Isabelle Arnulf

Isabelle Arnulf
Hôpital La Pitié Salpêtrière (Groupe Hospitalier "La Pitié Salpêtrière - Charles Foix") · Service des Explorations des Pathologies du Sommeil

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628
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21,563
Citations
Citations since 2016
262 Research Items
10983 Citations
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201620172018201920202021202205001,0001,500
201620172018201920202021202205001,0001,500
201620172018201920202021202205001,0001,500

Publications

Publications (628)
Article
Study Objectives Kleine-Levin Syndrome (KLS) is characterized by relapsing-remitting episodes of hypersomnia, cognitive impairment, and behavioral disturbances. We quantified cerebrospinal fluid (CSF) and serum proteins in KLS cases and controls. Methods SomaScan was used to profile 1133 CSF proteins in 30 KLS cases and 134 controls, while 1109 se...
Article
Isolated REM sleep behaviour disorder (iRBD) is a synucleinopathy characterized by abnormal behaviours and vocalizations during REM sleep. Most iRBD patients develop dementia with Lewy bodies, Parkinson’s disease, or multiple system atrophy over time. Patients with iRBD exhibit brain atrophy patterns that are reminiscent of those observed in overt...
Preprint
Full-text available
Sleep has long been considered as a state of disconnection from the environment, with absent reactivity to external stimuli. Here, we questioned this sleep disconnection dogma by directly investigating behavioral responsiveness in 49 napping subjects (27 with narcolepsy and 22 healthy volunteers) engaged in a lexical decision task. Participants wer...
Article
Background Insomnia is a frequent complaint of patients with Parkinson's disease, and it negatively affects quality of life. Drugs that improve both sleep and parkinsonism would be of major benefit to patients with Parkinson's disease-related insomnia. We aimed to test the safety and efficacy of subcutaneous night-time only apomorphine infusion in...
Preprint
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Every night, we pass through a transitory zone at the borderland between wakefulness and sleep, named the first stage of non-rapid eye movement sleep (N1). N1 sleep is associated with an increased hippocampal activity and dreamlike experiences that incorporate recent wake materials, suggesting that it may be associated with memory processing. Here,...
Article
Disorders of arousal (DOA) is an umbrella term initially covering classical sleepwalking, sleep terrors, and confusional arousals, and now including a wider spectrum of specialised forms of non rapid eye movement (non REM) parasomnias such as sexsomnia, sleep‐related eating disorder, and sleep‐related choking syndrome. Growing evidence has shown th...
Article
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Prader–Willi syndrome (PWS) is a rare, genetic, multisymptomatic, neurodevelopmental disease commonly associated with sleep alterations, including sleep-disordered breathing and central disorders of hypersomnolence. Excessive daytime sleepiness represents the main manifestation that should be addressed by eliciting the detrimental effects on qualit...
Article
La somnolence (distincte de l’apathie et de la fatigue) est souvent secondaire aux troubles de l’humeur, aux sédatifs, au manque de sommeil ou à un sommeil fragmenté. Les hypersomnies neurologiques rares du sujet jeune sont des modèles d’atteinte des systèmes d’éveil : la narcolepsie (déficit en hypocrétine) cause des endormissements irrésistibles,...
Article
Introduction Les TNF sont fréquents et difficiles à traiter. Nous avons proposé une vidéo-polysomnographie à une patiente suspectée d’avoir une paraplégie fonctionnelle à but diagnostique et thérapeutique. Observation Une femme de 31 ans développa une paraplégie spastique à distance d’une myéloradiculite herpétique (syndrome d’Elsberg) bien traité...
Article
Full-text available
This manuscript presents an overview of REM sleep behaviour disorder (RBD) with a special focus on European contributions. After an introduction examining the history of the disorder, we address the pathophysiological and clinical aspects, as well as the diagnostic issues. Further, implications of RBD diagnosis and biomarkers are discussed. Contrib...
Article
Objectif Les émotions des rêves pourraient avoir un rôle majeur dans la régulation émotionnelle des individus. Leur étude est cependant limitée au récit de rêve, sujet à des biais de mémorisation et de reconstruction. Notre objectif est d’accéder pour la première fois au contenu émotionnel subjectif des rêves, directement depuis le sommeil paradoxa...
Conference Paper
Objectif Évaluer la fréquence, les déterminants et l’impact clinique des parasomnies cliniques NREM et REM chez les patients adultes atteints de narcolepsie de type 1 (NT1), de narcolepsie de type 2 (NT2) et d’hypersomnie idiopathique (HI) par rapport à des témoins sains. Méthodes Les parasomnies familiales et personnelles ont été évaluées par que...
