Isabella Annesi-Maesano

French Institute of Health and Medical Research | Inserm · Institut Desbrest of Epidemiology and Public Health INSERM and Universtiy of Montpellier

Recent studies revealed that the high production of reactive oxidative species due to exposure to fine or ultrafine particles are involved in many chronic respiratory disorders. However, the poor standard of clinical data in sub-Saharan countries makes the assessment of our knowledge on the health impacts of air pollution in urban cities very diffi...

Recent studies releaved that the high production of reactive oxidative species due to exposure of fine or ultrafine particles are implicated in many chronical respiratory disorders. However, the poor standard of clinical data in sub-Saharan countries makes very difficult the assessment of knowledge of air pollution health impact in urban cities. Ob...

BACKGROUND The aim of these clinical standards is to provide guidance on ‘best practice’ care for the diagnosis, treatment and prevention of post-COVID-19 lung disease. METHODS A panel of international experts representing scientific societies, associations and groups active in post-COVID-19 lung disease was identified; 45 completed a Delphi proce...

B A C K G R O U N D : The aim of these clinical standards is to provide guidance on ‘best practice’ care for the diagnosis, treatment and prevention of post-COVID-19 lung disease. M E T H O D S : A panel of international experts representing scientific societies, associations and groups active in post-COVID-19 lung disease was identified; 45 comple...

Objective: To quantify the impact of different air pollutants on respiratory health based on robust estimates based on international data and to summarise the evidence of associations between indoor exposure to those pollutants and respiratory morbidity in the Portuguese population. Results: Several systematic reviews and meta-analyses (MA) at t...

Firefighters are exposed to a range of harmful substances during firefighting. Exposure to fire smoke has been associated with a decrease in their lung function. However, the cause–effect relationship between those two factors is not yet demonstrated. This meta-analysis aimed to evaluate the potential associations between firefighters’ occupational...

Produits à quelque 3 millions de tonnes par an dans le monde, les phtalates utilisés comme plastifiants sont omniprésents dans l'environnement et contaminent de façon significative l'être humain par contact, inhalation et ingestion. Les phtalates ont été reconnus comme étant des perturbateurs endocriniens et ils ont été associés à plusieurs maladie...

Outbreak caused by coronavirus disease 2019 (COVID-19) started in Wuhan, Hubei Province, China and quickly spread around the world. Current evidence is contradictory on the association of asthma with COVID-19 and associated severe outcomes. Type 2 inflammation may reduce the risk for severe COVID-19. Whether asthma diagnosis may be a risk factor fo...

Background The age at onset of the association between poverty and poor health is not understood. Our hypothesis was that individuals from highest household income (HI), compared to those with lowest HI, will have increased fetal size in the second and third trimester and birth. Methods Second and third trimester fetal ultrasound measurements and...

The impact of air pollution and climate change on the environment, biosphere and biodiversity has become more evident in the recent years. Air pollution, climate change and the correlated global warming affect the quantity, intensity and frequency of precipitation type as well as extreme climate change events such as heat waves, droughts, thunderst...

Objectives Farming is filled with respiratory hazards: pesticide vapors, dusty fields, dangerous hydrogen sulfide accumulations in manure pits and pump sumps, nitrogen dioxide in conventional silos, and many others. Despite the recognition of respiratory hazards, this problem has not been fully investigated at the world level after harmonization of...

In recent decades, increased burning of fossil fuels for electricity, heating and transportation have led to increases in greenhouse gases (e.g., carbon dioxide (CO2), methane, nitrous oxide, and fluorinated gases) while deforestation and decreased biodiversity has reduced the Earth’s ability to remove CO2, the major greenhouse gas emission. Greenh...

Background Low income is a known prognostic indicator of various chronic respiratory diseases but has not been studied in idiopathic pulmonary fibrosis (IPF). We hypothesize that a low income has an adverse prognostic impact on IPF. Methods Patients were selected from the French national prospective cohort COFI. Patient's income was assessed throu...

