Irin Dewan

University of Asia Pacific · Department of Pharmacy

The purpose of the present work was to prepare and evaluate olmesartan-loaded non-ionic surfactant vesicles (niosomes) to get sustained release by increasing the solubility and bioavailability. Ether injection and thin-film hydration methods were used for the preparation of all formulations as per the factorial design to study the effect of the thr...

Niosomes

Microspheres

The purpose of this study was to formulate and investigate metoprolol tartrate (MT) loaded non-ionic surfactant vesicles using 2 3 factorial designs. Preparation of niosomal drug delivery of MT increased its bioavailability which led to being better therapeutic effects, reduced the frequency of dosing and decreased side effects of hypertensive pati...

A simple, selective and rapid reversed phase High Performance Liquid Chromatographic (RP-HPLC) method for the analysis of atorvastatin in self emulsifying drug delivery system (SEDDS) has been developed and validated. The chromatographic system consisted of a LC-20 AT pump, SPD-20 A UV/visible detector. The separation was achieved from C 18 column...

Aim: The aim of this work was to increase the bioavailability of linagliptin, a BCS class-III drug, by improving permeability. For this purpose, linagliptin loaded different non-ionic surfactant vesicles were formulated and evaluated using statistical optimization. Methods: Two independent variables selected were surfactant span 60 (X1), cholestero...

A convenient and rapid reverse phase-HPLC (RP-HPLC) method has been developed and validated for simultaneous estimation of rosuvastatin (RSV) and glibenclamide (GBC) according to international conference on harmonization (ICH) guideline. The separation of these two drugs was attained on C 18 (ZORBAX Eclipse Plus 4.6 mm×150 mm, 5μm) with isocratic m...

The present experiment shows how clinically two important drugs, amlodipine besylate (AB) and benazepril hydrochloride (BH), bind with serum protein and their mutual effect to displace each other from their binding sites. Binding chemistry of amlodipine besylate and benazepril hydrochloride to bovine serum albumin (BSA) was evaluated by equilibrium...

Objective: The aim of the current exploration is to formulate and evaluate the metformin and glipizide, both are type II anti-diabetic agents, loaded microspheres with an objective to sustained release as well as improve bioavailability. Materials and method: Microspheres were prepared by solvent evaporation method using different rate retardant po...

The present study has been performed to microencapsulate the antidiabetic drug of Vildagliptin to get sustained release of drug. The attempt of this study was to formulate and evaluate the Vildagliptin loaded microspheres by emulsion solvent evaporation technique using different polymers like Eudragit RL100, Eudragit RS100, Ethyl cellulose, and Met...

Glibenclamide is an oral anti-hyperglycemic agent designed intended for the management of non-insulin-dependent diabetes mellitus (NIDDM). In certain conditions conventional drug release pattern is not suitable similar to Diabetes mellitus, cardiovascular diseases and many more diseases, this present study has taken a challenge to formulate control...

The rationale of the present study was to design and prepare a combination product of naproxen and esomeprazole tablet by layer by layer tableting method. In this method shellac, cellulose acetate phthalate, methacrylic acid (copolymers), polyvinyl acetate phthalate and hypromellose phthalate were used as an enteric coating agent, to provide delaye...

Objective: The attempt of the present study was to improve bioavailability and dissolution rate along with reduction in dosing frequency of Zidovudine from microspheres. Methods: In this study an effort was taken to devise and evaluate Zidovudine sustained release microspheres using different polymers such as Ethyl cellulose (EC), Eudragit RS100, H...

Objective: The attempt of the present study was to improve bioavailability and dissolution rate along with reduction in dosing frequency of Zidovudine from microspheres. Methods: In this study an effort was taken to devise and evaluate Zidovudine sustained release microspheres using different polymers such as Ethyl cellulose (EC), Eudragit RS100, H...

Metronidazole (MTZ) has extremely broad spectrum of protozoal and antimicrobial activity and is clinically effective in trichomoniasis, amoebic colitis, and giardiasis. This study was performed to formulate and evaluate the MTZ loaded microspheres by coacervation phase separation and surface deposition and coalescence methods using different polyme...

The aspire of this attempt was to design and evaluate aceclofenac loaded sustained release microspheres by emulsion solvent evaporation method, using different polymers like Ethyl cellulose (EC), Kollidon SR (KSR), Eudragit RS 100, Eudragit RL 100 and Hydroxypropylmethyl Cellulose (HPMC K100M). Microspheres were prepared using different stirring ra...

Bi-layer tablet is a new era for winning development of controlled release formulation along with various features to provide successful drug delivery. Bi-layer tablets can be crucial option to avoid chemical incompatibilities between active pharmaceutical ingredients (APIs) by physical separation and to facilitate the development of different drug...

The present study was designed towards the design and development of fast disintegrating tablets by direct compression technology using Ranitidine HCl as a model drug. Fast disintegrating tablet of Ranitidine HCl was formulated using two Superdisintegrants in different concentrations i.e. 30 mg and 35 mg. Kollidon CL and Sodium Starch Glycolate are...

