Irene Sendiña-Nadal

• PhD Physics
• Rey Juan Carlos University

A network model based on players' aspirations is proposed and analyzed theoretically and numerically within the framework of evolutionary game theory. In this model, players decide whether to cooperate or defect by comparing their payoffs from pairwise games with their neighbors, driven by a common aspiration level. The model also incorporates a de...

We propose to use the ordinal pattern transition (OPT) entropy measured at sentinel central nodes as a potential predictor of explosive transitions to synchronization in networks of various dynamical systems with increasing complexity. Our results demonstrate that the OPT entropic measure surpasses traditional early warning signals (EWS) measures a...

Cooperation and defection are social traits whose evolutionary origin is still unresolved. Recent behavioral experiments with humans suggested that strategy changes are driven mainly by the individuals' expectations and not by imitation. This work theoretically analyzes and numerically explores an aspiration-driven strategy updating in a well-mixed...

We explore the interplay between the topological relevance of a neuron and its dynamical traces in experimental cultured neuronal networks. We monitor the growth and development of these networks to characterise the evolution of their connectivity. Then, we explore the structure-dynamics relationship by simulating a biophysically plausible dynamica...

Although the cooperative dynamics emerging from a network of interacting players has been exhaustively investigated, it is not yet fully understood when and how network reciprocity drives cooperation transitions. In this work, we investigate the critical behavior of evolutionary social dilemmas on structured populations by using the framework of ma...

Cultured neuronal networks (CNNs) have recently achieved major relevance as an alternative to in vivo models. While many works investigate the evolution of functional connectivity alone, experimental evidence of the simultaneous change of the structural neuronal network substrate is scarce. In the present study, we monitored the coevolution of stru...

Although the cooperative dynamics emerging from a network of interacting players has been exhaustively investigated, it is not yet fully understood when and how network reciprocity drives cooperation transitions. In this work, we investigate the critical behavior of evolutionary social dilemmas on structured populations by using the framework of ma...

We address the problem of retrieving the full state of a network of Rössler systems from the knowledge of the actual state of a limited set of nodes. The selection of nodes where sensors are placed is carried out in a hierarchical way through a procedure based on graphical and symbolic observability approaches applied to pairs of coupled dynamical...

A chaotic dynamics is typically characterized by the emergence of strange attractors with their fractal or multifractal structure. On the other hand, chaotic synchronization is a unique emergent self-organization phenomenon in nature. Classically, synchronization was characterized in terms of macroscopic parameters, such as the spectrum of Lyapunov...

We address the problem of retrieving the full state of a network of R\"ossler systems from the knowledge of the actual state of a limited set of nodes. The selection of the nodes where sensors are placed is carried out in a hierarchical way through a procedure based on graphical and symbolic observability approaches. By using a map directly obtaine...

A chaotic dynamics is typically characterized by the emergence of strange attractors with their fractal or multifractal structure. On the other hand, chaotic synchronization is a unique emergent self-organization phenomenon in nature. Classically, synchronization was characterized in terms of macroscopic parameters, such as the spectrum of Lyapunov...

Elucidating the mechanisms that lead to the emergence, evolution, and survival of cooperation in natural systems is still one of the main scientific challenges of current times. During the last three decades, theoretical and computational models as well as experimental data have made it possible to unveil and explain, from an evolutionary perspecti...

Networks determine our social circles and the way we cooperate with others. We know that topological features like hubs and degree assortativity affect cooperation, and we know that cooperation is favored if the benefit of the altruistic act divided by the cost exceeds the average number of neighbors. However, a simple rule that would predict coope...

Networks determine our social circles and the way we cooperate with others. We know that topological features like hubs and degree assortativity affect cooperation, and we know that cooperation is favoured if the benefit of the altruistic act divided by the cost exceeds the average number of neighbours. However, a simple rule that would predict coo...

Synchronization has been the subject of intense research during decades mainly focused on determining the structural and dynamical conditions driving a set of interacting units to a coherent state globally stable. However, little attention has been paid to the description of the dynamical development of each individual networked unit in the process...

Cultured neuronal networks (CNNs) are a robust model to closely investigate neuronal circuits’ formation and monitor their structural properties evolution. Typically, neurons are cultured in plastic plates or, more recently, in microfluidic platforms with potentially a wide variety of neuroscience applications. As a biological protocol, cell cultur...

The past two decades have seen significant successes in our understanding of networked systems, from the mapping of real-world networks to the establishment of generative models recovering their observed macroscopic patterns. These advances, however, are restricted to pairwise interactions and provide limited insight into higher-order structures. S...

