Iris Paola Guzmán-Guzmán

Iris Paola Guzmán-Guzmán
Universidad Autónoma de Guerrero · Facultad de Ciencias Químico Biológicas

PhD

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84
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Publications

Publications (84)
Article
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Interferons (IFNs) are a group of cytokines with antiviral, antiproliferative, antiangiogenic, and immunomodulatory activities. Type I IFNs amplify and propagate the antiviral response by interacting with their receptors, IFNAR1 and IFNAR2. In COVID-19, the IFNAR2 (interferon alpha and beta receptor subunit 2) gene has been associated with the seve...
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Background: Genetic susceptibility to infectious diseases is partly due to the variation in the human genome, and COVID-19 is not the exception. This study aimed to identify whether risk alleles of known genes linked with emphysema (SERPINA1) and pulmonary fibrosis (MUC5B) are associated with severe COVID-19, and whether plasma mucin 5B differs ac...
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Background: Hypertension (HTN) is recognized as a significant public health problem in the world. The objective of this study is to evaluate emergent anthropometric indices as predictors of preHTN and HTN according to age and sex in a sample of Mexican adults. Methods: A cross-sectional study was conducted in 1,150 participants aged 18-80 years...
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Background: Evidence suggests that physical self-concept (PSC) is linked to well-being in children and adolescents. Objective: The objective was to investigate the association of PSC with mental health (i.e., depression and body image), physical status (i.e., fitness and weight status) and lifestyle (physical activity (PA) patterns and nutrition...
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Protozoa, nematodes, and platyhelminths are of clinical interest due to their role on the modulation of the immune responses. To determine the frequency of infection by intestinal parasites as well as the status of single or mixed infection (coinfection) and its relation with inflammation and intestinal permeability markers in patients with rheumat...
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There is a close relationship between the development of complex motor skills and executive functions during childhood. This study aimed to analyze the differences in different dimensions of executive functions in children practicing an open-skill sport (handball), a closed-skill sport (athletics), and controls who did not participate in sports act...
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Background The impact of genetic variants in the expression of TNF-α and its receptors in COVID-19 severity has not been previously explored. We evaluated the association of TNF (rs1800629 and rs361525), TNFRSF1A (rs767455 and rs1800693), and TNFRSF1B (rs1061622 and rs3397) variants with COVID-19 severity, assessed as invasive mechanical ventilatio...
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Physical activity during childhood and adolescence favors brain development and cognitive functioning, particularly the executive functions. This study aimed to assess potential associations between anthropometric parameters, physical activity, physical fitness, and executive functions among elementary school children returning to school after the...
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Background: Identifying environmental factors that influence health in children are necessary to develop preventive strategies. Objective: To determine the association between the lifestyles of children (i.e., Mediterranean diet (MD), physical activity (PA), fitness and screen time (ST) with abdominal obesity (AO) of preschoolers from three Span...
Article
Objective The purpose was to determine the association of lifestyle (i.e., Mediterranean diet [MD] adherence, physical activity [PA], screen time [ST]) and fitness with abdominal obesity (AO) and excess weight in the Chilean and Colombian schoolchildren. Research methods & procedures This cross-sectional study included 969 schoolchildren, girls (n...
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Background: handgrip strength (HGS) is a health-status parameter associated with multicomorbidity in the adult population. Objective: the aim of the present study was to determine the association between HGS (i.e., absolute and relative) and abdominal obesity (AO), type-2 diabetes (T2D), and hypertension (HT), as well as to determine the associa...
Article
The present study comprises a comparison of the Mel Frequency Cepstral Coefficients (MFCC), Principal Component Analysis (PCA) and Independent Component Analysis (ICA) as feature extraction methods using ten different regression algorithms (AdaBoost, Bayesian Ridge, Decision Tree, Elastic Net, k-NN, Linear Regression, MLP, Random Forest, Ridge Regr...
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Background: In healthy pregnancies, components of the Renin-Angiotensin system (RAS) are present in the placental villi and contribute to invasion, migration, and angiogenesis. At the same time, soluble fms-like tyrosine kinase 1 (sFlt-1) production is induced after binding of ANG-II to its receptor (AT-1R) in response to hypoxia. As RAS plays an...
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Background: Sleep is an important modulator of neuroendocrine function and glucose metabolism. Poor sleep quality is related to metabolic and endocrine alterations, including decreased glucose tolerance, decreased insulin sensitivity, and increased hunger and appetite. Objective: The aim of the present study was to determine the association betw...
