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Introduction
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Publications
Publications (52)
Background
Throughout the evolution of the COVID‐19 pandemic, the severity of the disease has varied. The aim of this study was to determine how patients' comorbidities affected and were related to, different outcomes during this time.
Methods
Retrospective cohort study of all patients testing positive for SARS‐CoV‐2 infection between March 1, 202...
Logistic regression models are widely applied in daily practice. Hence, it is necessary to ensure they have an adequate predictive performance, which is usually estimated by means of the receiver operating characteristic (ROC) curve and the area under it (area under the curve [AUC]). Traditional estimators of these parameters are thought to be appl...
Purpose
To identify 5-year survival prognostic variables in patients with colorectal cancer (CRC) and to propose a survival prognostic score that also takes into account changes over time in the patient’s health-related quality of life (HRQoL) status.
Methods
Prospective observational cohort study of CRC patients. We collected data from their diag...
In complex survey data, each sampled observation has assigned a sampling weight, indicating the number of units that it represents in the population. Whether sampling weights should or not be considered in the estimation process of model parameters is a question that still continues to generate much discussion among researchers in different fields....
Objective:
We identify factors related to SARS-CoV-2 infection linked to hospitalization, ICU admission, and mortality and develop clinical prediction rules.
Methods:
Retrospective cohort study of 380,081 patients with SARS-CoV-2 infection from March 1, 2020 to January 9, 2022, including a subsample of 46,402 patients who attended Emergency Depa...
Despite the publication of great number of tools to aid decisions in COVID-19 patients, there is a lack of good instruments to predict clinical deterioration. COVID19-Osakidetza is a prospective cohort study recruiting COVID-19 patients. We collected information from baseline to discharge on: sociodemographic characteristics, comorbidities and asso...
Background. Factors related to an adverse evolution in COVID19 infection are needed for proper decision making. We try to identify factors related to hospitalization, ICU admission, and mortality related to the infection. Methods. Retrospective cohort study of patients with SARS-CoV-2 infection from March 1st 2020 to January 9th 2022. The sample wa...
The technological growth and progressive maturity of digital manufacturing ecosystems in industrial environments have improved the retrieval of information from many devices, hence laying a rich data substrate that allows for manifold possibilities around industrial data. Among them, information collected by sensors deployed over machines has bloss...
Background
Despite the publication of great number of tools to aid decisions in COVID-19 patients, there is a lack of good instruments to predict clinical deterioration.
Methods
COVID19-Osakidetza is a prospective cohort study recruiting COVID-19 patients. We collected information from baseline to discharge on: sociodemographic characteristics, co...
Background:
The aim of this study was to identify predictors of mortality in elderly patients undergoing colorectal cancer surgery and to develop a risk score.
Methods:
This was an observational prospective cohort study. Individuals over 80 years diagnosed with colorectal cancer and treated surgically were recruited in 18 hospitals in the Spanis...
Background:
The aim was to investigate the association of injuries with male football player continuity, progression and chances of reaching the First team in an elite academy.
Methods:
Injuries and exposure time were prospectively recorded, following the FIFA guidelines, over 6 seasons (2011-2017) in Under (U)12, U14, U16, U19, 2nd/3rd team and...
The high impact of the lymph node ratio as a prognostic factor is widely established in colorectal cancer, and is being used as a categorized predictor variable in several studies. However, the cut-off points as well as the number of categories considered differ considerably in the literature. Motivated by the need to obtain the best categorization...
Objective
Our aim was to assess the impact of comorbidities on existing COPD prognosis scores.
Patients and methods
A total of 543 patients with COPD (FEV1 <80% and FEV1/FVC <70%) were included between January 2003 and January 2004. Patients were stable for at least 6 weeks before inclusion and were followed for 5 years without any intervention by...
Background
The aim of this study was to assess factors associated with outcomes after surgery for colorectal cancer and to design and internally validate a simple score for predicting perioperative mortality.
Methods
Patients undergoing surgery for primary invasive colorectal cancer in 22 centres in Spain between June 2010 and December 2012 were i...
Background:
Chronic obstructive pulmonary disease (COPD) is a common chronic disease. Exacerbations of COPD (eCOPD) contribute to the worsening of the disease and the patient's evolution. There are some clinical prediction rules that may help to stratify patients with eCOPD by their risk of poor evolution or adverse events. The translation of thes...