Elucidating the mechanisms that lead to cooperation is still one of the main scientific challenges of current times, as many common cooperative scenarios remain elusive and at odds with Darwin's natural selection theory. Here, we study evolutionary games on populations that are structured beyond pairwise interactions. Specifically, we introduce a g...

Synchronization has been the subject of intense research during decades mainly focused on determining the structural and dynamical conditions driving a set of interacting units to a coherent state globally stable. However, little attention has been paid to the description of the dynamical development of each individual networked unit in the process...

Evolutionary games provide the theoretical backbone for many aspects of our social life: from cooperation to crime, from climate inaction to imperfect vaccination and epidemic spreading, from antibiotics overuse to biodiversity preservation. An important, and so far overlooked, aspect of reality is the diverse strategic identities of individuals. W...

The past two decades have seen significant successes in our understanding of networked systems, from the mapping of real-world networks to the establishment of generative models recovering their observed macroscopic patterns. These advances, however, are restricted to pairwise interactions and provide limited insight into higher-order structures. S...

The past two decades have seen significant successes in our understanding of complex networked systems, from the mapping of real-world social, biological and technological networks to the establishment of generative models recovering their observed macroscopic patterns. These advances, however, are restricted to pairwise interactions, captured by d...

Evolutionary games provide the theoretical backbone for many aspects of our social life: from cooperation to crime, from climate inaction to imperfect vaccination and epidemic spreading, from antibiotics overuse to biodiversity preservation. An important, and so far overlooked, aspect of reality is the diverse strategic identities of individuals. W...

We propose a metric to characterize the complex behavior of a dynamical system and to distinguish between organized and disorganized complexity. The approach combines two quantities that separately assess the degree of unpredictability of the dynamics and the lack of describability of the structure in the Poincaré plane constructed from a given tim...

We explore the consequences of introducing higher-order interactions in a geometric complex network of Morris-Lecar neurons. We focus on the regime where traveling synchronization waves are observed from a first-neighbors-based coupling to evaluate the changes induced when higher-order dynamical interactions are included. We observe that the travel...

Retinal fundus imaging is a non-invasive method that allows visualizing the structure of the blood vessels in the retina whose features may indicate the presence of diseases such as diabetic retinopathy (DR) and glaucoma. Here we present a novel method to analyze and quantify changes in the retinal blood vessel structure in patients diagnosed with...

A dynamical network, a graph whose nodes are dynamical systems, is usually characterized by a large dimensional space which is not always accesible due to the impossibility of measuring all the variables spanning the state space. Therefore, it is of the utmost importance to determine a reduced set of variables providing all the required information...

We propose a new metric to characterize the complex behavior of a dynamical system and to distinguish between organized and disorganized complexity. The approach combines two quantities that separately assess the degree of unpredictability and the lack of structure in the Poincar\'e plane constructed from a given time series. As for the former, we...

We explore the consequences of introducing higher-order interactions in a geometric complex network of Morris-Lecar neurons. We focus on the regime where travelling synchronization waves are observed out of a first-neighbours based coupling, to evaluate the changes induced when higher-order dynamical interactions are included. We observe that the t...

When large ensembles of phase oscillators interact globally, and when bimodal frequency distributions are chosen for the natural frequencies of the oscillators themselves, Bellerophon states are generically observed at intermediate values of the coupling strength. These are multi-clustered states emerging in symmetric pairs. Oscillators belonging t...

This work analyzes the morphological evolution of assemblies of living neurons, as they self-organize from collections of separated cells into elaborated, clustered, networks. In particular, we introduce and implement a graph-based unsupervised segmentation algorithm that automatically retrieves the whole network structure from large scale phase-co...

A dynamical network, a graph whose nodes are dynamical systems, is usually characterized by a large dimensional space which is not always accessible due to the impossibility of measuring all the variables spanning the state space. Therefore, it is of the utmost importance to determine a reduced set of variables providing all the required informatio...

We explore the interplay between the topological relevance of a neuron and its dynamical traces in experimental cultured neuronal networks. We monitor the growth and development of these networks to characterise the evolution of their connectivity. Then, we explore the structure-dynamics relationship by simulating a biophysically plausible dynamica...

We explore the relation between the topological relevance of a node in a complex network and the individual dynamics it exhibits. When the system is weakly coupled, the effect of the coupling strength against the dynamical complexity of the nodes is found to be a function of their topological roles, with nodes of higher degree displaying lower leve...

One of the main tasks in network theory is to infer relations among interacting elements. We propose global modeling as a tool to detect links between nodes and their nature. Various situations using small network motifs are investigated under the assumption that the variable to be measured at each node provides full observability when isolated. Su...

