Isabel Prieto

Fundación Jiménez Díaz | IIS-FJD · Servicio de Oncología Radioterápica

Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of cancer, including colon cancer (CC). However, we recently reported no influence of T2DM on CC prognosis, suggesting that any effect might be at the early stages of tumor development. We hypothesized that T2DM may create an environment in the healthy tissue which acts as a...

Table S1. Mutational, immunohistochemical, and proliferation characterization of samples. Table S2. Common overrepresented pathways in diabetic conditions in two comparisons: (i) tumors from diabetic patients versus tumors from nondiabetic patients and (ii) normal colonic mucosas from diabetic patients versus normal colonic mucosas from nondiabeti...

The potential involvement of type 2 diabetes mellitus (T2DM) as a risk factor for colon cancer (CC) has been previously reported. While several clinical studies show a higher incidence of CC and a lower survival rate in diabetics, others report no association. Our own experience indicates that diabetes does not seem to worsen the prognosis once the...

The potential involvement of type 2 diabetes mellitus (T2DM) as a risk factor for colon cancer (CC) has been previously reported. While several clinical studies show a higher incidence of CC and a lower survival rate in diabetics, others report no association. Our own experience indicates that diabetes does not seem to worsen the prognosis once the...

Merkel cell carcinoma is a rare primary cutaneous carcinoma of the skin, which shows high aggressiveness, high risk of locoregional and distant spread, a mortality rate considerably higher than that of cutaneous melanoma, and a poor survival. Its incidence has increased during the past 20 years. The studies published from 2008 have introduced inter...

La diabetes mellitus tipo 2 y el cáncer son enfermedades de epidémicas proporciones a nivel mundial. Las muertes atribuidas a estas dos enfermedades se han incrementado entre un 90% y un 57% respectivamente a lo largo de los últimos 20 años. El riesgo de cáncer colorrectal se estima un 27% más alto en pacientes con diabetes tipo 2 que en controles...

Background Multiple observational studies suggest an increased risk of colon cancer in patients with diabetes mellitus (DM). This can theoretically be the result of an influence of the diabetic environment on carcinogenesis or the tumor biologic behavior. Aim To gain insight into the influence of a diabetic environment on colon cancer characterist...

Schematic representation of the selection of patients who met the inclusion criteria for database development. (TIF)

The significant role of the immune system in cancer treatment has given rise to an emerging field of study within oncology, and one that is attracting increasing attention from researchers. Immunotherapy has demonstrated that the immune system is crucial in the fight against cancer. This challenge has led researchers to analyze whether the immunein...

Determinar si existen diferencias en los patrones de prescripción frente al dolor neuropático (DN) entre la oncología y res- to de especialidades en práctica clínica habitual. 2. Valorar el nivel de formación y conoci- miento en DN entre el oncólogo y resto de especialidades. 3. Determinar si estos aspectos influyen en la selección del opioide más...

Neuropathic pain is one of the most difficult to diagnose and treat. Knowledge among clinicians regarding this kind of pain is scarce and clinical practice depends on the expertise and on the specialization.

Frame-based stereotactic radiosurgery (SRS) using rigid immobilization with head ring continues to be the standard treatment when it comes to intracranial SRS. We wanted to assess setup accuracy and intrafraction errors of patients treated with single fraction intracranial stereotactic radiosurgery using the Elekta Fraxion® immobilization system (F...

Between March 2011 and December 2013 we performed 66 prostate brachytherapy in patients with low / intermediate risk prostate cancer. 4 patients also received external radiotherapy. 14 patients received previous hormone therapy. A 145 Gy dose was prescribed if exclusive brachytherapy was given and 108 Gy if combined with external radiotherapy. All...

The co-existence of diabetes mellitus in colorectal cancer patients has a reflection in the tissue proteome, both in tumor and in adjacent (normal) mucosa. In particular, 14 proteins were found significantly varied in diabetic group (8 up-regulated and 6 down-regulated), both in tumor and in normal mucosa. This sub-set represent alterations which c...

