLWH) are particularly affected in their sexual life. Medical support of PLWH's sexuality is increasingly proposed however no data are available. We assessed the interest of PLWH for sexual and emotional health support within a French HIV outpatient care facility. Population and methods Anonymous questionnaire pr...
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Introduction L’infection par le VIH et l’infection par le VHC ont toutes deux étaient associées à une augmentation du risque de diabète mais les résultats sont contradictoires. L’objectif de cette étude était de déterminer s’il existe une association entre l’infection chronique par le VHC et l’incidence du diabète et d’évaluer le rôle des facteurs...
Article
Objectives People living with HIV (PLHIV) are at a higher risk of dying by suicide than the general population. Epidemiological data regarding determinants of suicide in PLHIV are scarce. The aim of this study was thus to study demographic, socio‐economic, psychiatric history and immunovirological characteristics associated with death from suicide...
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Identifying risk factors associated with overweight and obesity in HIV-infected patients. A cross-sectional study analyzing data from patients attending an HIV outpatient unit. Overweight was defined as body mass index (BMI) ≥25 kg/m²; <30 kg/m², obesity was ≥30 kg/m². Patients’ characteristics contemporary to BMI assessment were collected. Multiva...
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Background Both human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections have been reportedly associated with a higher risk of diabetes mellitus (DM) but results are conflicting. Aims To determine whether there is an association between chronic HCV and the incidence of DM, and to study the role of factors such as cirrhosis, IFN‐ba...
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Background Identifying determinants for histologically proven high-grade anal intraepithelial lesions (hHSIL) in HIV-positive MSM would allow better targeted screening. Methods APACHES is a prospective study of anal HPV and related-lesions in 513 HIV-positive MSM aged ≥35 in six clinics across France. At baseline, participants underwent high resol...
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Primary HIV‐1 infections (PHI) with non‐B subtypes are increasing in developed countries while transmission of HIV‐1 harboring antiretroviral resistance‐associated mutations (RAMs) remains a concern. This study assessed non‐B HIV‐1 subtypes and RAMs prevalence among patients with PHI in university hospitals of Marseille, Southeastern France, in 200...