Background The potential role of socio-economic status (SES) in COVID-19 remains unknown. The highest excess mortality rate in France linked to COVID-19 is reported in the Seine-Saint-Denis (SSD) district, which is the poorest district of the Greater Paris Area. Our objective was to compare patient characteristics between two districts of Greater P...

Background: Gene-environment interactions are relevant for several respiratory diseases. This communication raises the hypothesis that the severity of COVID-19, a complex disease where the individual response to the infection may play a significant role, could partly result from a gene-environment interaction between air-pollution and Alpha-1 Anti...

SETTING: Indoor volatile organic compound (VOC) levels, which are generally correlated with each other, may have an additive or synergistic effect on health. VOC synergy with allergens is a suspected mechanism affecting respiration. OBJECTIVE: To determine the effect of exposure to interactions between VOCs and allergens on respiratory symptoms in...

Urban air pollution, despite its dangerous health impact, is poorly studied in sub-Saharan Africa (sSA). Epidemiological data on this silent killer are almost non-existent for cities of Cameroon, which seems to be one of the sSA countries where populations are highly exposed to air pollutants. Objective: The present study was conducted in Douala ci...

Background: Health information records in many countries, especially developing countries, are still paper based. Compared to electronic systems, paper-based systems are disadvantageous in terms of data storage and data extraction. Given the importance of health records for epidemiological studies, guidelines for effective data cleaning and sorting...

Introduction Le rôle du statut socio-économique (SSE) dans l’infection au COVID-19 est mal inconnu. En France mars-avril 2020, le taux de surmortalité lié au COVID-19 le plus élevé a touché la Seine-Saint-Denis (SSD), le département le plus pauvre du Grand Paris. Méthodes Objectifs: comparer le SSE des patients entre deux départements du Grand Par...

Background The analysis of mobile health (mHealth) data has generated innovative insights into improving allergic rhinitis control, but additive information is needed. A cross-sectional real-world observational study was undertaken in 17 European countries during and outside the estimated pollen season. The aim was to collect novel information incl...

Résumé Les maladies allergiques sont le résultat d’interactions entre de multiples facteurs génétiques et environnementaux et seuls des changements environnementaux récents peuvent expliquer leur augmentation au cours des dernières décennies. Le concept d’exposome englobe l’ensemble des facteurs d’exposition à l’environnement extérieur, spécifiques...

Résumé Peu d’études se sont intéressées aux effets de la pollution de l’air dans les pneumopathies interstitielles diffuses et elles ont porté sur de petits effectifs de patients. C’est dans la fibrose pulmonaire idiopathique que le plus de données sont disponibles, suggérant que le niveau d’exposition aux polluants pourrait influencer la survenue...

The European Academy of Allergy and Clinical Immunology (EAACI) organized the first European Strategic Forum on Allergic Diseases and Asthma. The main aim was to bring together all relevant stakeholders and decision‐makers in the field of allergy, asthma and clinical Immunology around an open debate on contemporary challenges and potential solution...

Introduction Les faibles revenus sont des indicateurs pronostiques connus dans diverses maladies respiratoires chroniques mais peu étudiés dans la fibrose pulmonaire idiopathique (FPI). La FPI est la plus fréquente et grave des pneumopathies interstitielles diffuses. Son histoire naturelle reste mal comprise. Nous faisons l’hypothèse que les faible...

MeDALL (Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015) has proposed an innovative approach to develop early indicators for the prediction, diagnosis, prevention and targets for therapy. MeDALL has linked epidemiological, clinical and basic research using a stepwise, large-scale and integrative approach: MeDAL...

Conclusions:-cantly associated with the severity of NCCL at tooth level. Results: Ninety-three subjects with LA were included and 2,480 teeth were examined. More than 20% of the teeth were diagnosed Objective: To analyse in periodontitis patients the association between the severity of periodontal loss of attachment (LA) and NC-CLs and to identify...

Aims Mobile Airways Sentinel NetworK (MASK) belongs to the Fondation Partenariale MACVIA-LR of Montpellier, France and aims to provide an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle, whatever their gender or socio-economic status, in order to reduce health and social inequities incurre...

