Iraida Stepanovna Sidorova

• MD
• Professor at Sechenov University

Objective. To study the molecular mechanisms of fetal growth restriction and preeclampsia de-velopment based on a comparative analysis of the placental microRNA expression profile. Materials and methods. The study included 60 patients: Group 1 included 20 pregnant women with preeclampsia (PE) (main group), Group 2 (comparison group) included 20 pre...

Analysis of literature sources dealing with the problems of metabolism and mechanisms of estrogen effects. Specific features of combined oral contraceptives containing ethinyl estradiol and estradiol valerate as an estrogen component are described. As is pointed out, low doses of ethinyl estradiol in combination with new progestogens have reduced t...

This publication examines the existing risks of obstetric complications and other reproductive disorders in women with gynecological diseases. The paper also discusses the issues of the pre-school training of women with gynecological diseases, with special emphasis on the use of dipyridamole, due to its pleiotropic action.

This publication is devoted to the most common problem in women of reproductive age - dysmenorrhea. Unfortunately, the underestimation of the importance of dysmenorrhea often occurs on the part of both patients and doctors. Meanwhile, dysmenorrhea causes not only a decrease in the quality of life, but also a number of serious disorders, including t...

The article is devoted to the subject of topical interest to women of reproductive age. Affecting not only the health of women, but also various aspects of their life, dysmenorrhea is a medical and social problem. The use of nonsteroidal anti-inflammatory agents in this condition is an effective means of pathogenetic therapy that significantly impr...

The aim of the study is to identify the most significant clinical and anamnestic risk factors for the onset and progression of endometrial hyperplastic processes and the development of malignant transformation of endometrium in women of perimenopausal age, with taking into account their importance on the basis of statistical analysis. Methods. Base...

Morphofunctional state of the endometrium is one of the key factors determining both the successful implantation and full development of the embryo, including in cycles of «in vitro fertilization» (IVF). The most common cause of the impairment of the structure and function of the endometrium being chronic endometritis (CE), the frequency of its det...

The article focuses on the identification of causal relationships between dysmenorrhea, endometrioid and tumor processes. Studies have shown that dysmenorrhea, apart from a decline in the quality of life, can be the cause of development of a number of serious health disturbances, including endometriosis, adenomyosis and even tumoral diseases. Non-s...

Objective. To develop and substantiate a predictive system for the management of pregnant women with risk factors of preeclampsia. Subjects and methods. A prospective cohort study was conducted in 150 pregnant women at risk for preeclampsia. Of them, there were 42 patients who subsequently developed preeclampsia (18 had early preeclampsia, 24 had l...

In article various ways of increase of efficiency of treatment of is mixed the bacterial-virus infection of the bottom department of sexual ways at women by means of application in complex therapy of homologous bacteriophages, pectovit, antiviral -immunomodulation therapies and sated with oxygen (oxygenic) water solutions of antiseptic tanks are co...

In ankle various ways of increase of efficiency of treatment of is mixed the bacterial-virus infection of the bottom department of sexual ways at women by means of application in complex therapy of homologous bacteriophages, pectovit, antiviral -immunomodulation therapies and sated with oxygen (oxygenic) water solutions of antiseptic tanks are cons...

Aim of investigation is establishment of the lipid peroxidation (LPO) and antioxidant protection system (AOPS) of blood value use possibility for assessment of the chronic placental insufficiency (ChPI) development risk, a degree of its gravity and a control of the conducted treatment. Materials and Methods. 140 females in the pregnancy dates of 2...

The purpose of the study was to reveal clinical and morphological parallels and to define molecular mechanisms, the regulation of proliferation, apoptosis, neoangiogenesis, and the extent of abnormal tissue in adenomyosis (AM). The surgical material obtained from 492 patients of late reproductive age was examined. The data of clinicoanamnestic and...

VEGF expression was immunohistochemically studied in 35 placental fragments and 15 placental bed biopsy specimens in a control group and in 34 placental fragments and 16 biopsy specimens in women with preeclampsia. The female serum concentrations of VEGF and sFlt-1 were measured in both groups. There was a drastic reduction in VEGF expression in th...

Various virus serotypes were found in 35.3% of cases and their detection rate frequency reducing with age. They were detectable in 35.3 -52.9% of cases of atypical glandular hyperplasia, highly and moderately differentiated adenocarcinoma of the endometrium and only in 17.6% of cases of poorly differentiated adenocarcinomas. Serotypes 58 and 51 wer...

Immune inflammation is a typical pathophysiological process caused by exogenous and endogenous factors. Fibrinoid necrosis and cell infiltrations are the morphological features of tissue lesion caused by immune inflammation. Tissue lesion in immune inflammation may be connected with immune complex (IC) formation or T-cell aggression. Lesion caused...

