Irfan Sencan

• MD
• Dışkapı Yıldırım Beyazıt Training and Research Hospital

Objective To investigate and compare the demographic characteristics, clinical findings, and laboratory results of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) patients, among Turkish citizens, and foreign nationals. Methods This study included patients aged 18 and over, both Turkish citizens and foreign nationals, diagnosed...

Objectives With the rise in antimicrobial resistance, there is a growing demand for rapid antimicrobial susceptibility testing (RAST). In this study, we applied the EUCAST RAST method to ESBL/carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolates without using advanced identification systems and analysed the effect of this meth...

Background: Diabetes foot infection is a very important public health problem that causes serious health problems, mortality, and high health expenditures, and is one of the most important complications of diabetes mellitus. There are concerns that approaches such as limited personal visits to doctors, avoidance of hospitals, and restrictions on no...

Background: Bloodstream infections caused by Gram-negative bacteria are highly mortal. In this study, we aimed to investigate the relationship between antimicrobial resistance profile and novel serological biomarkers and mortality in bloodstream infections (BSIs) caused by Gram-negative bacteria in intensive care units (ICUs).

Objective: Hepatitis B is a common health problem and deaths from acute or chronic hepatitis B are more than 600,000 per year. Liver damage that develops throughout the course of the disease forms the basis of mortality and morbidity. The most accurate and most difficult method to detect the extent of liver damage is liver biopsy. There are conflic...

Abstract Background This study aims to contribute to peritonitis management strategies by comparing the demographic, clinical,and laboratory characteristics of patients diagnosed with spontaneous bacterial peritonitis (SBP), peritonealdialysis-related peritonitis (PDrP), and secondary peritonitis. Methods This study included 86 patients diagnose...

The Disease Of All Times: A Retrospective Study Of 272 Syphilis Cases

Aim Mediastinitis, a rare yet serious infection, affects the mediastinum. This study aims to compare the demographic, clinical, and laboratory characteristics of patients diagnosed with post-sternotomy mediastinitis (PSM) or descending necrotizing mediastinitis (DNM) to identify features of non-surviving patients. Materıal and Methods This study in...

Background The change in hepatitis B surface antibody (anti-HBs) titers after chemotherapy (CT) in patients with hematological malignancy, affecting factors, and its clinical implications have not been sufficiently understood. Therefore, we aim to evaluate the change in anti-HBs titers and hepatitis B virus reactivation (HBVr) after CT. Methods Thi...

Objectives: It is known that COVID-19 has multisystemic effects. However, its early effects on muscle tissue have not been clearly elucidated. The aim of this study is to investigate early changes in the pectoral muscle in patients with COVID-19 infection. Materials and methods: The pectoral muscle areas (PMA) and pectoral muscle index (PMI) of...

Purpose: The objective of this study is to identify antibiotic-related adverse events and risk factors in hospitalized patients. Materials and Methods: This prospective cohort study included 776 inpatients who received antibiotic treatment between January 2019 and December 2020. Patients who experienced "definite" or "probable" adverse drug events...

Background: To have country-wide information about multidrug resistance (MDR) in isolates from community-acquired urinary tract infections (CAUTI) of Turkey, in terms of resistance rates and useful options. Methods: We used a geocode standard, nomenclature of territorial units for statistics (NUTS), and a total of 1588 community-acquired isolate...

Objective: To determine frequency, microbiologic characteristics and risks of secondary infections in patients with Coronavirus disease 2019 (COVID-19) associated acute respiratory distress syndrome (ARDS). Study design: An Observational study. Place and duration of study: COVID-19 intensive care unit (ICU), University of Health Sciences, Disk...

Objectives: It is known that COVID-19 has multisystemic effects. However, its early effects on muscle tissue have not been clearly elucidated. The aim of this study is to investigate early changes in the pectoral muscle in patients with COVID-19 infection. Materials and methods: The pectoral muscle areas (PMA) and pectoral muscle index (PMI) of...

Background and aim: Crimean-Congo hemorrhagic fever (CCHF) is a viral hemorrhagic fever, which is common in Turkey and globally. The pathogenesis of coagulation disorders, which is seen in viral hemorrhagic fevers remains to be elucidated. Thrombin-activatable fibrinolysis inhibitor (TAFI) has a key role in this process In this study, we aimed to...