In this study solid dispersion (SDs) of gliclazide were prepared by solvent evaporation technique using poloxamer 407 as carrier. Drug carrier weight ratio were 1:1, 1:3 and 1:5. Physical mixtures of the same ratio were also prepared for comparison. The solid dispersions were investigated for drug loading and dissolution behavior and were found eff...

Bi-layer tablet technology for bimodal release of drug and co-administration of drugs via oral route has been engaged a significant place in the field of drug delivery technology. At present, several pharmaceutical companies are developing bilayer tablet for co-administration of drugs to improve the therapeutic efficacy as well as to reduce the cha...

A simple, reproducible and efficient reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for quantitative determination of azithromycin in drug substance. The separations were carried out on a Xterra C 18 column (150 ×4.6 mm; 5µ) with UV detection at 215 nm. The mobile phase consisting of acetonitrile and phos...

The aim of our study was to improve the dissolution of Tramadol hydrochloride (TH) via its semisolid filled lipid based capsules. Sustained release formulation is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. Semisolid matrixes of TH were...

Four Bangladeshi medicinal plants Withania somnifera, Terminalia arjuna, Moringa olifera and Asparagus racemosus have been investigated for their in vitro thrombolytic and membrane stabilizing. Among the four plants, the methanol extract of W. somnifera exhibited highest thrombolytic activity with clot lysis value of 36.50%. Standard streptokinase...

This paper describes the evaluation of the in vitro equivalence of tablets containing a poorly water-soluble compound, ator-vastatin, marketed in Bangladesh under biowaiver conditions. Drug release was compared with that of a reference product. The in vitro equivalence test was carried out in three different media (pH 1.2, pH 4.5, and pH 6.8). Test...

This paper describes the evaluation of the in vitro equivalence of tablets containing a poorly water-soluble compound, ator-vastatin, marketed in Bangladesh under biowaiver conditions. Drug release was compared with that of a reference product. The in vitro equivalence test was carried out in three different media (pH 1.2, pH 4.5, and pH 6.8). Test...

Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; however in many cases immediate onset of action is required than conventional therapy. There are novel types of dosage forms that act very quickly after adminstration. The basic approach used in dev...

Purpose: In the present study, a simple liquid chromatography (RP-HPLC) method has been developed and validated for the analysis of marketed ciproxacin tablets. Methods: HPLC method was validated for the parameters like system suitability, selectivity, linearity, accuracy, precision and robustness. Dissolution study was done in hydrochloric acid so...

In this study binary and ternary solid dispersions (SDs) of spironolactone were prepared by solvent evaporation technique using Poloxamer 407, kollicoat IR, kollidon VA 64 and PEG 6000 as carrier. In binary solid dispersion drug –carrier weight ratio was 1:5, 1:10, 1:15 and 1:20. In ternary solid dispersions drug was dispersed with mixture of PEG 6...

The objective of the study was to improve the aqueous solubility and dissolution of carbamazepine, a poorly water soluble anti-epileptic drug by solid dispersion technique, using water soluble polymers. Solid dispersion of drugs was prepared by physical mixing, fusion and solvent evaporation method. The drug along with the polymers was heated first...

In this study quality performance of four immediate release and three extended release acetaminophen tablets were evaluated by using in vitro dissolution and drug content studies. Other general quality parameters of these tablets like weight variation, hardness, friability, disintegration time were also determined according to established protocols...

The main objective of study was to formulate SEDDS of Spironolactone in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. SEDDS are isotropic mixtures of oils and surfactants, sometimes containing cosolvents. The present research work describes a Self Emulsifying Drug Delivery System (SEDDS) of S...

In this study quality performance of acetaminophen tablets were evaluated by using general quality parameters of these tablets like weight variation, hardness, friability, disintegration time were also determined according to established protocols. UV spectroscopic and RP were validated and used to determine the active ingre with the official speci...

INTRODUCTION Carvedilol is a novel, multiple-action cardiovascular drug that is currently approved in many countries for the treatment of hypertension. The reduction in blood pressure, produced by carvedilol, results primarily from beta-adrenoceptor blockade and vasodilation, the latter resulting from alpha 1-adrenoceptor blockade.

The objective of the study was to improve the aqueous solubility and dissolution of carbamazepine, a poorly water soluble anti-epileptic drug by solid dispersion technique, using water soluble polymers. Solid dispersion of drugs was prepared by physical mixing, fusion and solvent evaporation method. The drug along with the polymers was heated first...

The aim of our study was to improve the dissolution of Tramadol hydrochloride (TH) via its semisolid filled lipid based capsules. Sustained release formulation is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of single dose. Semisolid matrixes of TH were...

In the present study UV-spectrophotometric and RP-HPLC methods were validated for the simultaneous analysis of acetaminophen and caffeine in marketed tablets. The methods were validated in terms of linearity, accuracy (% Recovery), precision (inter day, intra day and reproducibility) and robustness. Both the methods were linear (R 2 = 0.998-0.999)...