. La pollution atmosphérique et ses effets sur la santé respiratoire. Document d'expertise collective de la Société pneumologique de langue Française. Mise à jour de la publication de 2016.

The field of small air quality sensors is of growing interest within the scientific community, especially because this new technology is liable to improve air pollutant monitoring as well as be used for personal exposure quantification. Amongst the myriad existing devices, the performances are highly variable; this is why the sensors must be rigoro...

Supplemental Digital Content is available in the text.

Background: Air pollution is a major public health issue and remains a major concern in France and around the world. Proof of this is that air pollution is one of the first environmental concerns of the French population. The purpose of this study was to establish a system for monitoring the actual concentrations of different atmospheric pollutant...

Purpose of review: To analyze the status of precision medicine in atopic diseases. Recent findings: Atopic diseases are increasingly recognized as heterogeneous in nature and they can be quite different in severity, response to therapy, triggers, genetic back ground, ancestral risk and type of inflammation. This significant variability in the la...

The number of older siblings a child has is negatively correlated with the child’s verbal skills, perhaps because of competition for parents’ attention. In the current study, we examined the role of siblings’ sex and age gap as moderating factors, reasoning that they affect older siblings’ tendency to compensate for reduced parental attention. We h...

Background: Mobile health can be used to generate innovative insights into optimizing treatment to improve allergic rhinitis (AR) control. Objectives: A cross-sectional real-world observational study was undertaken in 22 countries to complement a pilot study and provide novel information on medication use, disease control, and work productivity...

Introduction L’allergie alimentaire à la pêche est fréquente, par réaction croisée pollens-aliments ou comme allergie alimentaire primaire. Au Japon et dans la région de Marseille, la sensibilisation à Pru p 7 a été proposée récemment comme marqueur de gravité de l’allergie à la pêche. Nous avons étudié la distribution et les caractéristiques clini...

Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis pat...

Background: An initial epidemiological study carried out 18 years ago in Marseilles indicated that the air quality in schools was poor and that there was an association between the level of fine particulates and the occurrence of asthma in children. The aim of the present study was to evaluate the change in the prevalence of childhood asthma and a...

Abstract mHealth, such as apps running on consumer smart devices is becoming increasingly popular and has the potential to profoundly affect healthcare and health outcomes. However, it may be disruptive and results achieved are not always reaching the goals. Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the be...

Introduction: The diversity of epidemiological studies shows that the short-term effects of exposure to air pollutants in terms of increased symptoms and use of care are beyond doubt. However, few studies have considered drug consumption among the general population, with most investigations relying on either patient panels or small groups in cross...

Background Mobile technology may help to better understand the adherence to treatment MASK‐rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient‐centered ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives To assess the adherence to treatment in allergic rhinitis patie...

Objective: Deficiency in 25-hydroxyvitamin D (25OHD) has been associated with sleep disorders in adults. Only three cross-sectional studies were performed in children; which showed an association between 25OHD deficiency and both obstructive sleep apnea syndrome and primary snoring. No longitudinal study has been performed in children from the gen...

Background/AimAir quality is catching the attention of public opinion due to its impact on human health.In Côte d'Ivoire, there is no national air quality measurement system. However, data concerning cardiorespiratory and skin diseases in relation to poor air quality exist.In order to estimate the impact of air pollution on health in the city of Ab...

RÉSUMÉ Au cours des dernières décennies, la prévalence de l’asthme et des allergies a doublé. Cette élévation du nombre d’asthmatiques et d’allergiques est due à des causes environnementales ; les modifications génétiques nécessitant des périodes plus longues que quelques décennies pour se produire. Les facteurs de risque environnementaux peuvent e...

Indoor pollution poses a serious threat to human health. Plants represent a sustainable but underexploited solution to enhance indoor air quality. However, the current selection of plants suitable for indoors fails to consider the physiological processes and mechanisms involved in phytoremediation. Therefore, the capacity of plants to remove indoor...