Introduction: nutrition is an important influence on treatments and quality of life of cancer patients. The relationship between different nutritional components and radiotherapy is today a topic of growing interest. Objective: to evaluate the influence of macro and micronutrients on tolerance and effectiveness of radiotherapy and their role in...

Purpose: To provide effective and accurate radiotherapy (RT) for advanced cancer patients who experience breakthrough pain (BP) due to positioning manoeuvres, through the use of FPNS. Secondary endpoints were the dose and time required to achieve a 50% numeric rating scale (NRS) reduction and conduction of a pharmacoeconomic analysis. Patients an...

La nutrición ejerce una importante influencia sobre los tratamientos y la calidad de vida del paciente oncológico. En la actualidad, la relación de los distintos componentes nutricionales con el tratamiento radioterápico es un tema de creciente interés. OBJETIVOS: Evaluar la posible influencia de los macro y micronutrientes sobre la tolerancia y ef...

Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine tumor of the skin. Therapeutic approach is often unclear, and considerable controversy exists regarding MCC pathogenesis and optimal management. Due to its rising incidence and poor prognosis, it is imperative to establish the optimal therapy for both the tumor and the lymph node b...

OBJECTIVES To provide effective and accurate radiotherapy with controlled breakthrough pain (BP) episodes in advanced cancer patients while undergoing procedures necessary to receive radiotherapy, and also to assess the ability of Fentanyl Pectin Nasal Spray (FPNS) to control these episodes. RESULTS CONCLUSION Certain necessary procedures for radio...

Worldwide deaths from diabetes mellitus (DM) and colorectal cancer increased by 90% and 57%, respectively, over the past 20 years. The risk of colorectal cancer was estimated to be 27% higher in patients with type 2 DM than in non-diabetic controls. However, there are potential confounders, information from lower income countries is scarce, across...

74 year old woman. Diagnosis of endometrial endometrioid adenocarcinoma, affecting uterine corpus and cervical extension. Myometrium Infiltration > 50%. Free surgical margins. pT2. Pelvic lymphadenectomy 0/12. Para-aortic lymph 0/19. Adjuvant radiotherapy (pelvis, 45 Gy) and brachytherapy (Colpotomy, 4 x 4 Gy). At 26 months follow up: Recurrence at...

􏰛􏰑􏰈􏰕􏰩􏰑􏰎􏰊 􏰪􏰨􏰫􏰬􏰚􏰛􏰭􏰦 Breakthrough cancer pain; Mucositis; Fentanyl pectin nasal spray; Radiotherapy Aproximadamente un 60% de los pacientes diagnosticados de cáncer requiere, en algún momento de su enfermedad, radioterapia. Aunque suelen ser tratamientos bien tole- rados, en ocasiones los pacientes presentan dolor de intensidad moderada-severa en rela...

Purpose/Objective: The aim of this study was to evaluate and compare the Volumetric Modulated Arc Therapy (VMAT) and the Dynamic Conformal Arc (DCA) techniques for the treatment of brain metastasis and their influence on the absorbed dose by the healthy brain tissue (HBT). Materials and Methods: Fourteen patients with one or two brain metastasis we...

Introduction/Objetives: Dose to the oral mucosa and its contribution to acute mucositis is a dose/volume/outcome relationships recommended for investigation. Higher Dmean and Dmax would be supposed to produce more severe toxicity as such as other surveys have suggested. The aim of this study is to evaluate how different oral cavity (OC) contours in...

Objective: Oral cavity (OC) includes different structures that are affected in advanced head and neck cancer irradiation. The QUANTEC report has not well-defined which structures should be included as organ at risk (OAR) and has not determined the constraints to apply. The aim of this study is to demonstrate that different structures included in th...

En pacientes oncológicos, especialmente en aquellos con diseminación ósea, las maniobras de radiotera- pia pueden producir episodios de dolor irruptivo que ocasionan el retraso o suspensión de la radioterapia. PecFent® por rápida absorción y alivio, que ade- más puede administrarse en decúbito supino (lo que minimiza la manipulación del paciente),...

