Ioannis Androulakis

Erasmus MC | Erasmus MC · Department of Radiotherapy

OBJECTIVE In High Dose Rate Brachytherapy for prostate cancer there is a need for a new way of increasing cancer cell kill in combination with a stable dose to the organs at risk. In this study, we propose a novel ThermoBrachy applicator that offers the unique ability to apply interstitial hyperthermia while simultaneously serving as an afterloadi...

The combination of interstitial hyperthermia treatment (IHT) with high dose rate brachytherapy (HDR-BT) can improve clinical outcomes since it highly enhances the efficiency of cell kill, especially when applied simultaneously. Therefore, we have developed the ThermoBrachy applicators. To effectively apply optimal targeted IHT, treatment planning i...

In high-dose-rate brachytherapy (HDR-BT) for prostate cancer treatment, interstitial hyperthermia (IHT) is applied to sensitize the tumor to the radiation (RT) dose, aiming at a more efficient treatment. Simultaneous application of HDR-BT and IHT is anticipated to provide maximum radiosensitization of the tumor. With this rationale, the ThermoBrach...

The evaluation of the biological effects of therapeutic hyperthermia in oncology and the precise quantification of thermal dose, when heating is coupled with radiotherapy or chemotherapy, are active fields of research. The reliable measurement of hyperthermia effects on cells and tissues requires a strong control of the delivered power and of the i...

Objective The addition of hyperthermia in the treatment of intact breast cancer with the aim to improve local response is currently in a research phase. First, optimal hyperthermia devices need to be developed, for which a diverse, anatomically and pathologically accurate set of patient models is necessary. Methods To investigate the effects of in...

Background and Objective Magnetic hyperthermia is an oncological therapy that employs magnetic nanoparticles activated by alternating current (AC) magnetic fields with frequencies between 50 kHz and 1 MHz, to release heat in a diseased tissue and produce a local temperature increase of about 5 °C. To assess the treatment efficacy, in vivo tests on...

The combination of interstitial hyperthermia treatment (IHT) with high dose rate brachytherapy (HDR-BT) for prostate cancer treatment and has the potential to improve clinical outcome, since it highly enhances the efficiency of cell kill, especially when applied simultaneously. Therefore, we have developed the ThermoBrachy applicators. To effective...

Cardiac computed tomography (CT) is a valuable tool for functional mechanical heart valve (MHV) assessment. An important aspect of bileaflet MHV assessment is evaluation and measurement of leaflet opening and closing angles. Performed manually however, it is a laborious and time consuming task. In this paper, we propose an automated approach for bi...

Introduction Computed tomography angiography (CTA) is a valuable tool for functional prosthetic heart valve (PHV) assessment. An important aspect of PHV assessment is evaluation of leaflet motion and measurement of leaflet opening and closing angles. Performed manually this is however a laborious and time consuming task. We developed a semiautomati...

Objective: The purpose of this study was to investigate the effect of heart rate on the coronary artery calcium (CAC) score estimate provided by a modern 64-slice multi-slice CT system. Methods and Materials: Cylindrical calcified lesion phantoms of varying size and calcium concentration were constructed to mimic atheromatic plaques occurring in a...

This thesis, after an extended analysis of the theory and the recent advances of medical image registration and fusion, investigates the output quality of a voxel based rigid registration algorithm that is being used in commercial radiotherapy treatment planning systems, when it is applied on monomodal intersubject CT images. This is being done by...