Irene Owusu

Irene Owusu
University of Ghana | Legon · Department of Biochemistry, Cell and Molecular Biology

BSc. Zoology_MPhil. Microbiology_PhD Fellow Molecular Cell Biology of Infectious Disease

About

8
Publications
932
Reads
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13
Citations
Citations since 2016
8 Research Items
13 Citations
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20162017201820192020202120220246810
20162017201820192020202120220246810
Introduction
A PhD Scholar in Molecular Cell biology of Infectious Diseases at the University of Ghana and an affiliate of the University of Michigan. WACCBIP fellow under DELTAS-Africa. Research interests are investigating the basic biology and molecular mechanisms of viral pathogenesis. Currently investigating norovirus infection and cell signaling.

Publications

Publications (8)
Article
Full-text available
Human norovirus (HNoV) is a global health and socioeconomic burden, estimated to infect every individual at least five times during their lifetime. The underlying mechanism for the potential lack of long-term immune protection from HNoV infections is not understood and prompted us to investigate HNoV susceptibility of primary human B cells and its...
Article
Full-text available
Babesia and Theileria are protozoan parasites belonging to the order piroplasmida, transmitted by hard ticks, and can cause diseases known as piroplasmosis. Human infections are usually asymptomatic, except in immuno-compromised persons who present malaria-like symptoms. Moreover, microscopically, the morphologies of Babesia and Theileria can resem...
Article
Akt (Protein kinase B) is a key signaling protein in eukaryotic cells that controls many cellular processes such as glucose metabolism and cell proliferation for survival. As obligate intracellular pathogens, viruses modulate host cellular processes, including Akt signaling, for optimal replication. The mechanisms by which viruses modulate Akt and...
Article
Full-text available
Macrophages possess mechanisms for reinforcing the integrity of their endolysosomes against damage. This property, termed inducible renitence, was previously observed in murine macrophages stimulated with LPS, peptidoglycan, IFNγ, or TNFα, which suggested roles for renitence in macrophage resistance to infection by membrane‐damaging pathogens. This...
Preprint
Full-text available
Human norovirus (HNoV) is a global health and socio-economic burden, estimated to infect every individual at least five times during their lifetime. The underlying mechanism for the potential lack of long-term immune protection from HNoV infections is not understood and prompted us to investigate HNoV susceptibility of primary human B cells and its...
Article
Full-text available
A long-standing paradigm in virology was that non-enveloped viruses induce cell lysis to release progeny virions. However, emerging evidence indicates that some non-enveloped viruses exit cells without inducing cell lysis, while others engage both lytic and non-lytic egress mechanisms. Enteric viruses are transmitted via the faecal–oral route and a...
Article
Human astroviruses (HAstV) are non-enveloped, positive-sense single stranded RNA viruses that typically cause gastroenteritis in children, the elderly and among immunocompromised individuals. Some HAstV species have also been implicated in neurological diseases. It is important to study these viruses to understand the pathogenesis and develop th...
Article
Full-text available
Background: Schistosomiasis is the second major human parasitic disease next to malaria, in terms of socioeconomic and public health consequences, especially in sub-Saharan Africa. Schistosoma haematobium (S. haematobium) is a trematode and one of the species of Schistosoma that cause urogenital schistosomiasis (urinary schistosomiasis). Although...

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Projects

Projects (2)
Project
NOROVIRUS INFECTION AND SIGNALLING
Archived project
To detect Babesia infection in humans, cattle and dogs