Exposure of pregnant women to fine particulate matter<2.5μm in diameter (PM2.5) is responsible for low birthweight (LBW) and intellectual disabilities, as expressed by a lower intelligence quotient (IQ). We estimated the attributable cost due to PM2.5 of healthcare at birth and cognitive retardation of children with LBW in metropolitan France in 20...

Introduction An increasing body of evidence shows the occurrence of asthma epidemics, sometimes also severe, during thunderstorms in the pollen season, in various geographical zones. Thunderstorms have been linked to asthma epidemics and there are descriptions of asthma outbreaks associated with thunderstorms in several cities, prevalently Australi...

Objective: Sleep duration may vary both interindividually and intraindividually over time. We aimed to identify night-sleep duration (NSD) trajectories among preschoolers and to study associated factors. Methods: NSD was collected within the French birth-cohort study EDEN at ages 2, 3, and 5-6 years through parental questionnaires, and were used...

Introduction Les atteintes extra thoraciques sont fréquentes au cours de la sarcoïdose (30 à 50 %). Si l’expression clinique dans chaque organe est décrite, on a peu de données sur l’association de ces atteintes entre elles. L’objectif était de définir les atteintes extrapulmonaires de la sarcoïdose (Tableau 1). Méthodes Il s’agissait d’une étude...

Introduction Certaines granulomatoses, locales ou systémiques, surviennent dans un contexte tumoral, dans un délai variable par rapport au cancer. Les caractéristiques de ces granulomatoses associées aux cancers (GAC) sont mal connues. Le but de cette étude était de comparer les présentations cliniques, fonctionnelle, radiologique et évolutive des...

Air pollution constitutes one of the main threats to public health in Europe. Significant impacts on the health of Europeans in terms of morbidity and mortality have been observed, even in cases of low exposure and where pollutant levels are within limits set by the European Union (EU). The respiratory system is a primary target of the harmful effe...

A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life dat...

Introduction La sarcoïdose est une granulomatose multisystémique de cause inconnue caractérisée par une atteinte médiastino-pulmonaire fréquente (90 % des cas). Les atteintes extrapulmonaires s’observent chez 30 à 50 % des patients. Si l’expression clinique de la sarcoïdose dans chaque organe a été bien décrite, on a peu de données sur l’associatio...

Background & aims: Programming of infant development and later health may depend on early-milk polyunsaturated fatty acids (PUFA) contents, that are very variable between women for reasons not well elucidated. Indeed, a high n-6/n-3 PUFA in milk was associated with higher adiposity, arterial pressure and lower psychomotor scores in childhood. We a...

Mobile technology has been used to appraise allergic rhinitis control but more data are needed. In order to better assess the importance of mobile technologies in rhinitis control, the ARIA (Allergic Rhinitis and its Impact on Asthma) score ranging from 0 to 4 of the Allergy Diary was compared with EQ-5D (EuroQuol) and WPAI-AS (Work Productivity an...

Background: Visual Analogue Scale (VAS) is a validated tool to assess control in allergic rhinitis patients. Objective: The aim of the present study was to validate the use of VAS in the MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) on smartphones screens to evaluate allergic rhinitis symptoms and disease...

Background: Allergic rhinitis (AR) is a worldwide health problem with rising prevalence. To enhance the estimation of AR prevalence in epidemiological studies, the Score for AR (SFAR), a screening tool, has been developed and widely used. An 8-item SFAR is a handy, self-administered instrument assessing the information on nasal and eye symptoms, s...

The scientific challenges abound to better assess the relationship between air pollutants, their biological effects on the human health and the responses of the exposed populations. In Asia, atmospheric chemists have to consider much higher levels of air pollution but also an original aerosol chemical composition which results from multiple sources...

The overarching goals of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) are to enable European citizens to lead healthy, active and independent lives while ageing. The EIP on AHA includes 74 Reference Sites. The aim of this study is to transfer innovation from an App developed by the MACVIA-France EIP on AHA reference...