The synchronization of coupled chaotic systems represents a fundamental example of self organization and collective behavior. This well-studied phenomenon is classically characterized in terms of macroscopic parameters, such as Lyapunov exponents, that help predict the system's transitions into globally organized states. However, the local, microsc...

We explore the relation between the topological relevance of a node in a complex network and the individual dynamics it exhibits. When the system is weakly coupled, the effect of the coupling strength against the dynamical complexity of the nodes is found to be a function of their topological role, with nodes of higher degree displaying lower level...

Explosive synchronization, an abrupt transition to a collective coherent state, has been the focus of an extensive research since its first observation in scale-free networks with degree-frequency correlations. In this work, we report several scenarios where a first-order transition to synchronization occurs driven by the presence of a dependence b...

Relay (or remote) synchronization between two not directly connected oscillators in a network is an important feature allowing distant coordination. In this work, we report a systematic study of this phenomenon in multiplex networks, where inter-layer synchronization occurs between distant layers mediated by a relay layer that acts as a transmitter...

Model validation from experimental data is an important and not trivial topic which is too often reduced to a simple visual inspection of the state portrait spanned by the variables of the system. Synchronization was suggested as a possible technique for model validation. By means of a topological analysis, we revisited this concept with the help o...

A faithful description of the state of a complex dynamical network would require, in principle, the measurement of all its $d$ variables, an infeasible task for systems with practical limited access and composed of many nodes with high dimensional dynamics. However, even if the network dynamics is observable from a reduced set of measured variables...

When the state of the whole reaction network can be inferred by just measuring the dynamics of a limited set of nodes the system is said to be fully observable. However, as the number of all possible combinations of measured variables and time derivatives spanning the reconstructed state of the system exponentially increases with its dimension, the...

In real-world networked systems, the underlying structure is often affected by external and internal unforeseen factors, making its evolution typically inaccessible. An adaptive strategy was introduced for maintaining synchronization on unpredictably evolving networks [Sorrentino and Ott, Phys. Rev. Lett. 100, 114101 (2008)], which yet does not con...

Relay (or remote) synchronization between two not directly connected oscillators in a network is an important feature allowing distant coordination. In this work, we report a systematic study of this phenomenon in multiplex networks, where inter-layer synchronization occurs between distant layers mediated by a relay layer that acts as a transmitter...

Synchronization is a very generic process commonly observed in a large variety of dynamical systems which, however, has been rarely addressed in systems with low dissipation. Using the Rössler, the Lorenz 84, and the Sprott A systems as paradigmatic examples of strongly, weakly, and non-dissipative chaotic systems, respectively, we show that a para...

Understanding the conditions under which a collective dynamics emerges in a complex network is still an open problem. A useful approach is the master stability function—and its related classes of synchronization—which offers a necessary condition to assess when a network successfully synchronizes. Observability coefficients, on the other hand, quan...

Inter-layer synchronization is a dynamical state occurring in multi-layer networks composed of identical nodes. The state corresponds to have all layers synchronized, with nodes in each layer which do not necessarily evolve in unison. So far, the study of such a solution has been restricted to the case in which all layers had an identical connectiv...

Percolation and synchronization are two phase transitions that have been extensively studied since already long ago. A classic result is that, in the vast majority of cases, these transitions are of the second-order type, i.e. continuous and reversible. Recently, however, explosive phenomena have been reported in com- plex networks' structure and d...

Percolation and synchronization are two phase transitions that have been extensively studied since already long ago. A classic result is that, in the vast majority of cases, these transitions are of the second-order type, i.e. continuous and reversible. Recently, however, explosive phenomena have been reported in com- plex networks' structure and d...

Inter-layer synchronization is a dynamical state occurring in multi-layer networks composed of identical nodes. The state corresponds to have all layers synchronized, with nodes in each layer which do not necessarily evolve in unison. So far, the study of such a solution has been restricted to the case in which all layers had an identical connectiv...

Inter-layer synchronization is a distinctive process of multiplex networks whereby each node in a given layer undergoes a synchronous evolution with all its replicas in other layers, irrespective of whether or not it is synchronized with the other units of the same layer. We analytically derive the necessary conditions for the existence and stabili...

Many real-world networks exhibit degree-assortativity, with nodes of similar degree more likely to link to one another. Particularly in social networks, the contribution to the total assortativity varies with degree, featuring a distinctive peak slightly past the average degree. The way traditional models imprint assortativity on top of pre-defined...