BACKGROUND
Chronic obstructive pulmonary disease (COPD) is a common chronic disease. Exacerbations of COPD (eCOPD) contribute to the worsening of the disease and the patient’s evolution. There are some clinical prediction rules that may help to stratify patients with eCOPD by their risk of poor evolution or adverse events. The translation of these...
Objectives:
To validate the EAHFE-3D scale, based on the Acute Heart Failure in Emergency Departments registry, in a cohort of patients attended for acute heart failure.
Material and methods:
Study of a multipurpose cohort of patients with acute heart failure in 3 hospitals in the Basque Country between 2011 and 2013. We extracted age, baseline...
This paper consists of the reflections of the authors on their participation in a discussion at the young researchers roundtable organised as part of the 3rd Biostatnet General Meeting in Santiago de Compostela, in January 2017 with a focus on three current topics in Biostatistics and the points of views of early career researchers; reproducibility...
Purpose:
To investigate the association of candidate single nucleotide polymorphisms (SNPs) with non-contact hamstring muscle injuries in elite soccer players, and to create and validate a model to assess the risk of hamstring injury.
Methods:
107 elite male outfield players were prospectively followed for 6 seasons. Players were genotyped for 3...
The Cox proportional hazards model is themost widely used survival prediction model for analysing time-to-event data. To measure the discrimination ability of a survival model the concordance probability index is widely used. In this work we studied and compared the performance of two different estimators of the concordance probability when a conti...
Recent advances in information technologies are generating a growth in the amount of available biomedical data. In this paper, we studied the impact sample size may have on the categorisation of a continuous predictor variable in a logistic regression setting. Two different approaches to categorise predictor variables were compared.
Cellular and molecular mechanisms of toxicity of silver nanoparticles (NPs) and their toxicity to fish embryos after waterborne exposure have been widely investigated, but much less information is available regarding the effect of Ag NPs on physiological functions such as growth or reproduction. In this work, the effects of waterborne exposure of a...
The extensive use and release to the aquatic environment of silver nanoparticles (NPs) could lead to their incorporation into the food web. Brine shrimp larvae of 24 h showed low sensitivity to the exposure to PVP/PEI-coated Ag NPs (5 nm), with EC50 values at 24 h of 19.63 mg Ag L− 1, but they significantly accumulated silver after 24 h of exposure...
Rapid advances in digital technology alongside the drastic reduction in the cost of data generation is creating a huge amount of stored data. Within this context, the notion of Big Data opens up new analytical possibilities to investigate aspects of data resources such as variability, reliability
and complexity. In practical terms, this is revoluti...
The transport and yield of suspended sediment (SS) in catchments all over the world have long been topics of great interest. This paper addresses the scarcity of information on SS delivery and its environmental controls in small catchments, especially in the Atlantic region. Five steep catchments in Gipuzkoa (Basque Country) with areas between 56 a...
Prediction models are gaining importance in many areas such as medicine, meteorology, finance, toxicology, etc. In this context, a common distribution for the response variable is the binomial distribution and hence the logistic regression model is a commonly used regression modelling approach. Although it is not recommended from a statistical poin...
When developing prediction models for application in clinical practice, health practitioners usually categorise clinical variables that are continuous in nature. Although categorisation is not regarded as advisable from a statistical point of view, due to loss of information and power, it is a common practice in medical research. Consequently, prov...
Epidemiological evidence suggests an association between psychological factors and functional dyspepsia (FD). Yet few randomized controlled trials (RCTs) of psychological interventions have been conducted for FD. We conducted an RCT to evaluate the efficacy of psychotherapy among chronic FD.
One hundred fifty-eight consecutive patients with FD were...
Medikuntzan parametro kliniko asko kategorizatzen dira erabaki prozesuak errazteko. Areago arau aurresale klinikoen garapenean ohiko teknika bat da aldagaien kategorizazio hau. Aldagai aurresale bat kategorizatzerakoan kategoria kopurua aldagai aurresale eta erantzulearen arteko erlazioaren menpe dagoenez bi kategoria baino gehiagoren beharra azter...