In the present study UV-spectrophotometric and RP-HPLC methods were validated for the simultaneous analysis of acetaminophen and caffeine in marketed tablets. The methods were validated in terms of linearity, accuracy (% Recovery), precision (inter day, intra day and reproducibility) and robustness. Both the methods were linear (R 2 = 0.998-0.999)...

INTRODUCTION Carvedilol is a novel, multiple-action cardiovascular drug that is currently approved in many countries for the treatment of hypertension. The reduction in blood pressure, produced by carvedilol, results primarily from beta-adrenoceptor blockade and vasodilation, the latter resulting from alpha 1-adrenoceptor blockade.

In this study five marketed brands of aceclofenac 100 mg tablets have been evaluated using dissolution test in two different media with the aim to assess bioequivalence and to select a proper dissolution medium. Other general quality parameters of these tablets like weight variation, hardness, friability, disintegration time were also determined ac...

The primary objective of this study is to evaluate the effect of drug loading and the effect of excipients on the release pattern of Dexamethasone Sodium Phosphate from in situ PLGA implants formed in vitro in gelatin gel. This system is prepared by dissolving a biodegradable polymer (DL-PLGA 70K) in dimethyl sulfoxide (DMSO). Then the drug with ex...

In this experiment, lipid matrices were prepared by mixing and dissolving atorvastatin in lipidic excipients in presence of surfactants. The solid solutions were analyzed by differential scanning calorimetry (DSC) to predict whether or not the crystalline structure of atorvastatin can be converted into solid solution. DSC thermogram of atorvastatin...

Direct extraction of DNA from natural environment and clinical samples has become a useful alternative for the phylogenetic identification and in situ detection of individual microbial cells without cultivation. In this study, three different Gram positive microorganisms (B. cereus, B. subtilis, and S. aureus) were chosen for genomic DNA extraction...

The primary objective of this study is to evaluate the effect of drug loading and the effect of excipients on the release pattern of Dexamethasone Sodium Phosphate from in situ PLGA implants formed in vitro in gelatin gel. This system is prepared by dissolving a biodegradable polymer (DL-PLGA 70K) in dimethyl sulfoxide (DMSO). Then the drug with ex...

In the present study, a simple, sensitive and specific liquid chromatography (RP-HPLC) method has been developed and validated for the quantification of hydrochlorothiazide and losartan potassium in tablet dosage form. A shim-pack CLC-ODS column (250 mm X 4.6 mm, 5µ and a mobile phase constituting 0.025 M phosphoric acid solution: acetonitrile (60:...

In the present study, a simple, sensitive and specific liquid chromatography (RP-HPLC) method has been developed and validated for the quantification of chloramphenicol and dexamethasone phosphate in eye preparation. A shim-pack CLC-ODS column (250 mm X 4.6 mm, 5µ and a mobile phase constituting phosphate buffer: methanol (50:50 v/v) was used. The...

The main objective of the current study was to formulate poorly water soluble drug Spirinolactone by using solid dispersion technique in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. Solid dispersions were prepared using two methods; solvent method and fusion method. Solid dispersion was prep...

The objective of this study was to design acetaminophen extended release bi layer tablets containing immediate release layer and extended release layer. Tablets were prepared by wet granulation technique using different grades of hydroxypropylmethyl cellulose (HPMC 15 cps, HPMC 100 cps and Methocel K4m CR) as release rate retardant and tablets were...

This study is aimed to assess the bioequivalence of five generic ciprofloxacin tablets from different manufacturer using in vitro dissolution study under biowaiver conditions by RP-HPLC. Dissolution media were USP buffer solutions at pH 1.2 (hydrochloric acid solution), pH 4.5 (acetate buffer solution), and pH 6.8 (phosphate buffer solution). Other...

In the present study, a simple, sensitive and specific liquid chromatography (RP-HPLC) method has been developed and validated for the quantification of hydrochlorothiazide and losartan potassium in tablet dosage form. A shim-pack CLC-ODS column (250 mm X 4.6 mm, 5µ and a mobile phase constituting 0.025 M phosphoric acid solution: acetonitrile (60:...

The objective of this study was to evaluate the effect of drug loading and the effect of excipients on the release pattern of tamsulosin tydrochloride from in situ PLGA implants formed in vitro in gelatin gel. This system is prepared by dissolving a biodegradable polymer (DL-PLGA 70K) in biocompatible solvent, dimethyl sulfoxide (DMSO). Then either...

The widespread application of hydrogels in a number of applications like control of microfluidic flow, development of muscle-like actuators, filtration/separation and drug delivery makes it important to properly understand these materials. Understanding hydrogel properties is also important from the standpoint of their similarity to many biological...

In situ implants containing Progesterone (PRG) were prepared by using biodegradable Poly (DL-lactide-co-glycolide) polymer. Dimethyl sulfoxide (DMSO) was used as an aprotic solvent in this implant formulation. This system was prepared by dissolving a water insoluble and biodegradable polymer (PLGA) in a biocompatible organic solvent (DMSO) and then...