Synchronization of networked oscillators is known to depend fundamentally on the interplay between the dynamics of the graph's units and the microscopic arrangement of the network's structure. For non identical elements, the lack of quantitative tools has hampered so far a systematic study of the mechanisms behind such a collective behavior. We her...

We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patie...

We study the organization of finite-size, large ensembles of phase oscillators networking via scale-free topologies in the presence of a positive correlation between the oscillators' natural frequencies and the network's degrees. Under those circumstances, abrupt transitions to synchronization are known to occur in growing scale-free networks, whil...

Large scale phase-contrast images taken at high resolution through the life of a cultured neuronal network are analyzed by a graph-based unsupervised segmentation algorithm with a very low computational cost, scaling linearly with the image size. The processing automatically retrieves the whole network structure, an object whose mathematical repres...

In the past years, network theory has successfully characterized the interaction among the constituents of a variety of complex systems, ranging from biological to technological, and social systems. However, up until recently, attention was almost exclusively given to networks in which all components were treated on equivalent footing, while neglec...

We discuss the behavior of large ensembles of phase oscillators networking via scale-free topologies in the presence of a positive correlation between the oscillators' natural frequencies and network's degrees. In particular, we show that the further presence of degree-degree correlation in the network structure has important consequences on the na...

In vitro primary cultures of dissociated invertebrate neurons from locust ganglia are used to experimentally investigate the morphological evolution of assemblies of living neurons, as they self-organize from collections of separated cells into elaborated, clustered, networks. At all the different stages of the culture's development, identification...

The emergence of dynamical abrupt transitions in the macroscopic state of a system is currently a subject of the utmost interest. Given a set of phase oscillators networking with a generic wiring of connections and displaying a generic frequency distribution, we show how combining dynamical local information on frequency mismatches and global infor...

The emergence of dynamical abrupt transitions in the macroscopic state of a system is currently a subject of the utmost interest. The occurrence of a first-order phase transition to synchronization of an ensemble of networked phase oscillators was reported, so far, for very particular network architectures. Here, we show how a sharp, discontinuous...

We introduce a new methodology to characterize the role that a given node plays inside the community structure of a complex network. Our method relies on the ability of the links to reduce the number of steps between two nodes in the network, which is measured by the number of shortest paths crossing each link, and its impact on the node proximity....

We introduce an easily computable topological measure which locates the effective crossover between segregation and integration in a modular network. Segregation corresponds to the degree of network modularity, while integration is expressed in terms of the algebraic connectivity of an associated hyper-graph. The rigorous treatment of the simplifie...

We introduce an easily computable topological measure which locates the effective crossover between segregation and integration in a modular network. Segregation corresponds to the degree of network modularity, while integration is expressed in terms of the algebraic connectivity of an associated hyper-graph. The rigorous treatment of the simplifie...

We report on a generic procedure to steer (target) a network's dynamics towards a given, desired evolution. The problem is here tackled through a Master Stability Function approach, assessing the stability of the aimed dynamics, and through a selection of nodes to be targeted. We show that the degree of a node is a crucial element in this selection...

Critical phenomena in complex networks, and the emergence of dynamical abrupt transitions in the macroscopic state of the system are currently a subject of the outmost interest. We report evidence of an explosive phase synchronization in networks of chaotic units. Namely, by means of both extensive simulations of networks made up of chaotic units,...

Critical phenomena in complex networks, and the emergence of dynamical abrupt transitions in the macroscopic state of the system are currently a subject of the outmost interest. We report evidence of an explosive phase synchronization in networks of chaotic units. Namely, by means of both extensive simulations of networks made up of chaotic units,...

We report on the spontaneous emergence of computation from adaptive synchronization of networked dynamical systems. The fundamentals are nonlinear elements, interacting in a directed graph via a coupling that adapts itself to the synchronization level between two input signals. These units can emulate different Boolean logics, and perform any compu...

We report synchronization of networked excitable nodes embedded in a metric space, where the connectivity properties are mostly determined by the distance between units. Such a high clustered structure, combined with the lack of long-range connections, prevents full synchronization and yields instead the emergence of synchronization waves. We show...

We propose a new methodology to evaluate the balance between segregation and integration in functional brain networks by using singular value decomposition techniques. By means of magnetoencephalography, we obtain the brain activity of a control group of 19 individuals during a memory task. Next, we project the node-to-node correlations into a comp...

Supporting Information. (PDF)

Whether the balance between integration and segregation of information in the brain is damaged in Mild Cognitive Impairment (MCI) subjects is still a matter of debate. Here we characterize the functional network architecture of MCI subjects by means of complex networks analysis. Magnetoencephalograms (MEG) time series obtained during a memory task...

