Iris Kilsdonk

• Doctor of Medicine
• Radiologist at Deventer Ziekenhuis

Background Standardized consensus-based radiological reports for shoulder instability may improve clinical quality, reduce heterogeneity, and reduce workload. Therefore, the aim of this study was to determine important elements for the x-ray, magnetic resonance imaging (MRI) arthrography (MRA), and computed tomography (CT) report, the extent of var...

Developmental dysplasia of the hip comprises a broad spectrum of abnormalities in hip development, of variable severity. Besides physical examination, ultrasound is the preferred imaging modality for screening for developmental dysplasia of the hip in children aged younger than six months. The Graf method is the most widely used ultrasound techniqu...

Purpose: To determine the prevalence and spectrum of incidental findings (IFs) identified in patients undergoing chest CT as a primary triage tool for COVID-19. Methods: In this study 232 patients were triaged in our COVID-19 Screening Unit by means of a chest CT (March 25 - April 23, 2020). Original radiology reports were evaluated retrospectiv...

The use of magnetic resonance imaging (MRI) has taken a prominent place in the diagnosis and classification of sports-related muscle injury. However, its role in follow-up and monitoring of muscle and tendon repair is still debated. Muscle injuries have a common nature and are most often self-limiting; therefore they are usually evaluated clinicall...

Purpose In pandemic COVID-19, a rapid clinical triage is crucial to determine which patients are in need for hospitalisation. We hypothesised that chest CT and alveolar-arterial oxygen (A-a) gradient may be useful to triage these patients, since it reflects the severity of the pneumonia-associated ventilation/perfusion abnormalities. Methods A ret...

Background Rockwood I and II acromioclavicular joint injuries are generally treated nonoperatively. The long-term outcome is considered to be good but has not yet been properly investigated. Purpose To assess the long-term outcome after nonoperative therapy for Rockwood I and II acromioclavicular joint injuries regarding functional and radiologic...

Objective: In the work-up of patients presenting with a clinically isolated syndrome (CIS), 3T MRI might offer a higher lesion detection than 1.5T, but it remains unclear whether this affects the fulfilment of the diagnostic criteria for multiple sclerosis (MS). Methods: We recruited 66 patients with CIS within 6 months from symptom onset and 26...

Background Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. Objectives The purpose of this study was to investigate how 3 T MRI affects the agreement between r...

Background and purpose: In vivoidentification of white matter lesions plays a key-role in evaluation of patients with multiple sclerosis (MS). Automated lesion segmentation methods have been developed to substitute manual outlining, but evidence of their performance in multi-center investigations is lacking. In this work, five research-domain auto...

View largeDownload slide A substantialsproportion of multiple sclerosis cortical lesions go undetected with standard field (3T) MRI. Kilsdonk et al. compare the sensitivities of 7T versus 3T multi-contrast MRI protocols by validating them against histopathology in 19 patients and 4 controls. Ultra-high field 7T MRI more than doubles lesion detecti...

Background Virchow-Robin spaces (VRS) are associated with vascular and neurodegenerative disease. In multiple sclerosis (MS), VRS have been associated with neuroinflammation. Ultra-high field imaging may be used to gain insight in these contradictory findings. Objective The objective of this paper is to analyze VRS in MS patients using high-resolu...

Background Iron accumulation in deep grey matter (GM) structures is a consistent finding in multiple sclerosis (MS) patients. This study focused on the identification of independent determinants of iron accumulation using R2* mapping. Subjects and methods Ninety-seven MS patients and 81 healthy controls were included in this multicentre study. R2*...

Recently, a new MRI technique was developed at 3 Tesla (T), called fluid attenuated inversion recovery* (FLAIR*). In this study, we implemented FLAIR* in an existing MS cohort at 7 T, to investigate whether we could corroborate results of previous 7 T studies that introduced specific MS lesion characteristics. Furthermore, we aimed to investigate t...

Purpose: The R2* relaxation rate constant has been suggested as a sensitive measure for iron accumulation. The aim of this multi-center study was to assess the inter-scanner and inter-subject variability of R2* mapping and to investigate the relationship between brain volume and R2* in specific structures. Methods: R2* mapping was performed in 8...

To investigate whether a new magnetic resonance image (MRI) technique called T2*-weighted fluid attenuation inversion recovery (FLAIR*) can differentiate between multiple sclerosis (MS) and vascular brain lesions, at 7 Tesla (T). We examined 16 MS patients and 16 age-matched patients with (risk factors for) vascular disease. 3D-FLAIR and T2*-weight...

The first publications about in vivo application of ultra-high field MRI in multiple sclerosis (MS) appeared in 2008. From then on, the number of studies performed at 7 Tesla (T) has rapidly increased. The main advantage of ultra-high field MRI is its higher signal-to-noise ratio, which can be used to increase spatial resolution greatly. This has l...

Background and purpose: 7T MR imaging has led to improved detection and classification of cortical MS lesions, mainly based on T2*-weighted gradient-echo sequences. Depiction of cortical GM by using the recommended MS imaging protocol has not yet been investigated at 7T. We aimed to investigate prospectively which recommended sequence for clinical...

Objectives: Seven-Tesla MRI demonstrated new pathological features of multiple sclerosis (MS) using T2-weighted sequences. However, a clinical MRI protocol at 7 T has never been investigated. We evaluated the clinical value of 7-T MRI by investigating the sensitivity of lesion detection compared with 3 T. Methods: Thirty-eight MS patients and ei...

Multiple sclerosis (MS) is the most common inflammatory demyelinating disorder of the central nervous system (CNS). MS has been subject to high-field magnetic resonance (MR) imaging research to a great extent during the past years, and much data has been collected that might be helpful in the investigation of other inflammatory CNS disorders. This...