75 cases of simple, cellular and mitotically active leiomyoma (LM) were studied immunohistochemically with the use of monoclonal antibodies against bcl-2 ("DAKO", 1:80), bax ("Calbiochem, 1:80), c-myc ("Novocastra", 1:100), CD 95 ("Dianova, 1:50), Ki67 ("Dianova", 1:40), PCNA ("Novacastra", 1:100). Apoptosis was assessed by the Tunnel method (ENZO...

Ordinary and cellular leiomyomas of 147 patients (age 23 - 65 years) were studied histologically and immunomorphologically. Five females with rapidly growing tumors were operated after therapy with gonadotropines blockers. Variants with weak and pronounced proliferative activity of neoplastic myocytes and various activity of neoangiogenesis were di...

Etiology, pathogenesis of intrauterine infection of the fetus, factors promoting such infection and the status of the local immune system are elucidated in the paper. A changed reactivity of the immune homeostasis of a pregnant woman with a chronic infection was shown to be potentially an important factor of pathogenesis of defects in her baby. The...

To estimate platelet and endothelial condition in pregnant women with chronic glomerulonephritis (CGN), prognostic value of these changes and efficacy of acetylsalicylic acid (ASA) and dipiridamol in prevention of unfavourable outcomes of pregnancy in CGN. The examination covered 74 CGN pregnant patients, 14 non-pregnant CGN patients, 11 pregnant w...

The role of the infection component in etiopathogenesis of dysphasia and cervical carcinoma as well as optimization of their diagnosis and treatment schemes are discussed in the paper. On the basis of published data and authors' independent examinations, a tense relationship between the presence of dysphasia and cervical carcinoma, on the one hand,...

65 pregnant women with the exacerbation of chronic pyelonephritis in the III trimester of gestation and 34 healthy pregnant women were examined. The quantitative content of immunoglobulins, the activity of interferon in cervico = vaginal washings and the composition of the vaginal microflora were determined. All patients with the relapse of chronic...

To study gestational changes in renal and uterine hemodynamics and their relation to systemic and intracardiac hemodynamics in pregnant hypertensive women with chronic glomerulonephritis (CGN). Echocardiography, ultrasonic dopplerography of renal and uterine arteries were made in 16 pregnant women with CGN and AH syndrome in trimester II-III and 1-...

Aim. To study gestational changes in renal and uterine hemodynamics and their relation to systemic and intracardiac hemodynamics in pregnant hypertensive women with chronic glomerulonephritis (CGN). Material and methods. Echocardiography, ultrasonic dopplerography of renal and uterine arteries there made in 16 pregnant women with CGN and All syndro...

To study gestational alterations of renal and uterine hemodynamics, their relationships with systemic and intracardiac hemodynamics in pregnant women (PW) with essential hypertension (EH). Echocardiography, ultrasound dopplerography of renal and uterine arteries, roll-over test were made in the course of trimester II-III and 3 months after the deli...

Results of the right uterine artery dopplerometry at pregnancy 39-39 weeks and those of subsequent histotopographic and immunomorphologic study of the placental bed in the amputated uteri were compared in 50 pregnant women. Morphofunctional equivalent of a considerable reduction of the uterine-placental circulation depending on the myomatous tissue...

To assess platelet changes in pregnant women with chronic glomerulonephritis (CGN) and essential hypertension (EH) we estimated platelet lactic dehydrogenase activity (LDH), beta-thromboglobulin and thromboxane B2 (TxB2) plasma levels and ADP-stimulated platelet aggregability. Five groups of gravidae (26-40 weeks of gestation) were studied: with EH...

To assess platelet changes in pregnant women with chronic glomerulonephritis (CGN) and essential hypertension (EH) we esti mated platelet lactic dehydrogenase activity (LDH), β-thromboglobulin and thromboxane B 2 (TxB 2) plasma levels and ADP-stimulated platelet aggregability Five groups of gravidae (26-40 weeks of gestation) were studied: with EH...

Prepidil gel developed by Upjohn company containing 0.5 mg of dinoprostone (prostaglandin E2) was endocervically administered in dose 2.5 ml to 30 pregnant women at a high risk of perinatal diseases to prepare the cervix uteri to labor. Cardiotocography, ultrasonic scanning, dopplerometry were used in the course of studies. Status of the cervix ute...

48 females with uterine endometriosis stage 1 and 2, 26 female with mild and moderate external endometriosis and 9 females with external in combination with internal endometriosis with the disease duration from 6 months to 10 years were given danazol in doses 200-400 mg/day for 6 months. The effect of the treatment proved to be very high: 37 patien...

