Irina F Roshchina

Russian Academy of Medical Sciences | RAMS · Mental Health Research Centre

Introduction Patients with amnestic mild cognitive impairment (aMCI) have a high risk of transition to Alzheimer’s disease. Analysis of potential biomarkers of conversion to dementia in this clinical group is crucial for prognosis and early intervention. Objectives The aim of the pilot study was to compare whole-brain functioning characteristics (...

The aim of the study: evaluation of the impact of long-term effects of repeated courses of Actovegin therapy on indicators of minimal cognitive dysfunction (MCD) in relatives of patients with Alzheimer’s disease (AD). Study participant: 76 people with signs of minimal cognitive dysfunction objectively confirmed by clinical and neuropsychological ex...

Background : the development of programs for the correction of cognitive impairment in elderly patients with various types of mild cognitive decline is an urgent task of geriatric medicine and clinical psychology. The aim of the study was to conduct neuropsychological and psychometric evaluation of the results of a modified neurorehabilitation prog...

Objectives. To study the effectiveness of the inhibition of interfering visual stimuli using a flanker task in groups of cognitively healthy young, middle-aged, and elderly people and patients with mild cognitive impairment. Materials and methods. The rate and accuracy of responses were analyzed and a diffusion model of reaction times which extract...

The problem of preventing factors associated with the risks of cognitive decline and hindering active longevity in old age is becoming increasingly important. According to the United Nations in 2019, about 10% of the total population in the world is over the age of 65, and by 2050 this figure will already be 20%. The syndrome of mild cognitive decl...

The aim was to study immediate and long-term (post-therapeutic) effects of a three-month course of therapy with citicoline in 1st-degree relatives of patients with Alzheimer’s disease (AD). All the included relatives of patients with AD revealed signs of minimal cognitive dysfunction (MCD) and mild cognitive decline syndrome (MCI — Mild Cognitive I...

The article is devoted to the traditional conference on clinical psychology held on November 25-26, 2021 in Moscow for the third time. The Conference was dedicated in the memory of Susanna Yakovlevna Rubinstein. A hybrid format of the conference is described, a wide geography of participants from Russia and abroad is shown, detailed topics of the p...

The aim of the paper was to provide an overview of the reports presented at the congress on the main problems of clinical and biological psychiatry . Discussion and conclusion : A representative forum of domestic psychiatrists and narcologists, psychotherapists and psychologists, organizers of psychiatric care and the leading scientists in the fi e...

Objective: To study the effectiveness of interfering visual stimuli inhibition using the flanker task in a group of healthy young and healthy old participants, and in a group of participants with mild cognitive impairment (MCI). Material and methods: Reaction times and accuracy, as well as the diffusion model of reaction times with parameters re...

Objective: To study the effects of a three-month course of therapy with citicoline, aimed at preventing the progression of cognitive deficit in 1st-degree relatives of patients with Alzheimer's disease (AD), depending on the carriage of the ApoE4(+) genotype. Material and methods: Study participants: 82 blood relatives of AD patients, 66 of them...

The article shows the influence of pen calligraphy classes according to the method of Ya. A. Galeeva "School of Russian Calligraphy" on the cognitive sphere of younger schoolchildren with learning difficulties. The authors present the results of an experiment conducted by them in 2018-2019 in two schools in Moscow (the average age of children is 8...

Task switching performance was assessed in a group of healthy young, healthy old, and MCI-diagnosed participants. Highly significant RT-related local switch costs were found in the MCI group. This contrasts the typical finding that in normal aging local switch costs show no age-related deficit. Local switch costs deficits may be a diagnostic tool i...

Conflict adaptation effect in interference control tasks (like Stroop task or flanker task) consists in better interference suppression in incongruent trials following an incongruent trial. In a flanker task is shown that in normal cognitive aging there is a null conflict adaptation effect and that in mild cognitive impairment there is a reversed (...

