Irfan Ullah

Irfan Ullah
University of Sargodha Sub-campus, Bhakkar · Department of Chemistry

Ph.D

About

16
Publications
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90
Citations

Publications

Publications (16)
Preprint
A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino-and 4-amino-1,2,4-triazoles. Condensation of the amino-trizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3-5 minutes of exposure to ultra-sound. The synthesized compounds were chara...
Article
Full-text available
A facile method has been developed for the synthesis of Schiff bases derived from substituted and unsubstituted 3-amino- and 4-amino-1,2,4-triazoles. Condensation of the aminotrizoles with a variety of aromatic aldehydes afforded desired Schiff bases in excellent yields in 3–5 minutes of exposure to ultra-sound. The synthesized compounds were chara...
Article
3,5-bis(2,5-dimethylphenyl)pyridine (1); a novel derivative of 3,5-dibromopyridine was synthesized via Pd(0) catalyzed cross coupling reaction. The compound under investigation was characterized by XRD and different spectroscopic techniques. Density functional theory (DFT) was applied to compound 1 and experimental XRD data and DFT data are found i...
Article
Full-text available
Quite a high percentage of newly discovered drugs are discorded due to their low aqueous solubility and variable bioavailability. Therefore, it is need of the day to explore new methodology for enhancing the aqueous solubility of such drugs. Several mechanisms have been proposed for the purpose, including salt formation, particle size reduction or...
Article
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Self-assembling behavior of block copolymers having water-soluble portion as one of the blocks plays key role in the properties and applications of the copolymers. Therefore, we have synthesized block copolymers of different block length and investigated their self-assembling behavior with reference to concentration and temperature using surface te...
Article
Amphiphilic substances, surfactants, are in common use to enhance the aqueous solubility of organic compounds. Solubilization of 3-{3,5-bis (trifluoromethyl)phenyl}quinoline was investigated by employing spectrophotometry, light scattering and tensiometry in micellar solutions of nonionic surfactants {dimethyldodecylamine-N-oxide, DDAO; polyoxyethy...
Article
Full-text available
The development of a meaningful dissolution procedure for drug products with limited water solubility has been a challenge to both the pharmaceutical industry and the agencies that regulate them. On the other hand, poorly soluble drugs present a big problem in pharmaceutical formulations. Therefore, various methods to improve the dissolution of poo...
Article
The title compounds 3-(3,5-bis(trifluoromethyl)phenyl)quinoline (1) and 3-(4-fluoro-3-methylphenyl)quinoline (2) were synthesized through Suzuki-Miyaura Cross coupling reaction of 3-bromoquinoloine with aryl boronic acids. The title compounds were characterized by single-crystal X-ray diffraction, 1H NMR, 13C NMR, EI-MS, elemental analysis and IR....
Article
Solubility of drugs in aqueous media is a real issue for scientists and a lot of work is going on to resolve the issue. The same is the case for ibuprofen, which is a derivative of propionic acid, belongs to the NSAIDs family and has low solubility in pure water. Therefore, its solubility has been investigated in dimethyl dodecyl ammonium-propane s...
Article
The solubility of an anesthetic drug, LIDOCAINE, in water was investigated in the presence of ionic, nonionic and zwitterionic surfactants at 25 °C, and the solubility was found to increase linearly with the surfactant concentration. The molar solubilization ratio, R m,s, and Gibbs free energy, \(\Delta G_{\mathrm{s}}^{\mathrm{o}}\) values for noni...
Article
Solubility of drugs in aqueous media is a real issue for scientists and a lot of work is going to resolve the issue. Same is the case for Ibuprofen which is a derivative of propionic acid, belongs to NSAIDs family and has low solubility in neat water. Therefore, its solubility has been investigated in DDAPS micellar solution, DDAPS/Butanol mixtu...
Article
Full-text available
Critical micelle concentration of CTAB and its mixture was determined in the presence of Naproxen sodium at diffrent temperature using surface tension technique.Naproxen sodium is nomsteroidal anti-infkamatory drug whch exhibit amphiphillic nature in aqueous solution in that it accumulates over the interface depressing the surface tension, and form...
Article
The solubilities of two nonsteroidal anti-inflammatory (MELOXICAM and CELECOXIB) drugs, were determined in aqueous solutions of nonionic (Tween 20, Tween 80, Brij 30, Brij 35, Triton X 100, Triton X 114) surfactants. These surfactants have different numbers of oxyethylene units and their micelles showed different aggregation numbers. It is shown th...

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