Irina Huica

Irina Huica
Stefan S. Nicolau Institute of Virology (IVN) | IVN · Molecular Virology

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37
Publications
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314
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Publications

Publications (37)
Article
Full-text available
Objective: Laryngeal cancer is the second most common malignancy in the head and neck, with Epstein-Barr virus infection as a risk factor. Our aim is to evaluate correlations between the expression of lncRNA H19 and EBV infection in laryngeal cancer and H19 involvement in neoplastic progression through EZH2 association. Materials and methods: 30...
Article
Purpose: DNA methylation plays an important role in thyroid oncogenesis. The aim of this study was to investigate the connection between global and local DNA methylation status and to establish the levels of important DNA methylation regulators (TET family and DNMT1) in thyroid tumours: follicular adenoma-FA, papillary thyroid carcinoma-PTC (class...
Article
In this study several non-invasive and minimally-invasive techniques were employed for the discovery of the original aspect of an old iconostasis belonging to a small wooden church in Vâlcea County (southern Romania). Preliminary examination of the iconostasis raised suspicions upon its actual age, the wooden carved decorations style pointing towar...
Article
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The sudden outbreak of the 2019 novel coronavirus "Severe Acute Respiratory Syndrome coronavirus 2” (SARS-CoV-2) in Wuhan, China, has affected the healthcare system and economy by its rapidly worldwide spreading. The present review intends to describe some of the current molecular and immunological assays used in SARS-CoV-2 detection from an epidem...
Article
Full-text available
The aim of the study was to assess the role of behavioral factors in persistence of human papillomavirus (HPV) genital infection. Out of a cohort of 605 women included in a study of HPV infection prevalence, 142 HPV positive women (aged 18-57) were retested after a 12-month interval. None of the patients underwent surgical treatment during that per...
Article
Full-text available
Introduction: Romania has the highest incidence and mortality rate of cervical cancer in Europe. The objective was to estimate the prevalence of high-risk human papillomavirus (hrHPV) genotypes and to evaluate the role of certain socio-behavioral factors in acquiring viral infection, in a cohort of Romanian women with negative Pap. Methodology:...
Article
Background: Thyroid carcinoma is the most common endocrine malignancy worldwide. Changes in DNA methylation can cause silencing of normally active genes, especially tumour suppressor genes (TSG) or activation of normally silent genes. Objective: The aim of this study is to evaluate the degree of promoter methylation for a panel of markers for th...
Article
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Recently long non-coding RNAs were identified as new factors involved in gene expression regulation. To gain insight into expression pattern of these factors related to E7 HPV18 oncogene, this study uses HeLa cell culture transfected with E7-siRNA. Gene expression profile was investigated using microarray analysis. After analysing the microarray re...
Article
Epidemiologic data confirmed high-risk human papillomaviruses as etiological agents of cervical cancer. On the other hand genetic and epigenetic modifications are known to play an important role in carcinogenesis. Histone lysine-specific demethylases (KDMs) have been shown to contribute to development and progression of many types of cancer. We eva...
Article
With over 180 million people affected worldwide, hepatitis C is considered a global problem. In order to establish chronic infections, the virus interferes with cellular mechanisms coordinated by cytokines' network. Chronic HCV infection is associated with oral manifestations including periodontal disease. The aim of this study was to evaluate the...
Article
Full-text available
Human papilloma virus (HPV) may cause mostly transient infections of cutaneous and mucous epithelia. Persistent HPV genital infections may induce pre-malignant or malignant lesions. While E6 and E7 HPV genes' malignant character is known, E5 is still under debate. We evaluated the possible role of E5 gene in cervix oncogenesis, in patients with abn...
Article
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Recent works focus on the role microRNAs (miRNAs) play in regulation of cardiovascular pathology. One of the miRNAs highly expressed in cardiovascular system is miR-21. The aim of this study was to investigate the relationship between the expression level of miR–21 in cardiac disease and correlate with TGF-β1, one of its targets. Methods: Plasma sa...
Article
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The aim of this study was to identify and associate the sequence variations of human Papillomavirus 16 (HPV16) genes from women who live in two different areas of Romania and associate them with malignant progression. One hundred twenty-four HPV16-positive cervical isolates were collected, and the E2, E4, E5, E6 and E7 viral genes were sequenced. T...
Conference Paper