The article is dedicated to the 80th anniversary of the outstanding Russian scientist, follower of B.V. Zeygarnik and A.R. Luria, a classic of Russian neuropsychology and neuroherontology, a representative of the Moscow school of psychology Natalya Korsakova, her scientific biography is traced, a significant contribution to the development of psych...

Aim: To evaluate the efficacy of course neurotrophic therapy with cerebrolysin in a group of first-degree relatives of Alzheimer's disease (AD) patients who had minimal cognitive dysfunction. Material and methods: Sixty-seven relatives (mean age 57.6±14.2 y.o.) received cerebrolysin in the dose of 20 ml/day in intravenous drips in 100 ml isotoni...

The article is devoted to the results of the All-Russian Scientific and Practical Conference with International Participation held on May 18-19, 2017 in St. Petersburg, dedicated to the 160th anniversary of the birth of V.M. Bekhterev and the 110th anniversary of the St. Petersburg Psycho-Neurological Research Institute named after V.M. Bekhterev.

We report a family case of type II early-onset Alzheimer's disease (AD) inherited over three generations. None of the patients in the family had mutations in the genes believed to be the major risk factors for AD, such as APP, presenilin 1 or 2. Targeted exome sequencing of 249 genes that were previously reported to be associated with AD revealed a...

Cognitive and noncognitive spectrum impairments were studied in first-degree relatives of patients with Alzheimer’s disease (AD). A total of 134 relatives (mean age 47.6 years) were studied, of which 110 were children of probands and 24 were sisters or brothers. A high incidence of cognitive and noncognitive spectrum mental impairments was found in...

Efficacy of actovegin was investigated in the treatment of mild cognitive impairment (MCI) of cerebrovascular genesis. Thirty patients (7 men and 23 women, mean age 71.2 years) received actovegin intramuscularly in dosage 5 ml (200 mg) daily during 4 weeks. Patient's were assessed before and after treatment using CGI and MMSE, verbal association te...

Neuropsychological syndrome was defined in 94 patients with mixed Alzheimer's/vascular dementia, 75 patients with vascular dementia and 114 patients with Alzheimer's disease (AD) without clinical signs of cerebrovascular disease. Based on this data, the authors singled out main components of neuropsychological disorders in mild and moderate mixed d...

Mental disorders of cognitive and non-cognitive spectrum in the first-degree relatives of patients with Alzheimer's disease (AD) were studied in 134 relatives, mean age 47.6 years, including 110 children and 24 siblings of probands. Compared to the age-matched controls (22 normals without relatives with AD), the higher frequency of the following me...

Studies were performed in three Russian centers (Moscow, St. Petersburg, Nizhnii Novgorod). The cohort consisted of 110 patients whose mental state corresponded to the concept of "mild cognitive impairment" (MCI). Patient status was assessed using widely accepted scales (MMSE, GDS, CDR, etc.) and a battery of neuropsychological tests. ApoE genotype...

Efficacy, safety and tolerability of acetyl-L-carnitine (ALC) were studied during the double-blind placebo-controlled 12-week trial in patients with mild (initial) dementia caused by the Alzheimer's disease (AD) and vascular dementia (VD). ALC was administered in doses from 2250 to 3000 mg per day. Patient's state was assessed with some scales (MMS...

The study was conducted in 3 Russian centers (Moscow, St. Petersburg and Nizhniy Novgorod). The total sample included 110 patients whose mental state met the definition of (MCI). Patient's status was assessed with widely used scales (MMSE, GDS, CDR etc) and a battery of neuropsychological tests. Genotyping for the APOE polymorphism was performed as...

By applying the neuropsychological approach, the authors describe the specific features of cognitive activity in normal aging on the brain structural and functional model as described by A.R. Luria. Four variants of normal aging are identified. Clinical and neuropsychological syndromes are shown in presenile (early) and senile (late) types of Alzhe...

The authors suggest a new express-method for assessment of memory and intellect in the late age. This method allows to assess not only disturbed functions but also the intact patterns of mental processes and to conduct a quantitative assessment as well as a qualitative (syndrome) analysis of mental activity changes using a Luria's structural-functi...

