
Irshad HussainLahore University of Management Sciences | LUMS · Department of Chemistry & Chemical Engineering
Irshad Hussain
PhD
Professor at the Department of Chemistry & Chemical Engineering, SBASSE, Lahore University of Management Sciences (LUMS)
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236
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Introduction
Dr. Hussain, a Fellow of Pakistan Academy of Sciences and FRSC, has led the efforts to develop a world-class Chemistry Department at SBASSE, LUMS, Lahore, Pakistan. Currently, He is a Full Professor and the Chair of Department of Chemistry & Chemical Engineering and is known for the establishment of a world-class chemistry department at LUMS and the quality of research in nanomaterials, while regularly publishing high impact research articles throughout his academic career.
Additional affiliations
January 2008 - present
January 2001 - December 2005
Publications
Publications (236)
One of the main impediments during the CO2 photocatalytic reduction process is controlling a particular product’s selectivity while keeping a high conversion rate. The adsorption and affinity of the catalyst...
Covalent organic frameworks (COFs) have garnered attention for their potential in photocatalytic hydrogen peroxide (H2O2) production. However, their photocatalytic efficiency is impeded by insufficient exciton dissociation and charge carrier transport. Constructing COFs with superior planarity is an effective way to enhance the π‐conjugation degree...
Nucleus is the central regulator of cells that controls cell proliferation, metabolism, and cell cycle, and is considered the most important organelle in cells. The precision medicine that can achieve nuclear targeting has achieved good therapeutic effects in anti‐tumor therapy. However, the presence of biological barriers such as cell membranes an...
Hierarchical porous hypercrosslinked monoliths (PolyHIPE‐HCP) with ultrahigh specific surface areas are prepared via a solvent knitting strategy. Compared to previous work, the solvent knitting strategy is carried out in a relatively low air‐controlled atmosphere with gradient heating starting from low temperature while using DCM (Dichloromethane)...
Covalent organic frameworks (COFs) have garnered attention for their potential in photocatalytic hydrogen peroxide (H2O2) production. However, their photocatalytic efficiency is impeded by insufficient exciton dissociation and charge carrier transport. Constructing COFs with superior planarity is an effective way to enhance the π‐conjugation degree...
The use of plant seed-based hydrogels to design drug delivery systems (DDSs) has increased due to their swellable, pH-responsive, biocompatible, biodegradable, and non-toxic nature. Herein, the chia seeds hydrogel (CSH) was extracted through an aqueous extraction method to explore its pH and salt-responsive swelling behavior and sustained release p...
Highly crystalline organic semiconductors are ideal materials for photocatalytic hydrogen evolution in water splitting. However, the instability and complex synthesis processes of most reported organic molecule‐based photocatalysts restrict their applications. In this study, we introduce benzo [1,2‐b:4,5‐bʹ] bis [1] benzothiophene‐3,9‐dicarboxylic...
This review explores the viability of selectively upgrading methanol to formate as a potential route for hydrogen production, with a particular emphasis on replacing the anodic oxygen evolution reaction in electrolyzers. Transition metal-based electrocatalysts demonstrate significant potential for selectively upgrading methanol to formate. The revi...
Microorganism contamination on substrate surfaces is arousing increasingly concern as a serious health issue. In this research work, antimicrobial water-based acrylic paint containing silver nanoparticles (Ag NPs) was prepared using the facile Ag+ in situ reduction process, in which AgNO3 and reducing agent sodium acrylate were refluxed with acryli...
The present study deals with the green synthesis of silver nanoparticles (Ag NPs) using a chemically modified polysaccharide as a reducing and capping agent. Dextran succinate (Dex-Suc) was synthesized by succinylation of the dextran with succinic anhydride at 80 °C for 24 h under stirring and N2. The Dex-Suc was used as a reducing and capping agen...
Electro-induced water splitting module is a fascinating strategy for the conversion of electricity into scalable and clean H2 as a future energy carrier and has significantly attracted the attention of the scientific community. However, despite countless research, cost-effective and durable electrode materials with high conversion efficiency remain...
The emergence of antimicrobial resistance is an alarming global health concern and has stimulated the development of novel functional nanomaterials to combat multi-drug-resistant (MDR) bacteria. In this work, we demonstrate for the first time the synthesis and application of surfactin-coated silver nanoparticles as an efficient antibacterial and an...
Water is essential for human survival and existence. Although everyone acknowledges the importance of water reserves, increasing industrialization and other human activities are drastically reducing the quality of the water. Polymeric composite membranes provide a dependable answer for removing water pollutants and thus improving its quality. In th...
Highly crystalline, hydrophilic and visible-light responsible molecular semiconductor materials are promising photocatalysts for water splitting to produce green hydrogen. However, hydrophobic nature, instability, high cost and the tedious synthesis process of most of the reported organic photocatalysts limit their photocatalytic activity and hinde...