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The enzymes of the family peptidylarginine deiminases (PADs) have an important role in the pathogenesis of rheumatoid arthritis (RA) due to their association with the anti-citrullinated protein antibodies (ACPA) production. To evaluate the association between single-nucleotide polymorphisms (SNPs) in the PADI2 gene and RA susceptibility, related cl...
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The purpose of this cross-cultural study was to determine the association between the sociodemographic background of a child’s parents (i.e., their socioeconomic level, marital status, and educational level) with the child’s lifestyle (i.e., Mediterranean diet (MD), physical activity (PA) and screen time (ST)), and health markers. Material: This cr...
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Objective: to determine lifestyle changes, such as physical activity, nutrition, and sleep in an Argentinean university population, caused by confinement during the COVID-19 pandemic. Methods: Cross-sectional study via web survey. 1021 the Argentinean university population (women, n = 645 and men, n = 376) aged between 18-70 years old was participa...
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Background: The purpose of this study was to determine the reliability for the strength and movement velocity of the concentric phase from the five Sit-to-Stand (5STS), using three incre-mental loads measured by a functional electromechanical dynamometer (FEMD) in healthy young adults. Methods: The average and peak strength and velocity values of s...
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The main purpose of the present study was to determine the association of physical activity (PA) patterns prior to COVID-19 confinement with severe respiratory distress consistent with COVID-19 symptoms. Participants were recruited by sending a survey through various social network channels via the snowball method. A voluntary sample of 420 individ...
Article
A healthy lifestyle, including food habits, physical activity (PA) and screen time (ST), is an important factor for well-being. The main purpose of this study was to analyze the association between lifestyle (i.e., PA, ST and food habits), self-esteem and health-related quality of life (HRQoL). A second objective was to determine the association be...
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Background: The main purpose of the present study was to determine the socio demographic parameters associated to physical activity (PA) patterns changes during the COVID-19 lockdown in the Spanish population. Methods: Participants were recruited by sending a survey through various social network channels via the snowball method. A voluntary sam...
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Background: The aim of the present study was to determine the association between the health-related quality of life (HRQoL) with sociodemographic parameters and lifestyle during COVID-19 confinement in Mexico, Chile, and Spain. Methods: A cross-sectional pilot study, with 742 observations of online surveys in 422, 190, and 130 individuals from...
Article
Objective The purpose was to determine the association of lifestyle (i.e., Mediterranean diet [MD] adherence, physical activity [PA], screen time [ST]) and fitness with abdominal obesity (AO) and excess weight in the Chilean and Colombian schoolchildren. Research methods & procedures This cross-sectional study included 969 schoolchildren, girls (n...
Article
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Background: The reemergence of measles represents a public health problem. The aim of the study was to determine the seroprevalence of IgG antibodies against measles in children of three ethnic groups in southern Mexico and the nutritional status and demographic risk factors associated. Methods: A cross-sectional study in 416 school-age children...
Article
Rheumatoid arthritis (RA) is an autoimmune disorder that typically affects people between 23 and 60 years old causing chronic synovial inflammation, symmetrical polyarthritis, destruction of large and small joints, and chronic disability. Clinical diagnosis of RA is stablished by current ACR-EULAR criteria, and it is crucial for starting convention...
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The objective of the present study was to determine the association between lifestyle parameters (i.e., physical activity (PA) level, screen time (ST), fitness and food habits) and health-related quality of life (HRQoL) in ethnic ascendant schoolchildren (i.e., Mapuche ascendant). This cross-sectional study included 619 schoolchildren with ethnic (...
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Due to its immunomodulatory effects and the limitation in the radiological damage progression, disease-modifying antirheumatic drugs (DMARDs) work as first-line rheumatoid arthritis (RA) treatment. In recent years, numerous research projects have suggested that the metabolism of DMARDs could have a role in gut dysbiosis, which indicates that the mi...
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Mental health during the preadolescent years may be determinant for later periods of life; therefore, the factors that influence it need to be studied deeply. The aim of this study was to determine the association between depressive symptoms with physical activity (PA), body image dissatisfaction and weight status in preadolescents. A total of 269...
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The objective of the present study was to determine the association of academic performance with personal and social development indicators in Chilean schools from the results of the 2016 national education study and to determine the relationship of these results with the schools' socioeconomic background. The results from 2891 schools that partici...