Article
Objectif L’évolution naturelle de l’hypersomnie idiopathique (HI) est mal connue. Notre objectif est d’évaluer 10 ans après le diagnostic les mesures cliniques et polysomnographiques (PSG) d’une cohorte de patients avec HI. Méthodes La plainte de somnolence et les données PSG (bilan de 48 heures) de patients avec une HI ont été comparées au diagno...
Article
Objectif L’encéphalite auto-immune anti-Ma2 a déjà été associée à de rares cas de narcolepsies secondaires de type 1. Nous rapportons deux nouveaux cas avec narcolepsie. Méthodes Les patients ont bénéficié de recherche d’autoanticorps neuronaux dans le sérum et le LCR (et des taux d’hypocrétine), de deux vidéo-polysomnographies suivies de tests it...
Article
Objectif Les troubles neurologiques fonctionnels (TNF, ex : paraplégie fonctionnelle) représentent jusqu’à 20 % des troubles neurologiques et sont difficiles à diagnostiquer et à traiter. Certains filment les mouvements réalisés sous Propofol puis les montrent aux patients. Si une personne paralysée le jour bouge quand même la nuit lors des microév...
Article
Objectif La baisse de l’odorat et le trouble comportemental en sommeil paradoxal isolé (TCSPi) peuvent précéder la maladie de Parkinson. Nous avons évalué si la diminution du goût (rapportée dans la maladie de Parkinson et suggérant une implication du tronc cérébral) est déjà présente au stade du TCSPi. Méthodes Nous avons mesuré les performances...
Article
Objectif Le sommeil paradoxal (SP) joue un rôle majeur dans la régulation émotionnelle. Ce rôle pourrait être médié par les émotions survenant au cours des rêves. L’étude de la dynamique émotionnelle (comment les émotions fluctuent dans le temps) pendant le SP est à ce jour limitée au rapport de rêve, qui présente des biais d’oublis de reconstructi...
Article
Objectif Nous avons récemment montré que les rêveurs lucides pouvaient répondre à des stimuli durant le sommeil paradoxal via des codes musculaires. Cette capacité de communication avec l’extérieur s’étend-elle aux somnambules, qui exhibent des comportements complexes en sommeil lent profond ? Méthodes Nous avons interrogé 41 somnambules sur le li...
Article
Objectif L’hypersomnie est une plainte fréquente chez les patients atteints de troubles de l’humeur. Il n’existe cependant à ce jour que très peu d’études avec enregistrements polysomnographiques (PSG) de cette problématique. Notre objectif était de décrire les enregistrements PSG de patients avec trouble de l’humeur et plainte de somnolence et/ou...
Article
Objectif Le somnambulisme a longtemps été considéré comme un phénomène mystérieux, source d’inspiration pour les artistes. On retrouve notamment des somnambules au cinéma dès son début, ce qui a pu jouer un rôle dans la représentation collective de la pathologie. Nous avons étudié la représentation des somnambules au cinéma, de 1903 à 2019. Méthod...
Article
Objectif L’appareillage respiratoire des patients atteints de dystrophie myotonique de type 1 (DM1) est difficile. Notre objectif était d’identifier des facteurs prédictifs d’une mauvaise observance (utilisation < 4 h/nuit). Méthodes Étude monocentrique, rétrospective, incluant les patients atteints de DM1 adressé au CHU de Limoges pour une assist...
Article
Objectif Évaluer l’impact des restrictions liées au COVID-19 sur la narcolepsie de type 1 (NT1), la narcolepsie de type 2 (NT2) et l’hypersomnie idiopathique (HI). Méthodes Enquête en ligne évaluant les caractéristiques clinico-démographiques et professionnelles pendant le premier confinement a été proposée aux patients ayant une NT1, NT2 et HI, s...
Article
Objectif Déterminer, chez les conducteurs narcoleptiques et hypersomniaques (experts en gestion de la somnolence), quels symptômes et contre-stratégies sont utilisés pour détecter et contrer la somnolence au volant. Méthodes Recueil par entretien des symptômes « sentinelles » de somnolence perçus en situation active, et des contre-stratégies adopt...
Article
Objectif Le syndrome de Kleine-Levin (SKL) est caractérisé par des épisodes récurrents d’hypersomnie, de troubles cognitifs, d’apathie, de déréalisation et de troubles du comportement. Entre les épisodes, la plupart des patients ont un sommeil et des comportements normaux, mais peuvent présenter des anomalies résiduelles au niveau de la tomographie...
