Irina Rais

Irina Rais
University of Cologne | UOC · Department of Chemistry

Bachelor of Science

About

6
Publications
1,569
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Citations

Publications

Publications (6)
Article
With the rise of synthetic biology, dual-use research risks are not confined to pathogen-related research. However, existing measures to mitigate the risks of dual-use research, such as export control, are still designed to hinder access to pathogens and do not address the risks of nonpathogen-related dual-use research. The current self-regulatory...
Article
Full-text available
Although synthetic biology and biological engineering are often portrayed as emerging disciplines, there is over a decade of experience in their interactions with biosecurity. The International Genetically Engineered Machine competition (iGEM) brings together nearly 6000 students on multidisciplinary teams to engineer biology following synthetic bi...
Poster
Full-text available
Final project poster from team Bielefeld-CeBiTec 2018 (nanoFactory) for the presentation at the iGEM Giant Jamboree 2018 from October 24th to 28th in Boston, Massachusetts, USA.
Presentation
Full-text available
A set of presentation slides to give an overview on the topics Biosecurity, Dual Use and Dual Use Research of Concern (DURC). We encourage everyone to use the open source slides to spread awareness and prevent issues concerning this topics.
Poster
Full-text available
Nanoparticles can be used for a wide range of applications. Especially if used in the medical field they need to be free from toxic chemicals, which are used in the conventional way of nanoparticle formation. Therefore, our goal is to use synthetic biology to create a way of generating environmentally friendly nanoparticles. Our Escherichia coli ta...
Poster
Full-text available
Nanoparticles can be used for a wide range of applications. Especially if used in the medical field they need to be free from toxic chemicals, which are used in the conventional way of nanoparticle formation. Therefore, our goal is to use synthetic biology to create a way of generating environmentally friendly nanoparticles. Our Escherichia coli ta...

Projects

Project (1)
Project
Copper, silver and gold - metals are essential for our daily life but resources are dwindling. Industrial mining of metals and electronic waste cause pollution of the environment. Therefore, we established new approaches to recover valuable resources through synthetic biology. By enhancing bacterial abilities to scavenge metal ions from the environment we generated nanoparticles. We optimized Escherichia coli to accumulate metal ions as copper and iron by overexpression of dedicated importers and silencing of exporters while reducing the effects of oxidative stress. To gather nanoparticles from various metal ions we engineered the iron storage protein ferritin. Recycled into nanoparticles the metals could be used for various applications as demonstrated by printing electronics. Considering Dual Use aspects we decided to extract metal ions from pit water instead of dissolving electronics directly. Therefore, in close collaboration with leading experts we developed a customized cross-flow bioreactor for the mining industry.