Purpose/Objective(s) To control the chronic pain and improve the quality of life in these patients suffering from neck fibrosis and neuropathy secondary to radical neck dissection plus radio-chemotherapy. Materials/Methods Nine patients with severe persistent chronic pain due to late sequelae after radical treatments based on surgery and radio-che...

Purpose/Objective(s) To evaluate and control breakthrough pain (BP) episodes in advanced cancer patients (ACP) undergoing radiation therapy during proceedings and maneuvers necessary to receive treatment, and to assess the ability of Fentanyl pectin nasal citrate (FPNC) to control these episodes. Materials/Methods Seventeen patients with severe BP...

Introduction: Despite being a very safe treatment, errors and near misses can occur in radiotherapy and affect patient’s safety. Protocols defining riskiest areas and tools designing a map of processes and risks are needed. Objectives: To analyze experiences regarding processes and risks mapping development, its applicability, requirements and adva...

Introduction: RT is a very safe treatment for cancer disease. However, errors and near-misses occur and could impact the safety and well-being of patients. Objectives: To analyze if the international recommendations regarding patient’s safety are included inside the current spanish RD1566/1998 (Quality Criteria in Radiotherapy), RD815/2001 (Justifi...

Introduction: In radiation-induced-cancer development are implicated low range radiation doses (up to 20 to 30 Gy, depending the tumor type) received by the healthy tissue, except for secondary sarcoma, induced at higher doses. The breast receives 50 Gy, so this dose is outside this range. Objective: To analyze the effects of 10-16 Gy boost given [...

Purpose: Head and neck cancer treatment is associated with significant morbidities. Both exclusive radiotherapy (RT) and chemoradiotherapy (CHRT) treatments can produce, as side effects, increased rates of long-term dysphagia. The purpose of the study here presented was to evaluate the ability of videofluoroscopy (VDF) in detecting and measuring sw...

Introduction: Radiotherapy is a very safe and effective treatment for cancer disease. However, errors and near-misses occur and could impact safety and well-being of patients. Automated checklists have been applied successfully in other fields as a way of systematically reducing risk. Objectives: To analyze the experience regarding the implementati...

La RT juega un papel fundamental en el tratamiento del CCC. El desarrollo de nuevos esquemas radicales ha producido un aumento de la incidencia y de la severidad de la toxicidad asociada. La mucositis es la manifestación más común asociada a la RT en estos pacientes. Algunos estudios estiman que entre el 85% y el 100% de los pacientes que reciben a...

Purpose/Objective(s) To evaluate the breakthrough pain control and the improvement of the dysphagia in head and neck cancer patients (HNCP) who develop mucositis and moderate-severe dysphagia radiation therapy-induced. Materials/Methods Eleven patients with breakthrough pain due to radiation therapy-induced mucositis were selected to start treatme...

The presentation of scalp metastases from leiomyosarcoma of the vena cava is an extremely infrequent event. There are no other publications that describe such finding and very few of leiomyosarcoma in vessels. About this event we have reviewed the English literature describing studies on scalp metastases and skin metastases in general: their incide...

Merkel cell carcinoma (MCC) is a rare primary cutaneous carcinoma of the skin that is highly aggressive, and has a high risk of locoregional and distant spread, a mortality rate considerably higher than that of cutaneous melanoma and poor survival. Its incidence has increased during the past twenty years. The studies published since 2008 have intro...

Objective: To assess the incidence of toxicity in LAHNSCC patients (pts) treated with concurrent cetuximab and RT at our institution. Material and Methods: We retrospectively revised the clinical records of the first 17 LAHNSCC pts treated in our institution between January 2009 and December 2011 with cetuximab plus RT, and extracted data of the a...

Objective: To assess which have been the treatments performed to MCC patients treated at our institution, its uniformity and, therefore, if treatment nomograms are needed. Material and Methods: We retrospectively revised the clinical records of 11 MCC patients treated from January 2006 to December 2011 in our institution. Age at presentation: Me...