Article
Full-text available
Growing evidence suggests that sleep plays a key role in regulating emotions. Rapid eye movements (REMs) in REM sleep could be associated with dreams emotions, but supporting evidence is indirect. To highlight this association, we studied the REM sleep during video-polysomnography of 20 subjects with REM sleep behaviour disorder (RBD), a model of e...
Article
Full-text available
Background: Isolated REM sleep behavior disorder (iRBD) is considered a prodromal stage of parkinsonism. Neurodegenerative changes in the substantia nigra pars compacta (SNc) in parkinsonism can be detected using neuromelanin-sensitive MRI. Objective: To investigate SNc neuromelanin changes in iRBD patients using fully automatic segmentation. M...
Article
Full-text available
Background Speech disorders are amongst the first symptoms to appear in Parkinson's disease (PD). Objectives We aimed to characterize PD voice signature from the prodromal stage (isolated rapid eye movement sleep behavior disorder, iRBD) to early PD using an automated acoustic analysis and compare male and female patients. We carried out supervise...
Article
Study objectives: To assess the frequency, determinants and clinical impact of clinical NREM and REM parasomnias in adult patients with narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH) compared to healthy controls. Methods: Familial and past and current personal parasomnias were assessed by questionnaire and medica...
Article
Objectives To follow up predictive factors for α-synuclein-related neurodegenerative diseases in a multicenter cohort of idiopathic/isolated REM sleep behavior disorder (iRBD). Methods Patients with iRBD from 12 centers underwent a detailed assessment for potential environmental and lifestyle risk factors via a standardized questionnaire at baseli...
Article
Background Idiopathic hypersomnia is a central hypersomnolence disorder mainly characterised by excessive daytime sleepiness, with prolonged night-time sleep and pronounced sleep inertia. Until August, 2021, no medication had regulatory approval for the treatment of idiopathic hypersomnia. This study aimed to evaluate the safety and efficacy of low...
Preprint
Full-text available
Isolated REM sleep behaviour disorder (iRBD) is a synucleinopathy characterized by abnormal behaviours and vocalizations during REM sleep. Most iRBD patients develop dementia with Lewy bodies, Parkinson's disease, or multiple system atrophy over time. Patients with iRBD exhibit brain atrophy patterns that are reminiscent of those observed in overt...
Article
Full-text available
(1) Background: osteopathic manipulation of the sphenopalatine ganglia (SPG) blocks the action of postganglionic sensory fibres. This neuromodulation can reduce nasal obstruction and enhance upper airway stability. We investigated the manipulation of the SPG in 31 patients with obstructive sleep apnoea syndrome (OSAS); (2) Methods: Randomised, cont...
Article
Full-text available
Background: Even though Parkinson's disease (PD) is typically viewed as largely affecting gray matter, there is growing evidence that there are also structural changes in the white matter. Traditional connectomics methods that study PD may not be specific to underlying microstructural changes, such as myelin loss. Objective: The primary objectiv...
Article
Study objectives: We created a Dutch version of the Paris Arousal Disorders Severity Scale, which assesses non-rapid eye movement (NREM) parasomnia symptoms over the past year (PADSS-year). This questionnaire was previously validated in patients with sleep walking and/or sleep terrors ('SW/ST'). We validated the questionnaire in SW/ST patients, an...
Article
The ability to think creatively is paramount to facing new challenges, but how creativity arises remains mysterious. Here, we show that the brain activity common to the twilight zone between sleep and wakefulness (nonrapid eye movement sleep stage 1 or N1) ignites creative sparks. Participants (N = 103) were exposed to mathematical problems without...
Article
Background Arousals are common, sudden and transient elevations of the vigilance level during normal sleep, but arousal-associated behaviors have not yet been studied. Objective We aimed to describe the duration as well as motor and autonomic patterns associated with arousals across sleep stages in normal subjects. Methods The spontaneous arousal...
Preprint
Extended sleep time, circadian delay (in IH patients) and teleworking resulted in decreased symptoms of central hypersomnias. These findings suggest that people with IH, NT1 and NT2 may benefit from a decrease in social and professional constraints on sleep-wake habits, and support advocacy efforts aimed at facilitating workplace and schedule accom...
Article
Background: PSAP encodes saposin C, the co-activator of glucocerebrosidase, encoded by GBA. GBA mutations are associated with idiopathic/isolated REM sleep behavior disorder (iRBD), a prodromal stage of synucleinopathy. Objective: To examine the role of PSAP mutations in iRBD. Methods: We fully sequenced PSAP and performed Optimized Sequence K...