Objectives: To develop and validate a simple scale for assessing the severity of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: Prospective study of a cohort of consecutive patients who came to the hospital emergency department with symptoms consistent with AECOPD. Clinical and sociodemographic data were recorded. Th...
Celebration of The International Year of Statistics was the main reason to organizing the meeting "Statistics in Research vs. Research in Statistics" at the University of the Basque Country UPV/EHU on 2013 October 9th. The goal was to meet statisticians and statistical users from other scientific areas and to discuss about the field. A main confere...
Limited information is available about predictors of short-term outcomes in patients with exacerbations of chronic obstructive pulmonary disease (eCOPD) attending an emergency department (ED). Such information could help stratify these patients and guide medical decision making. The aim of this study was to develop a clinical prediction rule for sh...
Partially covered self-expanding metal stents (SEMS), have been suggested as an alternative to surgery in the treatment of esophageal fistulas of benign etiology. Nevertheless, uncomplicated removal remains difficult. The use of fully covered (FC) SEMSs could solve this problem.
To review our experience with FC-SEMS placement in patients with benig...
OBJECTIVE: To identify factors predictive of hospital admission among patients attending an emergency department (ED) with exacerbation of chronic obstructive pulmonary disease (COPD) and to determine if these were consistent with Global Initiative for Chronic Obstructive Lung Disease
(GOLD) recommendations.DESIGN: In a prospective cohort of 2487 C...
Background
In medical practice many, essentially continuous, clinical parameters tend to be categorised by physicians for ease of decision-making. Indeed, categorisation is a common practice both in medical research and in the development of clinical prediction rules, particularly where the ensuing models are to be applied in daily clinical practic...
The IRYSS-COPD appropriateness study was developed in 16 hospitals belonging to the Spanish National Health Service from June 2008 to September 2010 (n = 2,877). The objectives were to apply a set of explicit criteria for the appropriateness of hospital admission created by the RAND/UCLA methodology to patients evaluated in the emergency department...
Predictive models allow populations to be stratified according to their health requirements for the following year. They offer health care organizations the opportunity to act proactively, designing specific interventions adapted to the level of need of different groups of people. The “Strategy for tackling the challenge of chronic illness in the B...
One of the few instruments to evaluate coping skills among patients with chronic illnesses is the Cuestionario de Afrontamiento al Estrés para Pacientes Oncológicos (CAEPO), created initially for cancer patients. We evaluate how well CAEPO applies to patients with non-cancer chronic illnesses. A total of 344 patients (115 with chronic hepatitis C,...
Background:
To date, factors that influence satisfaction with cataract surgery have not been broadly explored.
Objective:
To identify variables related to patient satisfaction after cataract extraction by phacoemulsification and to determine the relationship between satisfaction and visual acuity (VA) and visual function (VF).
Design:
Prospect...
We evaluated patient satisfaction with total hip replacement (THR) to establish cut points of sufficient improvement based on the patient acceptable symptom state (PASS) and receiver operating characteristic (ROC) curves, and compared them with measures derived from the minimum clinically important difference (MCID), taking into account patients' b...
Predictive models allow populations to be stratified according to their health requirements for the following year. They offer health care organizations the opportunity to act proactively, designing specific interventions adapted to the level of need of different groups of people. The "Strategy for tackling the challenge of chronic illness in the B...
Introducción: Las patologías crónicas suponen una amenaza creciente para la salud y calidad de vida de las personas. La Estrategia de Crónicos de Euskadi fue diseñada para transformar su modelo de provisión sanitaria, adecuándolo al nuevo contexto epidemiológico. Entre sus políticas plantea una asistencia estratificada y proactiva, adaptada a las n...
Patients with chronic obstructive pulmonary disease (COPD) often experience exacerbations of the disease that require hospitalization. Current guidelines offer little guidance for identifying patients whose clinical situation is appropriate for admission to the hospital, and properly developed and validated severity scores for COPD exacerbations ar...
Introduction
Falls with hip or wrist fractures in elderly people are common situations. The goal of this study was to determine the joint function and which clinical and social factors predict change after those fractures, measured by the short-WOMAC or QuickDASH questionnaires.
Methods Patients older than 65 years who attended the emergency room...