Porous carbons have spurred tremendous interest as cutting-edge materials for diverse energy and environmental applications. To this end, hard and soft templating routes have developed various porous carbon-based materials with uniform and ordered porosities. Notwithstanding, the pores of carbons obtained via most of these preparation methods are v...
Elucidating single‐atom effects on the fundamental properties of nanoparticles is challenging because single‐atom modifications are typically accompanied by appreciable changes to the overall particle's structure. Herein, we report the synthesis of a [Cu58H20PET36(PPh3)4]²⁺ (Cu58; PET: phenylethanethiolate; PPh3: triphenylphosphine) nanocluster—an...
Elucidating single‐atom effects on the fundamental properties of nanoparticles is challenging because single‐atom modifications are typically accompanied by appreciable changes to the overall particle's structure. Herein, we report the synthesis of a [Cu 58 H 20 PET 36 (PPh 3 ) 4 ] ²⁺ ( Cu 58 ; PET: phenylethanethiolate; PPh 3 : triphenylphosphine)...
Mixed self‐assembled monolayers (mixed SAMs)‐based molecular‐scale electronic devices in recent years have gained great achievement in the fundamental study on charge transport mechanism and electronic functionalities. This review aims to summarize the preparation and characterization, structure modulation, and applications of heterogeneous mixed S...
The use of light to regulate photocatalyzed reversible deactivation radical polymerization (RDRP) under mild conditions, especially driven by broadband light or sunlight directly, is highly desired. But the development of a suitable photocatalyzed polymerization system for large-scale production of polymers, especially block copolymers, has remaine...
The purpose of this study was to design and engineer a simple approach to enhance the catalytic activity and thermal stability of Lipase. Lipase is an enzyme with exciting multifarious applications in the industry. In this respect, we observed that the catalytic activity of Lipase was enhanced when it was subjected to in situ synthesis of silver na...
Background:
Conventional techniques to diagnose (HCV) and assess non-cirrhotic/cirrhotic status of the patient for appropriate treatment regime are expensive and invasive. Present available diagnostic tests are expensive as they include multiple screening steps. Therefore, there is a need of cost-effective, less time consuming and minimally invasi...
Herein, we synthesized sodium salt of succinylated Salvia spinosa hydrogel (NaS-SSH), a novel and green polysaccharide-based ion-exchanger for cadmium uptake from deionized water (DW) and spiked high-hard ground water (HGW). The S. spinosa hydrogel (SSH), succinylated SSH (S-SSH) and its sodic form (NaS-SSH) were characterized through Fourier trans...
DNA nanogel exhibits properties of both the DNA and hydrogel, for example, remarkable biocompatibility, programmability, high drug loading capacity, and rapid stimuli‐responsive nature to microenvironment, which make it a potential ideal carrier for drug and gene delivery. In this review, DNA nanogels are categorized into two types, that is, rollin...
Herein, a drug delivery system (SSH-co-MAA) based on the mucilage from seeds of Salvia spinosa (SSH; polymer) and methacrylic acid (MAA; monomer) is introduced for the controlled delivery of venlafaxine HCl using a sustainable chemical approach. The optimized conditions for the designing of the ideal formulation (M4) of SSH-co-MAA were found to be...
Increasing energy demand to find everlasting and eco-friendly resources is now mainly dependent on green hydrogen production technology. Water electrolysis has been regarded as a clean route for green H2 production with zero carbon emission, but different bottlenecks in the development of electrodes impeded its realization. Recently, transition met...
Owing to the increasing demand for pH-responsive excipients based on natural polysaccharides, a copolymeric biocomposite material was developed for sustained-release drug delivery system (DDS). A novel pH-responsive, non-toxic, and superabsorbent graft co-polymeric hydrogel (SSH-co-AA) based on mucilage from Salvia spinosa seeds (SSH) and acrylic a...
The consistent oil spill incidents and industrial wastewater disposal impart an adverse impact on human health and nature. The utilization of porous membranes to address these problems has been predominantly investigated. Recently, hydrophilic membranes, have revealed the promising potential in oil-water separation. Thus, the present work focuses o...
Herein, we optimized eco-friendly extraction parameters to get the maximum yield of a novel polysaccharide-based mucilage (SSH) from seeds of Salvia spinosa. The dependency of the extraction yield of SSH on the pH of the extraction medium (pH 6-8), extraction temperature (25-75 °C), seed/water ratio (1:10-1:40 w/v), and seed–water contact time (1-4...
Porous metallic foams play a vital role in a diverse range of applications including electrocatalysis, electrochemical sensing, energy conversion and storage systems. Recently, template‐free electrochemical deposition or dynamic bubbles templating techniques have been very useful to precisely control the nanostructured metallic architecture without...
The high energy demand for electrochemical water splitting arises from sluggish oxygen evolution reaction (OER) kinetics. In this regard, Layered double hydroxide (LDH) has been introduced as an outstanding catalyst for the OER due to its exceptional physiochemical and 2D infrastructure properties. Herein, we report the design and synthesiss of cor...