The psychopathological structure and prognostic significance of mild cognitive impairment syndrome (MCI) were studied in a two-year prospective study of randomized cohorts of elderly subjects whose mental state corresponded to the criteria for MCI. A total of 40 patients aged from 50 to 80 years were studied. Patients underwent clinical history-tak...

A potential of prolonged 2-years course of cerebrolysin therapy with courses repeated every 6 months to slow down or prevent the transition of the syndrome of mild cognitive impairment, amnestic type, to clinically relevant dementia has been studied in the open comparative study of 73 patients divided into 2 groups, one of which included patients t...

Structure and prognostic significance of the syndrome of mild cognitive impairment (MCI) were studied in a prospective biennial study of a randomized cohort of elderly people meeting current MCI criteria. The study comprised 40 patients aged from 50 to 80 years. Clinical follow up study included psychopathological, psychometric, neuropsychological,...

Clinical efficacy and safety of tanakan has been studied in 30 patients with the syndrome of mild cognitive impairment. The results suggest a clear therapeutic effect of the 6 month course therapy. The efficacy of tanakan was confirmed by significant improvement of cognitive functioning of patients measured with MMSE, MDRS, FAST and other scales. T...

An open comparative randomized clinico-neuropsychological study of 4 cerebrolysin treatment courses was conducted during 19 months. The differences in long-term effects of different medication dosages (10 and 30 ml) were revealed. The higher cerebrolysin dose was more effictive for cognitive functioning of patients. In patients receiving a dosage o...

Increased central-parietal EEG theta-2 activity (about 6.5 per sec) was found in children with cognitive disorders (in Rett's syndrome, fragile X-syndrome, infantile autism) and in elderly patients with Alzheimer-type dementia (with prevalence of neuropsychological "frontal" disorders) in the presence of suppressed alpha rhythm. This theta-activity...

Correlations between the impairments of higher cortical functions (assessed by clinical scores and neuropsychological tests) and multichannel EEG spectra were analyzed in elderly patients with mild dementia and children with cognitive problems. A decrease in the regional cerebral blood flow, an imbalance between neocortical and limbic structures, a...

The paper presents a study concerning an influence of cerebrolysin on the efficiency of subsequent therapy with amiridin in patients with mild and moderate dementia of Altzheimer's type (DAT). A study included 2 groups of patients similar in terms of clinical and demographic parameters. The patients of group 1 (23 cases) were treated by amiridin in...

Clinical neuropsychologic investigation was performed in 95 patients of elderly and senile age with mild dementia: 20 individuals with Alzheimer's disease (AD), 25 patients with senile dementia of Alzheimer's type (SDAT), 25 patients with vascular dementia (VD) and 25 patients with combined dementia of vascular and Alzheimer's types (DAT/VD). Clini...

The investigations of recent years have shown that the neuropsychological method which has been developed on the basis of the syndromal analysis of local brain pathology makes it possible to identify the functional insufficiency of specific areas of the brain, as well as diffuse cerebral pathology. The great sensitivity of the neuropsychologieal me...

A total of 160 patients with Alzheimer-type dementias (ATD), including 84 with Alzheimer's diseases (AD) and 76 with senile dementia (SD), were examined. The initial signs of the disease were analyzed by making a retrospective assessment of informative history data. The prospective follow-up involved clinical, neuropsychological and electrophysiolo...

A comparative neuropsychological study was made of the two groups of patients: with Alzheimer's disease [AD] (n = 40) and senile dementia [SD] (n = 54). The correlation and role of different factors in the formation of syndromes of higher mental functions (HMF) impairment in AD and SD were determined. The analysis was based on the concept of the pr...

Using clinico-psychopathological, clinico-neuropsychological and computer-aided tomography approaches, material differences were ascertained between groups of patients with Alzheimer's disease (AD) and senile dementia (SD) in terms of the clinical parameters, including the age at which the disease sets in; the disease standing; the build-up feature...