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Background: feelings and behaviours are an important tool that should be considered to prevent early unhealthy lifestyles. Objective: the objective was to determine the association between feelings (i.e., sadness, loneliness, and school behaviour) with lifestyle (i.e., physical activity patterns and nutritional level), and as secondary endpoint...
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The association between the changes in lifestyle during coronavirus disease 2019 (COVID-19) confinement and body weight have not been studied deeply. Therefore, the aim of the present study was to determine lifestyle changes, such as eating habits and physical activity (PA) patterns, caused by confinement during the COVID-19 pandemic and to analyze...
Article
Introduction/objective: Paraoxonase 1 (PON1) promotes antioxidant and antiatherogenic activity related to the hydrolysis of oxidized lipids of low-density lipoproteins. In rheumatoid arthritis (RA) patients, it has been reported that low PON1 activity is related to an impaired lipid profile, increasing cardiovascular risk (CVR). The goal of this s...
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Introduction: children's food habits have an influence on physical and mental health and should be monitored. Objective: the purpose of this study was to determinate the association between children's food habits (i.e., Mediterranean diet adherence), anthropometric parameters and health-related quality of life (HRQoL) in Chilean schoolchildren....
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Patients diagnosed with diabetes mellitus must monitor their blood glucose levels in order to control the glycaemia. Consequently, they must perform a capillary test at least three times per day and, besides that, a laboratory test once or twice per month. These standard methods pose difficulty for patients since they need to prick their finger in...
Conference Paper
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Background: The risk of cardiovascular disease in rheumatoid arthritis (RA) patients is 1.5 times higher compared to the general population. Some factors relationships to cardiovascular disease in RA are high clinic activity of the disease, the autoantibodies-positive, the disease duration and pharmacological treatment 1 , as well as single nucleot...
Conference Paper
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Background The use of antirheumatic drugs is key to limit or prevent inflammation and joint damage in rheumatoid arthritis (RA). Recently, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) has been considered markers of clinical activity in RA¹, however its relationship with serological and clinical parameters in patients receiv...
Conference Paper
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Background Sarcopenia play an important role in the quality of life, morbidity and mortality of the patients, especially in who suffer chronic disease. In rheumatoid arthritis (RA) sarcopenia risk is higher due to joint dysfunction, pharmacological therapy and chronic inflammation¹; these conditions may induce changes in body composition such as an...
Article
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Objectives: Maximum oxygen consumption (VO2max ) plays a fundamental role in firefighters' occupational activities due to the high intensity tasks they perform in their professional duties. In Chile, firefighters are volunteers (non-salary) and their lack of continuous and programmed physical activity may affect their physical fitness and health....
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Escherichia coli is the main etiological agent of urinary tract infections. Its virulence factors are important during the initial interaction stage with the host as they enable colonization of urinary tract tissues. The genetic markers evidencing susceptibility to develop recurrent infections have been previously described. Toll-like receptors are...
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BACKGROUND: adequate exposure to Physical Education (PE) classes contributes to a healthier lifestyle among children during their lifespan. OBJECTIVE: the main objective of this research was to evaluate the perception of obese schoolchildren regarding their participation in PE class and to determine their self-esteem compared with overweight and n...
Article
Background /Aim: The hypertriglyceridaemic waist (HTGW) phenotype has been described and suggested in general population as a cardiovascular risk marker. The aim of the present study was to evaluate the HTGW phenotype as a marker related to HUC and MetS in rheumatoid arthritis (RA). Materials and methods This was a cross-sectional study was design...
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The hip abductor muscles are vitally important for pelvis stability, and common strength deficits can negatively affect functionality. The muscle strength can be measured using different dynamometers and be evaluated in three positions (side-lying, standing, and supine). Obtained strength data can be expressed in different ways, with data normaliza...
Data
Functional electromechanical dynamometer, Haefni Health (HHe). (JPG)
Article
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Introducción. La fibrosis pulmonar idiopática (FPI) es un tipo de enfermedad intersticial, crónica y progresiva que suele manifestarse con disnea y deterioro progresivo de la tolerancia al ejercicio y a las actividades de la vida diaria, llegando a comprometer el nivel psicológico y la interacción social. Objetivos. Seleccionar y sintetizar informa...
