Irina Gravel

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• Professor
• Professor (Full) at Sechenov University

Introduction. Analysis of mineral content of food and cultural medicinal plants is necessary in the quality assessment. Quantity and essential trace elements may do complexes with biological active substances in the plants and effect at the food nutritional value and pharmacological effects. Vac-cinium myrtillus and Caucasian endemic V. arctostaphy...

Introduction. Currently, medicines based on antler raw materials are gaining popularity due to their rich biological composition and biostimulating ac-tivity. However, these drugs must be safe for medical use, so it is necessary to study their mineral composition. The aim of the study – to determine the mineral composition, including heavy metals a...

Introduction. Liquid dosage forms based on medicinal plant raw materials are very convenient to use and must meet safety requirements. In the context of harmonization of pharmacopoeial requirements, determining the total content of heavy metals in tinctures is not enough. Risk assessment is necessary to calculate the permissible concentrations of h...

Introduction. Extraction dosage forms based on medicinal plant materials are very popular for medical use and must meet safety requirements. As part of the harmonization of pharmacopeial requirements, determining the total content of heavy metals in dry extracts is not enough. It is necessary to unify methods for determining heavy metals and arseni...

Introduction. Determination of pesticide residues presence in herbal plants and preparations based on them is an important step in confirming safety at the stage of the quality control of herbal plants. The usage of organophosphate pesticides (OPs) for the purposes of treatment of medicinal plants in the growing process is increasing. Scientific so...

Introduction. The secretome of mesenchymal stem cells (SMSC) is widely used in medicine. It is most often used due to its immune-modulating and regenerative properties in the treatment of autoimmune, immuno-mediated and other diseases due to its anti-inflammatory, neuroprotective and regenerating action. In many studies, exosomes isolated from SMSC...

Introduction. Aflatoxins and ochratoxin A are secondary metabolites of microscopic mold fungi. They seriously threaten human and animal health. These toxins are carcinogenic, teratogenic, hepatotoxic, nephrotoxic substances. International Agency for Research on Cancer (IARC) has classified them as class IA and IIB carcinogens. The maximum permissib...

SCIENTIFIC RELEVANCE. The influence of anthropogenic factors on the content of toxic elements in plants increases the need for monitoring the content of toxic elements in medicinal plant raw materials and the corresponding herbal medicinal products. In addition, studying the elemental composition of herbal medicinal products will help determine the...

Scientific relevance. In the context of pharmacopoeial harmonisation, the available methods for quantifying the total heavy metal content in tinctures are not sufficient to demonstrate the safety of liquid dosage forms based on herbal drugs. However, the establishment of individual limits for the heavy metal content requires analysing the patterns...

Актуальность. В растениях марганец, цинк и медь находятся в биологически доступных формах, которые легко усваиваются при приеме лекарственных растительных препаратов. Однако лекарственные растительные препараты не рассматриваются как источник минеральных веществ. Цель исследования – изучение содержания марганца, цинка и меди в грудном сборе № 4 и е...

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), known to cause the coronavirus disease 2019 (COVID-19), was declared a pandemic in early 2020. During the past time, several infections control methods have been developed. Nevertheless, all of them have certain limitations: uncertainty in duration, limited efficacy of vaccines, and...

Herbal drugs and herbal medicinal products remain of interest to Russian researchers both in terms of the development, efficacy, and safety of medicines, and in terms of the research methodology applicable to these medicine, as well as the use of new analytical methods expanding the boundaries of contemporary science and medicine. In this interview...

Introduction. Trace elements are an essential part of the human body, but about 80 % of the human population notes an imbalance in their content. Medicinal plants contain minerals in an accessible and digestible form together with biologically active substances. Medicinal herbal preparations are very popular for the prevention and as part of the co...

A combination of TLC‐bioautography, MALDI‐TOF‐MS and LC–MS/MS methods was used to identify flavonoids with anti‐α‐amylase activity in extracts of Lathyrus pratensis L. (herb), L. polyphillus L. (fruits), Thermopsis lanceolata R. Br. (herb) and S. japonica L. (buds). After the TLC‐autobiography assay, substances with anti‐amylase activity were ident...