Identification of multi-functional proteins. (A) Dynamical behavior of the new set of overlapping proteins. In blue, values of the set of overlapping proteins between modules and with the new cured classification (same as in Fig. 3). As in Fig. S2, we plot the value of the overlapping node with circles when is in and with squares when in . In red w...

List of proteins. Full list with the 211 overlapping proteins resulting from the second iteration of the dynamical overlap method for the curated PIN of the yeast (see Text and Fig. 3). The curation of the PIN consists in exchanging the annotated function by MIPS of the 418 proteins from with the function predicted by the overlap and removing those...

Identification of misclassified proteins. The proposed tool is providing the behavior of each protein in the PIN through the indicator , that crucially depends on its original functional classification. Each panel corresponds to the competition trial between module at frequency (in black symbols) and the rest of modules at frequency (in different s...

List of proteins. Full list with the 418 overlapping proteins resulting from the first iteration of the dynamical overlap method for the PIN of the yeast (see Materials and Methods and Fig. 2). For each protein, we provide the OLN (Ordered Locus Names), the MIPS classification, whether or not this function is annotated in GOslim, the predicted func...

Identification of misclassified proteins. (A) Dynamical behavior of the 418 overlapping nodes. In blue when the modules are defined according to the original classification (MIPS). Given that the overlapping node is simultaneously in and , we represent with a circle its value in and with a square its value in . In red we represent the same values a...

Multifunctional distribution of proteins in . Module index. Number of proteins within the -module. Overlapping nodes belonging to . Number of proteins belonging to the -module overlapping with module . (PS)

Protein interaction networks have become a tool to study biological processes, either for predicting molecular functions or for designing proper new drugs to regulate the main biological interactions. Furthermore, such networks are known to be organized in sub-networks of proteins contributing to the same cellular function. However, the protein fun...

Although the functioning of real complex networks is greatly determined by modularity, the majority of articles have focused, until recently, on either their local scale structure or their macroscopical properties. However, neither of these descriptions can adequately describe the important features that complex networks exhibit due to their organi...

Modularity is a fundamental feature of real networks, being intimately bounded to their functionality, i.e., to their capability of performing parallel tasks in a coordinated way. Although the modular structure of real graphs has been intensively studied, very little is known on the interactions between functional modules of a graph. Here, we prese...

In natural systems, many processes can be represented as the result of the interaction of self-sustained oscillators on top of complex topological wirings of connections. We review some of the main results on the setting of collective (synchronized) behaviors in globally and locally identical coupled oscillators, and then discuss in more detail the...

The response of a random and modular network to the simultaneous presence of two frequencies is considered. The competition for controlling the dynamics of the network results in different behaviors, such as frequency changes or permanent synchronization frustration, which can be directly related to the network structure. From these observations, w...

To shed light on how biological and technological systems can establish or maintain a synchronous functioning, we address the problem of how to engineer an external pinning action on a network of dynamical units. In particular, we study the regulation of a network toward a synchronized behavior by means of a bidirectional interaction with an extern...

A collection of connected phase oscillators, initially unsynchronised, are subjected to a growing process. In such a process, pacemaker oscillators attach to the original network following an exclusively dynamical criterion oriented to entrain the network. Under these conditions, we show that successful entrainment always corresponds to the generat...

We show that the topology and dynamics of a network of unsynchronized Kuramoto oscillators can be simultaneously controlled by means of a forcing mechanism which yields a phase locking of the oscillators to that of an external pacemaker in connection with the reshaping of the network's degree distribution. The entrainment mechanism is based on the...

In a small-world network of mainly attractively coupled nonidentical neurons, we show that a small fraction of phase-repulsive couplings is able to strongly improve synchronization for certain values of the link strength, and long-range connection probability. By means of a spectral analysis we relate the observed dynamical behavior with the struct...

We show that a complex network of phase oscillators may display interfaces between domains (clusters) of synchronized oscillations. The emergence and dynamics of these interfaces are studied for graphs composed of either dynamical domains (influenced by different forcing processes), or structural domains (modular networks). The obtained results all...

We show that a complex network of phase oscillators may display interfaces between domains (clusters) of synchronized oscillations. The emergence and dynamics of these interfaces are studied in the general framework of interacting phase oscillators composed of either dynamical domains (influenced by different forcing processes), or structural domai...

An initial unsynchronized ensemble of networking phase oscillators is further subjected to a growing process where a set of forcing oscillators, each one of them following the dynamics of a frequency pacemaker, are added to the pristine graph. Linking rules based on dynamical criteria are followed in the attachment process to force phase locking of...