Conference Paper
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Background: The risk of cardiovascular disease (CVD) is increased in rheumatoid arthritis (RA); about 50% of associated deaths in rheumatoid arthritis (RA) are attributed to CVD.1 Both traditional cardiovascular risk (CVR) factors and inflammation contribute to this risk. The hyperuricemia (HUC) and metabolic syndrome (MetS) are considered paramete...
Article
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Background: Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL)-associated antioxidant enzyme with anti-atherogenic roperties. Although genetic polymorphisms are known to modulate PON-1 activity,1 other factors as the consumption of disease-modifying anti-rheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs) can also modu...
Conference Paper
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Background The hand is an anatomical structure with a large number of joints; its prehensile grasp capability constitutes a highly specialised biomechanical function. In rheumatoid arthritis (RA), the structures of the joint are damaged by the characteristic inflammatory process¹ The Disease Activity Score (DAS28) considers twenty hand joints in th...
Article
Abstract Background and objective: The treatment and care of patients with chronic diseases depends directly on the evolution of biomedical parameters. It is important to have a monitoring health care system that provides biomedical data at any time and place. Here, a multi-sensing health care monitoring system with a built-in non-invasive blood g...
Conference Paper
Introduction Bacterial vaginosis (BV) is a polymicrobial syndrome characterised by the decrease in Lactobacilli and an increase of anaerobic bacteria, mainly G. vaginalis a Gram-positive coccobacillus that is isolated in up to 98% of BV cases. This bacteria produces differents virulence factors like sialidase, succinate, biofilm formation, phosphol...
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Background: Anthropometric and blood pressure measurements are significant parameters in the assessment of cardiovascular risk (CVR). The aim was to establish the distribution of clinical-anthropometric parameters in health care workers according to the criteria established by WHO/JNC 7/ATP III. Methods: Observational, cross-sectional study in 3...
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Introducción. La obesidad infantil es un problema grave de salud pública, ya que genera resultados adversos para la salud física y mental. Objetivo. Relacionar el estado nutricional con los niveles de autoestima y rendimiento físico en escolares de 8 a 10 años de edad. Materiales y métodos. Participaron 236 escolares: 117 hombres y 119 mujeres, d...
Article
Inflammation and endothelial dysfunction are considered the primary manifestations of the cardiovascular disease. Studies have established a relationship among components of metabolic syndrome (MetS) with inflammatory markers and the loss of permeability, vasoconstriction and vasodilatation endothelial.
Article
INTRODUCTION Inflammation and endothelial dysfunction are considered the primary manifestations of the cardiovascular disease. Studies have established a relationship among components of metabolic syndrome (MetS) with inflammatory markers and the loss of permeability, vasoconstriction and vasodilatation endothelial. OBJECTIVE To determine the rela...
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Antecedentes: la prevalencia de obesidad infantil ha aumentado considerablemente en Chile y el mundo, presentando asociación negativa con el rendimiento físico. Objetivo: el propósito del estudio fue determinar el rendimiento físico en escolares y asociarlos a los niveles de sobrepeso, obesidad y riesgo cardiometabólico.Material y métodos: 342 esco...
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Obesity is associated with a state of chronic low-grade inflammation. Generally, there are significant correlations between body mass index and increased C-reactive protein levels. We investigated the relationship of high sensitivity C-reactive protein (hsCRP) levels with body adiposity distribution and blood cell count in obese children. A cross-s...
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Background: in Chile, the increase of childhood obesity has become a pandemic, and it has become a major public health problem. Objective: the purpose of this study was to determine the prevalence of malnutrition in children-adolescents and to analyze its association with cardiometabolic risk and physical performance. Material and methods: 342...
Article
Previous studies have shown that organophosphate pesticide (OP) exposure is associated with oxidative stress. Methamidophos (MET) is an OP widely used in agriculture, which is regarded as a highly toxic pesticide and it is a potent inhibitor of acetylcholinesterase. The aim of this study was to evaluate whether MET can induce oxidative stress at lo...
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The aim of this study was to investigate if anthropometric parameters are associated with both leptin and soluble leptin receptor (sLEPR) levels in newborns and their mothers. This cross-sectional study was performed in 118 mother-newborn pairs. The venous blood sample of mothers was taken before delivery and immediately after delivery an umbilical...
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Background: Diet is an important environmental factor that interacts with genes to modulate the likelihood of developing disorders in lipid metabolism and the relationship between diet and genes in the presence of other chronic diseases such as obesity. The objective of this study was to analyze the interaction of a high fat diet with the APOA2 (r...