Time course of 187 pregnancies was followed up in 103 females with chronic renal diseases (CRD), 76 females with essential hypertension (EH) and 14 posteclampsia females. Three variants of arterial pressure (AP) and 5 types of proteinuria changes were recognized in CRD and EH patients. The pattern of these changes was compared to that in posteclamp...

Red cell surface architectonics and ultrastructure were studied in pregnant women, their fetuses, and newborns in normal and complicated pregnancy. The results were correlated to dopplerometric blood stream parameters of uterine artery and fetal umbilical artery. The most grave changes in red cell structure were detected in women with medium-severe...

Pregnancy complications have been analyzed in 124 females suffering from essential hypertension (EH) and chronic glomerulonephritis (CGN). Such complications, as late gestosis (8.9%), ablation placentae (1.6%), premature delivery (14.5%), intrauterine growth retardation (14.5%) occurred more frequently than in population. Pre- and perinatal deaths...

A controlled clinical trial included 64 pregnant females suffering from chronic glomerulonephritis (CGN) and hypertension: 31 patients received acetylsalicylic acid (ASA) in a dose 125 mg/day and curantyl (150-225 mg/day) from gestation week 12-19 till delivery, 33 control females were not given the drugs. Prenatal care and labour management were s...

Biophysical profile of the fetus (BPF) was determined with the use of ultrasonic scanning and cardiotocography in 21 pregnant women with the pelvic presentation of the fetus and 32 patients with gestosis. Uteroplacental and fetoplacental circulation were also under study. The results of studies were analyzed together with the data on the labor outc...

Ultrasonic Doppler scanning was used to study the fetoplacental blood flow before labor, at the height of pang (uterine contraction), and 5-15 seconds following it. 53 parturients were examined during the active phase of labor. They were divided into two groups with different blood flow parameters. The findings evidence a deterioration of umbilical...

Fluorescent microscopic examination of 20 placental samples from women in whom pregnancy ran a normal course and from those who suffered from gestosis was carried out to study lipofuscin accumulation in the placenta. Lipofuscin accumulation in the placenta was found to be a normal process, reflecting activation of lipid peroxidation. Placental lipo...

As many as 56 patients with uterine myoma underwent conservative myomectomy. In 40 patients (group I), it was performed by laparotomy and in 16 (group II) ++trans-cervically under the control of hysteroscopy. The group I patients' age amounted on the average to 33.2 +/- 0.6 years, in group II, it was 46.3 +/- 0.8 years. Before operation the size of...

Single-erythrocyte hemoglobin values have been obtained in 55 women with normal and gestosis-complicated pregnancies, and total hemoglobin and hematocrit have been followed up in the third trimester in 49 of them. It was found out that gestosis reduced hemoglobin levels and caused erythrocyte redistribution toward a higher proportion of "light" cel...

The features of histories, course of pregnancy and delivery were analyzed in 65 females with hypotonic bleeding developed during cesarean section. The bleeding resulted in uterine extirpation. The factors that predisposed to the abnormality were revealed. Morphological examination of uterine specimens demonstrated that in 95% hypotonic bleedings ha...

Electrical response of electro-active points (EAP) in reflexogenic areas of body surface that are communicated with the uterus was examined in 146 patients, admitted to hospital for surgical treatment of benign or malignant genital tumors. Thirty normal females were taken as controls. Specific time needed for EAP potential to become close to consta...

Antimicrobial polymer films were used at cesarean section in 81 patients. The method is described, and the results are reported. Pharmacokinetic and microbiologic studies, and the immediate assessment of postoperative uterine contractility as well as late assessment of the uterine scar have demonstrated that polymer materials, used in patients at h...

An experimental study in 20 pregnant female rabbits was carried out in order to evaluate possible use of biocompatible connective elements and cyanacrylate glue MK-7M for fixing and sealing the uterine scar at cesarean section. Morphologic changes in the surgical area within three postoperative months have been demonstrated. Combined use of biocomp...

Obstetric bleeding continues to be one of the most severe complications of pregnancy and childbirth. According to the statistical data of obstetric institutions of the USSR and foreign countries, the frequency of hypotensive bleeding has tended to increase in recent years. Over the past decades, they inevitably occupy one of the first places among...

It was found during the study of pharmacokinetics of gentamycin and cephamesine being constituents of antimicrobial conjunctive elements for the internal organs that in the process of diffusion of the antibiotics from the polymer film gentamycin level in the organism increased by the 1st day of observation and cephamesine level by the 3rd day. Ther...