Crimean-Congo Hemorrhagic Fever (CCHF) is an acute viral disease with fever and bleeding caused by a tick-borne virus belonging to the Bunyaviridae family. Coronavirus Disease-2019 (COVID-19) is a novel disease caused by Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), which can lead to acute respiratory distress syndrome (ARDS) H...

Objective: Coronavirus disease 2019 is a disease caused by severe acute respiratory syndrome coronavirus 2, a novel type of coronavi- rus, which causes pneumonia in some hosts. No specific scoring method exists for mortality evaluation in novel coronavirus pneumonia. The aim of this study was to investigate factors affecting coronavirus disease 20...

Introduction: The prognostic nutritional index (PNI) is calculated using total serum lymphocyte counts and albumin levels. We aimed to analyze the role of PNI in predicting intensive care unit (ICU) referral and mortality in patients with Crimean Congo Hemorrhagic Fever (CCHF). Materials and methods: Our target population was adult (age>18) pati...

Background: Broad-spectrum empirical antimicrobials are frequently prescribed for patients with coronavirus disease 2019 (COVID-19) despite the lack of evidence for bacterial coinfection. Aims: We aimed to cross-sectionally determine the frequency of antibiotics use, type of antibiotics prescribed, and the factors influencing antibiotics use in hos...

The outbreak of the novel coronavirus has started to appear in 2019, and has become an epidemic. Practices of quarantine, reported to have negative psychological effects in the past, have become widespread. In this study our aim was to examine the psychological conditions of individuals who were taken under quarantine. The sample of this study cons...

Background Doctors and nurses are frequently exposed to needlestick and sharps injuries (NSIs) because of their work. It is estimated that NSIs are more common than the reported rates to Infection Control Committee. The purpose of this study was to determine the incidence and reporting rates of NSIs in our hospital. Methods After their consent for...

Objective: Recent advances have contributed to a better understanding of the shared and specific roles of HLA alleles in outcome of Covid-19 disease. We aimed to determine if a severe prognosis could be predicted. Methods: Covid-19 patients were divided into severe (n=30) and non-severe (n=29) patient groups. All patients’ demographic, clinical, la...

Objectives: EUCAST published its recommendations for rapid antimicrobial susceptibility tests (RASTs) directly from positive signal blood culture (BC) bottles. The objective of the present study was to investigate the accuracy and applicability of the predicted RAST (p-RAST) method without using automated identification systems, and the effects of...

Introduction The transmission risk of Severe Acute Respiratory Syndrome Coronavirus‐2 virus infection is increased in maintenance hemodialysis (MHD) patients, and also the disease causes much higher mortality than the normal population. The aim of this study is to define the predictive value of neutrophil‐to‐lymphocyte ratio (NLR) in terms of worse...

GİRİŞ ve AMAÇ: COVID-19 aşıları ile bağışıklanma, pandemiden çıkış stratejisi olarak tüm dünyada geniş çapta kabul edilmiştir. Aşının etkililiği ve bunu etkileyen faktörlerin tespit edilmesi, aşı başarısını arttırarak pandemi kontrolünü sağlayabilir. COVID-19 hastalarının mortalitesinde; düzensiz immunizasyon, çoklu organ yetmezliği gibi nedenler g...

Objective: The impact of the coronavirus disease 2019 (COVID-19) pandemic has been unceasingly ongoing worldwide. Recent bioinformatics analysis and epidemiologic studies have highlighted that the functional polymorphisms on the angiotensin converting enzyme (ACE) gene may have an impact on the clinical progress of COVID-19. In this study, we aime...

In this review, we evaluated health care problems which were not common before pandemic began but have been common issues after its appereance and approaches to control pandemic considering its influences on people. We revised present health care developing approaches under the light of experience obtained throughout the pandemic up to now. Aim is...

Background: Critical COVID-19 is associated with intensive care unit (ICU) admission, increased secondary infection rate, and would lead to significant worsened prognosis. Risks and characteristics relating to secondary infections in critical patients with COVID-19 associated acute respiratory distress syndrome (ARDS) have not been described. Metho...

Beginning from China on December 2019, COVID-19 epidemic has spreaded all over the world in a short period of time and been a pandemic. In challenge with this pandemic quarantine technique has been used widely after tens of years. In the course of the pandemic, many countries evacuated their citizens from affected regions and combined the evacuatio...

Purpose: To evaluate ciprofloxacin resistance (CR) and extended-spectrum beta-lactamase (ESBL) positivity in the rectal flora, antibiotic prophylaxis received, and post-biopsy infectious complications in patients undergoing prostate biopsy. Material & methods: Rectal swab samples collected from 99 patients suspected of prostate cancer two days b...