Preprint
Full-text available
REM sleep behavior disorder (RBD) represents both an early marker and key symptom of synucleinopathies, mainly Parkinson disease (PD) and Lewy body dementia (LBD), and a strong opportunity for early clinical intervention for these conditions. Yet, the genetics of RBD are currently not well characterized. In this study, we perform the first genome-w...
Article
Background Long before being described as a disorder, sleepwalking was considered as a mysterious phenomenon inspiring artwork. From the early beginning of cinema, sleepwalkers were shown to populations, playing a crucial role in storytelling and collective knowledge. Objective We characterized how sleepwalking has been portrayed in a large number...
Article
Résumé L’hypersomnie idiopathique (HI) est une maladie neurologique rare du sujet jeune, caractérisée par une somnolence diurne excessive malgré un sommeil de nuit de qualité normale, et de durée normale ou prolongée. Elle se distingue de la narcolepsie par sa prédominance féminine, des difficultés à se réveiller le matin (ivresse de sommeil), une...
Article
Full-text available
Study objectives: To assess the impact of COVID-19 related restrictions on narcolepsy type 1 (NT2), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH). Methods: Participants with NT1, NT2 and IH followed in a university hospital completed an online 78-question survey assessing demographic, clinical and occupational features of the populati...
Preprint
Full-text available
PSAP encodes saposin C, the co-activator of glucocerebrosidase, encoded by GBA. Since GBA mutations are associated with idiopathic/isolated REM sleep behavior disorder (iRBD), a prodromal stage of synucleinopathy, we examined the role of PSAP mutations in iRBD. We fully sequenced PSAP and performed Optimized Sequence Kernel Association Test in 1,11...
Article
Full-text available
Kleine-Levin syndrome is a rare disorder characterized by relapsing-remitting episodes of severe hypersomnia, cognitive impairment, apathy, derealization and behavioural disturbances. Between episodes, most patients experience normal sleep, mood and behaviour, but they may have some residual abnormalities in brain functional imaging; however, the f...
Article
Full-text available
A variety of neuropsychiatric complications has been described in association with Covid-19 infection. Large scale studies presenting a wider picture of these complications and their relative frequency are lacking. The objective of our study was to describe the spectrum of neurological and psychiatric complications in patients with Covid-19 seen in...
Article
Background: Hyposmia and isolated REM sleep behavior disorder are well-established features of prodromal Parkinson's disease (PD). Objectives: The objective of the present study was to evaluate whether taste loss (reported in PD and possibly suggesting brain stem involvement) is present at the isolated REM sleep behavior disorder stage. Methods...
Article
Introduction Le syndrome d’apnées obstructives du sommeil (SAOS) est considéré un facteur de risque cardiovasculaire. La fermeture répétée des voies aériennes supérieures pendant le sommeil déclenche des phénomènes physiopathologiques responsables d’un déséquilibre sympathovagal, médiateur central des conséquences cardiovasculaires. Par contre l’ef...
Conference Paper
Full-text available
Driven by life and various motivations, human beings are used to restricting their own sleep, considered as time wasted, and staying awake late at night. Thus, every civilization has its own culture to enhance wake, e.g. by consuming tea and coffee. Psychostimulants like caffeine and amphetamine constitute the first generation of wake-promoting com...
Article
Full-text available
In Parkinson’s disease, there is a progressive reduction in striatal dopaminergic function, and loss of neuromelanin-containing dopaminergic neurons and increased iron deposition in the substantia nigra. We tested the hypothesis of a relationship between impairment of the dopaminergic system and changes in the iron metabolism. Based on imaging data...
Article
Introduction Idiopathic hypersomnia (IH) is a rare central hypersomnolence disorder characterized by excessive daytime sleepiness. A common feature is sleep inertia, which is prolonged difficulty waking up accompanied by confusion, disorientation, poor motor coordination, and repeated returns to sleep. Sleep inertia is burdensome to patients, resul...
Article
Introduction Idiopathic hypersomnia (IH) is a rare central hypersomnolence disorder characterized by excessive daytime sleepiness, prolonged nighttime sleep, and sleep inertia. No US/EU medication is approved for treatment of IH. Lower-sodium oxybate (LXB; Xywav™; previously designated JZP-258) is a novel oxybate treatment with 92% less sodium than...
Article
Introduction Idiopathic hypersomnia (IH) is a rare central hypersomnolence disorder. In a randomized, controlled study of lower-sodium oxybate (LXB; Xywav™) in adults with IH (NCT03533114), significant differences for LXB compared with placebo were observed in Epworth Sleepiness Scale (ESS; primary efficacy endpoint), self-reported Patient Global I...
