Isabel Heyde

• Doctor of Philosophy
• Senior Researcher at University of Lübeck

Citation: Hirose, M.; Leliavski, A.; de Assis, L.V.M.; Matveeva, O.; Skrum, L.; Solbach, W.; Oster, H.; Heyde, I. Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ Abstract: Internal circadian clocks coordinate 24 h rhythms in behavior and physiology. Many immune functions show daily oscillations, and cellular circadian clocks can imp...

A network of cellular timers ensures the maintenance of homeostasis by temporal modulation of physiological processes across the day. These so-called circadian clocks are synchronized to geophysical time by external time cues (or zeitgeber s). In modern societies, natural environmental cycles are disrupted by artificial lighting, around-the-clock a...

Objective: Snacking, i.e., the intake of small amounts of palatable food items, is a common behavior in modern societies, promoting overeating and obesity. Shifting food intake into the daily rest phase disrupts circadian rhythms and is also known to stimulate weight gain. We therefore hypothesized that chronic snacking in the inactive phase may p...

A network of cellular timers ensures the maintenance of homeostasis by temporal modulation of physiological processes across the day. These so-called circadian clocks are synchronized to geophysical time by external time cues (or zeitgeber s). In modern societies, natural environmental cycles are disrupted by artificial lighting, around-the-clock a...

24-h rhythms in physiology and behaviour are orchestrated by an endogenous circadian clock system. In mammals, these clocks are hierarchically organized with a master pacemaker residing in the hypothalamic suprachiasmatic nucleus (SCN). External time signals—so-called zeitgebers— align internal with geophysical time. During shift work, zeitgeber in...

Stress and teamwork in fire operations Successful teamwork plays an essential role for efficient and safe fire operations. By contrast, suboptimal teamwork processes are a frequent but avoidable source of danger and can lead to increased stress levels in firefighters. The project "Gemeinsam stark" (“Strong together”), aims to develop and evaluate t...

24-hour rhythms in physiology and behaviour are orchestrated by an endogenous circadian clock system. In mammals, these clocks are hierarchically organized with a master pacemaker residing in the hypothalamic suprachiasmatic nucleus (SCN). External time signal – so-called zeitgebers – align internal with geophysical time. During shift work, zeitgeb...

The term energy metabolism comprises the entirety of chemical processes associated with uptake, conversion, storage, and breakdown of nutrients. All these must be tightly regulated in time and space to ensure metabolic homeostasis in an environment characterized by cycles such as the succession of day and night. Most organisms evolved endogenous ci...

During pregnancy, maternal endocrine signals drive fetal development and program the offspring’s physiology. A disruption of maternal glucocorticoid (GC) homeostasis increases the child’s risk of developing psychiatric disorders later in life. We here show in mice, that the time of day of antenatal GC exposure predicts the behavioral phenotype of t...

Circadian clocks regulate physiological functions, including energy metabolism, along the 24-hour day cycle. The mammalian clock system is organized in a hierarchical manner with a coordinating pacemaker residing in the hypothalamic suprachiasmatic nucleus (SCN). The SCN clock is reset primarily by the external light-dark cycle while other zeitgebe...

24-h rhythms in physiology and behaviour are organized by a body-wide network of endogenous circadian clocks. In mammals, a central pacemaker in the hypothalamic suprachiasmatic nucleus (SCN) integrates external light information to adapt cellular clocks in all tissues and organs to the external light-dark cycle. Together, central and peripheral cl...

The 24-hour sleep-wake cycle is one of the most prominent outputs of the circadian clock system. At the same time, changes in sleep-wake behavior feedback on behavioral and physiological circadian rhythms, thus altering the coordination of the body's clock network. Sleep and circadian rhythm disruption have similar physiological endpoints including...

The different types of adipose tissues fulfill a wide range of biological functions—from energy storage to hormone secretion and thermogenesis—many of which show pronounced variations over the course of the day. Such 24‐h rhythms in physiology and behavior are coordinated by endogenous circadian clocks found in all tissues and cells, including adip...

The different types of adipose tissues fulfill a wide range of biological functions—from energy storage to hormone secretion and thermogenesis—many of which show pronounced variations over the course of the day. Such 24-h rhythms in physiology and behavior are coordinated by endogenous circadian clocks found in all tissues and cells, including adip...

The circadian clock which is present in nearly almost living organisms has a fundamental role in regulating biological temporal rhythms. It is tightly controlled by molecular components consisting of positive and negative regulatory elements that share a high degree of homology from one organism to the next. Circadian rhythms have been extensively...