Amaç: Bu çalışmada, imipenem dirençli Acinetobacter spp. enfeksiyonlarında direnç gelişimini etkileyen faktörlerin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmamızda 1 Ocak 2008 ve 31 Aralık 2011 tarihleri arasında hastanemiz ana yoğun bakım ünitelerinde yatarak takip edilen hastaların dosyaları restrospektif olarak incelenmiştir. Bu in...

Objective To investigate whether the neutrophil-to-lymphocyte ratio (NLR) may be used in the early stage risk assessment and follow-up in diabetic foot infection Methods Over a five-year study, NLR values on admission and day 14 of treatment were matched with their laboratory and clinical data in a cohort study. Patients were followed-up or consul...

Aim: Tuberculosis (TB) is one of the earliest and most contagious diseases of history with high morbidity and mortality. EÛective surveillance is crucial for disease control. One component of active surveillance is screening of all biopsy reports regarding TB, and reporting them once identiÜed. In this study, pathol- ogy reports were evaluated for...

Aim: This study aimed to measure cytokine and lactate levels in the cerebrospinal fluid (CSF) of patients with suspected post-neurosurgical meningitis. Material and methods: Interleukin-8,12,and 13, interferon gamma, and lactate concentrations were determined in the CSF of patients diagnosed with meningitis, who were undergoing follow-up after n...

Tenosynovitis is a rare complication in the course of brucellosis, and may cause relapse if it is not treated with appropriate treatment options. We describe a case of peroneal tenosynovitis primarily associated with Brucella, the first one reported in the literature to the best of our knowledge. A 45-year-old woman suffering from fever and night s...

Objective: Our aim is to evaluate trends in the direct and indirect causes’ distribution using data from National Maternal Mortality Surveillance (2012–2015). Study design: A population-based retrospective review was performed on all pregnancy-associated maternal deaths in Turkey from 2012 to 2015. Causes of death were grouped into direct and indir...

Amaç: Sürveyans, verilerin sistematik biçimde devamlı olarak toplanması, sınıflandırılması, analizi ve yorumlanması ile bu bilgilerin, önlem almak için bu bilgilere ihtiyaç duyanlara dağıtılmasıdır. Hastalıkların görülme sıklıkları tespitinde güvensizlik olması bulaşıcı hastalık önleme çalışmalarının etkin yapılamamasına neden olmakta ve toplum sağ...

Background: The risk of occupational transmission of bloodborne pathogens to health care workers is primarily associated with needlestick and sharps injuries (NSIs). However, most NSIs are not reported, and most health care workers are not aware of postexposure procedures. Methods: Data for NSIs reported in our hospital between 2008 and 2016 wer...

The aim of this research is to determine the seropositivity levels of tetanus vaccine according to age groups in Ankara province, to identify possible factors that could affect the immune status, and to make recommendations especially in people aged 50 years and older. This cross-sectional epidemiological study covers people over three years of age...

Background Infectious diseases are one of the primary healthcare problems worldwide, leading to millions of deaths annually. To develop effective control and prevention strategies, we need reliable computational tools to understand disease dynamics and to predict future cases. These computational tools can be used by policy makers to make more info...

The total numbers of infected cases reported in 81 provinces of Turkey during 2007. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

The total numbers of infected cases reported in 81 provinces of Turkey during 2012. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

Training and test set split of 81 provinces for spatial and spatiotemporal modeling scenarios. Red-colored 41 provinces were used as the training set, whereas gray-colored 40 provinces were used as the test test. Province IDs were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www....

The total numbers of infected cases reported in 81 provinces of Turkey during 2006. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

The total numbers of infected cases reported in 81 provinces of Turkey during 2011. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

The total numbers of infected cases reported in 81 provinces of Turkey during 2013. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

The total numbers of infected cases reported in 81 provinces of Turkey during 2015. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

The total observed and predicted case counts by each algorithm for years 2014 and 2015 over the 15 provinces with the highest case counts among 40 common test provinces of all scenarios. The time periods were annotated by their seasonal group information at the top (yellow: cold; orange: warm; red: hot). (TIFF)

Surveillance data set of 9,636 CCHF infection cases reported in Turkey between years 2004 and 2015, which was collected by the Ministry of Health of Turkey. Province IDs reported in this file correspond to numbers shown in S13 Fig. (XLSX)