Article
Introduction The Idiopathic Hypersomnia Severity Scale (IHSS) is a 14-item, self-reported questionnaire that assesses core Idiopathic Hypersomnia (IH) symptom severity. The relationship between IHSS scores and other IH symptom measures, such as the Epworth Sleepiness Scale (ESS; measures daytime sleepiness), sleep inertia visual analog scale (VAS-S...
Article
Introduction Idiopathic hypersomnia (IH) is a rare central hypersomnolence disorder with no approved treatment, characterized by excessive daytime sleepiness, prolonged sleep time, and sleep inertia. The Idiopathic Hypersomnia Severity Scale (IHSS) is a 14-item, self-reported questionnaire that assesses severity of IH symptoms, including symptoms r...
Article
Full-text available
Objective: To evaluate sleepiness and central hypersomnia in multiple sclerosis (MS) associated fatigue, we performed long term polysomnography in MS patients and healthy controls. Methods: Patients with MS and healthy controls completed questionnaires on sleep, fatigue, sleepiness, and depression. They underwent nocturnal polysomnography, multi...
Article
Full-text available
La consommation de tabac, de caféine, mais aussi le sevrage tabagique et les traitements validés du sevrage tabagique (traitements de substitution nicotinique, varénicline, bupropion) peuvent entraîner des troubles du sommeil et de l’éveil : insomnie, rêves anormaux, fatigue en journée. Les conséquences de ces troubles du sommeil se voient au nivea...
Article
Negative facial expressions and frowns have been studied (albeit more rarely than smiles) in fetus’ and neonate’ sleep, but they have not been investigated during adult sleep. Video polysomnography (including corrugator muscle electromyography and face‐focussed video) was used to study negative facial expressions in sleeping adults, including healt...
Article
Full-text available
Significance Genetic markers in TRANK1 gene and its vicinity have been weakly associated with bipolar disorder and schizophrenia (10% increased risk). We found that the same polymorphisms are associated with Kleine-Levin syndrome (50% increased risk), a rare sleep disorder characterized by recurrent episodes of severe hypersomnia and cognitive abno...
Article
Full-text available
Objectif Comparer les symptômes et les caractéristiques du sommeil chez les patients diagnostiqués avec narcolepsie-cataplexie (NC) avant et après l’âge de 18 ans. Méthodes Les patients de novo avec un diagnostic de NC ont rempli un questionnaire et un entretien standardisés, suivis d’une étude sur le sommeil. Les mesures cliniques du sommeil ont...
Article
Objectif Dans le syndrome d’apnées obstructives du sommeil (SAOS), la fermeture répétée des voies aériennes supérieures déclenche un déséquilibre sympathovagal, médiateur central des conséquences cardiovasculaires. L’effet de la CPAP sur les complications cardiovasculaires reste controversé. Probablement car l’IAH représente mal les phénomènes sous...
Article
Objectif Déterminer si le niveau objectif d’éveil mesuré par le test de maintien de l’éveil (TME) est associé à la survenue de presque-accidents ou d’accidents auto-déclarés liés à la somnolence au cours de l’année passée chez les patients souffrant de troubles du sommeil. Méthodes Cette étude cas-témoins a été menée sur une période de trois ans d...
Article
Full-text available
Objective Narcolepsy is a rare sleep disorder in which psychotic‐like symptoms can present diagnostic and therapeutic challenges. We aimed to review the association between, and medical management of, narcolepsy and psychosis in children and adults. Methods We reviewed the full text of 100 papers from 187 identified by a PubMed search on narcoleps...
Article
Sleep apnea test (SAT) is a cost-effective approach to evaluate subjects without associated comorbidities suspected for obstructive sleep apnea (OSA), a disorder particularly common in obese subjects. The association of obesity with awake hypercapnia (carbon dioxide arterial pressure, PaCO2 ≥45 mmHg) defines the obesity-hypoventilation syndrome (OH...
Article
Full-text available
Introduction. Sleep-related breathing disorders, including sleep apnea and hypoxemia during sleep, are common in pulmonary arterial hypertension (PAH), but the underlying mechanisms remain unknown. Overnight fluid shift from the legs to the upper airway and to the lungs promotes obstructive and central sleep apnea, respectively, in fluid retaining...
Article
None: Sleep disorders are prevalent in patients with multiple sclerosis. In contrast, a frank increase of REM sleep time is a rare phenomenon, mostly described in the context of REM sleep rebound (after sleep deprivation, abrupt withdrawal of antidepressants or neuroleptics, and during the first night of ventilation for severe sleep apnea), but no...