The roots of licorice (Glycyrrhiza glabra L.) have been widely used in traditional and officinal medicines for the treatment of different diseases. Natural deep eutectic solvents (NADES) have become popular for the extraction of active principles from medicinal plants. However, the ability of NADES to co-extract trace elements during the isolation...

Introduction . Usage of organophosphate pesticides (OPPs) in agriculture, including farming of medical herbs, is a necessary measure for producing regular harvest. In order to maintain an adequate degree of herbal medicines security a variety of countries developed normative documents that regulate the limits of proportion of pesticides (including...

To ensure the safety of herbal medicinal products, particularly in liquid dosage forms, it is necessary to control environmental toxins to acceptable levels. However, there is no methodology for individual elemental impurities in tinctures. The aim of the study was to select sample preparation conditions for quantitative determination of heavy meta...

The article discusses the clinical and pathogenetic features of cough in patients with coronavirus disease 2019 as a symptom caused by virus-induced damage to respiratory epithelium, olfactory nerve receptor system, and the central regulation of cough reflex. Recommendations on choice of herbal medicines and mucolytic agents are given.

Medicinal plant raw material contains not only biologically active substances but also mineral elements. Currently, medicinal herbal preparations as sources of macronutrients are practically not studied. The aim of the research is to study the amount of macronutrients that can promote to manifestation of therapeutic effects on the example of a pect...

Herbal medicinal products (HMPs) are widely used in medical practice due to their availability, ease of use, and relatively safe pharmacological profile. However, medicinal plants are capable of accumulating heavy metals and arsenic which can have toxic effect on the human body when found in HMPs. The aim of the study was to summarise and analyse req...

Two methods were compared to select the optimum sample-preparation option for determining the heavy-metal contents in fatty oils. The first (GOST 26929–94) employed extraction of the metal ions from an oil sample by refluxing aqueous HCl solution. The second (European Pharmacopoeia, 8th Ed.) employed complex oxidative thermal destruction of an oil...

The article presents the results of a qualitative and quantitative analysis of the content of heavy metals in herbal medicinal products used in Ayurveda.

Moringa oleifera is widely used in Asia and Africa as an anti-inflammatory, anti-diabetic, and cold agent. However, there are no Moringa medicines on the Russian pharmaceutical market; therefore, it is of interest for research as a promising source of raw materials and introduction to the State Pharmacopoeia of Russian Federation. This study was c...

Introduction: Aflatoxin B1 (AFB1) is a toxic low-molecular-weight secondary metabolite of Aspergillus flavus and A. parasiticus. AFB1 was classified as a Group I carcinogen by the World Health Organisation for Research on Cancer in 1993. AFB1 is an unavoidable natural contaminant of some herbal medicine, able to cause serious health issues for hum...

Introduction. There is steady upward trend in demand for herbal formulation necessitates the expansion of their range. Recent studies have shown that one of the promising research direction is the development of herbal collection based water-soluble dry extracts. Pectoral species № 4 is one of the most popular among multi-component herbal preparati...

The chemical composition of Asparagus racemosus roots is studied by the methods of gas chromatography and high-performance liquid chromatography. Marker substances characteristic of this type of raw materials are revealed. The dioscin content in the roots of A. racemosus is quantitatively determined.

The aim of the investigation was to study in experiment total toxicity and immunological safety of a novel domestic therapeutic vaccine against recurrent respiratory papillomatosis and anogenital condylomatosis, the vaccine injected intramuscularly. Materials and Methods. We studied acute toxicity of the vaccine by the following parameters: clinica...

Development of therapeutic vaccines directed on induction of specific T-cell immune response against human papillomavirus early oncoprotein E7 is required for monitoring and suppression of infectious agent in invaded organism. Available techniques for vaccine efficacy testing based on experimental animal models would not result in relevant informat...

Data concerning selection and validation of analytical methods for quality assessment of recombinant proteins used for preparation of therapeutic vaccine against recurrent respiratoiy papillomatosis and anogenital condilomatose are represented. Selection of methods for purity, homogeneity and identity estimation of recombinant proteins containing d...

The content of polychlorobiphenyls (PCBs) in 129 samples of raw medicinal plant materials collected in the Rubtsovsk Region of the Altai Territory was determined by methods of capillary chromatography and gas chromatography/mass spectrometry (GC/MS) using an HP 5890A gas chromatograph equipped with an HP 5972A mass-spectrometric detector and an aut...