The total numbers of infected cases reported in 81 provinces of Turkey during 2005. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

The total numbers of infected cases reported in 81 provinces of Turkey during 2008. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

The total numbers of infected cases reported in 81 provinces of Turkey during 2009. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

The total numbers of infected cases reported in 81 provinces of Turkey during 2014. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

The total numbers of infected cases reported in 81 provinces of Turkey during 2004. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

The total numbers of infected cases reported in 81 provinces of Turkey during 2010. The numbers were shown on the province centers. This map was generated using the Turkish administrative map downloaded from https://www.gadm.org and the R package maps version 3.3.0 at https://cran.r-project.org/web/packages/maps. (TIFF)

The total observed and predicted case counts by each algorithm for years 2014 and 2015 over the 10 provinces with the highest case counts among 40 common test provinces of all scenarios. The time periods were annotated by their seasonal group information at the top (yellow: cold; orange: warm; red: hot). (TIFF)

The total observed and predicted case counts by each algorithm for years 2014 and 2015 over the 20 provinces with the highest case counts among 40 common test provinces of all scenarios. The time periods were annotated by their seasonal group information at the top (yellow: cold; orange: warm; red: hot). (TIFF)

The observed (x-axis) and predicted case counts (y-axis) by each algorithm in time periods of years 2014 and 2015 for the five provinces with the highest case counts among 40 common test provinces of all scenarios. Each province was represented with a distinct marker. We also reported NRMSE values for each algorithm and scenario pair at the bottom-...

Background: Our aim was to evaluate maternal mortality causes among Turkish women giving birth after assisted reproductive techniques (ARTs). Methods: All maternal deaths following conception with ART pregnancies were identified through the National Maternal Mortality Surveillance System. We analyzed the system data collected between 2007 and 20...

Objective: The aim of this study was to determine the epidemiological characteristics of maternal mortality due to postpartum hemorrhage, and to investigate whether national preventative measures of the Maternal Mortality Program have been successful in Turkey. Design: A population-based cohort study. Setting: Turkish National Maternal Mortality Da...

Objective: To analyse the value of autopsy reports for determining the cause of maternal deaths in Turkey. Material and methods: In this descriptive retrospective study, case files of 992 maternal deaths except for accidental causes occurred in Turkey between 2012 and 2016 were reviewed. An autopsy examination was performed in 177 (17.8%) out of...

Objective: This study aimed to determine the demographical and clinical characteristics of patients followed with severe acute respiratory illness (SARI) during 2015-2016 influenza season. Methods: Patients followed with a diagnosis of SARI between 15 December, 2015 and 22 May, 2016 were included in the study. The patients were evaluated for demogr...

Objective: To evaluate the Turkey's nationwide HPV DNA screening program on the basis of first 1 million screened women. Methods: Women over age 30 were invited for population based screening via HPV DNA and conventional cytology. Samples were collected by family physicians and the evaluations and reports had been performed in the National Centr...

Background: Adherence to medication is an important aspect of preventing drug resistance and treatment failure in patients receiving nucleos(t)ide analogues for chronic hepatitis B. Aims: To assess adherence to nucleoside/nucleotide analogues in chronic hepatitis B treatment and to determine factors associated with non-adherence. Study design:...

Objective To analyze maternal deaths in Turkey due to hypertensive disorders. Material and Methods In this retrospective study 812 maternal deaths were analyzed. Maternal demographic features, presence of antenatal care, medical and obstetric history, mode of delivery, and use emergency antihypertensive therapy were recorded. The delay model for e...

Background: Myasthenia Gravis (MG) is an autoimmune disease which is characterised by disruption of signal transmission at neuromuscular junction. We aimed to search about a newly reported association between MG and West Nile Virus (WNV) infection. Methods: We searched WNV IgG by ELISA in serum samples of 50 available MG patients and 38 controls...

Objectives: To evaluate the mammography image and reporting quality in Turkey. Materials and Methods: One hundred sixty five units which provide mammography examination services were included in the audit. Samples of mammographic examinations conducted between July 1st and December 31st, 2012 were evaluated. Auditors completed web-based evaluation...

Pulmonary embolism is a major cause of death during pregnancy or the puerperium. The hemostatic changes in pregnancy creates a prothrombotic milieu. Hyperemesis gravidarum is one of the recognised risk factors for venous tromboembolism.Two cases of maternal mortality were attributed to PE associated with severe hyperemesis gravidarum in 2014 in Tur...