Introduction: In human cancer cells DNMTs are responsible for both de novo and maintenance methylation of tumor suppressor genes. Many studies have analyzed the relationship between the altered expression of DNMT1 and DNA methylation in cancer. Aim: To analyze DNMT1 expression in thyroid papillary carcinoma. Design: 49 patients aged 10–82 years h...
Article
Introduction: In human cancer cells DNMTs are responsible for both de novo and maintenance methylation of tumor suppressor genes. Many studies have analyzed the relationship between the altered expression of DNMT1 and DNA methylation in cancer. Aim: To analyze DNMT1 expression in thyroid papillary carcinoma. Design: 49 patients aged 10–82 years hos...
Article
Full-text available
The aim of this study was to investigate the role of methylenetetrahydrofolate reductase (MTHFR) polymorphisms and MTHFR methylation pattern in cervical lesions development among women from Romania, a country with high prevalence of human papillomavirus (HPV) cervical infections. To achieve this goal, blood samples and cervical cytology specimens (...
Article
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Cardiovascular disease represents a major cause of mortality worldwide but the genetic and epigenetic mechanisms involved are not entirely known. Atherosclerosis plays a major role, often leading to ischemic heart disease and stroke. Many studies linked the evolution of atherosclerosis with genetic factors but only a small number of them are well c...
Article
Infection with human papilloma virus (HP V) is the main cause of cervical cancer. Host genetic alterations, like modifications of gene expression levels can be induced as a response to the viral infection. Kruppel-like factor 5 (KLF5) is a transcription factor that has been implicated in pathways critical to carcinogenesis. Controversy persists as...
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Anton G, Peltecu G, Socolov D, Cornitescu F, Bleotu C, Sgarbura Z, Teleman S, Iliescu D, Botezatu A, Goia CD, Huica I, Anton A-C. Type-specific human papillomavirus detection in cervical smears in Romania. APMIS 2010. Although Romania has one of the highest incidence of cervical cancer in Europe (30 new cases/100 000 women), little is known about t...
Article
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Cervical cancer is a leading cause of mortality in women. Molecular and epidemiological data have unequivocally confirmed that high-risk human papillomaviruses (HPVs) are a major etiological agent of this malignancy, as host epigenetic alterations are induced in response to viral infection. The present study evaluated the methylation status of CpG...
Article
Full-text available
High risk human papillomaviruses (hr-HPV) are known to be the etiological agents of cervical cancer disease. On the other hand, other cofactors are considered to be important in cervix carcinogenesis. Mutations in mitochondrial DNA (mtDNA) as well as alterations in mtDNA content have been reported in numerous cancers examined to date. The D-loop re...
Article
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Human papillomaviruses (HPV) are considered the etiological agents of cervical cancer, especially high-risk genotypes. TGF-beta (transforming growth factor-beta) is well known for its anti-proliferative effects but the neoplastic cells often lose their sensitivity to TGF-beta. A characteristic alteration associated with malignant progression is the...
Article
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Unlabelled: The aim of this study was to investigate the correlation of p161NK4a expression levels with the cytological group of cervical carcinogenesis (NILM, ASCUS, LSIL, HSIL, cancer groups), in order to establish its value as potential diagnostic marker. Methods: The smears obtained from 50 women with/without suggestive HPV infection patholo...
Article
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Unlabelled: Cervical cancer remains one of the most important mortality causes worldwide. It is already known that high risk HPV (HR-HPV) has the main role in the development of pre- or cancerous lesions. Despite the fact that many studies focused on the HR-HPV viral loads as possible biomarkers, the viral load quantification utility for all HR-HP...
Article
Full-text available
The etiological role of high-risk human papillomavirus (HPV) in invasive cervical cancer has been demonstrated by epidemiological and molecular studies. In HPV-associated cervical carcinomas, the expression/ function of p16 is impaired by the action of viral E6 and E7 oncoproteins. In order to evaluate the potential of p16INK4a and E4 HPV16 mRNA as...
Article
High risk human papillomaviruses (HPV) are known to be the etiological agents of cervical cancer disease, but other cofactors are considered to be important in cervix carcinogenesis. In order to evaluate the role of Epstein-Barr Virus (EBV) and Chlamydia trachomatis infections in cervical carcinogenesis, cervical smears collected in liquid cytology...
Article
Full-text available
HPV (human papillomavirus) infection is associated with cervical carcinogenesis through an interaction between HPV oncogenic proteins and cell cycle regulators. However, the exact pathogenic mechanisms are not determined yet and therefore in the present study we evaluated the possible role of A1, B1, D1, E1 cyclins in a cohort of cervical cancer an...

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