Aqueous sodium-ion batteries are the promising candidates for large scale energy storage applications owing to their cost effectiveness and environmental safety. However, the development of a stable cathode material with high capacity is still a challenging task for the commercial viability of aqueous electrolyte-based sodium-ion batteries. This wo...
Fabrication of NiCu interconnected porous nanostructures for highly selective methanol oxidation coupled with hydrogen evolution reaction
Gold nanomaterials (GNMs) have unique optical properties with less antigenicity, and their physicochemical properties have strong relation with an immunological response at bio-interface including antigenicity. An interpretation of this correlation would significantly impact on the clinical and theranostic applications of GNMs. Herein, we studied t...
Multifunctional porous NiCo bimetallic foams toward water splitting and methanol oxidation-assisted hydrogen production
Recently, metal oxides-based have been widely used for catalytic reduction of nitro-aromatic compounds, which are notorious for their carcinogenic nature. The current study reports Sn-doped MnO2 as an efficient catalyst for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). The FE-SEM characterization of SnO2-doped MnO2 revealed the dif...
Volatile organic compounds (VOCs) are a major constituent of human breath which is being investigated as potential targets to be sensed in e-nose biosensors. Limonene is found in the breath of cirrhotic liver patients and can be used for early diagnosis using electrochemical biosensors. In the current study, electrochemical detection of limonene wa...
Covalent triazine frameworks have recently been demonstrated as promising materials for photocatalytic water splitting and are usually used in the form of suspended powder. From a practical point of view, immobilized CTFs materials are more suitable for large-scale water splitting, owing to their convenient separation and recycling potential. Howev...
Background
Mycobacterium tuberculosis’ rapid detection is still a formidable challenge to have control over the lethal disease. New diagnostic methods such as LED fluorescence microscopy, Genexpert, Interferon Gamma Release Assay (IGRA) are limited on efficacy spectrum owing to their high cost, time-intensive and laborious nature, in addition their...
Emulsion templating is at the forefront of producing a wide array of porous materials that offers interconnected porous structure, easy permeability, homogeneous flow-through, high diffusion rates, convective mass transfer, and direct accessibility to interact with atoms/ions/molecules throughout the exterior and interior of the bulk. These interes...
Aggregation-induced emission is a promising pathway to get high photoluminescence from metal nanocluster assemblies. The self-assembly of metal nanoclusters with regular morphologies can restrict the rotation and vibration modes of capping ligands, reduce nanoclusters' non-radiative decay, and finally result in an aggregation-induced strong emissio...
Sunlight driven heterostructured photocatalysts have attracted remarkable attention for the degradation of organic pollutants, including toxic dyes. In present study, the synthesis of TiO2 NPs anchored α-MnO2 nanorods based catalyst has been reported for the degradation of CBB R-250, a widely used textile dye. The FE-SEM analysis showed the rod-lik...
In the present study, we evaluated attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy for the differential diagnosis hepatitis C virus (HCV) and Dengue virus (DENV) infected freeze-dried sera along with healthy freeze-dried sera. Spectral signatures were recorded from 50 freeze-dried sera samples of each sample type. To...
Covalent triazine frameworks ( CTFs ) have recently been demonstrated as promising materials for photocatalytic water splitting and are usually used in the form of suspended powder. From a practical point of view, immobilized CTFs materials are more suitable for large-scale water splitting applications, owing to their convenient separation and recy...
Herein, we report a polysaccharide-based hydrogel isolated from psyllium husk (a well-known dietary fiber) and evaluated for its swelling properties in deionized water (DW) at different physiological pH values, i.e., 1.2, 6.8 and 7.4. Swelling of psyllium hydrogel (PSH) in DW under the influence of temperature and at different concentrations of NaC...
Aim: To fabricate and evaluate curcumin-loaded transfersomes (Cur-TF) for the targeted delivery and enhanced therapeutic efficacy of curcumin for the treatment of rheumatoid arthritis (RA). Methods: Modified thin-film hydration method was used to prepare Cur-TF which were then embedded into carbopol-934 gel. They were further evaluated through in v...
Salmonella typhi infections are difficult to treat due to poor penetration of current antibiotic ciprofloxacin (CIP)modalities into the intracellular compartments of macrophages owing to poor solubilization and oral bioavailability. Poor penetration and dissolution of CIP lead to development of intracellular pathogens induced multi-drug resistance...
Sunlight and water are among the most plentiful and sustainable resources of energy. Natural photosystem II in the plants uses these resources in ecofriendly manner for the production of atmospheric oxygen and energy. Inspired by this natural process, the development of artificial catalytic system to facilitate the solar-induced water splitting for...
Oxygen evolution reaction (OER) is a bottleneck process in the water-splitting module for sustainable and clean energy production. Transition metal-based electrocatalysts can be effective as water-splitting catalytic materials because of their appropriate redox properties and natural abundance, but the slow kinetics because of strong adsorption and...
The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has challenged health-care structures across the globe. Although a few therapies are approved by FDA, the search for better treatment options is continuously on rise. Clinical management includes infection prevention an...