Introduction: The aim of this study was to evaluate intensive care unit (ICU) performance using risk-adjusted ICU mortality rates nationally, assessing patients who died or had been discharged from the ICU. For this purpose, this study analyzed the Acute Physiology and Chronic Health Evaluation (APACHE) II and Sequential Organ Failure Assessment (S...

OZ Objective: The study was designed to evaluate the relationship between the methods of circumcision procedures used in the past and hepatitis B surface antigen (HBsAg), anti-HBs and anti-hepatitis C virus (HCV) positivity. Materials and Methods: Within the scope of “Public Hepatitis Awareness Activities” executed by the Viral Hepatitis Society, v...

The conflict in Syria is a big humanitarian emergency. More than 200,000 Syrians have been killed, with more than half of the population either having been displaced or having immigrated. Healthcare has been interrupted due to the destruction of facilities, a lack of medical staff, and a critical shortage of life-saving medications. It produced sui...

Continuing education and standardization are of utmost importance in apheresis science as every field in medicine. Especially, the last 5 years witnessed remarkable progress in apheresis science in Turkey, both in terms of increased numbers of therapeutic apheresis centers, therapeutic apheresis procedures performed per year, and also in terms of q...

Study Group for Diabetic Foot Infections of the Turkish Society of Clinical Microbiology and Infectious Diseases has called for collaboration of the relevant specialist societies and the Ministry of Health to issue a national consensus report on the diagnosis, treatment and prevention of diabetic foot (DF) wounds and diabetic foot infections (DFIs)...

Background: Members of triggering receptor expressed on myeloid cells (TREM) family are known as immunmodulators in several infectious or noninfectious inflammatory disorders. The information about their role in viral infections is very limited. To enlighten if there's a relation between soluble TREM-1(sTREM-1) and a viral infection, Crimean Congo...

Background Staphylococcus aureus is one of the causes of both community and healthcare-associated bacteremia. The attributable mortality of S. aureus bacteremia (SAB) is still higher and predictors for mortality and clinical outcomes of this condition are need to be clarified. In this prospective observational study, we aimed to examine the predict...

Hematopoietic cell transplantation is an established treatment option with curative potential for a variety of clinical conditions. Especially the last decade witnessed a remarkable increase in HCT activity in Turkey. In 2014, 696 pediatric and 2631 adult (total 3327) HCT were performed in Turkey, corresponding to transplant rates per 106 inhabitan...

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease of humans that affects a wide geographic area of Africa and Eurasia, including Turkey, Iran, Pakistan, Afghanistan and Russia. Since the first detection of CCHF cases in Turkey in 2002, more than 9700 patients have been reported, with an overall mortality rate just under 5%. This...

Background: Crimean-Congo hemorrhagic fever (CCHF) is a widespread disease in Turkey, and was responsible for many deaths in endemic regions during the last decade. The pathogenesis of the disease is not fully understood yet. Objectives: In this study we aimed to determine the levels of tissue plasminogen activator (tPA) and Plasminogen activato...

Ralstonia pickettii are considered contaminant bacteria and infections due to this bacteria are quite rare. Meningitis, pneumonia, bacteremia, septic arthritis, discitis and osteomyelitis cases due to these bacteria have been reported, but ventriculoperitoneal shunt infection due to R. pickettii in adult patients has not been reported so far. In th...

Anevrizma onariminda endovaskuler stent greft kullanimi hospitalizasyon suresi ve normal yasama donme suresinin kisaligi nedeniyle konvansiyonel cerrahiye ustundur. Endovaskuler stent greft uygulamasindan sonra gorulen en onemli komplikasyonlardan biri enfeksiyondur. Bu yazida ilk kez Enterecoccus faecium ve E.coli birlikteligi ile ortaya cikan ste...

DOI: 10.5152/kd.2015.29 Diyabetik Ayak Yarası ve İnfeksiyonunun Tanısı, Tedavisi ve Önlenmesi: Ulusal Uzlaşı Raporu Diagnosis, Treatment and Prevention of Diabetic Foot Wounds and Infections: Turkish Consensus Report Neşe Saltoğlu1, Önder Kılıçoğlu2, Selçuk Baktıroğlu3, Zeynep Oşar-Siva4, Şamil Aktaş3,5, Muzaffer Altındaş6, Caner Arslan7, Turan Asl...