Iryna Savinova

McMaster University | McMaster · Michael G. DeGroote School of Medicine

Background Prurigo nodularis (PN) is a complex chronic skin disease characterized by severe pruritic nodules. PN is often associated with mental health disorders and chronic medical comorbidities. Until recently, PN treatment has been challenging and difficult. Objectives This study aims to describe the demographic, clinical characteristics, and c...

What is this summary about? This is a plain language summary discussing the results of our study published in the journal Nanomedicine. The study describes how to improve the detection of blood cancer and chart the progress of recovery/remission to reassure patients living with cancer. What did we do? In our study, we used a new tool called Raman...

Anemia is associated with increased risk of Acute Kidney Injury (AKI), stroke and mortality in perioperative patients. We sought to understand the mechanism(s) by assessing the integrative physiological responses to anemia (kidney, brain), the degrees of anemia-induced tissue hypoxia, and associated biomarkers and physiological parameters. Experime...

Palmar hyperhidrosis (PH), a condition characterized by excess sweating of the palms, is a common concern that presents to the plastic surgeon, which can have major impacts on patient confidence and quality of life. While several studies summarize treatment options for hyperhidrosis in general, few outline the therapeutic options available specific...

Background: The Spontaneously Hypertensive Rat (SHR) Colony was established in 1963 and is the most commonly used rodent model for studying heart failure. Ideally, animal models should recapitulate the clinical disease as closely as possible. Any drift in a genetic model may create a new model that no longer adequately represents the human patholo...

Introduction Erythropoietin (EPO), in response to hypoxia, is produced by the kidney, which stimulates erythropoiesis in the bone marrow. While the kidney is regarded as the primary source of EPO, mainly in vitro expression has been shown from cells or tissues of the brain, liver, and reproductive organs. However, whether these organs are an endoge...